PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17922191-8 2007 MMC treatment resulted in higher caspase-8 enzymatic activity and apoptosis and could be synergistically enhanced by co-stimulation with interferon-alpha (IFNalpha) via independent transcriptional mechanisms. Mitomycin 0-3 interferon alpha 1 Homo sapiens 155-163 17652735-12 2007 Caspase-8, caspase-3, and broad caspase inhibitors, but not caspase-9 inhibitor, inhibited MMC-induced cell death in nonpretreated and IFN-pretreated cells. Mitomycin 91-94 interferon alpha 1 Homo sapiens 135-138 17652735-1 2007 PURPOSE: To investigate the effect of interferon (IFN)-alpha and IFN-gamma pretreatment on mitomycin C (MMC)-induced cell death in human Tenon fibroblasts (HTFs) and the mechanisms by which IFN-alpha and IFN-gamma modulate the susceptibility of HTFs to MMC. Mitomycin 91-102 interferon alpha 1 Homo sapiens 38-60 17652735-13 2007 CONCLUSIONS: IFN-alpha and IFN-gamma enhance the susceptibility of HTFs to MMC-induced cell death through a Fas-mediated and a caspase-3-dependent pathway. Mitomycin 75-78 interferon alpha 1 Homo sapiens 13-22 17652735-14 2007 Pretreatment with IFN primed HTFs to MMC, providing a potential means for initially slowing the healing response with IFN and subsequently terminating fibroblast activity through MMC-induced cell death. Mitomycin 37-40 interferon alpha 1 Homo sapiens 18-21 17652735-14 2007 Pretreatment with IFN primed HTFs to MMC, providing a potential means for initially slowing the healing response with IFN and subsequently terminating fibroblast activity through MMC-induced cell death. Mitomycin 37-40 interferon alpha 1 Homo sapiens 118-121 1346369-8 1992 The suppressive effects of IFN-alpha were overcome by addition of immobilized anti-CD3-preactivated T cells that had been treated with mitomycin C, but not by the addition of fresh T cells or soluble factors produced by activated T cells. Mitomycin 135-146 interferon alpha 1 Homo sapiens 27-36 2444657-4 1987 However, the effect of IFN in the presence of ADM or MMC was additive. Mitomycin 53-56 interferon alpha 1 Homo sapiens 23-26 7152202-4 1982 In combinations of Hu IFN-alpha with anticancer agents such as bleomycin, mitomycin C, and cytosine arabinoside in certain concentration ranges, antagonism was noticed when Hu IFN-alpha and anticancer agents were added simultaneously to the cell culture. Mitomycin 74-85 interferon alpha 1 Homo sapiens 22-31 7152202-4 1982 In combinations of Hu IFN-alpha with anticancer agents such as bleomycin, mitomycin C, and cytosine arabinoside in certain concentration ranges, antagonism was noticed when Hu IFN-alpha and anticancer agents were added simultaneously to the cell culture. Mitomycin 74-85 interferon alpha 1 Homo sapiens 176-185