PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18954562-8 2008 Production of cytokines (IFN-gamma, TNF-alpha and IL-2) in serum and cytotoxic T lymphocyte (CTL) activity of splenocytes from mice immunized with mitomycin C (MMC)-treated MFC/4-1BBL cells were significantly higher than that from mice immunized with MMC-treated parental MFC and MFC/pMKITneo cells. Mitomycin 147-158 interleukin 2 Mus musculus 50-54 11904059-6 1998 Mitomycin-C treated macrophages from traumatized mice could obviously suppress T lymphocyte transformation, IL-2 mRNA and IL-2Ralpha mRNA levels, IL-2 production, IL-2Ralpha expression, IL-2 mediated lymphocyte proliferation response of normal T cells, could not affect IL-2-IL-2R interaction but elevated suppressive action of Ts cells. Mitomycin 0-11 interleukin 2 Mus musculus 108-112 11904059-6 1998 Mitomycin-C treated macrophages from traumatized mice could obviously suppress T lymphocyte transformation, IL-2 mRNA and IL-2Ralpha mRNA levels, IL-2 production, IL-2Ralpha expression, IL-2 mediated lymphocyte proliferation response of normal T cells, could not affect IL-2-IL-2R interaction but elevated suppressive action of Ts cells. Mitomycin 0-11 interleukin 2 Mus musculus 122-126 11904059-6 1998 Mitomycin-C treated macrophages from traumatized mice could obviously suppress T lymphocyte transformation, IL-2 mRNA and IL-2Ralpha mRNA levels, IL-2 production, IL-2Ralpha expression, IL-2 mediated lymphocyte proliferation response of normal T cells, could not affect IL-2-IL-2R interaction but elevated suppressive action of Ts cells. Mitomycin 0-11 interleukin 2 Mus musculus 122-126 11904059-6 1998 Mitomycin-C treated macrophages from traumatized mice could obviously suppress T lymphocyte transformation, IL-2 mRNA and IL-2Ralpha mRNA levels, IL-2 production, IL-2Ralpha expression, IL-2 mediated lymphocyte proliferation response of normal T cells, could not affect IL-2-IL-2R interaction but elevated suppressive action of Ts cells. Mitomycin 0-11 interleukin 2 Mus musculus 122-126 14619517-2 2003 In the presence of IL-2, a remarkable proliferation of NK cells was observed when PBMC were co-cultured with MMC-treated K562, which is known as a highly sensitive in vitro target cell for the NK assay. Mitomycin 109-112 interleukin 2 Mus musculus 19-23 8933166-0 1996 The antitumor effect induced by local injections with interleukin-2 is diminished by combing with a local injection with mitomycin C. Mitomycin 121-132 interleukin 2 Mus musculus 54-67 8933166-9 1996 We further investigated a modulatory effect of a local injection with MMC on the IL-2-induced antitumor effect. Mitomycin 70-73 interleukin 2 Mus musculus 81-85 8933166-11 1996 Moreover, a delayed-type hypersensitivity response against Meth A, which was augmented by the local injections with IL-2, was significantly diminished by the local administration of MMC. Mitomycin 182-185 interleukin 2 Mus musculus 116-120 8933166-12 1996 Collectively, our results indicate that local injections with IL-2 could elicit the antitumor effect in vivo only when given at an optimal dose and that this effect could be rather diminished by combing with a local administration of MMC. Mitomycin 234-237 interleukin 2 Mus musculus 62-66 6180008-4 1982 This was confirmed by the demonstration that mitomycin C inhibition of IFN gamma production was reversed by IL 2 or AVP without concomitant reversal of blockage of DNA synthesis. Mitomycin 45-56 interleukin 2 Mus musculus 108-112 2497980-4 1989 The enhancement of NK cell activity and production of IL-2 were partially inhibited by the pretreatment of spleen cells with mitomycin C or irradiation, and were completely abolished by pretreatment with actinomycin D. Mitomycin 125-136 interleukin 2 Mus musculus 54-58 2556638-6 1989 Natural killer levels in mouse spleen cells treated with mitomycin C could be significantly augmented by IL-2. Mitomycin 57-68 interleukin 2 Mus musculus 105-109 2556638-7 1989 Moreover, the effector cells generated in control as well as mitomycin-C-treated spleen cells in response to IL-2 had the same low buoyant densities. Mitomycin 61-72 interleukin 2 Mus musculus 109-113 6208997-7 1984 Moreover, culture supernatants of ISL with or without mitomycin C-treated P815Ys contain helper factor, interferon, and interleukin 2, which enhanced the in vitro generation of cell-mediated cytotoxicity against P815Ys. Mitomycin 54-65 interleukin 2 Mus musculus 74-133 6088584-11 1984 The cytotoxic response was also quantitated in splenocytes from control and Multi-Strep mice (10 d after the first dose of SZ) before and after culture with mitomycin-treated RIN cells in the presence of T cell growth factor (TCGF). Mitomycin 157-166 interleukin 2 Mus musculus 204-224 6088584-11 1984 The cytotoxic response was also quantitated in splenocytes from control and Multi-Strep mice (10 d after the first dose of SZ) before and after culture with mitomycin-treated RIN cells in the presence of T cell growth factor (TCGF). Mitomycin 157-166 interleukin 2 Mus musculus 226-230 8514611-3 1993 Addition of mitomycin C-treated accessory cells to the culture inhibited IL-2 production and resulted in augmented and persistent growth inhibition. Mitomycin 12-23 interleukin 2 Mus musculus 73-77 2676272-5 1989 Splenic T cells from NOD mice responded with IL-2 production and proliferation when both islet cell antigens from NOD mice and mitomycin C-treated spleen cells (source of antigen-presenting cells) from NOD mice or major histocompatibility complex (MHC)-compatible ILI mice were present. Mitomycin 127-138 interleukin 2 Mus musculus 45-49 3495334-0 1987 Synergistic effect of recombinant interleukin-2 on the inhibition of growth of adenocarcinoma 755 by mitomycin. Mitomycin 101-110 interleukin 2 Mus musculus 34-47