PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29784813-3 2018 Here we show the kinetics of the Rag GTPase cycle during leucine signaling and that LRS serves as an initiating "ON" switch via GTP hydrolysis of RagD that drives the entire Rag GTPase cycle, whereas Sestrin2 functions as an "OFF" switch by controlling GTP hydrolysis of RagB in the Rag GTPase-mTORC1 axis. Guanosine Triphosphate 128-131 leucyl-tRNA synthetase 1 Homo sapiens 84-87