PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9620547-3	1998	We found that binding of PtdIns4,5P2 to 6-his-tagged recombinant mSOS in vitro inhibits the ability of SOS to catalyze the association of GTP on p21RAS.	Guanosine Triphosphate	138-141	xylosyltransferase 2	Homo sapiens	66-69	
16323045-3	2005	More recently, a new crystal structure of SOS has been determined in which this protein binds to two molecules of ras-p21, one unbound to GTP and one bound to GTP.	Guanosine Triphosphate	138-141	xylosyltransferase 2	Homo sapiens	42-45	
16323045-3	2005	More recently, a new crystal structure of SOS has been determined in which this protein binds to two molecules of ras-p21, one unbound to GTP and one bound to GTP.	Guanosine Triphosphate	159-162	xylosyltransferase 2	Homo sapiens	42-45	
11566491-3	2001	Ras activation (GTP binding) is induced by the GTP exchange factor Sos and its inactivation is regulated through the GAPs (p120GAP and neurofibromin).	Guanosine Triphosphate	16-19	xylosyltransferase 2	Homo sapiens	67-70	
10734312-2	2000	Shc is believed to be regulated by a change in subcellular localization from the cytosol to the plasma membrane, where it recruits Grb-2/Sos complexes and hence permits juxtaposition of the guanine nucleotide exchange factor Sos to Ras, resulting in GDP/GTP exchange and Ras activation.	Guanosine Triphosphate	254-257	xylosyltransferase 2	Homo sapiens	225-228	
9620547-6	1998	In addition, the inhibition of Ras GTP-binding is not blocked by excess free inositols suggesting that SOS binds to PtdIns4,5P2 with higher affinity than it binds to free inositols.	Guanosine Triphosphate	35-38	xylosyltransferase 2	Homo sapiens	103-106	
7592690-1	1995	Insulin and epidermal growth factor receptors transmit signals for cell proliferation and gene regulation through formation of active GTP-bound p21ras mediated by the guanine nucleotide exchange factor Sos.	Guanosine Triphosphate	134-137	xylosyltransferase 2	Homo sapiens	202-205	
8909796-2	1996	GTPase activating proteins (p120GAP, neurofibromin and GAP1) are negative regulators that stimulate hydrolysis of bound GTP to GDP, and guanine nucleotide exchange factors (Sos and Ras-GRF) are positive regulators that stimulate the exchange of GDP bound to Ras for fresh GTP from the cytosol.	Guanosine Triphosphate	0-3	xylosyltransferase 2	Homo sapiens	173-176	
7673108-1	1995	Activation of Ras by the exchange of bound GDP for GTP is predominantly catalyzed by the guanylnucleotide exchange factor SOS.	Guanosine Triphosphate	51-54	xylosyltransferase 2	Homo sapiens	122-125	
27412770-1	2016	The cycling between GDP- and GTP- bound forms of the Ras protein is partly regulated by the binding of Sos.	Guanosine Triphosphate	29-32	xylosyltransferase 2	Homo sapiens	103-106	
27412770-6	2016	The weak transient interaction between Sos and the second H-Ras GTPgammaS may provide a necessary mechanism for complex dissociation upon the completion of the native GDP   GTP exchange reaction, but also explains measurable GTP   GTP exchange activity of Sos routinely observed in in vitro assays that use fluorescently-labelled analogs of GTP.	Guanosine Triphosphate	64-67	xylosyltransferase 2	Homo sapiens	39-42	
27412770-6	2016	The weak transient interaction between Sos and the second H-Ras GTPgammaS may provide a necessary mechanism for complex dissociation upon the completion of the native GDP   GTP exchange reaction, but also explains measurable GTP   GTP exchange activity of Sos routinely observed in in vitro assays that use fluorescently-labelled analogs of GTP.	Guanosine Triphosphate	64-67	xylosyltransferase 2	Homo sapiens	256-259	
27412770-6	2016	The weak transient interaction between Sos and the second H-Ras GTPgammaS may provide a necessary mechanism for complex dissociation upon the completion of the native GDP   GTP exchange reaction, but also explains measurable GTP   GTP exchange activity of Sos routinely observed in in vitro assays that use fluorescently-labelled analogs of GTP.	Guanosine Triphosphate	173-176	xylosyltransferase 2	Homo sapiens	39-42	
27412770-6	2016	The weak transient interaction between Sos and the second H-Ras GTPgammaS may provide a necessary mechanism for complex dissociation upon the completion of the native GDP   GTP exchange reaction, but also explains measurable GTP   GTP exchange activity of Sos routinely observed in in vitro assays that use fluorescently-labelled analogs of GTP.	Guanosine Triphosphate	173-176	xylosyltransferase 2	Homo sapiens	256-259