PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9620547-3 1998 We found that binding of PtdIns4,5P2 to 6-his-tagged recombinant mSOS in vitro inhibits the ability of SOS to catalyze the association of GTP on p21RAS. Guanosine Triphosphate 138-141 xylosyltransferase 2 Homo sapiens 66-69 16323045-3 2005 More recently, a new crystal structure of SOS has been determined in which this protein binds to two molecules of ras-p21, one unbound to GTP and one bound to GTP. Guanosine Triphosphate 138-141 xylosyltransferase 2 Homo sapiens 42-45 16323045-3 2005 More recently, a new crystal structure of SOS has been determined in which this protein binds to two molecules of ras-p21, one unbound to GTP and one bound to GTP. Guanosine Triphosphate 159-162 xylosyltransferase 2 Homo sapiens 42-45 11566491-3 2001 Ras activation (GTP binding) is induced by the GTP exchange factor Sos and its inactivation is regulated through the GAPs (p120GAP and neurofibromin). Guanosine Triphosphate 16-19 xylosyltransferase 2 Homo sapiens 67-70 10734312-2 2000 Shc is believed to be regulated by a change in subcellular localization from the cytosol to the plasma membrane, where it recruits Grb-2/Sos complexes and hence permits juxtaposition of the guanine nucleotide exchange factor Sos to Ras, resulting in GDP/GTP exchange and Ras activation. Guanosine Triphosphate 254-257 xylosyltransferase 2 Homo sapiens 225-228 9620547-6 1998 In addition, the inhibition of Ras GTP-binding is not blocked by excess free inositols suggesting that SOS binds to PtdIns4,5P2 with higher affinity than it binds to free inositols. Guanosine Triphosphate 35-38 xylosyltransferase 2 Homo sapiens 103-106 7592690-1 1995 Insulin and epidermal growth factor receptors transmit signals for cell proliferation and gene regulation through formation of active GTP-bound p21ras mediated by the guanine nucleotide exchange factor Sos. Guanosine Triphosphate 134-137 xylosyltransferase 2 Homo sapiens 202-205 8909796-2 1996 GTPase activating proteins (p120GAP, neurofibromin and GAP1) are negative regulators that stimulate hydrolysis of bound GTP to GDP, and guanine nucleotide exchange factors (Sos and Ras-GRF) are positive regulators that stimulate the exchange of GDP bound to Ras for fresh GTP from the cytosol. Guanosine Triphosphate 0-3 xylosyltransferase 2 Homo sapiens 173-176 7673108-1 1995 Activation of Ras by the exchange of bound GDP for GTP is predominantly catalyzed by the guanylnucleotide exchange factor SOS. Guanosine Triphosphate 51-54 xylosyltransferase 2 Homo sapiens 122-125 27412770-1 2016 The cycling between GDP- and GTP- bound forms of the Ras protein is partly regulated by the binding of Sos. Guanosine Triphosphate 29-32 xylosyltransferase 2 Homo sapiens 103-106 27412770-6 2016 The weak transient interaction between Sos and the second H-Ras GTPgammaS may provide a necessary mechanism for complex dissociation upon the completion of the native GDP GTP exchange reaction, but also explains measurable GTP GTP exchange activity of Sos routinely observed in in vitro assays that use fluorescently-labelled analogs of GTP. Guanosine Triphosphate 64-67 xylosyltransferase 2 Homo sapiens 39-42 27412770-6 2016 The weak transient interaction between Sos and the second H-Ras GTPgammaS may provide a necessary mechanism for complex dissociation upon the completion of the native GDP GTP exchange reaction, but also explains measurable GTP GTP exchange activity of Sos routinely observed in in vitro assays that use fluorescently-labelled analogs of GTP. Guanosine Triphosphate 64-67 xylosyltransferase 2 Homo sapiens 256-259 27412770-6 2016 The weak transient interaction between Sos and the second H-Ras GTPgammaS may provide a necessary mechanism for complex dissociation upon the completion of the native GDP GTP exchange reaction, but also explains measurable GTP GTP exchange activity of Sos routinely observed in in vitro assays that use fluorescently-labelled analogs of GTP. Guanosine Triphosphate 173-176 xylosyltransferase 2 Homo sapiens 39-42 27412770-6 2016 The weak transient interaction between Sos and the second H-Ras GTPgammaS may provide a necessary mechanism for complex dissociation upon the completion of the native GDP GTP exchange reaction, but also explains measurable GTP GTP exchange activity of Sos routinely observed in in vitro assays that use fluorescently-labelled analogs of GTP. Guanosine Triphosphate 173-176 xylosyltransferase 2 Homo sapiens 256-259