PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1328204-1 1992 We have previously shown that the beta-adrenergic receptor (beta-AR) stimulates activity of the ubiquitous Na-H exchanger (NHE-1) independently of changes in cAMP accumulation and independently of a cholera toxin-sensitive stimulatory GTP-binding protein (Gs). Guanosine Triphosphate 235-238 solute carrier family 9 member A1 Canis lupus familiaris 123-128 1328204-2 1992 To further investigate the potential role of a GTP-binding protein in coupling the beta-AR to NHE-1, we have used a recently available nonhydrolyzable GTP analog, "caged" guanosine 5"-O-(3-thiotriphosphate) (GTP gamma S), to study time-dependent effects of GTP on NHE-1 in intact cells. Guanosine Triphosphate 47-50 solute carrier family 9 member A1 Canis lupus familiaris 94-99 1328204-7 1992 GTP gamma S, but not NaF, also increased beta-adrenergic stimulation of resting NHE-1 activity. Guanosine Triphosphate 0-3 solute carrier family 9 member A1 Canis lupus familiaris 80-85