PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15317909-3 2004 Some of these single transmembrane receptors have an intrinsic guanylyl cyclase activity and can stimulate the cyclic GMP second messenger system; however, over the last few years, several studies have shown the involvement of heterotrimeric GTP-binding proteins in mediating signals that eventually culminate in the biological actions of single transmembrane spanning receptors and proteins. Guanosine Triphosphate 242-245 5'-nucleotidase, cytosolic II Homo sapiens 118-121 15739119-0 2005 A role for heterotrimeric GTP-binding proteins and ERK1/2 in insulin-mediated, nitric-oxide-dependent, cyclic GMP production in human umbilical vein endothelial cells. Guanosine Triphosphate 26-29 5'-nucleotidase, cytosolic II Homo sapiens 110-113 19150356-7 2009 Our data also show that the N-terminal globular domain is able to perform only the first catalysis (GTP to GDP, an activity associated with basal level), but the helical domain in the full-length protein stimulates the hydrolysis of GTP to GMP with higher GMP formation by preventing the dissociation of GDP-bound enzyme dimer. Guanosine Triphosphate 233-236 5'-nucleotidase, cytosolic II Homo sapiens 240-243 19150356-7 2009 Our data also show that the N-terminal globular domain is able to perform only the first catalysis (GTP to GDP, an activity associated with basal level), but the helical domain in the full-length protein stimulates the hydrolysis of GTP to GMP with higher GMP formation by preventing the dissociation of GDP-bound enzyme dimer. Guanosine Triphosphate 233-236 5'-nucleotidase, cytosolic II Homo sapiens 256-259 10751430-6 2000 Although ATP also potently inhibits cGMP-activated currents in rod patches, the following findings indicate that ATP is used to transphosphorylate GMP, generated from cGMP, to GTP. Guanosine Triphosphate 176-179 5'-nucleotidase, cytosolic II Homo sapiens 37-40 16134022-3 2004 In many instances nitric oxide mediates its biological effects by activating guanylyl cyclase and increasing cyclic GMP synthesis from GTP. Guanosine Triphosphate 135-138 5'-nucleotidase, cytosolic II Homo sapiens 116-119 10513891-3 1999 In many instances nitric oxide mediates its biological effects by activating guanylyl cyclase and increasing cyclic GMP synthesis from GTP. Guanosine Triphosphate 135-138 5'-nucleotidase, cytosolic II Homo sapiens 116-119 7903953-1 1994 Nitric oxide and atrial natriuretic peptides are the main activators of guanylyl cyclases, which transform GTP into cyclic GMP and thereby contribute to the decrease of vascular tone. Guanosine Triphosphate 107-110 5'-nucleotidase, cytosolic II Homo sapiens 123-126 8780523-8 1996 The inhibitory potency trend (GTP approximately GDP > GMP > > guanosine) is consistent with bidentate chelation of Mn2+ by GDP-Fuc. Guanosine Triphosphate 30-33 5'-nucleotidase, cytosolic II Homo sapiens 57-60 8743501-4 1996 NO elicits its known physiological actions by activating cytosolic guanylate cyclase, which converts GTP to cyclic GMP. Guanosine Triphosphate 101-104 5'-nucleotidase, cytosolic II Homo sapiens 115-118 1333596-0 1992 Exogenous GTP increases cyclic GMP and inhibits thrombin-induced aggregation of washed human platelets: comparison with ATP, adenosine and guanosine. Guanosine Triphosphate 10-13 5'-nucleotidase, cytosolic II Homo sapiens 31-34 8297002-4 1993 If required, the mass amounts of cyclic AMP and cyclic GMP present could be determined by measurement of the specific radioactivities of the precursor [3H]ATP and [3H]GTP, respectively. Guanosine Triphosphate 167-170 5'-nucleotidase, cytosolic II Homo sapiens 55-58 1333596-9 1992 In conclusion, exogenous GTP inhibits thrombin-induced aggregation and serotonin secretion of washed human platelets by increasing cyclic GMP. Guanosine Triphosphate 25-28 5'-nucleotidase, cytosolic II Homo sapiens 138-141 1359526-2 1992 Incubation of lymphocytes in the presence of GTP (0.1 mM) and GTP gamma S (0.1 mM) increased cyclic GMP more than twofold. Guanosine Triphosphate 45-48 5'-nucleotidase, cytosolic II Homo sapiens 100-103 1359526-4 1992 GTP and GTP gamma S potentiated SIN-1 and sodium nitroprusside-induced cyclic GMP formation. Guanosine Triphosphate 0-3 5'-nucleotidase, cytosolic II Homo sapiens 78-81 1370468-6 1992 Cyclic GMP alone with increase the conductance with a Km of 3.7 +/- 0.6 x 10(-7) M. In the absence of calcium, the unitary conductance with insulin + GTP or cGMP at 150 mM NaCl is 153 picosiemens. Guanosine Triphosphate 150-153 5'-nucleotidase, cytosolic II Homo sapiens 7-10 1326934-3 1992 These products stimulate an enzyme, the soluble guanylate cyclase in the sarcoplasm of the smooth muscle cell; giving rise to the formation of intracellular cyclic GMP from GTP. Guanosine Triphosphate 173-176 5'-nucleotidase, cytosolic II Homo sapiens 164-167 2826436-8 1988 Invertebrate rhodopsin is homologous in sequence and function to vertebrate visual pigment, which modulates the concentration of cyclic GMP through the mediation of the GTP-binding protein transducin. Guanosine Triphosphate 169-172 5'-nucleotidase, cytosolic II Homo sapiens 136-139 1676598-1 1991 Light activation of cyclic GMP hydrolysis in rod outer segments is mediated by a G-protein which is active in the GTP-bound form. Guanosine Triphosphate 114-117 5'-nucleotidase, cytosolic II Homo sapiens 27-30 1676598-2 1991 Substitution of GTP with a nonhydrolyzable GTP analogue is thought to leave the G-protein in a persistently activated state, thereby prolonging the hydrolysis of cyclic GMP. Guanosine Triphosphate 16-19 5'-nucleotidase, cytosolic II Homo sapiens 169-172 1676598-2 1991 Substitution of GTP with a nonhydrolyzable GTP analogue is thought to leave the G-protein in a persistently activated state, thereby prolonging the hydrolysis of cyclic GMP. Guanosine Triphosphate 43-46 5'-nucleotidase, cytosolic II Homo sapiens 169-172 1676598-3 1991 Restoration of cyclic GMP concentration in the cell also depends upon GTP since it is the substrate for guanylate cyclase, but little is known about the effects of GTP analogues on this enzyme. Guanosine Triphosphate 70-73 5'-nucleotidase, cytosolic II Homo sapiens 22-25 1676598-5 1991 The rate of cyclic GMP synthesis from GTP in rod disk membranes was about 50 pmol min-1 (nmol of rhodopsin)-1. Guanosine Triphosphate 38-41 5'-nucleotidase, cytosolic II Homo sapiens 19-22 1848125-2 1991 Using differently skinned smooth muscle preparations, two pathways involved in the change of calcium sensitivity of force have been identified: in microarteries skinned with beta-escin, GTP (possibly via a G protein) is involved in sensitization to Ca2+, while in porcine coronary arteries skinned with Triton X-100 cyclic AMP and possibly cyclic GMP are involved in desensitization. Guanosine Triphosphate 186-189 5'-nucleotidase, cytosolic II Homo sapiens 347-350 1848931-0 1991 Exogenous GTP enhances the effects of sodium nitrite on cyclic GMP accumulation, vascular smooth muscle relaxation and platelet aggregation. Guanosine Triphosphate 10-13 5'-nucleotidase, cytosolic II Homo sapiens 63-66 2121131-2 1990 These proteins, with molecular masses in the range 18-29 kDa, specifically bind [alpha-32P]GTP, which can be displaced by unlabelled GTP, GDP and their non-hydrolysable analogues guanosine 5"-[delta-thio]triphosphate (GTP[S]) and guanosine 5"-[beta-thio]diphosphate (GDP[S]), but not by GMP, ATP, ADP, AMP and other unrelated nucleotides. Guanosine Triphosphate 91-94 5'-nucleotidase, cytosolic II Homo sapiens 287-290 1848931-1 1991 Exogenous guanosine triphosphate (GTP) (1-2 x 10(-4)M) resulted in increased concentrations of cyclic GMP both in endothelium denuded rat mesenteric artery (RMA) and in human ADP-stimulated platelets. Guanosine Triphosphate 10-32 5'-nucleotidase, cytosolic II Homo sapiens 102-105 1848931-1 1991 Exogenous guanosine triphosphate (GTP) (1-2 x 10(-4)M) resulted in increased concentrations of cyclic GMP both in endothelium denuded rat mesenteric artery (RMA) and in human ADP-stimulated platelets. Guanosine Triphosphate 34-37 5'-nucleotidase, cytosolic II Homo sapiens 102-105 2550453-2 1989 The complexation of the purified guanosine 5"-O-(3-thiotriphosphate) (GTP gamma S)-bound form of alpha T (alpha T.GTP gamma S) with AS/7 results in a 2-5-fold enhancement in the total levels of cyclic GMP hydrolysis measured after 1 min. Guanosine Triphosphate 70-73 5'-nucleotidase, cytosolic II Homo sapiens 201-204 3040978-1 1987 Photoactivated rhodopsin (R) catalyses, by repetitively interacting with many copies of a guanosine nucleotide binding protein (transducin), the amplified binding of GTP to transducin molecules which then activate cyclic GMP phosphodiesterase. Guanosine Triphosphate 166-169 5'-nucleotidase, cytosolic II Homo sapiens 221-224 2457686-21 1988 In the absence of IBMX and the presence of GTP, the cyclic GMP-induced current could be suppressed by light. Guanosine Triphosphate 43-46 5'-nucleotidase, cytosolic II Homo sapiens 59-62 3023016-4 1986 Under these conditions GTP and the GTP analog, guanylylimidodiphosphate (GMP-PNP), stimulated a time- and dose-dependent increase in LH release and inositol phosphate accumulation. Guanosine Triphosphate 23-26 5'-nucleotidase, cytosolic II Homo sapiens 73-76 3023016-4 1986 Under these conditions GTP and the GTP analog, guanylylimidodiphosphate (GMP-PNP), stimulated a time- and dose-dependent increase in LH release and inositol phosphate accumulation. Guanosine Triphosphate 35-38 5'-nucleotidase, cytosolic II Homo sapiens 73-76 6746657-19 1984 Alkaline hydrolysis of these products yielded GMP and pppGp, indicating that the primer was initiated with GTP. Guanosine Triphosphate 107-110 5'-nucleotidase, cytosolic II Homo sapiens 46-49 6282835-5 1982 In the reverse of Reaction i, E(P68--GMP) reacts with PPi to regenerate GTP. Guanosine Triphosphate 72-75 5'-nucleotidase, cytosolic II Homo sapiens 37-40 6327365-3 1984 Adding GTP in the dark stimulates the production of 0.0003-0.001 mol cyclic GMP/mol rhodopsin per min. Guanosine Triphosphate 7-10 5'-nucleotidase, cytosolic II Homo sapiens 76-79 6327365-4 1984 GTP and light cause a 2-fold faster increase in cyclic GMP. Guanosine Triphosphate 0-3 5'-nucleotidase, cytosolic II Homo sapiens 55-58 1795-2 1975 This method employs the rate of conversion of [32P]GTP to [32P]cyclic-GMP. Guanosine Triphosphate 51-54 5'-nucleotidase, cytosolic II Homo sapiens 70-73 6101203-4 1981 The intermediate is able to complete the excision of the IVS when it is incubated with a monovalent cation (75 mM (NH4)2SO4), a divalent cation (5-10 mM MgCl2) and a guanosine compound (1 microM GTP, GDP, GMP or guanosine). Guanosine Triphosphate 195-198 5'-nucleotidase, cytosolic II Homo sapiens 205-208 217445-4 1979 GTP or the non-hydrolysable guanyl-5"-ylimidodiphosphate (GMP-PNP) is required for the normal light-activation of the phosphodiesterase and in its absence both the speed of activation and the sensitivity are greatly reduced. Guanosine Triphosphate 0-3 5'-nucleotidase, cytosolic II Homo sapiens 58-61 200909-12 1977 These findings reveal yet another facet of light regulation of photoreceptor/cyclic GMP levels and also provide a striking analogy to the GTP regulation of nonphotoreceptor, hormone-sensitive adenylate cyclase. Guanosine Triphosphate 138-141 5'-nucleotidase, cytosolic II Homo sapiens 84-87 1002690-3 1976 The mRNA guanylyltransferase catalyzes the transfer of a residue of GMP from GTP to acceptors which possess a 5"-terminal diphosphate. Guanosine Triphosphate 77-80 5'-nucleotidase, cytosolic II Homo sapiens 68-71 30063056-5 2018 In the case of modified GTP analogues, a modified procedure using a special promoter and GMP as initiator needed to be used to obtain efficient RNA synthesis. Guanosine Triphosphate 24-27 5'-nucleotidase, cytosolic II Homo sapiens 89-92 237753-1 1975 An enzyme, guanyl cyclase, which catalyzes formation of CYCLIC 3",5"-GMP from 5"-GTP, has been identified in human peripheral lymphocytes. Guanosine Triphosphate 78-84 5'-nucleotidase, cytosolic II Homo sapiens 69-72 30189250-4 2019 GUCY2C is activated upon binding of paracrine hormones (guanylin and uroguanylin) that lead to formation of cyclic GMP from GTP and activation of downstream signaling pathways that are associated with normal homeostasis. Guanosine Triphosphate 124-127 5'-nucleotidase, cytosolic II Homo sapiens 115-118 29229701-9 2018 The results of this study suggest that elevated c-di-GMP levels decrease the activity of the coordinator of metabolism and virulence, CodY, possibly via lower GTP levels, and that decreased CodY activity suppresses L. monocytogenes virulence by the decreased expression of the PrfA virulence regulon.IMPORTANCEListeria monocytogenes is a pathogen causing listeriosis, a disease responsible for the highest mortality rate among foodborne diseases. Guanosine Triphosphate 159-162 5'-nucleotidase, cytosolic II Homo sapiens 53-56 26041283-2 2015 This enzyme harbors methyltransferase (MTase) and nsP1 guanylylation (GT) activities catalyzing the transfer of the methyl group from S-adenosylmethionine (AdoMet) to the N7 position of a GTP molecule followed by the formation of an m(7)GMP-nsP1 adduct. Guanosine Triphosphate 188-191 5'-nucleotidase, cytosolic II Homo sapiens 237-240 26542736-7 2016 GTP binding induced similar effects on H/D exchange to its non-hydrolysable analog, GMP-PCP. Guanosine Triphosphate 0-3 5'-nucleotidase, cytosolic II Homo sapiens 84-87 25189859-2 2015 Cyclic di-GMP is synthesised from two GTP molecules by diguanylate cyclases that have a GGDEF domain and is degraded by phosphodiesterases with either an EAL or an HD-GYP domain. Guanosine Triphosphate 38-41 5'-nucleotidase, cytosolic II Homo sapiens 10-13