PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12871749-5 2003 On the other hand, a spontaneous NO donor (+/-)-(E)-4-ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexanamide (FK409) significantly attenuated the basal and tumor necrosis factor-alpha-induced endothelin-1 production and NF-kappaB activation in endothelial cells. FK 409 103-108 nuclear factor kappa B subunit 1 Homo sapiens 213-222 12871749-6 2003 In addition, we found that FK409 suppressed NF-kappaB activation by the induction and stabilization of the inhibitory protein alpha, IkappaBalpha. FK 409 27-32 nuclear factor kappa B subunit 1 Homo sapiens 44-53 12647268-8 2003 Preincubation with 4-ethyl-2-hydroxyimino-5-nitro-3-hexenamide, a NO donor, abrogated increased expression of MCP-1 mRNA and high NF-kappaB activity induced by PLA2-treated LDL and by LDL isolated from diabetic patients. FK 409 19-62 nuclear factor kappa B subunit 1 Homo sapiens 130-139 12193057-6 2002 In addition, FK409 diminished basal and TNF-alpha-stimulated NF-kappa B activation in ECs. FK 409 13-18 nuclear factor kappa B subunit 1 Homo sapiens 61-71 12193057-8 2002 These findings suggest that the suppression of NF-kappa B activation is at least partly involved in the FK409-induced inhibition of ET-1 production in ECs. FK 409 104-109 nuclear factor kappa B subunit 1 Homo sapiens 47-57 10386988-7 1999 In the adult rat, stimulation with NOR-3 (2 mg/kg), a NO donor, increased NF-kappaB DNA binding activity in the striatum after 45 min. FK 409 35-40 nuclear factor kappa B subunit 1 Homo sapiens 74-83