PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12606519-1	2003	With ATP sites on K(ir)6.2 that inhibit activity and ADP sites on SUR1 that antagonize the inhibition, ATP-sensitive potassium channels (K(ATP) channels) are designed as exquisite sensors of adenine nucleotide levels that signal changes in glucose metabolism.	Adenine Nucleotides	191-209	ATP binding cassette subfamily C member 8	Homo sapiens	66-70	
11673467-1	2001	The mechanism by which ubiquitous adenine nucleotide-gated K(IR)6.0(4)/SUR(4) channels link membrane excitability with cellular metabolism is controversial.	Adenine Nucleotides	34-52	ATP binding cassette subfamily C member 8	Homo sapiens	71-74	
11585851-0	2001	Regulation of cloned ATP-sensitive K channels by adenine nucleotides and sulfonylureas: interactions between SUR1 and positively charged domains on Kir6.2.	Adenine Nucleotides	49-68	ATP binding cassette subfamily C member 8	Homo sapiens	109-113	
10615958-0	2000	Genetic analysis of Japanese patients with persistent hyperinsulinemic hypoglycemia of infancy: nucleotide-binding fold-2 mutation impairs cooperative binding of adenine nucleotides to sulfonylurea receptor 1.	Adenine Nucleotides	162-181	ATP binding cassette subfamily C member 8	Homo sapiens	185-208	
16885549-2	2006	It is inhibited by the binding of adenine nucleotides to subunit Kir6.2, which closes the channel, and activated by nucleotide binding or hydrolysis on SUR1, which opens the channel.	Adenine Nucleotides	34-53	ATP binding cassette subfamily C member 8	Homo sapiens	152-156	
29685928-2	2018	These hetero-octameric channels, comprising four inward rectifier K+ channel subunits (Kir6.1 or Kir6.2) and four sulfonylurea receptor (SUR1 or SUR2A/B) subunits, detect metabolic changes via three classes of intracellular adenine nucleotide (ATP/ADP) binding site.	Adenine Nucleotides	224-242	ATP binding cassette subfamily C member 8	Homo sapiens	137-141