PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26834769-7	2015	Furthermore, the application of the HO-1 inducer Ht and nitric oxide (NO) donor sodium nitroprusside (SNP) not only activated HO-1 gene expression, HO activity, and endogenous NO content, but also blocked GA-induced rapid vacuolation and accelerated aleurone layers PCD under drought stress.	Nitroprusside	80-100	heme oxygenase 1	Homo sapiens	36-40	
26834769-7	2015	Furthermore, the application of the HO-1 inducer Ht and nitric oxide (NO) donor sodium nitroprusside (SNP) not only activated HO-1 gene expression, HO activity, and endogenous NO content, but also blocked GA-induced rapid vacuolation and accelerated aleurone layers PCD under drought stress.	Nitroprusside	80-100	heme oxygenase 1	Homo sapiens	126-130	
20605906-5	2010	Sodium nitroprusside (SNP, an NO donor) and 3-(5"-hydroxymethyl-2"-furyl)-1-benzyl indazole [YC-1; acts directly on soluble guanylate cyclase (sGC)] led to further relaxation, yet the residual contraction remained 2 to 3 times higher in H(mox)1(-/-) than H(mox)1(+/+) mice (p < 0.001).	Nitroprusside	0-20	heme oxygenase 1	Homo sapiens	237-244	
25156196-11	2014	It was also demonstrated that HO-1 is modulated by NO, as shown by experiments performed in the presence of an NO donor (sodium nitroprusside), an NO scavenger (2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide), or an NO synthesis inhibitor (N-nitro-l-arginine methyl ester, NAME).	Nitroprusside	121-141	heme oxygenase 1	Homo sapiens	30-34	
20605906-5	2010	Sodium nitroprusside (SNP, an NO donor) and 3-(5"-hydroxymethyl-2"-furyl)-1-benzyl indazole [YC-1; acts directly on soluble guanylate cyclase (sGC)] led to further relaxation, yet the residual contraction remained 2 to 3 times higher in H(mox)1(-/-) than H(mox)1(+/+) mice (p < 0.001).	Nitroprusside	0-20	heme oxygenase 1	Homo sapiens	255-262	
17027882-6	2006	According to our data, sodium nitroprusside (SNP) increased HO-1 expression in a concentration dependent manner.	Nitroprusside	23-43	heme oxygenase 1	Homo sapiens	60-64	
19183882-0	2009	NS398 protects cells from sodium nitroprusside-mediated cytotoxicity through enhancing HO-1 induction independent of COX-2 inhibition.	Nitroprusside	26-46	heme oxygenase 1	Homo sapiens	87-91	
19183882-4	2009	Thus, we hypothesized that HO-1 are induced as an adaptive response to sodium nitroprusside (SNP) and play a protective role against cytotoxicity.	Nitroprusside	71-91	heme oxygenase 1	Homo sapiens	27-31	
15213303-5	2004	Using human Jurkat T cells, we found that the NO donor sodium nitroprusside (SNP) induced HO-1 expression and that preincubation with SNP suppressed T cell proliferation induced by concanavalin A and apoptosis triggered by anti-Fas antibody.	Nitroprusside	55-75	heme oxygenase 1	Homo sapiens	90-94	
16476785-2	2006	Besides other clinically established NO releasing drugs, sodium nitroprusside (SNP) has frequently been employed as an experimental tool to explore effects of NO on HO-1 and other biological targets.	Nitroprusside	57-77	heme oxygenase 1	Homo sapiens	165-169	
11728461-3	2001	We found that Hcy (0.5 mM) markedly reduced the increase in haem oxygenase activity and HO-1 protein expression induced by sodium nitroprusside (SNP, 0.5 mM) but did not affect HO-1 activation mediated by S-nitroso-N-acetyl-penicillamine.	Nitroprusside	123-143	heme oxygenase 1	Homo sapiens	88-92	
12112002-2	2002	Here we show that NO donors including sodium nitroprusside (SNP) and spermine nonoate (SP-NO), and PGE(2) significantly stimulate HO-1 expression in RAW264.7 macrophages, associated with alternative induction on NO and PGE(2) in medium, respectively.	Nitroprusside	38-58	heme oxygenase 1	Homo sapiens	130-134	
10423162-2	1999	The expression levels of heme oxygenase-1 mRNA were increased significantly in DLD-1 human colorectal adenocarcinoma cells by treatment with each of three NO donors: sodium nitroprusside (SNP), S-nitroso-L-glutathione (GSNO), and 3-morpholinosydnonimine (SIN-1).	Nitroprusside	166-186	heme oxygenase 1	Homo sapiens	25-41	
10997923-2	2000	In sublytic amounts, the nitric oxide donor sodium nitroprusside induced HO-1 mRNA and protein and HO activity in a dose-dependent and time-dependent fashion; this induction was specific for nitric oxide since the nitric oxide scavenger carboxy-2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide significantly reduced such induction.	Nitroprusside	44-64	heme oxygenase 1	Homo sapiens	73-77	
10872747-4	2000	In the present study, we have demonstrated that exposure of HeLa cells to the NO donor, sodium nitroprusside (SNP), results in concentration and time-dependent increase in HO-1 mRNA and activation of MAPKs: ERK (ERK1 and ERK2) and p38 pathways, but not SAPK/JNK pathway.	Nitroprusside	88-108	heme oxygenase 1	Homo sapiens	172-176	
8764571-4	1996	In a human glioblastoma cell line, T98G, treatment with any of three types of NO donors--sodium nitroprusside, 3-morpholinosydnonimine, and S-nitroso-L-glutathione--caused a significant increase in the levels of heme oxygenase-1 mRNA but not in the levels of heme oxygenase-2 and heat-shock protein 70 mRNAs.	Nitroprusside	89-109	heme oxygenase 1	Homo sapiens	212-228	
9425252-2	1997	We have examined the effect of the NO donor sodium nitroprusside (SNP) on heme oxygenase-1 (HO-1) expression in human epidermal keratinocytes and investigated the contribution of the heme oxygenase pathway in the control of keratinocyte proliferation.	Nitroprusside	44-64	heme oxygenase 1	Homo sapiens	74-90	
10349844-8	1999	Moreover, pretreatment with interferon-gamma partially suppressed the induction of heme oxygenase-1 mRNA expression caused by either sodium nitroprusside, cadmium, or hemin.	Nitroprusside	133-153	heme oxygenase 1	Homo sapiens	83-99	
9354392-4	1997	We showed that sodium nitroprusside also increased the levels of heme oxygenase-1 protein.	Nitroprusside	15-35	heme oxygenase 1	Homo sapiens	65-81	
9354392-5	1997	The sodium nitroprusside-mediated increase in heme oxygenase-1 mRNA levels was abolished by treatment with actinomycin D.	Nitroprusside	4-24	heme oxygenase 1	Homo sapiens	46-62	
8764571-5	1996	Sodium nitroprusside increased the levels of heme oxygenase-1 protein but not the levels of heat-shock protein 70 in T98G cells.	Nitroprusside	0-20	heme oxygenase 1	Homo sapiens	45-61	
8764571-6	1996	The increase in content of heme oxygenase-1 mRNA caused by sodium nitro-prusside was completely abolished by the treatment with actinomycin D.	Nitroprusside	59-80	heme oxygenase 1	Homo sapiens	27-43