PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9147366-7 1997 Superoxide generation was measured by cytochrome c reduction and myeloperoxidase (MPO) products by measurement of peak luminol chemiluminescence (CL). Luminol 119-126 myeloperoxidase Homo sapiens 82-85 12754093-7 2003 In the presence of neutrophils, the A1242-induced luminol chemiluminescence was decreased by the superoxide dismutase inhibitor diethyldithiocarbamic acid (DDC) and the myeloperoxidase inhibitor salicylhydroxamic acid (SHA). Luminol 50-57 myeloperoxidase Homo sapiens 169-184 10879688-6 2000 Luminol-dependent (mainly myeloperoxidase (MPO)-mediated) chemiluminescence (CL) response to latex and FMLP (formylmethionylleucylphenylalanine) was also high in these cell populations. Luminol 0-7 myeloperoxidase Homo sapiens 26-41 10879688-6 2000 Luminol-dependent (mainly myeloperoxidase (MPO)-mediated) chemiluminescence (CL) response to latex and FMLP (formylmethionylleucylphenylalanine) was also high in these cell populations. Luminol 0-7 myeloperoxidase Homo sapiens 43-46 16502478-1 2006 Luminol-amplified chemiluminescence (CL) from phagocytes has previously been shown to be almost completely dependent on the release of myeloperoxidase (MPO) from azurophilic granules. Luminol 0-7 myeloperoxidase Homo sapiens 135-150 16502478-1 2006 Luminol-amplified chemiluminescence (CL) from phagocytes has previously been shown to be almost completely dependent on the release of myeloperoxidase (MPO) from azurophilic granules. Luminol 0-7 myeloperoxidase Homo sapiens 152-155 16392333-4 2005 Luminol chemiluminescence recorded the whole pool of active oxygen and showed the summary activity of myeloperoxidase and NADPH-oxidase, while luceginin chemiluminescence measured formation of superoxide anion radical (*O(-)2) and evaluated the activity of NADPH-oxidase. Luminol 0-7 myeloperoxidase Homo sapiens 102-117 15056492-5 2004 Generation of reactive species by MPO/H(2)O(2) in Earl"s solution (pH=7.2) at 37 degrees C was investigated by monitoring of chemiluminescence using luminol as light emitter. Luminol 149-156 myeloperoxidase Homo sapiens 34-37 15570291-1 2004 INTRODUCTION: In this report, we propose the application of the p-iodophenol-enhanced luminol chemiluminescent technique to the determination of peroxidase (myeloperoxidase and/or platelet peroxidase) activity in blasts of minimally differentiated acute myeloblastic leukemia (AML-M0) and acute megakaryoblastic leukemia (AML-M7). Luminol 86-93 myeloperoxidase Homo sapiens 157-199 10814971-9 2000 The release of MPO, estimated by the chemiluminescence of the luminol/H(2)O(2) reaction in the supernatant of PMN incubated in the absence and presence of stimuli and absence and presence of cytochalasin B, was also higher for PMN isolated by a density gradient. Luminol 62-69 myeloperoxidase Homo sapiens 15-18 10452808-0 1999 A myeloperoxidase-specific assay based upon bromide-dependent chemiluminescence of luminol. Luminol 83-90 myeloperoxidase Homo sapiens 2-17 10452808-5 1999 The MPO-specific reaction is believed to proceed in two steps: (i) the enzymatic generation of hypobromous acid (HOBr) from KBr and H(2)O(2) at pH 5 and (ii) the spontaneous reaction of HOBr and H(2)O(2) with luminol to give a Br-CL signal. Luminol 209-216 myeloperoxidase Homo sapiens 4-7 9415643-6 1997 We measured the generation of superoxide by cytochrome c reduction and myeloperoxidase (MPO) dependent products using peak luminol chemiluminescence. Luminol 123-130 myeloperoxidase Homo sapiens 88-91 9337863-3 1997 Luminol-enhanced chemiluminescence generated by human neutrophils derives predominantly from the activity of myeloperoxidase (MPO) which produces hypochlorous acid from H2O2 and Cl-. Luminol 0-7 myeloperoxidase Homo sapiens 109-124 9337863-3 1997 Luminol-enhanced chemiluminescence generated by human neutrophils derives predominantly from the activity of myeloperoxidase (MPO) which produces hypochlorous acid from H2O2 and Cl-. Luminol 0-7 myeloperoxidase Homo sapiens 126-129 9558962-2 1996 We used both lucigenin-dependent CL (LgCL) for superoxide (O2-) detection and luminol-dependent CL (LmCL) which detects myeloperoxidase (MPO)-dependent formation of hypochlorous acid in combination with MPO inhibitor, sodium azide (NaN3). Luminol 78-85 myeloperoxidase Homo sapiens 120-135 8960464-5 1996 Characteristically, myeloperoxidase deficient granulocytes showed a strikingly decreased luminol-enhanced chemiluminescence while the lucigenin-enhanced chemiluminescence was significantly increased compared to normal granulocytes. Luminol 89-96 myeloperoxidase Homo sapiens 20-35 8889756-6 1996 In contrast, the 5-amino-2,3-dihydro-1,4-phthalazinedione (luminol)-dependent CL response of the neutrophils indicative of the myeloperoxidase (MPO)-mediated formation of highly reactive oxidants was significantly enhanced after exercise. Luminol 17-57 myeloperoxidase Homo sapiens 127-142 8805680-4 1996 In contrast, both myeloperoxidase (MPO)-dependent oxygenation activity (measured by luminol luminescence) and chloramine release were increased significantly in both CF homozygotes and heterozygotes as compared with controls. Luminol 84-91 myeloperoxidase Homo sapiens 18-33 8805680-4 1996 In contrast, both myeloperoxidase (MPO)-dependent oxygenation activity (measured by luminol luminescence) and chloramine release were increased significantly in both CF homozygotes and heterozygotes as compared with controls. Luminol 84-91 myeloperoxidase Homo sapiens 35-38 8889756-6 1996 In contrast, the 5-amino-2,3-dihydro-1,4-phthalazinedione (luminol)-dependent CL response of the neutrophils indicative of the myeloperoxidase (MPO)-mediated formation of highly reactive oxidants was significantly enhanced after exercise. Luminol 17-57 myeloperoxidase Homo sapiens 144-147 8889756-6 1996 In contrast, the 5-amino-2,3-dihydro-1,4-phthalazinedione (luminol)-dependent CL response of the neutrophils indicative of the myeloperoxidase (MPO)-mediated formation of highly reactive oxidants was significantly enhanced after exercise. Luminol 59-66 myeloperoxidase Homo sapiens 127-142 8889756-6 1996 In contrast, the 5-amino-2,3-dihydro-1,4-phthalazinedione (luminol)-dependent CL response of the neutrophils indicative of the myeloperoxidase (MPO)-mediated formation of highly reactive oxidants was significantly enhanced after exercise. Luminol 59-66 myeloperoxidase Homo sapiens 144-147 8177196-4 1994 Measurement of O2- production capacity was used as a reflection of the activity of NADPH oxidase, and the activity of myeloperoxidase-H2O2-halide system was evaluated using luminol-dependent chemiluminescence. Luminol 173-180 myeloperoxidase Homo sapiens 118-133 7762419-6 1995 Lucigenin-dependent CL of sulphite-treated and subsequently stimulated neutrophils was strongly inhibited by extracellularly added superoxide dismutase, whereas luminol-dependent CL was markedly reduced by the MPO inhibitor azide. Luminol 161-168 myeloperoxidase Homo sapiens 210-213 8726584-3 1996 The myeloperoxidase (MPO) inhibitor salicylhydroxamic acid (SHA) abrogated luminol but not lucigenin CL in both cell types, but did not further inhibit the already grossly subnormal luminol CL responses seen with MPO-deficient cells which produced normal lucigenin CL. Luminol 75-82 myeloperoxidase Homo sapiens 4-19 8726584-3 1996 The myeloperoxidase (MPO) inhibitor salicylhydroxamic acid (SHA) abrogated luminol but not lucigenin CL in both cell types, but did not further inhibit the already grossly subnormal luminol CL responses seen with MPO-deficient cells which produced normal lucigenin CL. Luminol 75-82 myeloperoxidase Homo sapiens 21-24 8726584-4 1996 SHA also profoundly inhibited the luminol CL response in a cell-free MPO-H2O2 system. Luminol 34-41 myeloperoxidase Homo sapiens 69-72 8726584-7 1996 However, analysis of the effects of various reactive oxygen species (ROS) scavengers, assessed on phagocyte and cell-free CL systems (both MPO-H2O2 and superoxide generating) suggest that the luminol CL signal is not entirely dependent on MPO activity. Luminol 192-199 myeloperoxidase Homo sapiens 139-142 8726584-7 1996 However, analysis of the effects of various reactive oxygen species (ROS) scavengers, assessed on phagocyte and cell-free CL systems (both MPO-H2O2 and superoxide generating) suggest that the luminol CL signal is not entirely dependent on MPO activity. Luminol 192-199 myeloperoxidase Homo sapiens 239-242 8594848-3 1995 Analysis of PMN functions revealed a deficiency in the luminol-enhanced chemiluminescence responses that seemed to be associated with the mobilization of myeloperoxidase (MPO) in the PMN of the patient group, as compared with the healthy controls. Luminol 55-62 myeloperoxidase Homo sapiens 154-169 8594848-3 1995 Analysis of PMN functions revealed a deficiency in the luminol-enhanced chemiluminescence responses that seemed to be associated with the mobilization of myeloperoxidase (MPO) in the PMN of the patient group, as compared with the healthy controls. Luminol 55-62 myeloperoxidase Homo sapiens 171-174 8588512-4 1995 Their light output was, however, greatly increased when horseradish peroxidase or myeloperoxidase was added, showing that the light-generating reaction with isoluminol as well as with luminol is peroxidase-dependent. Luminol 160-167 myeloperoxidase Homo sapiens 82-97 8667597-1 1995 A chemiluminescence (CL) procedure was developed to determine the time course of the release of myeloperoxidase (MPO) from activated human neutrophils using two CL probes, luminol, and MCLA. Luminol 172-179 myeloperoxidase Homo sapiens 96-111 1654772-2 1991 Since luminol chemiluminescence (LCL) in neutrophils can be blocked by azide, an inhibitor of myeloperoxidase, LCL has been believed to reflect mainly the myeloperoxidase-catalyzed reaction. Luminol 6-13 myeloperoxidase Homo sapiens 94-109 8047717-3 1994 Luminol-enhanced CL correlated to neutrophil percentage and myeloperoxidase levels in the bronchoalveolar lavage and was markedly increased in both pneumonia groups. Luminol 0-7 myeloperoxidase Homo sapiens 60-75 8250236-2 1993 MPO is determined through its ability to catalyze the oxidation of luminol, resulting in the emission of light which is recorded on a photographic film. Luminol 67-74 myeloperoxidase Homo sapiens 0-3 8407717-5 1993 The greatest luminol-dependent CL was observed for cell types high in myeloperoxidase (MPO). Luminol 13-20 myeloperoxidase Homo sapiens 70-85 8407717-5 1993 The greatest luminol-dependent CL was observed for cell types high in myeloperoxidase (MPO). Luminol 13-20 myeloperoxidase Homo sapiens 87-90 8407717-9 1993 Taken together, these data suggest that the reaction mechanism of luminol favors interaction with cytoplasmic MPO whereas that of DALM favors membrane interactions. Luminol 66-73 myeloperoxidase Homo sapiens 110-113 1332430-3 1992 These combined reductions in O2- generating ability and lower myeloperoxidase levels result in low levels of luminol chemiluminescence stimulated during the respiratory burst of monocytes. Luminol 109-116 myeloperoxidase Homo sapiens 62-77 1662316-8 1991 On the other hand, the luminol-enhanced CL, which reflects the myeloperoxidase-dependent oxidative metabolism, and the phagocytic ability of MN was not affected by the hormone. Luminol 23-30 myeloperoxidase Homo sapiens 63-78 8409752-0 1993 Luminol-enhanced chemiluminescence induced in peripheral blood-derived human phagocytes: obligatory requirement of myeloperoxidase exocytosis by monocytes. Luminol 0-7 myeloperoxidase Homo sapiens 115-130 1851410-3 1991 Over 95% of the luminol dependent chemiluminescence activated by all samples was inhibited by azide (indicating its dependence upon myeloperoxidase), but anti-(myeloperoxidase) IgG (which specifically inhibits only the extracellular activity of this enzyme) only inhibited the response stimulated by some samples: those fluids which activated the highest luminol dependent chemiluminescence also stimulated the greatest activity of an extracellular myeloperoxidase-H2O2 system. Luminol 16-23 myeloperoxidase Homo sapiens 132-147 1851410-3 1991 Over 95% of the luminol dependent chemiluminescence activated by all samples was inhibited by azide (indicating its dependence upon myeloperoxidase), but anti-(myeloperoxidase) IgG (which specifically inhibits only the extracellular activity of this enzyme) only inhibited the response stimulated by some samples: those fluids which activated the highest luminol dependent chemiluminescence also stimulated the greatest activity of an extracellular myeloperoxidase-H2O2 system. Luminol 16-23 myeloperoxidase Homo sapiens 160-175 1851410-3 1991 Over 95% of the luminol dependent chemiluminescence activated by all samples was inhibited by azide (indicating its dependence upon myeloperoxidase), but anti-(myeloperoxidase) IgG (which specifically inhibits only the extracellular activity of this enzyme) only inhibited the response stimulated by some samples: those fluids which activated the highest luminol dependent chemiluminescence also stimulated the greatest activity of an extracellular myeloperoxidase-H2O2 system. Luminol 16-23 myeloperoxidase Homo sapiens 160-175 1851410-4 1991 A clear correlation was shown to exist between the activity of myeloperoxidase already present in the fluids (after its secretion from neutrophils in situ within the rheumatoid joint) and the ability of the fluid to activate luminol dependent chemiluminescence. Luminol 225-232 myeloperoxidase Homo sapiens 63-78 1654772-2 1991 Since luminol chemiluminescence (LCL) in neutrophils can be blocked by azide, an inhibitor of myeloperoxidase, LCL has been believed to reflect mainly the myeloperoxidase-catalyzed reaction. Luminol 6-13 myeloperoxidase Homo sapiens 155-170 2169299-4 1990 However, the luminol response decreased form day to day, obviously due to a decrease in the myeloperoxidase (MPO) activity of the cells, whereas the lucigenin response showed no such MPO dependence. Luminol 13-20 myeloperoxidase Homo sapiens 109-112 1652248-4 1991 However, in the absence of horseradish peroxidase, the luminol-dependent chemiluminescence in the dimethylsulphoxide and butyrate-differentiated HL60 cells was significantly lower than that of the control cells isolated from human blood, reflecting the absence of myeloperoxidase in the differentiated cells. Luminol 55-62 myeloperoxidase Homo sapiens 264-279 2169299-4 1990 However, the luminol response decreased form day to day, obviously due to a decrease in the myeloperoxidase (MPO) activity of the cells, whereas the lucigenin response showed no such MPO dependence. Luminol 13-20 myeloperoxidase Homo sapiens 92-107 2169299-5 1990 The luminol response was inhibited by superoxide dismutase (SOD), catalase, and the MPO-inhibitor azide, while the lucigenin response was inhibited by SOD and catalase but stimulated by azide. Luminol 4-11 myeloperoxidase Homo sapiens 84-87 2843175-0 1988 Luminol-dependent photoemission from single neutrophil stimulated by phorbol ester and calcium ionophore--role of degranulation and myeloperoxidase. Luminol 0-7 myeloperoxidase Homo sapiens 132-147 1965118-2 1990 The purpose of this study was to investigate the effect of dichloromethylene bisphosphonate, a drug used to modify bone resorption, on extracted neutrophil myeloperoxidase activity directly, and indirectly, by means of a luminol-dependent chemiluminescence assay. Luminol 221-228 myeloperoxidase Homo sapiens 156-171 2176907-3 1990 In parallel the expression of myeloperoxidase (MPO) was investigated and its catalytic activity on H2O2 related to luminol-amplified CL responses. Luminol 115-122 myeloperoxidase Homo sapiens 30-45 2176907-3 1990 In parallel the expression of myeloperoxidase (MPO) was investigated and its catalytic activity on H2O2 related to luminol-amplified CL responses. Luminol 115-122 myeloperoxidase Homo sapiens 47-50 2552755-1 1989 The granulocyte luminol-dependent chemiluminescence (CL) reaction is linked to the enzyme myeloperoxidase reacting with products of the respiratory burst activation. Luminol 16-23 myeloperoxidase Homo sapiens 90-105 2538105-2 1989 As luminol dependent chemiluminescence largely measures the activity of the myeloperoxidase-H2O2 system, and as the extracellular activity of this enzyme may be responsible for the tissue damage associated with inflammatory conditions such as rheumatoid arthritis, the aim of this work was to distinguish between intracellular and extracellular chemiluminescence so that the extracellular activity of this enzyme could be evaluated. Luminol 3-10 myeloperoxidase Homo sapiens 76-91 2154347-4 1990 In preliminary experiments, the isolated IgG from one patient was shown to inhibit luminol-dependent chemiluminescence of fluid phase myeloperoxidase. Luminol 83-90 myeloperoxidase Homo sapiens 134-149 2843175-5 1988 These findings suggest a prerequisite role of degranulation and myeloperoxidase release in luminol-dependent photoemission from stimulated neutrophils. Luminol 91-98 myeloperoxidase Homo sapiens 64-79 3025094-11 1986 These findings may explain the increased luminol-dependent CL since this type of CL requires the presence of MPO. Luminol 41-48 myeloperoxidase Homo sapiens 109-112 3344932-12 1988 Indomethacin inhibited prostaglandin E2 release, and luminol-enhanced, myeloperoxidase-mediated chemiluminescence of activated PMN. Luminol 53-60 myeloperoxidase Homo sapiens 71-86 2827790-0 1987 [Characteristics of luminol chemiluminescence induced by the catalytic action of myeloperoxidase]. Luminol 20-27 myeloperoxidase Homo sapiens 81-96 2827790-1 1987 The effects of pH, luminol myeloperoxidase and hydrogen peroxide concentrations on the intensity of luminol chemiluminescence induced by myeloperoxidase catalysis were investigated. Luminol 19-26 myeloperoxidase Homo sapiens 137-152 2827790-6 1987 Luminol oxidation in the course of the myeloperoxidase reaction is induced by hypochlorite. Luminol 0-7 myeloperoxidase Homo sapiens 39-54 3031304-1 1987 The role of myeloperoxidase in luminol- and lucigenin-dependent chemiluminescence of stimulated human neutrophils has been investigated using purified myeloperoxidase and anti-(human myeloperoxidase) antiserum. Luminol 31-38 myeloperoxidase Homo sapiens 12-27 3031304-3 1987 The results show that luminol-dependent chemiluminescence is largely dependent on both oxidase activity and degranulation (of myeloperoxidase), while lucigenin monitors oxidase activity independently of the extent of degranulation. Luminol 22-29 myeloperoxidase Homo sapiens 126-141 6098130-4 1984 From these results it was concluded that the luminol- and the lucigenin-dependent chemiluminescence differed in the dependence of MPO. Luminol 45-52 myeloperoxidase Homo sapiens 130-133 2425843-6 1986 MA1 and MA3 inhibit MPO activities such as tetraguaiacol formation, iodide oxidation and luminol-dependent chemiluminescence, while MB1 shows no such inhibition. Luminol 89-96 myeloperoxidase Homo sapiens 20-23 6487320-1 1984 A method for investigating the cellular response of polymorphonuclear leukocytes to various stimuli was introduced using simultaneously native (luminol-independent) and luminol dependent luminescence as an indicator for myeloperoxidase (MPO)-H2O2-halide and O2- mediated reactions. Luminol 144-151 myeloperoxidase Homo sapiens 220-235 6487320-1 1984 A method for investigating the cellular response of polymorphonuclear leukocytes to various stimuli was introduced using simultaneously native (luminol-independent) and luminol dependent luminescence as an indicator for myeloperoxidase (MPO)-H2O2-halide and O2- mediated reactions. Luminol 169-176 myeloperoxidase Homo sapiens 220-235 6329953-2 1984 Luminol-dependent light emission from PMNL is linked to the myeloperoxidase (MPO)-H2O2 system. Luminol 0-7 myeloperoxidase Homo sapiens 60-75 6329953-2 1984 Luminol-dependent light emission from PMNL is linked to the myeloperoxidase (MPO)-H2O2 system. Luminol 0-7 myeloperoxidase Homo sapiens 77-80 6195265-5 1983 Although the polyanions heparin and dextran sulfate were effective in inhibiting luminol-dependent myeloperoxidase-H2O2-chloride chemiluminescence, the uncharged polysaccharide dextran T500 was without effect. Luminol 81-88 myeloperoxidase Homo sapiens 99-114 6195265-4 1983 This inhibition is due to a combination of the diminished release of myeloperoxidase and the scavenging of the luminol oxidant generated by the myeloperoxidase-H2O2-chloride system. Luminol 111-118 myeloperoxidase Homo sapiens 144-159 6299947-0 1983 Role of myeloperoxidase in luminol-dependent chemiluminescence of polymorphonuclear leukocytes. Luminol 27-34 myeloperoxidase Homo sapiens 8-23 6309658-8 1983 Studies with scavengers of oxygen intermediates and inhibitors of myeloperoxidase for the oxidation of luminol, which may occur in part through the formation of HOCl as well as through a non-HOCl-mediated mechanism. Luminol 103-110 myeloperoxidase Homo sapiens 66-81 6308951-0 1983 Role of myeloperoxidase in the luminol-dependent chemiluminescence response of phagocytosing human monocytes. Luminol 31-38 myeloperoxidase Homo sapiens 8-23 6308951-2 1983 A parallel decline in myeloperoxidase (MPO)-activity of monocyte cell lysates was observed during the same period, and a close correlation was found between peak luminol-dependent CL-response and MPO-activity. Luminol 162-169 myeloperoxidase Homo sapiens 196-199 6305176-3 1983 This study demonstrates the ability of ketamine, an injectable anesthetic, to interfere with the cytotoxic neutrophil myeloperoxidase-H2O2-Cl- reaction, as tested using a luminol-enhanced chemiluminescence assay. Luminol 171-178 myeloperoxidase Homo sapiens 118-133 6299947-7 1983 This indicated that luminol-dependent chemiluminescence is dependent on and directly related to the presence of myeloperoxidase in PMNL and that both intra- and extracellularly located myeloperoxidase has to be taken into account when interpreting the cellular response assayed as chemiluminescence. Luminol 20-27 myeloperoxidase Homo sapiens 112-127 6299947-7 1983 This indicated that luminol-dependent chemiluminescence is dependent on and directly related to the presence of myeloperoxidase in PMNL and that both intra- and extracellularly located myeloperoxidase has to be taken into account when interpreting the cellular response assayed as chemiluminescence. Luminol 20-27 myeloperoxidase Homo sapiens 185-200 31059237-2 2019 Luminol has been reported to detect myeloperoxidase (MPO) activity in an inflamed area through a light-emitting reaction. Luminol 0-7 myeloperoxidase Homo sapiens 36-51 6291348-0 1982 Antioxidation theory of non-steroidal anti-inflammatory drugs based upon the inhibition of luminol-enhanced chemiluminescence from the myeloperoxidase reaction. Luminol 91-98 myeloperoxidase Homo sapiens 135-150 6291348-9 1982 In this study, NSAIDs from various classes were tested for their ability to inhibit luminol-enhanced CL from MPO. Luminol 84-91 myeloperoxidase Homo sapiens 109-112 6282074-4 1982 Non-steroidal anti-inflammatory drugs (NSAIDs) able to act as antioxidant free radical scavengers have recently been shown to inhibit luminol-enhanced chemiluminescence (CL) which results from the MPO-H2O2-Cl- reaction. Luminol 134-141 myeloperoxidase Homo sapiens 197-200 31059237-2 2019 Luminol has been reported to detect myeloperoxidase (MPO) activity in an inflamed area through a light-emitting reaction. Luminol 0-7 myeloperoxidase Homo sapiens 53-56 28804681-8 2017 Myeloperoxidase (MPO), isolated from human neutrophils, was also able to enhance the superoxide- and hydrogen peroxide-dependent luminol-amplified chemiluminescence. Luminol 129-136 myeloperoxidase Homo sapiens 0-15 28804681-8 2017 Myeloperoxidase (MPO), isolated from human neutrophils, was also able to enhance the superoxide- and hydrogen peroxide-dependent luminol-amplified chemiluminescence. Luminol 129-136 myeloperoxidase Homo sapiens 17-20 25345916-4 2014 PMN or purified myeloperoxidase (MPO) triggers formation of reactive oxygen species (ROS), quantified by light emission from oxidized luminol. Luminol 134-141 myeloperoxidase Homo sapiens 16-31 26459032-8 2015 CONCLUSION: We show for the first time that inhibition of intragranular MPO activity, or neutralization of intragranular MPO-processed ROS by luminol effectively block NET formation. Luminol 142-149 myeloperoxidase Homo sapiens 121-124 27797335-1 2016 In the blood of children (n=16) with large thermal skin burns (> 20% of total body surface), luminol-dependent chemiluminescence (CL) of neutrophils stimulated with phorbol-12-myristate-13-acetate (PMA) and myeloperoxidase (MPO) activity in neutrophils and plasma were assayed in the early period (1-7 post-burn days). Luminol 96-103 myeloperoxidase Homo sapiens 210-225 27797335-1 2016 In the blood of children (n=16) with large thermal skin burns (> 20% of total body surface), luminol-dependent chemiluminescence (CL) of neutrophils stimulated with phorbol-12-myristate-13-acetate (PMA) and myeloperoxidase (MPO) activity in neutrophils and plasma were assayed in the early period (1-7 post-burn days). Luminol 96-103 myeloperoxidase Homo sapiens 227-230 25345916-4 2014 PMN or purified myeloperoxidase (MPO) triggers formation of reactive oxygen species (ROS), quantified by light emission from oxidized luminol. Luminol 134-141 myeloperoxidase Homo sapiens 33-36 23994743-6 2013 Oxidation of the hydroxylated coumarins by the neutrophil myeloperoxidase produced highly reactive coumarin radical intermediates, which mediated the prooxidant effect observed in the luminol-enhanced chemiluminescence assay. Luminol 184-191 myeloperoxidase Homo sapiens 58-73 24915973-4 2014 Myeloperoxidase activity was measured by luminol-dependent chemiluminescence. Luminol 41-48 myeloperoxidase Homo sapiens 0-15 23978851-6 2013 Luminol specifically reacts with the superoxide generated within the phagosomes of neutrophils since bioluminescence results from a myeloperoxidase (MPO) mediated reaction. Luminol 0-7 myeloperoxidase Homo sapiens 132-147 23978851-6 2013 Luminol specifically reacts with the superoxide generated within the phagosomes of neutrophils since bioluminescence results from a myeloperoxidase (MPO) mediated reaction. Luminol 0-7 myeloperoxidase Homo sapiens 149-152 24455888-3 2013 Inhibitor of myeloperoxidase--4-aminobenzoic acid hydrazide, without any effect on lucigenin-dependent chemiluminescence of neutrophils stimulated with PMA, effectively suppressed luminol-dependent chemiluminescence (IC50 = 20 microM) under the same conditions. Luminol 180-187 myeloperoxidase Homo sapiens 13-28 24455888-4 2013 The transfer of the cells from medium with HSA-Cl and myeloperoxidase to fresh medium abolished an increase in PMA-induced luminol-dependent chemiluminescence, but not the ability of neutrophils to respond to re-addition of HSA-Cl. Luminol 123-130 myeloperoxidase Homo sapiens 54-69 24455888-7 2013 A significant positive correlation was found between myeloperoxidase activity in blood plasma of children with severe burns and the enhancing effects of albumin fraction of the same plasma on luminol-dependent chemiluminescence of PMA-stimulated donor neutrophils. Luminol 192-199 myeloperoxidase Homo sapiens 53-68 22575975-2 2012 METHODS: Initially, the crude water and methanol extracts were probed for their capacity to trigger immune cells" NADPH oxidase and MPO-dependent activities as measured by lucigenin- and luminol-amplified chemiluminescence, respectively; as compared to receptor-dependent (serum opsonised zymosan- OPZ) or receptor-independent phorbol myristerate acetate (PMA). Luminol 187-194 myeloperoxidase Homo sapiens 132-135