PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18267146-2	2008	Modified thrombin binding aptamer (5"-NH-C3-GGTTGGTGTGGTTGG-C3-SH-3") carrying 6-carboxyfluorescein (FAM) and 7-amino-4-methyl-coumarin labels at 5" and 3", respectively, was used for the simultaneous combined measurement of Mg2+ and Ca2+ cations.	6-carboxyfluorescein	79-99	coagulation factor II, thrombin	Homo sapiens	9-17	
18481835-3	2008	In this work, based on high affinity between antithrombin aptamer and thrombin (their dissociation constant is 0.5 nM), a carboxyfluorescein-labeled 29-nucleotide (nt) aptamer (F29-mer) was used and an aptamer-based affinity probe CE (aptamer-based APCE) method was successfully established for high-sensitive detection and quantitative analysis of thrombin.	6-carboxyfluorescein	122-140	coagulation factor II, thrombin	Homo sapiens	70-78	
18481835-8	2008	Further binding experiments using one carboxyfluorescein-labeled aptamer and the other nonlabeled aptamer or vice versa were carried out to deduce the formation of ternary complex when these two aptamers coexisted in the free solution with thrombin.	6-carboxyfluorescein	38-56	coagulation factor II, thrombin	Homo sapiens	240-248	
28594110-4	2017	Second, the rapid binding kinetics between the thrombin and 6-carboxyfluorescein labeled G-quadruplex aptamer was measured.	6-carboxyfluorescein	60-80	coagulation factor II, thrombin	Homo sapiens	47-55	
15571349-3	2004	A human alpha-thrombin binding aptamer was labeled with 6-carboxyfluorescein and exploited as a selective fluorescent probe for studying thrombin-protein interactions using capillary electrophoresis with laser-induced fluorescence.	6-carboxyfluorescein	56-76	coagulation factor II, thrombin	Homo sapiens	14-22	
15571349-3	2004	A human alpha-thrombin binding aptamer was labeled with 6-carboxyfluorescein and exploited as a selective fluorescent probe for studying thrombin-protein interactions using capillary electrophoresis with laser-induced fluorescence.	6-carboxyfluorescein	56-76	coagulation factor II, thrombin	Homo sapiens	137-145	
2848827-3	1988	Accordingly, thrombin elicits a sustained alkalinization in 6-carboxyfluorescein-loaded endothelial cells, that is abolished in either Na+-free or 5-(N-ethyl-N-isopropyl)amiloride-containing medium.	6-carboxyfluorescein	60-80	coagulation factor II, thrombin	Homo sapiens	13-21