PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27458087-6 2016 These studies demonstrate that the presence of these +222 Da species is due to an unexpected reaction of the maleimide moiety in the MCC linker with antibody lysine residues to produce cross-linked species that cannot conjugate to DM1. maleimide 109-118 immunoglobulin heavy diversity 1-7 Homo sapiens 231-234 27174129-2 2016 Ado-trastuzumab emtansine utilizes the Ab-SMCC-DM1 format, in which the thiol-functionalized maytansinoid cytotoxic agent, DM1, is linked to the antibody (Ab) via the maleimide moiety of the heterobifunctional SMCC linker. maleimide 167-176 immunoglobulin heavy diversity 1-7 Homo sapiens 123-126