PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16371511-2 2006 The C-terminal region, derived from NAD(+) synthesizing enzyme Nmnat1, is reported to confer neuroprotection in vitro. NAD 36-42 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 63-69 16118205-1 2005 Nicotinamide mononucleotide adenylyltransferase (NMNAT) is the central enzyme of the NAD biosynthetic pathway. NAD 85-88 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 0-47 16118205-1 2005 Nicotinamide mononucleotide adenylyltransferase (NMNAT) is the central enzyme of the NAD biosynthetic pathway. NAD 85-88 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 49-54 16118205-6 2005 Moreover, as opposed to preferred NAD+ synthesis by NMNAT1, the other two isoforms could also form NADH directly from the reduced nicotinamide mononucleotide, supporting a hitherto unknown pathway of NAD generation. NAD 34-38 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 52-58 16118205-6 2005 Moreover, as opposed to preferred NAD+ synthesis by NMNAT1, the other two isoforms could also form NADH directly from the reduced nicotinamide mononucleotide, supporting a hitherto unknown pathway of NAD generation. NAD 99-103 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 52-58 16118205-6 2005 Moreover, as opposed to preferred NAD+ synthesis by NMNAT1, the other two isoforms could also form NADH directly from the reduced nicotinamide mononucleotide, supporting a hitherto unknown pathway of NAD generation. NAD 34-37 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 52-58 16857098-1 2004 In the present work we have quantified some enzymatic activities, related to NAD+ metabolism, in lymphocytes of healthy donors and of patients affected by B-cell chronic lymphocytic leukemia (B-CLL): NADase activity for NAD+ degradation and NMN adenylyltransferase (NMNAT) activity for NAD+ biosynthesis. NAD 77-81 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 241-264 16247974-1 2005 NAD analogs modified at the ribose adenylyl moiety, named N-2"-MeAD and Na-2"-MeAD, were synthesized as ligands of pyridine nucleotide (NMN/NaMN) adenylyltransferase (NMNAT). NAD 0-3 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 167-172 16857098-1 2004 In the present work we have quantified some enzymatic activities, related to NAD+ metabolism, in lymphocytes of healthy donors and of patients affected by B-cell chronic lymphocytic leukemia (B-CLL): NADase activity for NAD+ degradation and NMN adenylyltransferase (NMNAT) activity for NAD+ biosynthesis. NAD 77-81 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 266-271 16857098-1 2004 In the present work we have quantified some enzymatic activities, related to NAD+ metabolism, in lymphocytes of healthy donors and of patients affected by B-cell chronic lymphocytic leukemia (B-CLL): NADase activity for NAD+ degradation and NMN adenylyltransferase (NMNAT) activity for NAD+ biosynthesis. NAD 220-224 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 241-264 16857098-1 2004 In the present work we have quantified some enzymatic activities, related to NAD+ metabolism, in lymphocytes of healthy donors and of patients affected by B-cell chronic lymphocytic leukemia (B-CLL): NADase activity for NAD+ degradation and NMN adenylyltransferase (NMNAT) activity for NAD+ biosynthesis. NAD 220-224 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 266-271 16857098-1 2004 In the present work we have quantified some enzymatic activities, related to NAD+ metabolism, in lymphocytes of healthy donors and of patients affected by B-cell chronic lymphocytic leukemia (B-CLL): NADase activity for NAD+ degradation and NMN adenylyltransferase (NMNAT) activity for NAD+ biosynthesis. NAD 220-224 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 241-264 16857098-1 2004 In the present work we have quantified some enzymatic activities, related to NAD+ metabolism, in lymphocytes of healthy donors and of patients affected by B-cell chronic lymphocytic leukemia (B-CLL): NADase activity for NAD+ degradation and NMN adenylyltransferase (NMNAT) activity for NAD+ biosynthesis. NAD 220-224 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 266-271 15078171-1 2004 The enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT), a member of the nucleotidyltransferase alpha/beta phosphodiesterase superfamily, catalyzes the reaction NMN + ATP = NAD + PPi, representing the final step in the biosynthesis of NAD, a molecule playing a fundamental role as a cofactor in cellular redox reactions. NAD 184-187 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 60-65 12117413-6 2002 NMN-adenylyltransferase was then used to convert nicotinic acid-adenine dinucleotide into NAD in the presence of high concentrations of NMN. NAD 90-93 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 0-23 14565298-0 2003 Dinucleoside polyphosphate NAD analogs as potential NMN adenylyltransferase inhibitors. NAD 27-30 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 52-75 14516279-1 2004 NMNAT (nicotinamide 5"-mononucleotide adenylyltransferase; EC 2.7.7.1) catalyses the transfer of the adenylyl group from ATP to NMN to form NAD. NAD 140-143 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 0-5 14516279-1 2004 NMNAT (nicotinamide 5"-mononucleotide adenylyltransferase; EC 2.7.7.1) catalyses the transfer of the adenylyl group from ATP to NMN to form NAD. NAD 140-143 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 7-57 11788603-2 2002 Nicotinamide/nicotinate mononucleotide (NMN/ NaMN)adenylyltransferase (NMNAT) is an indispensable enzyme in the biosynthesis of NAD(+) and NADP(+). NAD 128-134 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 71-76 11788603-3 2002 Human NMNAT displays unique dual substrate specificity toward both NMN and NaMN, thus flexible in participating in both de novo and salvage pathways of NAD synthesis. NAD 152-155 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 6-11 11788603-6 2002 We have solved the crystal structures of human NMNAT in complex with NAD, deamido-NAD, and a non-hydrolyzable TAD analogue beta-CH(2)-TAD. NAD 69-72 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 47-52 11248244-0 2001 Characterization of recombinant human nicotinamide mononucleotide adenylyl transferase (NMNAT), a nuclear enzyme essential for NAD synthesis. NAD 127-130 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 38-86 11959140-1 2002 The final step in the biosynthesis of nicotinamide-adenine dinucleotide, a major coenzyme in cellular redox reactions and involved in intracellular signaling, is catalyzed by the enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT). NAD 38-71 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 235-240 11966438-5 2002 NMNAT is the rate-limiting step in the synthesis of NAD and NAD analogues. NAD 52-55 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 0-5 11966438-5 2002 NMNAT is the rate-limiting step in the synthesis of NAD and NAD analogues. NAD 60-63 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 0-5 11966442-3 2002 BR 5"-monophosphate is then converted to the active metabolite benzamide adenine dinucleotide (BAD) by NMN adenylyltransferase, the rate-limiting enzyme in the biosynthesis of NAD. NAD 176-179 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 103-126 11751893-2 2002 Nicotinamide mononucleotide adenylyltransferase (NMNAT), a member of the nucleotidyltransferase alpha/beta-phosphodiesterases superfamily, catalyzes a universal step (NMN + ATP = NAD + PP(i)) in NAD biosynthesis. NAD 179-182 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 0-47 11751893-2 2002 Nicotinamide mononucleotide adenylyltransferase (NMNAT), a member of the nucleotidyltransferase alpha/beta-phosphodiesterases superfamily, catalyzes a universal step (NMN + ATP = NAD + PP(i)) in NAD biosynthesis. NAD 179-182 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 49-54 11752792-1 2002 Nicotinamide mononucleotide adenylyltransferase catalyses the final step in the synthesis of nicotinamide-adenine dinucleotide (NAD(+)) by transferring the adenylyl moiety of ATP to nicotinamide mononucleotide (NMN) with the release of pyrophosphate. NAD 93-126 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 0-47 11752792-1 2002 Nicotinamide mononucleotide adenylyltransferase catalyses the final step in the synthesis of nicotinamide-adenine dinucleotide (NAD(+)) by transferring the adenylyl moiety of ATP to nicotinamide mononucleotide (NMN) with the release of pyrophosphate. NAD 128-134 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 0-47 11248244-0 2001 Characterization of recombinant human nicotinamide mononucleotide adenylyl transferase (NMNAT), a nuclear enzyme essential for NAD synthesis. NAD 127-130 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 88-93 11248244-1 2001 Nicotinamide mononucleotide adenylyl transferase (NMNAT) is an essential enzyme in all organisms, because it catalyzes a key step of NAD synthesis. NAD 133-136 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 0-48 11248244-1 2001 Nicotinamide mononucleotide adenylyl transferase (NMNAT) is an essential enzyme in all organisms, because it catalyzes a key step of NAD synthesis. NAD 133-136 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 50-55 8852039-1 1996 NMN adenylyltransferase (NAD pyrophosphorylase; NMNAT) reversibly catalyzes the synthesis of NAD from ATP and NMN. NAD 25-28 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 48-53 1524439-0 1992 NAD biosynthesis in human placenta: purification and characterization of homogeneous NMN adenylyltransferase. NAD 0-3 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 85-108 8572289-1 1995 NMN adenylyltransferase (NMNAT) reversibly catalyzes the synthesis of NAD+ or NaAD+ from ATP and NMN or NaMN. NAD 70-74 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 0-23 8572289-1 1995 NMN adenylyltransferase (NMNAT) reversibly catalyzes the synthesis of NAD+ or NaAD+ from ATP and NMN or NaMN. NAD 70-74 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 25-30 34445574-3 2021 Our previous results suggest that NMNAT1, a key enzyme in nuclear NAD+ synthesis, facilitates the survival of cisplatin-treated osteosarcoma cells. NAD 66-70 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 34-40 34866305-1 2021 The enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT) catalyzes a reaction central to all known NAD biosynthetic routes. NAD 109-112 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 60-65 34919052-5 2021 Mechanistic analysis suggests that NMNAT interferes with DNA damage-p53-caspase-3 apoptosis signaling pathway by enhancing NAD+-dependent posttranslational modifications (PTMs) poly(ADP-ribosyl)ation (PARylation) and deacetylation of p53. NAD 123-127 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 35-40 34919052-7 2021 Our findings reveal a novel tumorigenic mechanism involving protein complex formation of p53 with NAD+ synthetic enzyme NMNAT and NAD+-dependent PTM enzymes that regulates glioma growth. NAD 98-102 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 120-125 34878972-0 2021 Nuclear NAD+-biosynthetic enzyme NMNAT1 facilitates development and early survival of retinal neurons. NAD 8-12 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 33-39 34445574-7 2021 The reduced NAD+ content in NMNAT1 KO cells was further decreased by ActD, which partially inhibited NAD+-dependent enzymes, including the DNA nick sensor enzyme PARP1 and the NAD+-dependent deacetylase SIRT1. NAD 12-16 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 28-34 34445574-7 2021 The reduced NAD+ content in NMNAT1 KO cells was further decreased by ActD, which partially inhibited NAD+-dependent enzymes, including the DNA nick sensor enzyme PARP1 and the NAD+-dependent deacetylase SIRT1. NAD 101-105 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 28-34 32775493-2 2020 Although the causative gene, NMNAT1, plays an essential role in nuclear nicotinamide adenine dinucleotide (NAD)+ metabolism in tissues throughout the body, NMNAT1-associated disease is isolated to the retina. NAD 72-105 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 29-35 34290089-0 2021 Nuclear NAD+ homeostasis governed by NMNAT1 prevents apoptosis of acute myeloid leukemia stem cells. NAD 8-12 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 37-43 34290089-3 2021 We integrated whole-genome CRISPR screening and pan-cancer genetic dependency mapping to identify NAMPT and NMNAT1 as AML dependencies governing NAD+ biosynthesis. NAD 145-149 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 108-114 34290089-4 2021 While both NAMPT and NMNAT1 were required for AML, the presence of NAD+ precursors bypassed the dependence of AML on NAMPT but not NMNAT1, pointing to NMNAT1 as a gatekeeper of NAD+ biosynthesis. NAD 67-71 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 151-157 34290089-4 2021 While both NAMPT and NMNAT1 were required for AML, the presence of NAD+ precursors bypassed the dependence of AML on NAMPT but not NMNAT1, pointing to NMNAT1 as a gatekeeper of NAD+ biosynthesis. NAD 177-181 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 21-27 34290089-4 2021 While both NAMPT and NMNAT1 were required for AML, the presence of NAD+ precursors bypassed the dependence of AML on NAMPT but not NMNAT1, pointing to NMNAT1 as a gatekeeper of NAD+ biosynthesis. NAD 177-181 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 151-157 34290089-5 2021 Deletion of NMNAT1 reduced nuclear NAD+, activated p53, and increased venetoclax sensitivity. NAD 35-39 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 12-18 34290089-8 2021 Our findings identify NMNAT1 as a previously unidentified therapeutic target that maintains NAD+ for AML progression and chemoresistance. NAD 92-96 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 22-28 6295757-4 1982 With this assay, it appeared that the reaction catalysed by NMN adenylyltransferase proceeded with a rapid, early "burst" of NAD before steady-state velocities were established. NAD 125-128 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 60-83 32533184-0 2020 An Alu-mediated duplication in NMNAT1, involved in NAD biosynthesis, causes a novel syndrome, SHILCA, affecting multiple tissues and organs. NAD 51-54 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 31-37 35408818-5 2022 More importantly, through constitutively overexpressing NMNAT1 or NAMPT in human mesangial cells, we revealed NAD+ levels altered inversely with NMN levels in the context of DN and, further, their changes affect Sirt1/NF-kappaB P65, thus playing a crucial role in the pathogenesis of DN. NAD 110-114 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 56-62 2560924-3 1989 We have focused our attention on two chromatin enzymes: NMN-adenylyltransferase that catalyzes reversible synthesis of NAD+ utilizing ATP and NMN, and poly(ADP-ribose)polymerase that covalently modifies nucleosomal proteins through poly ADP-ribosylation reactions. NAD 119-123 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 56-79 33330464-6 2020 NAD+ is mainly synthesized from salvage pathway mediated by two enzymes, Nampt and Nmnat. NAD 0-4 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 83-88 33107823-1 2020 Leber congenital amaurosis type nine is an autosomal recessive retinopathy caused by mutations of the NAD+ synthesis enzyme NMNAT1. NAD 102-106 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 124-130 32775493-2 2020 Although the causative gene, NMNAT1, plays an essential role in nuclear nicotinamide adenine dinucleotide (NAD)+ metabolism in tissues throughout the body, NMNAT1-associated disease is isolated to the retina. NAD 72-105 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 156-162 32775493-2 2020 Although the causative gene, NMNAT1, plays an essential role in nuclear nicotinamide adenine dinucleotide (NAD)+ metabolism in tissues throughout the body, NMNAT1-associated disease is isolated to the retina. NAD 107-110 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 29-35 32775493-2 2020 Although the causative gene, NMNAT1, plays an essential role in nuclear nicotinamide adenine dinucleotide (NAD)+ metabolism in tissues throughout the body, NMNAT1-associated disease is isolated to the retina. NAD 107-110 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 156-162 30951610-1 2019 This chemoenzymatic procedure describes a strategy for the preparation of 4"-thioribose nicotinamide adenine dinucleotide (S-NAD+ ), including chemical synthesis of nicotinamide 4"-riboside (S-NR), recombinant expression and purification of two NAD+ biosynthesis enzymes nicotinamide riboside kinase (NRK) and nicotinamide mononucleotide adenylyltransferase (NMNAT), and enzymatic synthesis of S-NAD+ . NAD 123-129 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 310-357 31988240-3 2020 The nicotinamide salvage pathway, constituted by nicotinamide mononucleotide adenylyltransferase (NMNAT) and nicotinamide phosphoribosyltransferase (NAMPT), mainly replenishes NAD+ in eukaryotes. NAD 176-179 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 49-96 31988240-3 2020 The nicotinamide salvage pathway, constituted by nicotinamide mononucleotide adenylyltransferase (NMNAT) and nicotinamide phosphoribosyltransferase (NAMPT), mainly replenishes NAD+ in eukaryotes. NAD 176-179 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 98-103 31754102-4 2019 WRN regulates transcription of a key NAD+ biosynthetic enzyme nicotinamide nucleotide adenylyltransferase 1 (NMNAT1). NAD 37-41 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 62-107 31754102-4 2019 WRN regulates transcription of a key NAD+ biosynthetic enzyme nicotinamide nucleotide adenylyltransferase 1 (NMNAT1). NAD 37-41 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 109-115 31136762-1 2019 The three nicotinamide mononucleotide adenylyltransferase (NMNAT) family members synthesize the electron carrier nicotinamide adenine dinucleotide (NAD+) and are essential for cellular metabolism. NAD 113-146 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 10-57 31136762-1 2019 The three nicotinamide mononucleotide adenylyltransferase (NMNAT) family members synthesize the electron carrier nicotinamide adenine dinucleotide (NAD+) and are essential for cellular metabolism. NAD 113-146 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 59-64 31136762-1 2019 The three nicotinamide mononucleotide adenylyltransferase (NMNAT) family members synthesize the electron carrier nicotinamide adenine dinucleotide (NAD+) and are essential for cellular metabolism. NAD 148-152 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 10-57 31136762-1 2019 The three nicotinamide mononucleotide adenylyltransferase (NMNAT) family members synthesize the electron carrier nicotinamide adenine dinucleotide (NAD+) and are essential for cellular metabolism. NAD 148-152 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 59-64 32392755-4 2020 Here we report that expression level of the nuclear NAD synthesis enzyme, nicotinamide mononucleotide adenylyltransferase-1 (NMNAT1), increases in U-2OS cells upon exposure to DNA damaging agents, suggesting the involvement of the enzyme in the DNA damage response. NAD 52-55 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 74-123 32392755-4 2020 Here we report that expression level of the nuclear NAD synthesis enzyme, nicotinamide mononucleotide adenylyltransferase-1 (NMNAT1), increases in U-2OS cells upon exposure to DNA damaging agents, suggesting the involvement of the enzyme in the DNA damage response. NAD 52-55 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 125-131 32392755-7 2020 Activation of the DNA damage sensor enzyme poly(ADP-ribose) polymerase 1 (PARP1), a major consumer of NAD+ in the nucleus, was fully blocked by NMNAT1 inactivation, leading to increased DNA damage (phospho-H2AX foci). NAD 102-106 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 144-150 30951610-1 2019 This chemoenzymatic procedure describes a strategy for the preparation of 4"-thioribose nicotinamide adenine dinucleotide (S-NAD+ ), including chemical synthesis of nicotinamide 4"-riboside (S-NR), recombinant expression and purification of two NAD+ biosynthesis enzymes nicotinamide riboside kinase (NRK) and nicotinamide mononucleotide adenylyltransferase (NMNAT), and enzymatic synthesis of S-NAD+ . NAD 123-129 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 359-364 30951610-3 2019 In the second basic protocol, experimental methods are detailed for the production of recombinant human NRK1 and NMNAT1 to catalyze conversion of S-NR to S-NAD+ . NAD 156-160 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 113-119 30166529-2 2018 NMNAT1 is a nuclear enzyme essential for nicotinamide adenine dinucleotide (NAD) biosynthesis pathways, but the mechanisms underlying the LCA pathology and whether NMNAT1 has a role in normal retinal development remain unclear. NAD 41-74 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 0-6 30166529-2 2018 NMNAT1 is a nuclear enzyme essential for nicotinamide adenine dinucleotide (NAD) biosynthesis pathways, but the mechanisms underlying the LCA pathology and whether NMNAT1 has a role in normal retinal development remain unclear. NAD 76-79 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 0-6 30166529-5 2018 Decreased intracellular NAD content was observed and the addition of NAD to the culture medium attenuated sh-Nmnat1-induced apoptosis. NAD 69-72 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 109-115 28445802-0 2017 NMNAT: It"s an NAD+ synthase... NAD 15-18 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 0-5 29748257-4 2018 Adipogenic signaling rapidly induces cytoplasmic NMNAT-2, which competes with nuclear NMNAT-1 for the common substrate, nicotinamide mononucleotide, leading to a precipitous reduction in nuclear NAD+ levels. NAD 195-199 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 86-93 29029387-9 2017 Our findings suggest that CTCF PARylation is underpinned by a cellular metabolic context engendered by regulation of the beta-NAD+ salvage pathway in which NMNAT-1 acts as a rheostat to control localized beta-NAD+ synthesis at CTCF/PARP-1 complexes. NAD 121-130 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 156-163 29029387-9 2017 Our findings suggest that CTCF PARylation is underpinned by a cellular metabolic context engendered by regulation of the beta-NAD+ salvage pathway in which NMNAT-1 acts as a rheostat to control localized beta-NAD+ synthesis at CTCF/PARP-1 complexes. NAD 204-213 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 156-163 28445802-6 2017 New mechanistic studies have challenged the role of NMNAT-catalyzed NAD+ production in delaying Wallerian degeneration and have specified new mechanisms of NMNAT"s chaperone function critical for neuronal health. NAD 68-72 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 52-57 24155910-1 2013 Among the enzymes involved in NAD homeostasis, nicotinamide mononucleotide adenylyltransferases (NMNAT1-3) are central to intracellular NAD formation. NAD 30-33 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 97-103 26018082-1 2015 Leber congenital amaurosis 9 (LCA9) is an autosomal recessive retinal degeneration condition caused by mutations in the NAD(+) biosynthetic enzyme NMNAT1. NAD 120-126 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 147-153 24155910-1 2013 Among the enzymes involved in NAD homeostasis, nicotinamide mononucleotide adenylyltransferases (NMNAT1-3) are central to intracellular NAD formation. NAD 136-139 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 97-103 23737528-0 2013 The NAD+ synthesis enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT1) regulates ribosomal RNA transcription. NAD 4-8 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 75-81 23737528-1 2013 The chromosomal region encoding the nuclear NAD(+) synthesis enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT1) is frequently deleted in human cancer. NAD 44-50 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 117-123 23737528-3 2013 NMNAT1 binds to nucleomethylin and is recruited into a ternary complex containing the NAD(+)-dependent deacetylase SirT1. NAD 86-92 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 0-6 22334709-1 2012 NMNAT-1 and PARP-1, two key enzymes in the NAD(+) metabolic pathway, localize to the nucleus where integration of their enzymatic activities has the potential to control a variety of nuclear processes. NAD 43-49 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 0-7 22842227-5 2012 NMNAT1 resides in the previously identified LCA9 locus and encodes the nuclear isoform of nicotinamide mononucleotide adenylyltransferase, a rate-limiting enzyme in nicotinamide adenine dinucleotide (NAD(+)) biosynthesis(4,5). NAD 165-198 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 0-6 22842227-5 2012 NMNAT1 resides in the previously identified LCA9 locus and encodes the nuclear isoform of nicotinamide mononucleotide adenylyltransferase, a rate-limiting enzyme in nicotinamide adenine dinucleotide (NAD(+)) biosynthesis(4,5). NAD 165-198 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 44-48 22842227-5 2012 NMNAT1 resides in the previously identified LCA9 locus and encodes the nuclear isoform of nicotinamide mononucleotide adenylyltransferase, a rate-limiting enzyme in nicotinamide adenine dinucleotide (NAD(+)) biosynthesis(4,5). NAD 200-207 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 0-6 22842227-5 2012 NMNAT1 resides in the previously identified LCA9 locus and encodes the nuclear isoform of nicotinamide mononucleotide adenylyltransferase, a rate-limiting enzyme in nicotinamide adenine dinucleotide (NAD(+)) biosynthesis(4,5). NAD 200-207 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 44-48 22842229-1 2012 In addition to its activity in nicotinamide adenine dinucleotide (NAD(+)) synthesis, the nuclear nicotinamide mononucleotide adenyltransferase NMNAT1 acts as a chaperone that protects against neuronal activity-induced degeneration. NAD 31-64 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 143-149 22842229-1 2012 In addition to its activity in nicotinamide adenine dinucleotide (NAD(+)) synthesis, the nuclear nicotinamide mononucleotide adenyltransferase NMNAT1 acts as a chaperone that protects against neuronal activity-induced degeneration. NAD 66-72 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 143-149 22842230-4 2012 Functional assays of the proteins encoded by the mutant alleles identified in our study showed that the mutations reduce the enzymatic activity of NMNAT1 in NAD biosynthesis and affect protein folding. NAD 157-160 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 147-153 22334709-3 2012 Specifically, we show that PARP-1 recruits NMNAT-1 to promoters where it produces NAD(+) to support PARP-1 catalytic activity, but also enhances the enzymatic activity of PARP-1 independently of NAD(+) production. NAD 82-88 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 43-50 22334709-4 2012 Furthermore, using two-photon excitation microscopy, we show that NMNAT-1 catalyzes the production of NAD(+) in a nuclear pool that may be distinct from other cellular compartments. NAD 102-108 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 66-73 21517775-4 2011 NMNAT is a key enzyme in all organisms catalyzing coupling of ATP and NMN or NaMN yielding NAD or NaAD, respectively. NAD 91-94 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 0-5 21517776-0 2011 NMNAT expression and its relation to NAD metabolism. NAD 37-40 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 0-5 21517776-1 2011 Nicotinamide mononucleotide adenylyltransferease (NMNAT), a rate-limiting enzyme present in all organisms, reversibly catalyzes the important step in the biosynthesis of NAD from ATP and NMN. NAD 170-173 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 0-48 21517776-1 2011 Nicotinamide mononucleotide adenylyltransferease (NMNAT), a rate-limiting enzyme present in all organisms, reversibly catalyzes the important step in the biosynthesis of NAD from ATP and NMN. NAD 170-173 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 50-55 21517776-5 2011 NMNAT also catalyzes the metabolic conversion of potent antitumor prodrugs like tiazofurin and benzamide riboside to their active forms which are analogs of NAD. NAD 157-160 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 0-5 20457531-1 2010 Nicotinamide mononucleotide adenylyltransferase (NMNAT) catalyzes the formation of nicotinamide adenine dinucleotide (NAD). NAD 83-116 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 0-47 20954240-1 2010 Nicotinamide mononucleotide adenylyltransferase (NMNAT) catalyzes the formation of NAD by means of nucleophilic attack by 5"-phosphoryl of NMN on the alpha-phosphoryl group of ATP. NAD 83-86 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 0-47 20954240-1 2010 Nicotinamide mononucleotide adenylyltransferase (NMNAT) catalyzes the formation of NAD by means of nucleophilic attack by 5"-phosphoryl of NMN on the alpha-phosphoryl group of ATP. NAD 83-86 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 49-54 20591898-0 2010 Nicotinate/nicotinamide mononucleotide adenyltransferase-mediated regulation of NAD biosynthesis protects guard cells from reactive oxygen species in ABA-mediated stomatal movement in Arabidopsis. NAD 80-83 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 0-56 20591898-10 2010 These results indicate that NAD biosynthesis is involved in protecting guard cells from ABA-induced local oxidative stress via the regulation of NMNAT activity. NAD 28-31 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 145-150 20591898-11 2010 In this study, it is demonstrated that NMNAT is essential for the maintenance of NAD homeostasis enabling sustainable stomatal movement. NAD 81-84 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 39-44 19879981-9 2010 Recent studies on the NAD(+) biosynthetic enzymes in the salvage pathway, nicotinamide phosphoribosyltransferase (NAMPT) and nicotinamide mononucleotide adenylyltransferase 1 (NMNAT-1), have revealed important functions for these enzymes in SIRT1-dependent transcription regulation. NAD 22-28 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 125-174 19879981-9 2010 Recent studies on the NAD(+) biosynthetic enzymes in the salvage pathway, nicotinamide phosphoribosyltransferase (NAMPT) and nicotinamide mononucleotide adenylyltransferase 1 (NMNAT-1), have revealed important functions for these enzymes in SIRT1-dependent transcription regulation. NAD 22-28 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 176-183 20457531-1 2010 Nicotinamide mononucleotide adenylyltransferase (NMNAT) catalyzes the formation of nicotinamide adenine dinucleotide (NAD). NAD 118-121 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 0-47 20457531-1 2010 Nicotinamide mononucleotide adenylyltransferase (NMNAT) catalyzes the formation of nicotinamide adenine dinucleotide (NAD). NAD 118-121 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 49-54 20388704-8 2010 We further demonstrate that the Golgi-associated NMNAT is palmitoylated at two adjacent cysteine residues of its isoform-specific domain and thereby anchored at the cytoplasmic surface, a potential mechanism to regulate the cytosolic NAD pool. NAD 234-237 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 49-54 20457531-1 2010 Nicotinamide mononucleotide adenylyltransferase (NMNAT) catalyzes the formation of nicotinamide adenine dinucleotide (NAD). NAD 83-116 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 49-54 19448972-1 2009 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase (NMNAT) has long been known as the master enzyme in NAD biosynthesis in living organisms. NAD 115-118 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 0-62 19448972-1 2009 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase (NMNAT) has long been known as the master enzyme in NAD biosynthesis in living organisms. NAD 115-118 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 64-69 19448972-2 2009 A burst of investigations on NMNAT, going beyond enzymology, have paralleled increasing discoveries of key roles played by NAD homeostasis in a number or patho-physiological conditions. NAD 123-126 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 29-34 19478080-1 2009 In mammals, nicotinamide phosphoribosyltransferase (NAMPT) and nicotinamide mononucleotide adenylyltransferase 1 (NMNAT-1) constitute a nuclear NAD(+) salvage pathway which regulates the functions of NAD(+)-dependent enzymes such as the protein deacetylase SIRT1. NAD 144-150 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 63-112 19478080-1 2009 In mammals, nicotinamide phosphoribosyltransferase (NAMPT) and nicotinamide mononucleotide adenylyltransferase 1 (NMNAT-1) constitute a nuclear NAD(+) salvage pathway which regulates the functions of NAD(+)-dependent enzymes such as the protein deacetylase SIRT1. NAD 144-150 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 114-121 19478080-1 2009 In mammals, nicotinamide phosphoribosyltransferase (NAMPT) and nicotinamide mononucleotide adenylyltransferase 1 (NMNAT-1) constitute a nuclear NAD(+) salvage pathway which regulates the functions of NAD(+)-dependent enzymes such as the protein deacetylase SIRT1. NAD 200-206 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 63-112 19478080-1 2009 In mammals, nicotinamide phosphoribosyltransferase (NAMPT) and nicotinamide mononucleotide adenylyltransferase 1 (NMNAT-1) constitute a nuclear NAD(+) salvage pathway which regulates the functions of NAD(+)-dependent enzymes such as the protein deacetylase SIRT1. NAD 200-206 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 114-121 19478080-4 2009 In this study we show that stable short hairpin RNA-mediated knockdown of NAMPT or NMNAT-1 in MCF-7 breast cancer cells reduces total cellular NAD(+) levels and alters global patterns of gene expression. NAD 143-149 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 83-90 19403820-4 2009 The Wld(s) protein consists of the N-terminal portion of the ubiquitination factor Ube4b fused to the nicotinamide adenine dinucleotide (NAD(+)) biosynthetic enzyme nicotinamide mononucleotide adenylyl transferase 1 (Nmnat1). NAD 102-135 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 165-215 19403820-4 2009 The Wld(s) protein consists of the N-terminal portion of the ubiquitination factor Ube4b fused to the nicotinamide adenine dinucleotide (NAD(+)) biosynthetic enzyme nicotinamide mononucleotide adenylyl transferase 1 (Nmnat1). NAD 137-144 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 165-215 17402747-3 2007 Only the latter utilizes ITP efficiently in place of ATP, and while NMNH conversion to NADH by NMNAT1 and NMNAT3 occurs at similar rates, conversion by NMNAT2 is much slower. NAD 87-91 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 95-101 18275811-0 2008 Bifunctional NMN adenylyltransferase/ADP-ribose pyrophosphatase: structure and function in bacterial NAD metabolism. NAD 101-104 nicotinamide nucleotide adenylyltransferase 1 Homo sapiens 13-36