PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34149863-13	2021	SCDP key active ingredients are mainly quercetin, wogonin, baicalein, acacetin, oroxylin A, and beta-sitosterol, which function mainly by regulating targets, such as PTGS2, CASP3, TP53, IL-6, TNF, and AKT1, and are associated with multiple signaling pathways as pathways in cancer, PI3K-Akt signaling pathway, apoptosis, IL-17 signaling pathways.	gamma-sitosterol	96-111	tumor necrosis factor	Homo sapiens	192-195	
33963719-8	2021	Several key targets including AKT1, IL- 6, JUN, TNF and CASP3 were screened for molecular docking, which had good binding activities with berberrubine, epiberberine, stigmasterol and sitosterol.	gamma-sitosterol	183-193	tumor necrosis factor	Homo sapiens	48-51	
34035828-9	2021	Further analysis showed that the HGD activity of quercetin, formononetin, kaempferol, isorhamnetin, and beta-sitosterol ingredients is possible through VEGFA, IL6, TNF, AKT1, and TP53 targets involved in TNF, toll-like receptors, and MAPK-related pathways, which have anti-inflammatory, antiapoptosis, antioxidation, and autophagy effects, relieve renal fibrosis and renal cortex injury, and improve renal function, thus delaying the development of DN.	gamma-sitosterol	104-119	tumor necrosis factor	Homo sapiens	164-167	
34035828-9	2021	Further analysis showed that the HGD activity of quercetin, formononetin, kaempferol, isorhamnetin, and beta-sitosterol ingredients is possible through VEGFA, IL6, TNF, AKT1, and TP53 targets involved in TNF, toll-like receptors, and MAPK-related pathways, which have anti-inflammatory, antiapoptosis, antioxidation, and autophagy effects, relieve renal fibrosis and renal cortex injury, and improve renal function, thus delaying the development of DN.	gamma-sitosterol	104-119	tumor necrosis factor	Homo sapiens	204-207	
35388303-9	2022	The key active ingredients were mainly quercetin, beta-estradiol, berberine, wogonin, and beta-sitosterol, and the key targets were also identified, including IL-6, AKT1, MAPK3, PIK3CA, and TNF.	gamma-sitosterol	90-105	tumor necrosis factor	Homo sapiens	190-193	
34035828-10	2021	The molecular docking results showed that quercetin, formononetin, kaempferol, isorhamnetin, beta-sitosterol had a good binding activity with VEGFA, IL6, TNF, AKT1, and TP53.	gamma-sitosterol	93-108	tumor necrosis factor	Homo sapiens	154-157	
19937850-7	2010	Results showed that beta-sitosterol inhibits significantly vascular adhesion molecule 1 and intracellular adhesion molecule 1 expression in TNF-alpha-stimulated HAEC as well as the binding of U937 cells to TNF-alpha-stimulated HAEC and attenuates the phosphorylation of nuclear factor-kB p65.	gamma-sitosterol	20-35	tumor necrosis factor	Homo sapiens	140-149	
32854331-9	2020	In our network, GO and KEGG results yielded two compounds (beta-sitosterol (BS) and pelargonidin (PG)), targets (PTGS1 (COX-1) and PTGS2 (COX-2)), and pathways (nitric oxide, TNF) were involved in the inhibitory effects of FT on influenza-associated inflammation.	gamma-sitosterol	76-78	tumor necrosis factor	Homo sapiens	175-178	
32724650-4	2020	The results showed that serum concentrations of interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, and total Th1 cytokines were positively associated with serum beta-sitosterol level, adjusting for age, BMI, and serum cholesterol.	gamma-sitosterol	169-184	tumor necrosis factor	Homo sapiens	72-105	
20558233-0	2010	beta-sitosterol among other secondary metabolites of Piper galeatum shows inhibition of TNFalpha-induced cell adhesion molecule expression on human endothelial cells.	gamma-sitosterol	0-15	tumor necrosis factor	Homo sapiens	88-96	
20558233-6	2010	beta-sitosterol also significantly inhibited the TNFalpha-induced expression of VCAM-1 and E-selectin, which also play key role in various inflammatory diseases.	gamma-sitosterol	0-15	tumor necrosis factor	Homo sapiens	49-57	
20558233-9	2010	To elucidate the molecular mechanism of inhibition of cell adhesion molecules, we investigated the status of nuclear transcription factor-kappaB (NF-kappaB) and were able to establish that beta-sitosterol significantly blocked the TNFalpha-induced activation of NF-kappaB.	gamma-sitosterol	189-204	tumor necrosis factor	Homo sapiens	231-239	
19937850-7	2010	Results showed that beta-sitosterol inhibits significantly vascular adhesion molecule 1 and intracellular adhesion molecule 1 expression in TNF-alpha-stimulated HAEC as well as the binding of U937 cells to TNF-alpha-stimulated HAEC and attenuates the phosphorylation of nuclear factor-kB p65.	gamma-sitosterol	20-35	tumor necrosis factor	Homo sapiens	206-215