PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34821900-5	2021	Western blot experiment results also showed that appropriate concentrations of LPSs and beta-sitosterol could up-regulate the expression of the anti-apoptotic protein Bcl-2 and down-regulate the pro-apoptotic proteins Bax and caspase-3 in GES-1 cells.	gamma-sitosterol	88-103	BCL2 apoptosis regulator	Homo sapiens	167-172	
33959188-7	2021	The results demonstrated that quercetin, ephedrine, trigonelline, crocetin, and beta-sitosterol were major effective compounds of LPD responsible for the CG treatment by inhibiting the activation of the JAK 2-STAT 3 signaling pathway to reduce the expressions of cyclin D1 and Bcl-2 proteins.	gamma-sitosterol	80-95	BCL2 apoptosis regulator	Homo sapiens	277-282	
33204288-10	2020	The compounds-targets network analysis indicated that the 6 compounds, including quercetin, kaempferol, baicalein, wogonin, beta-sitosterol, and eugenol, were linked to >=10 target genes, and the 10 target genes (PTGS1, ESR1, AR, PGR, CHRM3, PPARG, CHRM2, BCL2, CASP3, and RELA) were core target genes in the network.	gamma-sitosterol	124-139	BCL2 apoptosis regulator	Homo sapiens	256-260	
18314257-0	2008	beta-Sitosterol induces G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways.	gamma-sitosterol	0-15	BCL2 apoptosis regulator	Homo sapiens	82-87	
19456133-5	2009	Cells treated with different concentrations of beta-sitosterol also showed changes typical of apoptosis: morphological changes, DNA damage, increased expression of pro-caspase-3 and bax (p < 0.05), and activation of pro-caspase-3 and suppression of bcl-2 expression (p < 0.05).	gamma-sitosterol	47-62	BCL2 apoptosis regulator	Homo sapiens	252-257	
19456133-7	2009	The decrease of the bcl-2/bax ratio and DNA damage may be the critical mechanisms of apoptosis induced by beta-sitosterol in SGC-7901 human stomach cancer cells.	gamma-sitosterol	106-121	BCL2 apoptosis regulator	Homo sapiens	20-25	
30400936-11	2018	The molecular docking showed that licochalcone a and beta-sitosterol can closely bind two targets (BCL2 and PRKCA) that involved in EGFR-TKI resistance pathway.	gamma-sitosterol	53-68	BCL2 apoptosis regulator	Homo sapiens	99-103	
17603173-0	2007	Beta-sitosterol induces anti-proliferation and apoptosis in human leukemic U937 cells through activation of caspase-3 and induction of Bax/Bcl-2 ratio.	gamma-sitosterol	0-15	BCL2 apoptosis regulator	Homo sapiens	139-144	
17603173-5	2007	The increase in apoptosis induced by beta-sitosterol was associated with down-regulation of Bcl-2, degradation of poly-(ADP-ribose) polymerase (PARP) and phospholipase C (PLC)-gamma1 protein, and activation of caspase-3.	gamma-sitosterol	37-52	BCL2 apoptosis regulator	Homo sapiens	92-97	
17603173-9	2007	Bcl-2 overexpression also significantly blocked caspase-3 activation and the decrease in PARP cleavage by beta-sitosterol, and effectively attenuated the apoptotic response to beta-sitosterol.	gamma-sitosterol	106-121	BCL2 apoptosis regulator	Homo sapiens	0-5	
17603173-9	2007	Bcl-2 overexpression also significantly blocked caspase-3 activation and the decrease in PARP cleavage by beta-sitosterol, and effectively attenuated the apoptotic response to beta-sitosterol.	gamma-sitosterol	176-191	BCL2 apoptosis regulator	Homo sapiens	0-5	
17603173-10	2007	These results show that beta-sitosterol potently induces apoptosis in U937 cells and that beta-sitosterol-induced apoptosis is related to the selective activation of caspase-3 and induction of Bax/Bcl-2 ratio.	gamma-sitosterol	90-105	BCL2 apoptosis regulator	Homo sapiens	197-202	
14612938-5	2003	In addition, beta-sitosterol-induced apoptosis in HT116 cells was associated with a decreased expression of the anti-apototic Bcl-2 protein and mRNA and a concomitant increase of the pro-apototic Bax protein and mRNA, and with release of cytochrome c from the mitochondria into the cytosol.	gamma-sitosterol	13-28	BCL2 apoptosis regulator	Homo sapiens	126-131	
34942456-12	2022	CONCLUSIONS: In summary, combined network pharmacology and biological experiments proved that the main ingredients of ZJC such as quercetin, (R)-Canadine, palmatine, rutaecarpine, evodiamine, beta-sitosterol and berberine can target CDKN1A, Bcl2, E2F1, PRKCB, MYC, CDK2 and MMP9 to combat colorectal cancer.	gamma-sitosterol	192-207	BCL2 apoptosis regulator	Homo sapiens	241-245