PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22661716-5 2012 Small angle x-ray scattering reveals that the helical domain of Galpha(13) docks onto the DH domain, opposite to the surface of DH that binds RhoA. 2-(3,5-dihydroxyphenyl)-6-hydroxybenzothiazole 128-130 ras homolog family member A Homo sapiens 142-146 20018869-8 2010 This reaction is markedly accelerated to 1179 x 10(-4) min(-1) in the presence of DH-PH(PRG) at a ratio of 1:8,000 relative to RhoA. 2-(3,5-dihydroxyphenyl)-6-hydroxybenzothiazole 82-84 ras homolog family member A Homo sapiens 127-131 12910478-4 2003 Moreover, this ox-LDL-increased AP-1 binding was inhibited by several protein kinase (PK) inhibitors: the protein kinase C (PKC) inhibitor Bisindolylmaleimide I, the cAMP-dependent PK (PKA) inhibitor H89, and the tyrosine PK (PTK) inhibitor genistein. Tyrosine 213-221 KIT proto-oncogene receptor tyrosine kinase Rattus norvegicus 70-84 14500382-4 2003 We found, when introduced into an interleukin 3-dependent cell line, TPR-MET induces factor independence and constitutive tyrosine phosphorylation of several cellular proteins. Tyrosine 122-130 translocated promoter region, nuclear basket protein Homo sapiens 69-72 14500382-5 2003 One major tyrosine phosphorylated protein was identified as the TPR-MET oncoprotein itself. Tyrosine 10-18 translocated promoter region, nuclear basket protein Homo sapiens 64-67 12928225-1 2003 BACKGROUND: The reverse transcription-PCR tyrosinase assay (TYR test) cannot reliably detect malignant melanoma (MM) cells in blood as the cells often circulate at low concentrations. Tyrosine 60-63 tyrosinase Homo sapiens 42-52 14506160-0 2003 Differential expression and clinical significance of tyrosine-phosphorylated STAT3 in ALK+ and ALK- anaplastic large cell lymphoma. Tyrosine 53-61 ALK receptor tyrosine kinase Homo sapiens 86-89 14506160-0 2003 Differential expression and clinical significance of tyrosine-phosphorylated STAT3 in ALK+ and ALK- anaplastic large cell lymphoma. Tyrosine 53-61 ALK receptor tyrosine kinase Homo sapiens 95-98 12941761-4 2003 This finding correlated with a prominent Shc/IGF-I receptor interaction, tyrosine phosphorylation of Shc, activation of extracellular signal-regulated protein kinase (ERK)-1 and -2, and stimulation of DNA synthesis by HMR 1153 and Asp(B10) insulin. Tyrosine 73-81 SHC adaptor protein 1 Homo sapiens 101-104 12949729-0 2003 Bile salt-induced hepatocyte apoptosis involves epidermal growth factor receptor-dependent CD95 tyrosine phosphorylation. Tyrosine 96-104 epidermal growth factor receptor Rattus norvegicus 48-80 12883649-2 2003 Functional activation of STAT 1 requires tyrosine and serine phosphorylation. Tyrosine 41-49 signal transducer and activator of transcription 1 Homo sapiens 25-31 14703945-0 2003 Ionizing radiation modules of the expression and tyrosine phosphorylation of the focal adhesion-associated proteins focal adhesion kinase (FAK) and its substrates p130cas and paxillin in A549 human lung carcinoma cells in vitro. Tyrosine 49-57 nucleolar and coiled-body phosphoprotein 1 Homo sapiens 163-167 12950452-3 2003 Following ischemia, tyrosine phosphorylation of NR2A and NR2B and activated Src-family kinases (SFKs) and Pyk2 were increased in post-synaptic densities (PSDs). Tyrosine 20-28 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 57-61 12950452-7 2003 The results are consistent with a role for PKC in the ischemia-induced increase in tyrosine phosphorylation of the NMDAR, via a pathway involving Pyk2 and Src-family kinases. Tyrosine 83-91 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 155-158 12774303-5 2003 The alpha-tubulin, which is the major component of microtubules, can be postranslationally modified and both the tyrosinated (tyr-tub) and acetylated (acet-tub) forms are considered markers of more dynamic or more stable microtubules, respectively. Tyrosine 113-116 TUB bipartite transcription factor Rattus norvegicus 10-13 12774303-6 2003 The aim of the present work was to investigate the expression of tyr-tub and acet-tub in the hippocampus of rats submitted to either acute (6 h for 1 day) or sub-chronic (6 h for 4 days every day) restraint stress. Tyrosine 65-68 TUB bipartite transcription factor Rattus norvegicus 69-72 12774303-8 2003 Our results showed that the expression of tyr-tub in the hippocampus was significantly decreased to 70 +/- 7% following sub-chronic restraint stress (P < 0.01). Tyrosine 42-45 TUB bipartite transcription factor Rattus norvegicus 46-49 14577637-5 2003 Anisic acid also inhibited the hydroxylation of L-tyrosine catalyzed by tyrosinase. Tyrosine 48-58 tyrosinase Homo sapiens 72-82 14503841-0 2003 Relative extent of tyrosine phosphorylation of the NR2A and NR2B subunits in the rat forebrain postsynaptic density fraction. Tyrosine 19-27 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 60-64 14503841-2 2003 I investigated the relative extent of tyrosine phosphorylation of NMDA receptor subunit 2A (NR2A) and 2B (NR2B) subunits in the rat forebrain postsynaptic density (PSD) fraction. Tyrosine 38-46 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 106-110 12777375-6 2003 In addition, G6PD-deficient cells demonstrated decreased tyrosine phosphorylation of the VEGF receptor Flk-1/KDR, Akt, and eNOS compared with cells with normal G6PD activity, whereas overexpression of G6PD enhanced phosphorylation of Flk-1/KDR, Akt, and eNOS. Tyrosine 57-65 vascular endothelial growth factor A Mus musculus 89-93 12783885-3 2003 In the present study, we have found that phosphorylation of SOCS3 at two tyrosine residues in the conserved SOCS box, Tyr204 and Tyr221, can inhibit the SOCS3-elongin C interaction and activate proteasome-mediated SOCS3 degradation. Tyrosine 73-81 elongin C Homo sapiens 159-168 12901876-5 2003 We also demonstrated that Raf1 is phosphorylated and involved in the production of TNF-alpha and tyrosine phosphorylation of PI3-K via ERK. Tyrosine 97-105 v-raf-leukemia viral oncogene 1 Mus musculus 26-30 12922168-1 2003 The Src-family tyrosine kinase, Lck, contains two key regulatory phosphotyrosine residues, tyrosine 394 (Tyr-394) and tyrosine 505 (Tyr-505), both of which can be dephosphorylated by CD45. Tyrosine 15-23 protein tyrosine phosphatase receptor type C Homo sapiens 183-187 12922168-3 2003 CD45 preferentially dephosphorylated Tyr-394 over Tyr-505 in Lck. Tyrosine 37-40 protein tyrosine phosphatase receptor type C Homo sapiens 0-4 12922168-3 2003 CD45 preferentially dephosphorylated Tyr-394 over Tyr-505 in Lck. Tyrosine 50-53 protein tyrosine phosphatase receptor type C Homo sapiens 0-4 12922168-5 2003 The interactions with the noncatalytic domains of Lck and CD45 enhanced the dephosphorylation of Tyr-394 whereas intramolecular interactions within Lck reduced, but did not abolish, the dephosphorylation of Tyr-505. Tyrosine 97-100 protein tyrosine phosphatase receptor type C Homo sapiens 58-62 12922168-6 2003 This demonstrates that the noncatalytic domains of Lck regulate the dephosphorylation of both Tyr-394 and Tyr-505 by CD45. Tyrosine 94-97 protein tyrosine phosphatase receptor type C Homo sapiens 117-121 12922168-6 2003 This demonstrates that the noncatalytic domains of Lck regulate the dephosphorylation of both Tyr-394 and Tyr-505 by CD45. Tyrosine 106-109 protein tyrosine phosphatase receptor type C Homo sapiens 117-121 14640038-8 2003 The Tyr-187 gelsolin mutation, corresponding to the naturally occurring mutation in the Danish subtype of FAF, required acidic conditions to form fibrils meeting the criteria of amyloid. Tyrosine 4-7 ubiquitin specific peptidase 9 X-linked Homo sapiens 106-109 12893238-4 2003 In UBP43 deficient cells, interferon induces a prolonged Stat1 tyrosine phosphorylation and DNA binding, which result in a prolonged and enhanced activation of interferon-stimulated genes. Tyrosine 63-71 ubiquitin specific peptidase 18 Mus musculus 3-8 12893238-4 2003 In UBP43 deficient cells, interferon induces a prolonged Stat1 tyrosine phosphorylation and DNA binding, which result in a prolonged and enhanced activation of interferon-stimulated genes. Tyrosine 63-71 signal transducer and activator of transcription 1 Mus musculus 57-62 15090252-2 2003 The EphB3 kinase domain was shown to phosphorylate a group of synthetic tyrosine-containing peptides derived from a proprietary biotinylated kinase-biased peptide substrate library. Tyrosine 72-80 EPH receptor B3 Homo sapiens 4-9 12879454-0 2003 Immunoreactivity of Stat5 phosphorylated on tyrosine as a cell-based measure of Bcr/Abl kinase activity. Tyrosine 44-52 BCR activator of RhoGEF and GTPase Homo sapiens 80-83 12879454-0 2003 Immunoreactivity of Stat5 phosphorylated on tyrosine as a cell-based measure of Bcr/Abl kinase activity. Tyrosine 44-52 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 84-87 12874221-7 2003 Biochemical analysis of macrophages from lyn(-/-) mice revealed that Lyn plays an essential role in the adhesion-dependent phosphorylation of the immunoreceptor tyrosine-based inhibitory motif of the inhibitory receptors SIRP1alpha and PIR-B, which in turn recruit the phosphatase SHP-1. Tyrosine 161-169 LYN proto-oncogene, Src family tyrosine kinase Mus musculus 41-44 12874221-7 2003 Biochemical analysis of macrophages from lyn(-/-) mice revealed that Lyn plays an essential role in the adhesion-dependent phosphorylation of the immunoreceptor tyrosine-based inhibitory motif of the inhibitory receptors SIRP1alpha and PIR-B, which in turn recruit the phosphatase SHP-1. Tyrosine 161-169 LYN proto-oncogene, Src family tyrosine kinase Mus musculus 69-72 12846735-0 2003 Clustering-induced tyrosine phosphorylation of nephrin by Src family kinases. Tyrosine 19-27 NPHS1 adhesion molecule, nephrin Homo sapiens 47-54 12846735-10 2003 RESULTS: Clustering of nephrin induced its own tyrosine phosphorylation. Tyrosine 47-55 NPHS1 adhesion molecule, nephrin Homo sapiens 23-30 12846735-14 2003 Interestingly, clustering of nephrin induced also tyrosine phosphorylation of a 46 kD protein that was as well found to be coimmunoprecipitated with nephrin. Tyrosine 50-58 NPHS1 adhesion molecule, nephrin Homo sapiens 29-36 12846735-14 2003 Interestingly, clustering of nephrin induced also tyrosine phosphorylation of a 46 kD protein that was as well found to be coimmunoprecipitated with nephrin. Tyrosine 50-58 NPHS1 adhesion molecule, nephrin Homo sapiens 149-156 12920240-6 2003 Such an autocrine loop is supported by constitutive VEGF receptor (Flk-1) tyrosine phosphorylation, Flk-1 and Flt-1 nuclear localization, and mitogen-activated protein kinase activation. Tyrosine 74-82 vascular endothelial growth factor A Mus musculus 52-56 12925758-6 2003 Phosphorylation of cortactin tyrosine 421 and 466 was elevated in response to Src, epidermal growth factor receptor and Rac1 activation, and tyrosine 421 phosphorylated cortactin localized with F-actin in lamellipodia and podosomes. Tyrosine 141-149 cortactin Homo sapiens 169-178 12925758-7 2003 Cortactin tyrosine phosphorylation is progressive, with tyrosine 421 phosphorylation required for phosphorylation of tyrosine 466. Tyrosine 10-18 cortactin Homo sapiens 0-9 12925758-7 2003 Cortactin tyrosine phosphorylation is progressive, with tyrosine 421 phosphorylation required for phosphorylation of tyrosine 466. Tyrosine 56-64 cortactin Homo sapiens 0-9 12925758-7 2003 Cortactin tyrosine phosphorylation is progressive, with tyrosine 421 phosphorylation required for phosphorylation of tyrosine 466. Tyrosine 56-64 cortactin Homo sapiens 0-9 12925758-8 2003 These results indicate that cortactin tyrosine phosphorylation requires Rac1-induced cortactin targeting to cortical actin networks, where it is tyrosine phosphorylated in hierarchical manner that is closely coordinated with its ability to regulate actin dynamics. Tyrosine 38-46 cortactin Homo sapiens 28-37 12925758-8 2003 These results indicate that cortactin tyrosine phosphorylation requires Rac1-induced cortactin targeting to cortical actin networks, where it is tyrosine phosphorylated in hierarchical manner that is closely coordinated with its ability to regulate actin dynamics. Tyrosine 38-46 Rac family small GTPase 1 Homo sapiens 72-76 12925758-8 2003 These results indicate that cortactin tyrosine phosphorylation requires Rac1-induced cortactin targeting to cortical actin networks, where it is tyrosine phosphorylated in hierarchical manner that is closely coordinated with its ability to regulate actin dynamics. Tyrosine 38-46 cortactin Homo sapiens 85-94 12925758-8 2003 These results indicate that cortactin tyrosine phosphorylation requires Rac1-induced cortactin targeting to cortical actin networks, where it is tyrosine phosphorylated in hierarchical manner that is closely coordinated with its ability to regulate actin dynamics. Tyrosine 145-153 cortactin Homo sapiens 28-37 12925758-8 2003 These results indicate that cortactin tyrosine phosphorylation requires Rac1-induced cortactin targeting to cortical actin networks, where it is tyrosine phosphorylated in hierarchical manner that is closely coordinated with its ability to regulate actin dynamics. Tyrosine 145-153 Rac family small GTPase 1 Homo sapiens 72-76 12888504-6 2003 Thus, a single amino acid substitution in which Gly433 residue of Pol mu was mutated to the consensus tyrosine present in Pol beta, produced a strong increase in the discrimination against ribonucleotides. Tyrosine 102-110 DNA polymerase mu Homo sapiens 66-72 12738779-5 2003 This consensus sequence was similar to that for other MMPs, which also cleave peptides containing Ala in position 3, Ala in position 1, and Leu/Tyr in position 1", but differed from most other MMP substrates in that proline was rarely found in position 3 and Asn was frequently found in position 1. Tyrosine 144-147 matrix metallopeptidase 11 Homo sapiens 54-58 12738779-5 2003 This consensus sequence was similar to that for other MMPs, which also cleave peptides containing Ala in position 3, Ala in position 1, and Leu/Tyr in position 1", but differed from most other MMP substrates in that proline was rarely found in position 3 and Asn was frequently found in position 1. Tyrosine 144-147 matrix metallopeptidase 11 Homo sapiens 54-57 12746446-0 2003 Glucose stimulates the tyrosine phosphorylation of Crk-associated substrate in pancreatic beta-cells. Tyrosine 23-31 BCAR1 scaffold protein, Cas family member Rattus norvegicus 51-75 12746446-1 2003 Several years ago, we demonstrated that glucose induced tyrosine phosphorylation of a 125-kDa protein (p125) in pancreatic beta-cells (Konrad, R. J., Dean, R. M., Young, R. A., Bilings, P. C., and Wolf, B. Tyrosine 56-64 Sec23 interacting protein Mus musculus 103-107 12746446-6 2003 Glucose induced p125 tyrosine phosphorylation in beta-TC3 insulinoma cells, beta-HC9 cells, and in freshly isolated rat islets, whereas increased tyrosine phosphorylation was not observed with other fuel secretagogues. Tyrosine 21-29 Sec23 interacting protein Mus musculus 16-20 12746446-11 2003 Commercially available antibodies against Cas were obtained and tested directly in beta-cells, confirming glucose-induced tyrosine phosphorylation of Cas. Tyrosine 122-130 BCAR1 scaffold protein, Cas family member Rattus norvegicus 42-45 12746446-11 2003 Commercially available antibodies against Cas were obtained and tested directly in beta-cells, confirming glucose-induced tyrosine phosphorylation of Cas. Tyrosine 122-130 BCAR1 scaffold protein, Cas family member Rattus norvegicus 150-153 12746446-12 2003 Further experiments demonstrated that in beta-cells the glucose-induced increase in Cas tyrosine phosphorylation occurs immediately and is not accompanied by increased focal adhesion kinase tyrosine phosphorylation. Tyrosine 88-96 BCAR1 scaffold protein, Cas family member Rattus norvegicus 84-87 12746446-14 2003 Together, these results show that the identity of the previously described p125 beta-cell protein is Cas and that Cas undergoes rapid glucose-induced tyrosine phosphorylation in beta-cells. Tyrosine 150-158 BCAR1 scaffold protein, Cas family member Rattus norvegicus 114-117 12850569-1 2003 It has been reported that the Src family kinases-mediated tyrosine phosphorylation of alpha(1C) subunits of L-type voltage-gated calcium channels (L-VGCCs) potentiates the channel currents. Tyrosine 58-66 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 30-33 12850569-9 2003 These results suggest a novel mechanism involving the ischemia/reperfusion-induced recruitment of L-VGCCs, Src and Fyn to the PSD-95 signaling complex that facilitates the tyrosine phosphorylation of alpha(1C) subunits by Src family kinases and may contribute to the up-regulation of L-VGCCs activity in postischemic hippocampus. Tyrosine 172-180 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 107-110 12850569-9 2003 These results suggest a novel mechanism involving the ischemia/reperfusion-induced recruitment of L-VGCCs, Src and Fyn to the PSD-95 signaling complex that facilitates the tyrosine phosphorylation of alpha(1C) subunits by Src family kinases and may contribute to the up-regulation of L-VGCCs activity in postischemic hippocampus. Tyrosine 172-180 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 222-225 12889478-0 2003 Endoglycan, a member of the CD34 family, functions as an L-selectin ligand through modification with tyrosine sulfation and sialyl Lewis x. Tyrosine 101-109 podocalyxin like 2 Homo sapiens 0-10 12889478-5 2003 However, endoglycan employs a different binding mechanism, interacting with L-selectin through sulfation on two tyrosine residues and O-linked sLex structures that are presented within its highly acidic amino-terminal region. Tyrosine 112-120 podocalyxin like 2 Homo sapiens 9-19 12721296-5 2003 Using a combination of immunoblotting, immunoprecipitation, and immunostaining we show that SHP-2 is present in nascent focal adhesions and undergoes phosphorylation on tyrosine 542 in response to IL-1 stimulation. Tyrosine 169-177 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 92-97 12649157-8 2003 Significant attenuation of CRP-induced tyrosine phosphorylation in known PI3K effectors such as Btk, Tec, PKB/Akt, and phospholipase Cgamma2 were observed with p85alpha-/- platelets, whereas no alteration was noted in upstream molecules of Syk, LAT, and SLP-76. Tyrosine 39-47 C-reactive protein, pentraxin-related Mus musculus 27-30 12649157-8 2003 Significant attenuation of CRP-induced tyrosine phosphorylation in known PI3K effectors such as Btk, Tec, PKB/Akt, and phospholipase Cgamma2 were observed with p85alpha-/- platelets, whereas no alteration was noted in upstream molecules of Syk, LAT, and SLP-76. Tyrosine 39-47 tec protein tyrosine kinase Mus musculus 101-104 12649157-8 2003 Significant attenuation of CRP-induced tyrosine phosphorylation in known PI3K effectors such as Btk, Tec, PKB/Akt, and phospholipase Cgamma2 were observed with p85alpha-/- platelets, whereas no alteration was noted in upstream molecules of Syk, LAT, and SLP-76. Tyrosine 39-47 spleen tyrosine kinase Mus musculus 240-243 12649157-8 2003 Significant attenuation of CRP-induced tyrosine phosphorylation in known PI3K effectors such as Btk, Tec, PKB/Akt, and phospholipase Cgamma2 were observed with p85alpha-/- platelets, whereas no alteration was noted in upstream molecules of Syk, LAT, and SLP-76. Tyrosine 39-47 linker for activation of T cells Mus musculus 245-248 12837289-5 2003 Here we demonstrate that treatment of vascular smooth muscle cells with angiotensin II results in activation of the Shc/Grb2/ERK2 signaling pathway as measured by (1) increased Shc tyrosine phosphorylation, (2) increased c-Src/Shc cellular co-localization, (3) increased Shc/Grb2 co-association, and (4) ERK2 activation. Tyrosine 181-189 SHC adaptor protein 1 Homo sapiens 116-119 12847253-3 2003 Importantly, one line (YF1,2) retains the constitutively tyrosine-phosphorylated p21 in the complete absence of inducible p23. Tyrosine 57-65 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 81-84 12847270-7 2003 15dPGJ(2) also attenuated IL-6-induced tyrosine phosphorylation of STAT1 and STAT3 in Hep3B hepatoma cells. Tyrosine 39-47 signal transducer and activator of transcription 1 Homo sapiens 67-72 12724322-5 2003 Stimulation of the human monocytic cell line THP-1 with LPS resulted in an increase in the level of tyrosine phosphorylation of Btk (indicative of activation). Tyrosine 100-108 Bruton tyrosine kinase Homo sapiens 128-131 12775584-8 2003 Additionally, tyrosine phosphorylation of Vsm-RhoGEF induced by EphA4 upon ephrin-A1 stimulation enhanced the Vsm-RhoGEF activity for RhoA. Tyrosine 14-22 EPH receptor A4 Homo sapiens 64-69 12832052-4 2003 In contrast EGCG stimulated tyrosine phosphorylation of platelet proteins, including Syk and SLP-76 but inhibited phosphorylation of focal adhesion kinase. Tyrosine 28-36 spleen associated tyrosine kinase Homo sapiens 85-88 12606549-2 2003 Tyrosine phosphorylation of the 22-residue cytoplasmic region of ephrinB induces its binding to the SH2 domain of Grb4, thus initiating reverse signaling pathways controlling cytoskeleton assembly and remodeling. Tyrosine 0-8 NCK adaptor protein 2 Homo sapiens 114-118 12606549-4 2003 However, because the binding to Grb4 is phosphorylation-dependent and the hairpin contains three conserved tyrosine residues that may be phosphorylated, the key events remain unknown as to how tyrosine phosphorylation affects the structure of this well packed beta-hairpin and which phosphorylation site is relevant to SH2 domain binding. Tyrosine 107-115 NCK adaptor protein 2 Homo sapiens 32-36 12606549-4 2003 However, because the binding to Grb4 is phosphorylation-dependent and the hairpin contains three conserved tyrosine residues that may be phosphorylated, the key events remain unknown as to how tyrosine phosphorylation affects the structure of this well packed beta-hairpin and which phosphorylation site is relevant to SH2 domain binding. Tyrosine 193-201 NCK adaptor protein 2 Homo sapiens 32-36 12637327-2 2003 ATRA treatment of myeloid cells induces up-regulation and tyrosine phosphorylation of Stat1, a member of the STAT (signal transducer and activator of transcription) transcription factor family that has been implicated in growth arrest in response to interferons. Tyrosine 58-66 signal transducer and activator of transcription 1 Homo sapiens 86-91 12839871-4 2003 Local treatment with PAF resulted in a time-dependent increase of oedema formation induced by the B(1) receptor agonist des-Arg(9)-BK (des-Arg(9)-bradykinin), but not by the B(2) receptor agonist tyrosine(8)-bradykinin. Tyrosine 196-204 PCNA clamp associated factor Rattus norvegicus 21-24 12606349-10 2003 Immunoprecipitation and immunoblots revealed that the induction of LIMK1 was mediated via an increase in its phospho-Ser but not phospho-Tyr content. Tyrosine 137-140 LIM domain kinase 1 Rattus norvegicus 67-72 12651850-14 2003 These results demonstrate that CCK stimulates tyrosine phosphorylation of each of the three homologous phosphorylation sites in FAK and PYK2. Tyrosine 46-54 cholecystokinin Rattus norvegicus 31-34 12753909-2 2003 This study establishes that HER2/HRG signaling selectively upregulates Tyr phosphorylation of c-Src at Tyr-215 located within the SH2 domain, increases c-Src kinase activity and selectively upregulates Tyr phosphorylation of FAK at Tyr-861. Tyrosine 71-74 histidine rich glycoprotein Homo sapiens 33-36 12753909-2 2003 This study establishes that HER2/HRG signaling selectively upregulates Tyr phosphorylation of c-Src at Tyr-215 located within the SH2 domain, increases c-Src kinase activity and selectively upregulates Tyr phosphorylation of FAK at Tyr-861. Tyrosine 103-106 histidine rich glycoprotein Homo sapiens 33-36 12753909-2 2003 This study establishes that HER2/HRG signaling selectively upregulates Tyr phosphorylation of c-Src at Tyr-215 located within the SH2 domain, increases c-Src kinase activity and selectively upregulates Tyr phosphorylation of FAK at Tyr-861. Tyrosine 103-106 histidine rich glycoprotein Homo sapiens 33-36 12753909-2 2003 This study establishes that HER2/HRG signaling selectively upregulates Tyr phosphorylation of c-Src at Tyr-215 located within the SH2 domain, increases c-Src kinase activity and selectively upregulates Tyr phosphorylation of FAK at Tyr-861. Tyrosine 103-106 histidine rich glycoprotein Homo sapiens 33-36 12753909-4 2003 These findings suggest that HER2/HRG influence metastasis of breast cancer cells through a novel signaling pathway involving phosphorylation of FAK tyrosine 861 via activation of c-Src tyrosine 215. Tyrosine 148-156 histidine rich glycoprotein Homo sapiens 33-36 12753909-4 2003 These findings suggest that HER2/HRG influence metastasis of breast cancer cells through a novel signaling pathway involving phosphorylation of FAK tyrosine 861 via activation of c-Src tyrosine 215. Tyrosine 185-193 histidine rich glycoprotein Homo sapiens 33-36 12637538-0 2003 Tyrosine phosphorylation of protein kinase D in the pleckstrin homology domain leads to activation. Tyrosine 0-8 protein kinase D1 Homo sapiens 28-44 12637538-4 2003 Here we report that PKD is tyrosine-phosphorylated within the PH domain, leading to activation. Tyrosine 27-35 protein kinase D1 Homo sapiens 20-23 12637538-6 2003 Mutational analysis revealed three tyrosine phosphorylation sites (Tyr(432), Tyr(463), and Tyr(502)), which are regulated by the Src-Abl pathway, and phosphorylation of only one of these (Tyr(463)) leads to PKD activation. Tyrosine 35-43 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 133-136 12637538-6 2003 Mutational analysis revealed three tyrosine phosphorylation sites (Tyr(432), Tyr(463), and Tyr(502)), which are regulated by the Src-Abl pathway, and phosphorylation of only one of these (Tyr(463)) leads to PKD activation. Tyrosine 35-43 protein kinase D1 Homo sapiens 207-210 12637538-6 2003 Mutational analysis revealed three tyrosine phosphorylation sites (Tyr(432), Tyr(463), and Tyr(502)), which are regulated by the Src-Abl pathway, and phosphorylation of only one of these (Tyr(463)) leads to PKD activation. Tyrosine 67-70 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 133-136 12637538-6 2003 Mutational analysis revealed three tyrosine phosphorylation sites (Tyr(432), Tyr(463), and Tyr(502)), which are regulated by the Src-Abl pathway, and phosphorylation of only one of these (Tyr(463)) leads to PKD activation. Tyrosine 67-70 protein kinase D1 Homo sapiens 207-210 12637538-6 2003 Mutational analysis revealed three tyrosine phosphorylation sites (Tyr(432), Tyr(463), and Tyr(502)), which are regulated by the Src-Abl pathway, and phosphorylation of only one of these (Tyr(463)) leads to PKD activation. Tyrosine 77-80 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 133-136 12637538-6 2003 Mutational analysis revealed three tyrosine phosphorylation sites (Tyr(432), Tyr(463), and Tyr(502)), which are regulated by the Src-Abl pathway, and phosphorylation of only one of these (Tyr(463)) leads to PKD activation. Tyrosine 77-80 protein kinase D1 Homo sapiens 207-210 12637538-6 2003 Mutational analysis revealed three tyrosine phosphorylation sites (Tyr(432), Tyr(463), and Tyr(502)), which are regulated by the Src-Abl pathway, and phosphorylation of only one of these (Tyr(463)) leads to PKD activation. Tyrosine 77-80 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 133-136 12700668-8 2003 Autophosphorylation of beta-PDGFR and tyrosine phosphorylation of PLC-gamma, PI3Kp85 and Shc were detected only in PDGF-BB-stimulated cells that express beta-PDGFR. Tyrosine 38-46 SHC adaptor protein 1 Homo sapiens 89-92 12556535-4 2003 The results presented here indicate that ASK1 forms a complex with the IGF-IR and becomes phosphorylated on tyrosine residue(s) in a manner dependent on IGF-IR activity. Tyrosine 108-116 insulin like growth factor 1 receptor Homo sapiens 71-77 12556535-4 2003 The results presented here indicate that ASK1 forms a complex with the IGF-IR and becomes phosphorylated on tyrosine residue(s) in a manner dependent on IGF-IR activity. Tyrosine 108-116 insulin like growth factor 1 receptor Homo sapiens 153-159 12670700-0 2003 Binding of purified Reelin to ApoER2 and VLDLR mediates tyrosine phosphorylation of Disabled-1. Tyrosine 56-64 reelin Mus musculus 20-26 12670700-2 2003 Binding of Reelin to ApoER2 and VLDLR induces a rapid increase in tyrosine phosphorylation of Dab1, an adaptor protein that associates with the cytoplasmic domain of the receptors. Tyrosine 66-74 reelin Mus musculus 11-17 12686100-3 2003 Substrates of SSAO such as benzylamine or tyramine in combination with vanadate potently stimulate tyrosine phosphorylation of both insulin-receptor substrates 1 (IRS-1) and 3 (IRS-3) and phosphatidylinositol 3-kinase (PI 3-kinase) activity in adipose cells, which occurs in the presence of a weak stimulation of insulin-receptor kinase. Tyrosine 99-107 insulin receptor substrate 3 Rattus norvegicus 177-182 12687004-3 2003 We recently described tyrosine-phosphorylation events restricted to subdomains of the plasma membrane that result in activation of the G protein TC10 (refs 3, 4). Tyrosine 22-30 ras homolog family member Q Homo sapiens 145-149 12676353-10 2003 By immunoprecipitation experiments, we identified two substrates that were tyrosine phosphorylated in adherent platelets as the tyrosine kinase Syk and the PLCgamma2 isozyme. Tyrosine 75-83 spleen associated tyrosine kinase Homo sapiens 144-147 12556528-0 2003 Tyrphostin A23 inhibits internalization of the transferrin receptor by perturbing the interaction between tyrosine motifs and the medium chain subunit of the AP-2 adaptor complex. Tyrosine 106-114 serotransferrin Melopsittacus undulatus 47-58 12681433-5 2003 KR-31372 (10(-6)-10(-4) M) and levcromakalim (10(-5) M) concentration-dependently suppressed the VEGF(165)-induced increases in KDR/Flk-1 tyrosine phosphorylation as well as the extracellular signal-related kinase 1/2 (ERK1/2), p38 MAK and p125(FAK) tyrosine phosphorylation. Tyrosine 250-258 kinase insert domain receptor Homo sapiens 128-131 12681433-7 2003 In conclusion, KR-31372 significantly inhibited the KDR/Flk-1 tyrosine phosphorylation-linked ERK1/2, p38 MAPK and p125(FAK) tyrosine phosphorylation via mediation of K(+)(ATP) channel opening, thereby resulting in antiangiogenesis. Tyrosine 62-70 kinase insert domain receptor Homo sapiens 52-55 12681433-7 2003 In conclusion, KR-31372 significantly inhibited the KDR/Flk-1 tyrosine phosphorylation-linked ERK1/2, p38 MAPK and p125(FAK) tyrosine phosphorylation via mediation of K(+)(ATP) channel opening, thereby resulting in antiangiogenesis. Tyrosine 62-70 kinase insert domain receptor Homo sapiens 56-61 12681433-7 2003 In conclusion, KR-31372 significantly inhibited the KDR/Flk-1 tyrosine phosphorylation-linked ERK1/2, p38 MAPK and p125(FAK) tyrosine phosphorylation via mediation of K(+)(ATP) channel opening, thereby resulting in antiangiogenesis. Tyrosine 62-70 SEC23 interacting protein Homo sapiens 115-119 12681433-7 2003 In conclusion, KR-31372 significantly inhibited the KDR/Flk-1 tyrosine phosphorylation-linked ERK1/2, p38 MAPK and p125(FAK) tyrosine phosphorylation via mediation of K(+)(ATP) channel opening, thereby resulting in antiangiogenesis. Tyrosine 125-133 kinase insert domain receptor Homo sapiens 52-55 12681433-7 2003 In conclusion, KR-31372 significantly inhibited the KDR/Flk-1 tyrosine phosphorylation-linked ERK1/2, p38 MAPK and p125(FAK) tyrosine phosphorylation via mediation of K(+)(ATP) channel opening, thereby resulting in antiangiogenesis. Tyrosine 125-133 kinase insert domain receptor Homo sapiens 56-61 12697053-4 2003 Searches of protein data bases for putative phosphorylation motifs revealed that lamins, NF-H, and GFAP each contain a single tyrosine phosphorylation motif with nearly identical amino acid sequence. Tyrosine 126-134 glial fibrillary acidic protein Homo sapiens 99-103 12466147-6 2003 BAY 11-7085 inhibited the former, but not the latter, phosphorylation pathway, whereas alpha-melanocyte-stimulating hormone, which is effective in limiting late ischemia-reperfusion injury to the intestine, inhibited tyrosine phosphorylation of IkappaB-alpha. Tyrosine 217-225 proopiomelanocortin Rattus norvegicus 87-123 12466150-7 2003 We therefore conclude that TNFR2 activates a novel Src-regulated pathway involving FAK tyrosine phosphorylation that enhances migration of intestinal epithelial cells. Tyrosine 87-95 tumor necrosis factor receptor superfamily, member 1a Mus musculus 27-32 12727621-7 2003 For example, rapid sorting of endocytosed receptor complexes through early endosomes requires the activation of the tyrosine Syk. Tyrosine 116-124 spleen associated tyrosine kinase Homo sapiens 125-128 12485116-2 2003 Proximal signalling pathways involve PTKs of the Src, Syk, Csk and Tec families, adapter proteins and effector enzymes in a highly organized tyrosine-phosphorylation cascade. Tyrosine 141-149 spleen associated tyrosine kinase Homo sapiens 54-57 12670344-5 2003 Immunoprecipitation of collagen-stimulated and FcR-crosslinked platelets demonstrated enhanced levels of tyrosine-phosphorylated Syk in diabetic platelets. Tyrosine 105-113 spleen associated tyrosine kinase Homo sapiens 129-132 12691918-9 2003 RESULTS: Jak2 was found to be constitutively tyrosine phosphorylated in ALCL cells and in NPM/ALK-transformed hematopoietic cells. Tyrosine 45-53 ALK receptor tyrosine kinase Homo sapiens 94-97 12586732-5 2003 Inhibition of EGFR tyrosine kinase activity prevented CD95 tyrosine phosphorylation and DISC formation but not hyperosmolarity-induced EGFR phosphorylation and EGFR association with CD95. Tyrosine 19-27 epidermal growth factor receptor Rattus norvegicus 14-18 12660814-6 2003 Western blot analysis using a antiphosphotyrosine antibody demonstrated that SIMA135/CDCP1 from HEp3 cells is tyrosine phosphorylated. Tyrosine 41-49 CUB domain containing protein 1 Homo sapiens 77-84 12660814-6 2003 Western blot analysis using a antiphosphotyrosine antibody demonstrated that SIMA135/CDCP1 from HEp3 cells is tyrosine phosphorylated. Tyrosine 41-49 CUB domain containing protein 1 Homo sapiens 85-90 12524436-10 2003 Here, we propose that the affinity of GTX to Na(v)1.4 sodium channels might be regulated by two residues (Phe and Tyr) at positions Phe-1579 and Tyr-1586, which, respectively, control access and binding of GTX to its receptor. Tyrosine 114-117 immunoglobulin lambda variable 2-14 Homo sapiens 45-53 12524436-10 2003 Here, we propose that the affinity of GTX to Na(v)1.4 sodium channels might be regulated by two residues (Phe and Tyr) at positions Phe-1579 and Tyr-1586, which, respectively, control access and binding of GTX to its receptor. Tyrosine 145-148 immunoglobulin lambda variable 2-14 Homo sapiens 45-53 12645577-0 2003 c-Src-dependent tyrosine phosphorylation of IKKbeta is involved in tumor necrosis factor-alpha-induced intercellular adhesion molecule-1 expression. Tyrosine 16-24 intercellular adhesion molecule 1 Homo sapiens 103-136 12410637-6 2003 The PZR intracellular domain contains two SHP-2 binding immunoreceptor tyrosine-based inhibitory motifs (VIY(246)AQL and VVY(263)ADI) which are not present in PZRa and PZRb. Tyrosine 71-79 myelin protein zero like 1 Homo sapiens 4-7 12410637-6 2003 The PZR intracellular domain contains two SHP-2 binding immunoreceptor tyrosine-based inhibitory motifs (VIY(246)AQL and VVY(263)ADI) which are not present in PZRa and PZRb. Tyrosine 71-79 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 42-47 12531427-2 2003 Tyrosine 14 is a consensus Abl phosphorylation site suggesting that caveolin-1 may be an Abl substrate. Tyrosine 0-8 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 27-30 12531427-2 2003 Tyrosine 14 is a consensus Abl phosphorylation site suggesting that caveolin-1 may be an Abl substrate. Tyrosine 0-8 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 89-92 12531427-6 2003 Oxidative stress-induced tyrosine phosphorylation of caveolin-1 occurs only at the Abl site, tyrosine 14. Tyrosine 25-33 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 83-86 12531427-6 2003 Oxidative stress-induced tyrosine phosphorylation of caveolin-1 occurs only at the Abl site, tyrosine 14. Tyrosine 93-101 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 83-86 12734778-3 2003 The ability of GH to stimulate lipogenesis and tyrosine phosphorylation of the GH receptor (GHR), Janus kinase 2 (Jak2), insulin receptor substrate-1 (IRS-1) and -2 (IRS-2) was greatly reduced in refractory as compared to responsive primary rat adipocytes. Tyrosine 47-55 growth hormone receptor Rattus norvegicus 79-90 12548551-3 2003 The experiments presented here were designed to test the role of epidermal growth factor receptor (EGFR) transactivation in the rapid increase of tyrosine phosphorylation of FAK and paxillin induced by GPCR agonists. Tyrosine 146-154 G protein-coupled bile acid receptor 1 Mus musculus 202-206 12548551-6 2003 Collectively, our results clearly dissociate EGFR transactivation from the tyrosine phosphorylation of FAK and paxillin induced by multiple GPCR agonists. Tyrosine 75-83 G protein-coupled bile acid receptor 1 Mus musculus 140-144 12496293-9 2003 The lack of a hyperpolarizing HCO(3)(-) current and the inhibition of the capacitation-dependent increase in protein tyrosine phosphorylation in the absence of Na(+) suggest that a Na(+)/HCO(3)(-) cotransporter is present in mouse sperm and is coupled to events regulating capacitation. Tyrosine 117-125 solute carrier family 4 (anion exchanger), member 4 Mus musculus 181-210 12589790-3 2003 Chemical inhibition of PKA suppressed forskolin-induced EGFR tyrosine phosphorylation and ERK1/2 activation in PC12 cells. Tyrosine 61-69 epidermal growth factor receptor Rattus norvegicus 56-60 12589790-5 2003 Forskolin-induced EGFR tyrosine phosphorylation was also observed in A431 cells and in membranes isolated from these cells. Tyrosine 23-31 epidermal growth factor receptor Rattus norvegicus 18-22 12589790-6 2003 Phosphoamino acid analysis indicated that the recombinant catalytic subunit of PKA elicited phosphorylation of the EGFR on both tyrosine and serine but not threonine residues in A431 membranes. Tyrosine 128-136 epidermal growth factor receptor Rattus norvegicus 115-119 12589790-8 2003 While PKA may directly phosphorylate the EGFR on serine residues, PKA-induced tyrosine phosphorylation of the EGFR occurs by an indirect mechanism. Tyrosine 78-86 epidermal growth factor receptor Rattus norvegicus 110-114 12468540-0 2003 The role of C-terminal tyrosine phosphorylation in the regulation of SHP-1 explored via expressed protein ligation. Tyrosine 23-31 protein tyrosine phosphatase non-receptor type 6 Homo sapiens 69-74 12468540-3 2003 Whereas SHP-1 has previously been shown to be phosphorylated on two tail tyrosine residues (Tyr(536) and Tyr(564)) by several protein-tyrosine kinases, the effects of these phosphorylation events have been difficult to address because of the intrinsic instability of the linkages within a protein-tyrosine phosphatase. Tyrosine 73-81 protein tyrosine phosphatase non-receptor type 6 Homo sapiens 8-13 12468540-3 2003 Whereas SHP-1 has previously been shown to be phosphorylated on two tail tyrosine residues (Tyr(536) and Tyr(564)) by several protein-tyrosine kinases, the effects of these phosphorylation events have been difficult to address because of the intrinsic instability of the linkages within a protein-tyrosine phosphatase. Tyrosine 92-95 protein tyrosine phosphatase non-receptor type 6 Homo sapiens 8-13 12468540-3 2003 Whereas SHP-1 has previously been shown to be phosphorylated on two tail tyrosine residues (Tyr(536) and Tyr(564)) by several protein-tyrosine kinases, the effects of these phosphorylation events have been difficult to address because of the intrinsic instability of the linkages within a protein-tyrosine phosphatase. Tyrosine 105-108 protein tyrosine phosphatase non-receptor type 6 Homo sapiens 8-13 12459556-1 2003 Participation of Tyr-713 in the interleukin-4 receptor alpha, the tyrosine phosphatase SHP-1, and the proteasome. Tyrosine 17-20 protein tyrosine phosphatase non-receptor type 6 Homo sapiens 87-92 12459556-7 2003 In the absence of functional Src homology-containing phosphatase-1 (SHP-1), the early loss of tyrosine-phosphorylated Stat6 was substantially reduced. Tyrosine 94-102 protein tyrosine phosphatase non-receptor type 6 Homo sapiens 29-66 12459556-7 2003 In the absence of functional Src homology-containing phosphatase-1 (SHP-1), the early loss of tyrosine-phosphorylated Stat6 was substantially reduced. Tyrosine 94-102 protein tyrosine phosphatase non-receptor type 6 Homo sapiens 68-73 12459556-10 2003 These results suggest that the loss of tyrosine phosphorylation of Stat6 is regulated by the action of SHP-1 and the proteasome but is not dependent on new protein synthesis. Tyrosine 39-47 protein tyrosine phosphatase non-receptor type 6 Homo sapiens 103-108 12538627-3 2003 Upon JAK2 activation, tyrosine phosphorylation of signal transducer and activator of transcription-1 (STAT-1), STAT-5b, insulin receptor substrate-1 (IRS-1), and Src homology and collagen homology (Shc) were detected. Tyrosine 22-30 Janus kinase 2 Rattus norvegicus 5-9 12538627-3 2003 Upon JAK2 activation, tyrosine phosphorylation of signal transducer and activator of transcription-1 (STAT-1), STAT-5b, insulin receptor substrate-1 (IRS-1), and Src homology and collagen homology (Shc) were detected. Tyrosine 22-30 signal transducer and activator of transcription 5B Rattus norvegicus 111-118 12645942-4 2003 Using as a model an Lck-/- mouse, we show that, while dispensable for B-1 cell development, Lck is required for full and sustained activation of the tyrosine phosphorylation and MAP kinase cascades triggered by the BCR in CD5+, B-1 cells. Tyrosine 149-157 CD5 antigen Mus musculus 222-225 12645944-7 2003 CD81 cross-linking increased and prolonged the anti-CD3-induced tyrosine phosphorylation of TCR1 and of other proteins, indicating that the CD81-mediated signal converges with the TCR/CD3 signaling cascade at its most upstream step. Tyrosine 64-72 CD81 molecule Homo sapiens 0-4 12645944-7 2003 CD81 cross-linking increased and prolonged the anti-CD3-induced tyrosine phosphorylation of TCR1 and of other proteins, indicating that the CD81-mediated signal converges with the TCR/CD3 signaling cascade at its most upstream step. Tyrosine 64-72 CD81 molecule Homo sapiens 140-144 12552015-8 2003 Deliberate overexpression of the murine wild-type (wt) TC-PTP gene, but not that of a cysteine-to-serine (C-S) mutant, caused tyrosine dephosphorylation of FKBP52, leading to efficient viral second-strand DNA synthesis and resulting in a significant increase in AAV-mediated transduction efficiency in HeLa cells in vitro. Tyrosine 126-134 protein tyrosine phosphatase, non-receptor type 2 Mus musculus 55-61 12556491-3 2003 Here we show that GPCR-stimulated Rac activity and the subsequent generation of reactive oxygen species are necessary for activating tyrosine phosphorylation of Jaks and STAT-dependent transcription. Tyrosine 133-141 Rac family small GTPase 1 Homo sapiens 34-37 12556491-6 2003 We further show that GPCR agonists stimulate tyrosine phosphorylation of STAT1 and STAT3 proteins in a Rac-dependent manner. Tyrosine 45-53 signal transducer and activator of transcription 1 Homo sapiens 73-78 12556491-6 2003 We further show that GPCR agonists stimulate tyrosine phosphorylation of STAT1 and STAT3 proteins in a Rac-dependent manner. Tyrosine 45-53 Rac family small GTPase 1 Homo sapiens 103-106 12744604-6 2003 Circular Dichroism studies in the aromatic and far-ultraviolet range and UV difference spectroscopy indicated that binding of substrates to dCK reduced its alpha-helical content and perturbed tryptophan and tyrosine. Tyrosine 207-215 Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster 140-143 12535670-4 2003 We found that PECAM-1 is dephosphorylated on tyrosine 686 during endothelial migration, resulting in diffuse dispersal of PECAM-1 and SHP-2. Tyrosine 45-53 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 134-139 12535670-9 2003 Thus homophilically engaged, tyrosine-phosphorylated PECAM-1 locally activates SHP-2 at cell-cell junctions; with disruption of the endothelial monolayer, selective dephosphorylation of PECAM-1 leads to redistribution of SHP-2 and pro-migratory changes in phosphorylation of cytoskeletal and focal contact components. Tyrosine 29-37 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 79-84 12535670-9 2003 Thus homophilically engaged, tyrosine-phosphorylated PECAM-1 locally activates SHP-2 at cell-cell junctions; with disruption of the endothelial monolayer, selective dephosphorylation of PECAM-1 leads to redistribution of SHP-2 and pro-migratory changes in phosphorylation of cytoskeletal and focal contact components. Tyrosine 29-37 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 221-226 12581886-8 2003 Our results suggest that nongenomic estrogen action induces tyrosine phosphatase activity that regulates stability of tyrosine phosphorylated proteins, including tuberin, which may play a crucial role in cellular specific functions such as endocytosis. Tyrosine 60-68 TSC complex subunit 2 Homo sapiens 162-169 12522270-4 2003 We used this methodology to follow changes in tyrosine phosphorylation patterns that occur over time during either the activation of human T cells or the inhibition of the oncogenic BCR-ABL fusion product in chronic myelogenous leukemia cells in response to treatment with STI571 (Gleevec). Tyrosine 46-54 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 182-189 12424257-4 2003 Through the characterization of chimeric PSTs where these two regions were exchanged between them, it was demonstrated that variable Region II of SULT1A3 is required for the stereospecificity of its Dopa/tyrosine-sulfating activity, whereas variable Region I of SULT1A3 is required for the stimulation by Mn(2+) of this activity. Tyrosine 204-212 sulfotransferase family 1A member 3 Homo sapiens 146-153 12424257-6 2003 Residue Asp-86 (in variable Region I of SULT1A3), on the other hand, is critical in the Mn(2+) stimulation of the Dopa/tyrosine-sulfating activity of SULT1A3. Tyrosine 119-127 sulfotransferase family 1A member 3 Homo sapiens 40-47 12424257-6 2003 Residue Asp-86 (in variable Region I of SULT1A3), on the other hand, is critical in the Mn(2+) stimulation of the Dopa/tyrosine-sulfating activity of SULT1A3. Tyrosine 119-127 sulfotransferase family 1A member 3 Homo sapiens 150-157 12918455-11 2003 After repeated transfection with the HGF gene, increased concentrations of HGF in plasma and tyrosine phosphorylation of the c-Met/HGF receptor in the liver were detected, and the established massive hepatic fibrosis had almost totally disappeared and all cirrhotic rats survived. Tyrosine 93-101 hepatocyte growth factor Rattus norvegicus 37-40 12518171-9 2003 Using immunoprecipitation and immunoblotting, we found that H1-A inhibits tyrosine phosphorylation of human mesangial proteins and that Bcl-2 and Bcl-XL were probably among these proteins. Tyrosine 74-82 H1.1 linker histone, cluster member Homo sapiens 60-64 12622692-8 2003 One of these factors is glucose, the metabolic products of which (ATP and NADPH) appear to participate in signalling pathways by supporting a precise onset of tyrosine phosphorylation in the sperm flagellum leading to successful fertilization. Tyrosine 159-167 2,4-dienoyl-CoA reductase 1 Homo sapiens 74-79 12376533-1 2002 Reelin is a large secreted protein that controls cortical layering by signaling through the very low density lipoprotein receptor and apolipoprotein E receptor 2, thereby inducing tyrosine phosphorylation of the adaptor protein Disabled-1 (Dab1) and suppressing tau phosphorylation in vivo. Tyrosine 180-188 reelin Homo sapiens 0-6 12376533-4 2002 Reelin-signaling components are enriched in axonal growth cones, where tyrosine phosphorylation of Dab1 is increased in response to Reelin. Tyrosine 71-79 reelin Homo sapiens 0-6 12376533-4 2002 Reelin-signaling components are enriched in axonal growth cones, where tyrosine phosphorylation of Dab1 is increased in response to Reelin. Tyrosine 71-79 reelin Homo sapiens 132-138 12431779-6 2002 On the other hand, either FAK inhibitor, tyrphostin or ROS scavenger, N-acetyl-L-cysteine (NAC) suppressed the tyrosine phosphorylation and cytoskeletal changes. Tyrosine 111-119 X-linked Kx blood group Homo sapiens 91-94 12431789-0 2002 Cholecystokinin-stimulated tyrosine phosphorylation of PKC-delta in pancreatic acinar cells is regulated bidirectionally by PKC activation. Tyrosine 27-35 cholecystokinin Rattus norvegicus 0-15 12431789-0 2002 Cholecystokinin-stimulated tyrosine phosphorylation of PKC-delta in pancreatic acinar cells is regulated bidirectionally by PKC activation. Tyrosine 27-35 protein kinase C, alpha Rattus norvegicus 55-58 12431789-3 2002 Many of these stimuli also activate phospholipase C (PLC) cascades and little is known about the relationship between these cascades and PKC-delta TYR-P. Cholecystokinin (CCK) stimulates PKCs but it is unknown if it causes PKC-delta TYR-P and if so, the relationship between these cascades is unknown. Tyrosine 147-150 cholecystokinin Rattus norvegicus 154-169 12431789-3 2002 Many of these stimuli also activate phospholipase C (PLC) cascades and little is known about the relationship between these cascades and PKC-delta TYR-P. Cholecystokinin (CCK) stimulates PKCs but it is unknown if it causes PKC-delta TYR-P and if so, the relationship between these cascades is unknown. Tyrosine 233-236 cholecystokinin Rattus norvegicus 154-169 12431789-3 2002 Many of these stimuli also activate phospholipase C (PLC) cascades and little is known about the relationship between these cascades and PKC-delta TYR-P. Cholecystokinin (CCK) stimulates PKCs but it is unknown if it causes PKC-delta TYR-P and if so, the relationship between these cascades is unknown. Tyrosine 233-236 cholecystokinin Rattus norvegicus 171-174 12431789-12 2002 Therefore, CCK activates both stimulatory and inhibitory PKC cascades regulating PKC-delta TYR-P and, hence, likely plays an important role in regulating PKC-delta degradation and cellular abundance. Tyrosine 91-94 cholecystokinin Rattus norvegicus 11-14 12431789-12 2002 Therefore, CCK activates both stimulatory and inhibitory PKC cascades regulating PKC-delta TYR-P and, hence, likely plays an important role in regulating PKC-delta degradation and cellular abundance. Tyrosine 91-94 protein kinase C, alpha Rattus norvegicus 57-60 12220227-1 2002 Signalling by the insulin receptor substrate (IRS) proteins is critically dependent on the tyrosine phosphorylation of specific binding sites that recruit Src homology 2 (SH2)-domain-containing proteins, such as the p85 subunit of phosphoinositide 3-kinase (PI 3-kinase), the tyrosine phosphatase SHP-2 and the adapter protein Grb2. Tyrosine 91-99 phosphoinositide-3-kinase regulatory subunit 2 Homo sapiens 216-219 12220227-1 2002 Signalling by the insulin receptor substrate (IRS) proteins is critically dependent on the tyrosine phosphorylation of specific binding sites that recruit Src homology 2 (SH2)-domain-containing proteins, such as the p85 subunit of phosphoinositide 3-kinase (PI 3-kinase), the tyrosine phosphatase SHP-2 and the adapter protein Grb2. Tyrosine 91-99 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 297-302 12379650-4 2002 We show here that c-Abl tyrosine kinase associates with and phosphorylates Rad52 on tyrosine 104. Tyrosine 24-32 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 18-23 12480817-5 2002 Antioxidants, including N-acetylcysteine (NAC), various NAD(P)H oxidase inhibitors, and N17Rac1 significantly attenuate not only VEGF-induced KDR tyrosine phosphorylation but also proliferation and migration of ECs. Tyrosine 146-154 vascular endothelial growth factor A Mus musculus 129-133 12270932-9 2002 Our findings demonstrate that SHP-2 is a dual-specificity protein phosphatase involved in Stat1 dephosphorylation at both tyrosine and serine residues and plays an important role in modulating STAT function in gene regulation. Tyrosine 122-130 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 30-35 12270932-9 2002 Our findings demonstrate that SHP-2 is a dual-specificity protein phosphatase involved in Stat1 dephosphorylation at both tyrosine and serine residues and plays an important role in modulating STAT function in gene regulation. Tyrosine 122-130 signal transducer and activator of transcription 1 Homo sapiens 90-95 12351647-5 2002 Remarkably, one of the peptides has ephrin-like activity in that it stimulates EphA2 tyrosine phosphorylation and signaling. Tyrosine 85-93 EPH receptor A2 Homo sapiens 79-84 12445832-4 2002 In this report we describe for the first time that c-Abl and Btk physically interact and that c-Abl can phosphorylate tyrosine 223 in the SH3 domain of Btk. Tyrosine 118-126 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 51-56 12445832-4 2002 In this report we describe for the first time that c-Abl and Btk physically interact and that c-Abl can phosphorylate tyrosine 223 in the SH3 domain of Btk. Tyrosine 118-126 Bruton tyrosine kinase Homo sapiens 61-64 12445832-4 2002 In this report we describe for the first time that c-Abl and Btk physically interact and that c-Abl can phosphorylate tyrosine 223 in the SH3 domain of Btk. Tyrosine 118-126 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 94-99 12445832-4 2002 In this report we describe for the first time that c-Abl and Btk physically interact and that c-Abl can phosphorylate tyrosine 223 in the SH3 domain of Btk. Tyrosine 118-126 Bruton tyrosine kinase Homo sapiens 152-155 12450381-1 2002 The protein kinase ZAP-70 is involved in T-cell activation, and interacts with tyrosine-phosphorylated peptide sequences known as immunoreceptor tyrosine activation motifs (ITAMs), which are present in three of the subunits of the T-cell receptor. Tyrosine 79-87 zeta chain of T cell receptor associated protein kinase 70 Homo sapiens 19-25 12450381-1 2002 The protein kinase ZAP-70 is involved in T-cell activation, and interacts with tyrosine-phosphorylated peptide sequences known as immunoreceptor tyrosine activation motifs (ITAMs), which are present in three of the subunits of the T-cell receptor. Tyrosine 145-153 zeta chain of T cell receptor associated protein kinase 70 Homo sapiens 19-25 12429573-9 2002 IFN-gamma-induced STAT1 activation, as assessed from its tyrosine phosphorylation, nuclear translocation, binding to specific DNA response element and evoked IRF-1 reporter gene assay, were concomitantly inhibited by ATA. Tyrosine 57-65 signal transducer and activator of transcription 1 Mus musculus 18-23 12429573-14 2002 Moreover, IL-4, IL-10, GM-CSF and M-CSF elicited tyrosine phosphorylation of STAT3, STAT5 and/or STAT6 in macrophages were diminished by the presence of ATA. Tyrosine 49-57 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 23-29 12429573-14 2002 Moreover, IL-4, IL-10, GM-CSF and M-CSF elicited tyrosine phosphorylation of STAT3, STAT5 and/or STAT6 in macrophages were diminished by the presence of ATA. Tyrosine 49-57 colony stimulating factor 1 (macrophage) Mus musculus 24-29 12464013-7 2002 In contrast, cells infected with an isogenic strain carrying a G1098A mutation at the FHA RGD site did not show any recruitment of PI3-K. We found that ligation of FHA by alphavbeta3/IAP induced RGD-dependent tyrosine phosphorylation of a 60 kDa protein, which associated with IAP and PI3-K in human monocytes. Tyrosine 209-217 CD47 molecule Homo sapiens 183-186 12447877-10 2002 EGF stimulated the tyrosine phosphorylation of Src, and induced its association with the IGF-IR. Tyrosine 19-27 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 47-50 12429984-4 2002 Bombesin and gastrin releasing peptide increase tyrosine phosphorylation and can act synergistically with EGF, as well as independently. Tyrosine 48-56 gastrin releasing peptide Homo sapiens 0-8 12429984-4 2002 Bombesin and gastrin releasing peptide increase tyrosine phosphorylation and can act synergistically with EGF, as well as independently. Tyrosine 48-56 gastrin releasing peptide Homo sapiens 13-38 12384979-14 2002 As a result, several Cdc25 substrates (Cdk1, Cdk2, Cdk4) involved in cell cycle progression are tyrosine phosphorylated and thereby inhibited by its action. Tyrosine 96-104 cyclin dependent kinase 2 Rattus norvegicus 45-49 12468515-2 2002 Recently, high densities of GRP receptors were identified by in vitro receptor autoradiography in human prostate and breast carcinomas using [(125)I-Tyr(4)]BN as radioligand. Tyrosine 149-152 gastrin releasing peptide Rattus norvegicus 28-31 12468515-7 2002 RESULTS: All BN analogs competitively inhibited the binding of [(125)I-Tyr(4)]BN to the GRP receptor with 50% inhibitory concentration values in the range of 2-9 nmol/L. Tyrosine 71-74 gastrin releasing peptide Rattus norvegicus 88-91 12468515-11 2002 Although [(111)In-DOTA-Pro(1),Tyr(4)]BN showed the highest uptake of radioactivity in GRP receptor-positive tissues as well as higher target-to-blood ratios, [(111)In-DTPA-Pro(1),Tyr(4)]BN was easier to handle and is more practical to use. Tyrosine 30-33 gastrin releasing peptide Rattus norvegicus 86-89 12468515-13 2002 CONCLUSION: [(111)In-DTPA-Pro(1),Tyr(4)]BN is a promising radioligand for scintigraphy of GRP receptor-expressing tumors. Tyrosine 33-36 gastrin releasing peptide Rattus norvegicus 90-93 12417718-2 2002 There are three conserved tyrosines in this linker region; Tyr317 of Syk and its equivalent residue in ZAP70 were previously shown to negatively regulate the function of Syk and ZAP70. Tyrosine 26-35 spleen associated tyrosine kinase Homo sapiens 69-72 12417718-2 2002 There are three conserved tyrosines in this linker region; Tyr317 of Syk and its equivalent residue in ZAP70 were previously shown to negatively regulate the function of Syk and ZAP70. Tyrosine 26-35 zeta chain of T cell receptor associated protein kinase 70 Homo sapiens 103-108 12417718-2 2002 There are three conserved tyrosines in this linker region; Tyr317 of Syk and its equivalent residue in ZAP70 were previously shown to negatively regulate the function of Syk and ZAP70. Tyrosine 26-35 spleen associated tyrosine kinase Homo sapiens 170-173 12417718-2 2002 There are three conserved tyrosines in this linker region; Tyr317 of Syk and its equivalent residue in ZAP70 were previously shown to negatively regulate the function of Syk and ZAP70. Tyrosine 26-35 zeta chain of T cell receptor associated protein kinase 70 Homo sapiens 178-183 12417718-7 2002 Compared to wild-type Syk, Y342F Syk had decreased binding to phosphorylated immunoreceptor tyrosine-based activation motifs and reduced kinase activity. Tyrosine 92-100 spleen associated tyrosine kinase Homo sapiens 33-36 12417718-9 2002 An anti-Syk-phospho-346 tyrosine antibody indicated that antigen stimulation induced only a very minor increase in the phosphorylation of this tyrosine. Tyrosine 24-32 spleen associated tyrosine kinase Homo sapiens 8-11 12417718-9 2002 An anti-Syk-phospho-346 tyrosine antibody indicated that antigen stimulation induced only a very minor increase in the phosphorylation of this tyrosine. Tyrosine 143-151 spleen associated tyrosine kinase Homo sapiens 8-11 12468645-3 2002 As chicken c-Src is known to be activated upon dephosphorylation of tyrosine 527 (Y527, corresponding to Y530 in human), we here employed a monoclonal antibody, clone 28, directed against the active form of human c-Src whose Y530 is dephosphorylated, and investigated whether c-Src became dephosphorylated at Y530 and thereby activated during decidualization. Tyrosine 68-76 SRC proto-oncogene, non-receptor tyrosine kinase Gallus gallus 11-16 12496362-7 2002 LAR mutants, with Cys to Ser mutation in the catalytic center of PTPase D1, bound to tyrosine-phosphorylated Lck and Fyn, and LAR PTPase domain 2 was tyrosine phosphorylated by Fyn tyrosine kinase. Tyrosine 85-93 Fyn proto-oncogene Mus musculus 177-180 12496362-7 2002 LAR mutants, with Cys to Ser mutation in the catalytic center of PTPase D1, bound to tyrosine-phosphorylated Lck and Fyn, and LAR PTPase domain 2 was tyrosine phosphorylated by Fyn tyrosine kinase. Tyrosine 150-158 Fyn proto-oncogene Mus musculus 177-180 12496362-9 2002 Moreover, LAR dephosphorylated phosphorylated tyrosine residues in both the COOH terminus and kinase domain of Fyn in vitro. Tyrosine 46-54 Fyn proto-oncogene Mus musculus 111-114 12431808-7 2002 Upon GH stimulation of the GHR-positive CMT-U335 canine mammary tumor cell line, the transcription factors STAT5A and STAT5B become phosphorylated on their tyrosine residues, which is likely to reflect the significance of mammary GH in vivo. Tyrosine 156-164 somatotropin Canis lupus familiaris 5-7 12431808-7 2002 Upon GH stimulation of the GHR-positive CMT-U335 canine mammary tumor cell line, the transcription factors STAT5A and STAT5B become phosphorylated on their tyrosine residues, which is likely to reflect the significance of mammary GH in vivo. Tyrosine 156-164 somatotropin Canis lupus familiaris 27-29 12153400-3 2002 Following incubation of mouse kidney proximal tubular epithelial cells with VEGF, we observed an increase in tyrosine phosphorylation of several proteins, including one of approximately 200 kDa, suggesting possible regulation of phosphorylation of IRS proteins. Tyrosine 109-117 vascular endothelial growth factor A Mus musculus 76-80 12419528-1 2002 Recent studies have indicated that tyrosine phosphorylation of NMDA receptor subunit 2A (NR2A) by Src family kinases (Src, Fyn, etc.) Tyrosine 35-43 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 98-101 12419528-1 2002 Recent studies have indicated that tyrosine phosphorylation of NMDA receptor subunit 2A (NR2A) by Src family kinases (Src, Fyn, etc.) Tyrosine 35-43 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 118-121 12419535-4 2002 BDNF stimulated much stronger interactions of PLCgamma with Trk than NGF and NT-3 in PC12 cells stably expressing TrkB and cultured cerebral cortical neurons, respectively, although BDNF, NGF and NT-3 induced similar levels of tyrosine phosphorylation of Trk. Tyrosine 227-235 brain derived neurotrophic factor Homo sapiens 0-4 12218049-2 2002 Here we show that an increase in the intracellular cAMP concentration induces tyrosine phosphorylation of two receptor tyrosine kinases, i.e. the epidermal growth factor (EGF) receptor and the high affinity receptor for nerve growth factor (NGF), also termed Trk(A). Tyrosine 78-86 epidermal growth factor receptor Rattus norvegicus 146-184 12218049-2 2002 Here we show that an increase in the intracellular cAMP concentration induces tyrosine phosphorylation of two receptor tyrosine kinases, i.e. the epidermal growth factor (EGF) receptor and the high affinity receptor for nerve growth factor (NGF), also termed Trk(A). Tyrosine 78-86 neurotrophic receptor tyrosine kinase 1 Rattus norvegicus 259-262 12218049-3 2002 cAMP-induced tyrosine phosphorylation of the EGF receptor is rapid and correlates with ERK1/2 activation. Tyrosine 13-21 epidermal growth factor receptor Rattus norvegicus 45-57 12218049-6 2002 Inhibition of EGF receptor tyrosine phosphorylation, but not of the NGF receptor, reduces cAMP-induced neurite outgrowth. Tyrosine 27-35 epidermal growth factor receptor Rattus norvegicus 14-26 12376557-8 2002 Crosslinking also decreased ErbB2-ErbB3 heteroassociation and the EGF- and heregulin-induced tyrosine phosphorylation of Shc. Tyrosine 93-101 SHC adaptor protein 1 Homo sapiens 121-124 12421917-3 2002 T cell stimulation by HSP70-instructed DCs is dependent on the Ag bound to HSP70 in that only DCs incubated with HSP70-PC purified from tyrosinase-positive (HSP70-PC/tyr(+)) but not from tyrosinase-negative (HSP70-PC/tyr(-)) melanoma cells resulted in the specific activation of the HLA-A*0201-restricted tyrosinase peptide-specific cytotoxic T cell clone. Tyrosine 136-139 heat shock protein family A (Hsp70) member 4 Homo sapiens 22-27 12421917-3 2002 T cell stimulation by HSP70-instructed DCs is dependent on the Ag bound to HSP70 in that only DCs incubated with HSP70-PC purified from tyrosinase-positive (HSP70-PC/tyr(+)) but not from tyrosinase-negative (HSP70-PC/tyr(-)) melanoma cells resulted in the specific activation of the HLA-A*0201-restricted tyrosinase peptide-specific cytotoxic T cell clone. Tyrosine 136-139 heat shock protein family A (Hsp70) member 4 Homo sapiens 75-80 12421917-3 2002 T cell stimulation by HSP70-instructed DCs is dependent on the Ag bound to HSP70 in that only DCs incubated with HSP70-PC purified from tyrosinase-positive (HSP70-PC/tyr(+)) but not from tyrosinase-negative (HSP70-PC/tyr(-)) melanoma cells resulted in the specific activation of the HLA-A*0201-restricted tyrosinase peptide-specific cytotoxic T cell clone. Tyrosine 136-139 heat shock protein family A (Hsp70) member 4 Homo sapiens 75-80 12421917-3 2002 T cell stimulation by HSP70-instructed DCs is dependent on the Ag bound to HSP70 in that only DCs incubated with HSP70-PC purified from tyrosinase-positive (HSP70-PC/tyr(+)) but not from tyrosinase-negative (HSP70-PC/tyr(-)) melanoma cells resulted in the specific activation of the HLA-A*0201-restricted tyrosinase peptide-specific cytotoxic T cell clone. Tyrosine 136-139 heat shock protein family A (Hsp70) member 4 Homo sapiens 75-80 12421917-3 2002 T cell stimulation by HSP70-instructed DCs is dependent on the Ag bound to HSP70 in that only DCs incubated with HSP70-PC purified from tyrosinase-positive (HSP70-PC/tyr(+)) but not from tyrosinase-negative (HSP70-PC/tyr(-)) melanoma cells resulted in the specific activation of the HLA-A*0201-restricted tyrosinase peptide-specific cytotoxic T cell clone. Tyrosine 136-139 heat shock protein family A (Hsp70) member 4 Homo sapiens 75-80 12421917-3 2002 T cell stimulation by HSP70-instructed DCs is dependent on the Ag bound to HSP70 in that only DCs incubated with HSP70-PC purified from tyrosinase-positive (HSP70-PC/tyr(+)) but not from tyrosinase-negative (HSP70-PC/tyr(-)) melanoma cells resulted in the specific activation of the HLA-A*0201-restricted tyrosinase peptide-specific cytotoxic T cell clone. Tyrosine 166-169 heat shock protein family A (Hsp70) member 4 Homo sapiens 22-27 12421917-3 2002 T cell stimulation by HSP70-instructed DCs is dependent on the Ag bound to HSP70 in that only DCs incubated with HSP70-PC purified from tyrosinase-positive (HSP70-PC/tyr(+)) but not from tyrosinase-negative (HSP70-PC/tyr(-)) melanoma cells resulted in the specific activation of the HLA-A*0201-restricted tyrosinase peptide-specific cytotoxic T cell clone. Tyrosine 166-169 heat shock protein family A (Hsp70) member 4 Homo sapiens 75-80 12421917-3 2002 T cell stimulation by HSP70-instructed DCs is dependent on the Ag bound to HSP70 in that only DCs incubated with HSP70-PC purified from tyrosinase-positive (HSP70-PC/tyr(+)) but not from tyrosinase-negative (HSP70-PC/tyr(-)) melanoma cells resulted in the specific activation of the HLA-A*0201-restricted tyrosinase peptide-specific cytotoxic T cell clone. Tyrosine 166-169 heat shock protein family A (Hsp70) member 4 Homo sapiens 75-80 12421917-3 2002 T cell stimulation by HSP70-instructed DCs is dependent on the Ag bound to HSP70 in that only DCs incubated with HSP70-PC purified from tyrosinase-positive (HSP70-PC/tyr(+)) but not from tyrosinase-negative (HSP70-PC/tyr(-)) melanoma cells resulted in the specific activation of the HLA-A*0201-restricted tyrosinase peptide-specific cytotoxic T cell clone. Tyrosine 166-169 heat shock protein family A (Hsp70) member 4 Homo sapiens 75-80 12421917-3 2002 T cell stimulation by HSP70-instructed DCs is dependent on the Ag bound to HSP70 in that only DCs incubated with HSP70-PC purified from tyrosinase-positive (HSP70-PC/tyr(+)) but not from tyrosinase-negative (HSP70-PC/tyr(-)) melanoma cells resulted in the specific activation of the HLA-A*0201-restricted tyrosinase peptide-specific cytotoxic T cell clone. Tyrosine 166-169 heat shock protein family A (Hsp70) member 4 Homo sapiens 75-80 12421971-5 2002 Preincubation of lymphoid B cells with an adhesion-blocking Ab directed against alpha(4)beta(1) integrin abrogated adhesion-mediated changes of endothelial cell tyrosine phosphorylation, suggesting that cell contact was essential. Tyrosine 161-169 integrin subunit beta 1 Homo sapiens 88-104 12421971-6 2002 Similar patterns of tyrosine phosphorylation, but with slightly different kinetics were induced after cross-linking of beta(1) integrin or CD40 on endothelial cells. Tyrosine 20-28 integrin subunit beta 1 Homo sapiens 119-135 12451275-8 2002 CONCLUSIONS: The tyrphostin AG-1295 reduces neointimal formation in aortic allograft vasculopathy by inhibition of PDGFR-beta-triggered tyrosine phosphorylation. Tyrosine 136-144 platelet derived growth factor receptor beta Rattus norvegicus 115-125 12055186-7 2002 Analysis of several T cell hybridomas indicated that three residues contacted the T cell receptor: Tyr-23 (P-1), Leu-25 (P3), and Trp-28 (P5). Tyrosine 99-102 crystallin gamma F, pseudogene Homo sapiens 107-110 12205101-10 2002 From these studies, a structural basis for the profound differences in the substrate and inhibition kinetics of the wild-type 1 and 2 3beta-HSD, plus a catalytic role for the Tyr(154) and Lys(158) residues in the 3beta-HSD reaction have been identified. Tyrosine 175-178 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 134-143 12205101-10 2002 From these studies, a structural basis for the profound differences in the substrate and inhibition kinetics of the wild-type 1 and 2 3beta-HSD, plus a catalytic role for the Tyr(154) and Lys(158) residues in the 3beta-HSD reaction have been identified. Tyrosine 175-178 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 213-222 12403624-4 2002 Reverting the Arg(19) substitution of [M]PTH(1-20) to the native Glu reduced cAMP signaling potency on P1R-delNt by 12-fold (EC(50) of [M]PTH(1-20)-Glu(19) = 27 +/- 4 nM), and it decreased the analog"s capacity to inhibit the binding of the J domain-selective radioligand, (125)I-[Aib(1,3),Nle(8),M,Tyr(21)]ratPTH(1-21), to the full-length P1R stably expressed in LLC-PK1 cells by 40-fold. Tyrosine 299-302 parathyroid hormone Sus scrofa 41-44 12445460-4 2002 Both the N-terminal regulatory domain of annexin XI (Anx11N) and the ALG-2-binding domain of Alix/AIP1 are rich in Pro, Gly, Ala, Tyr and Gln. Tyrosine 130-133 ALG2 alpha-1,3/1,6-mannosyltransferase Homo sapiens 69-74 12485888-0 2002 Signal transduction through tyrosine-phosphorylated carboxy-terminal fragments of APP via an enhanced interaction with Shc/Grb2 adaptor proteins in reactive astrocytes of Alzheimer"s disease brain. Tyrosine 28-36 SHC adaptor protein 1 Homo sapiens 119-122 12485888-4 2002 Here it is shown that in human brain, a subset of tyrosine-phosphorylated CTFs represent docking sites for the adaptor protein ShcA. Tyrosine 50-58 SHC adaptor protein 1 Homo sapiens 127-131 12485888-6 2002 Grb2 also is involved in complexes with ShcA and tyrosine-phosphorylated CTFs, and in AD brain the interaction between Grb2-ShcA and CTFs is enhanced. Tyrosine 49-57 SHC adaptor protein 1 Homo sapiens 124-128 12426206-3 2002 Because flow increases reactive oxygen species (ROS) production in ECs and because H(2)O(2) increases tyrosine phosphorylation of proline-rich tyrosine kinase (PYK2), we hypothesized that flow may activate PYK2 via ROS. Tyrosine 102-110 protein tyrosine kinase 2 beta Bos taurus 160-164 12426206-7 2002 Bovine aortic ECs transfected with kinase-inactive PYK2 showed attenuated flow-stimulated Cas tyrosine phosphorylation. Tyrosine 94-102 protein tyrosine kinase 2 beta Bos taurus 51-55 12384447-4 2002 In functional analyses we could show that this mutant is hyperphosphorylated on tyrosine and confers interleukin 3-independent growth to Ba/F3 cells, which can be inhibited by a specific FLT3 protein tyrosine kinase (PTK) inhibitor. Tyrosine 80-88 FMS-like tyrosine kinase 3 Mus musculus 187-191 12411404-6 2002 Treatment of B cells with Phx for 12 h inhibited BCR-stimulated tyrosine phosphorylation of cellular proteins. Tyrosine 64-72 BCR activator of RhoGEF and GTPase Gallus gallus 49-52 12414713-0 2002 (13)C-(1)H NMR relaxation and fluorescence anisotropy decay study of tyrosine dynamics in motilin. Tyrosine 69-77 motilin Homo sapiens 90-97 12414713-1 2002 Tyrosine ring dynamics of the gastrointestinal hormone motilin was studied using two independent physical methods: fluorescence polarization anisotropy decay and NMR relaxation. Tyrosine 0-8 motilin Homo sapiens 55-62 12414713-2 2002 Motilin, a 22-residue peptide, was selectively (13)C labeled in the ring epsilon-carbons of the single tyrosine residue. Tyrosine 103-111 motilin Homo sapiens 0-7 12414665-4 2002 Using the metalloprotease inhibitor batimastat, the EGFR-specific tyrphostin AG1478, and a dominant-negative EGFR mutant, we show that in HNSCC cell lines, EGFR tyrosine phosphorylation, recruitment of the adaptor proteins SHC and Gab1, and activation of the ERK/mitogen-activated protein kinase pathway in response to LPA depend both on metalloprotease function and EGFR tyrosine kinase activity. Tyrosine 161-169 SHC adaptor protein 1 Homo sapiens 223-226 12414665-4 2002 Using the metalloprotease inhibitor batimastat, the EGFR-specific tyrphostin AG1478, and a dominant-negative EGFR mutant, we show that in HNSCC cell lines, EGFR tyrosine phosphorylation, recruitment of the adaptor proteins SHC and Gab1, and activation of the ERK/mitogen-activated protein kinase pathway in response to LPA depend both on metalloprotease function and EGFR tyrosine kinase activity. Tyrosine 161-169 GRB2 associated binding protein 1 Homo sapiens 231-235 12431372-3 2002 Src family kinases activate N-WASP through tyrosine phosphorylation, which induces Arp2/3 complex-mediated actin polymerization. Tyrosine 43-51 WASP like actin nucleation promoting factor Homo sapiens 28-34 12431372-4 2002 Tyrosine phosphorylation of N-WASP also initiates its degradation through ubiquitination. Tyrosine 0-8 WASP like actin nucleation promoting factor Homo sapiens 28-34 12431372-7 2002 Collectively, neurite extension is regulated by the balance of N-WASP phosphorylation (activation) and degradation (inactivation), which are induced by tyrosine phosphorylation. Tyrosine 152-160 WASP like actin nucleation promoting factor Homo sapiens 63-69 12270548-2 2002 Recently, we established IL-3-dependent Ba/F3 pro-B cells ectopically expressing RON tyrosine kinase, a receptor for macrophage-stimulating protein (MSP), and showed that MSP stimulation specifically promoted cell morphological changes through tyrosine phosphorylation of the IL-3 common beta-chain receptor subunit (betac) by activated RON kinase without activation of JAK2 tyrosine kinase. Tyrosine 85-93 macrophage stimulating 1 (hepatocyte growth factor-like) Mus musculus 117-147 12270548-2 2002 Recently, we established IL-3-dependent Ba/F3 pro-B cells ectopically expressing RON tyrosine kinase, a receptor for macrophage-stimulating protein (MSP), and showed that MSP stimulation specifically promoted cell morphological changes through tyrosine phosphorylation of the IL-3 common beta-chain receptor subunit (betac) by activated RON kinase without activation of JAK2 tyrosine kinase. Tyrosine 85-93 macrophage stimulating 1 (hepatocyte growth factor-like) Mus musculus 149-152 12270548-2 2002 Recently, we established IL-3-dependent Ba/F3 pro-B cells ectopically expressing RON tyrosine kinase, a receptor for macrophage-stimulating protein (MSP), and showed that MSP stimulation specifically promoted cell morphological changes through tyrosine phosphorylation of the IL-3 common beta-chain receptor subunit (betac) by activated RON kinase without activation of JAK2 tyrosine kinase. Tyrosine 85-93 macrophage stimulating 1 (hepatocyte growth factor-like) Mus musculus 171-174 12270548-7 2002 Tyrosine phosphorylation of ERK was detected after stimulation with IL-3 or MSP, whereas treatment with U0126 specifically inhibited IL-3- or MSP-induced ERK phosphorylation but not tyrosine phosphorylation of betac. Tyrosine 0-8 macrophage stimulating 1 (hepatocyte growth factor-like) Mus musculus 76-79 12537755-6 2002 HSP70-peptide complexes purified from tyrosinase positive (HSP70-PC/tyr+) human melanoma cells, incubated with immature DCs, results in the activation of HLA-*A0201-restricted tyrosinase peptide-specific T-cells. Tyrosine 38-41 heat shock protein family A (Hsp70) member 4 Homo sapiens 0-5 12537755-6 2002 HSP70-peptide complexes purified from tyrosinase positive (HSP70-PC/tyr+) human melanoma cells, incubated with immature DCs, results in the activation of HLA-*A0201-restricted tyrosinase peptide-specific T-cells. Tyrosine 38-41 heat shock protein family A (Hsp70) member 4 Homo sapiens 59-64 12196526-5 2002 Nonetheless, incubation of purified p85-p110 with Tyr-phosphorylated peptides, which mimic the activated platelet-derived growth factor receptor, restored Ras-induced p85-p110 activation. Tyrosine 50-53 phosphoinositide-3-kinase regulatory subunit 2 Homo sapiens 36-39 12196526-5 2002 Nonetheless, incubation of purified p85-p110 with Tyr-phosphorylated peptides, which mimic the activated platelet-derived growth factor receptor, restored Ras-induced p85-p110 activation. Tyrosine 50-53 phosphoinositide-3-kinase regulatory subunit 2 Homo sapiens 167-170 12385003-6 2002 AS-ODN and LT also inhibited the tyrosine phosphorylation of FAK when cells were plated on vitronectin, fibronectin, or type-1 collagen. Tyrosine 33-41 vitronectin Mus musculus 91-102 12439288-4 2002 The authors found that STAT1 was phosphorylated at tyrosine and serine727 and translocated into neuronal nuclei within hours after middle cerebral artery occlusion. Tyrosine 51-59 signal transducer and activator of transcription 1 Mus musculus 23-28 12429724-5 2002 Expression of IFN regulatory factor (IRF)-7 was enhanced by CpG-DNA treatment, which was preceded by the phosphorylation of signal transducer and activator of transcription (STAT)1 on Tyr-701, as well as its enhanced phosphorylation on Ser-727. Tyrosine 184-187 signal transducer and activator of transcription 1 Homo sapiens 124-180 12403838-4 2002 This probe incorporated a photolabile (epsilon-p-benzoylbenzoyl)lysine in position 18 and a site for oxidative radioiodination [(tyrosine(10),(benzoyl-benzoyl)lysine(18))rat secretin-27]. Tyrosine 129-137 secretin Rattus norvegicus 174-182 12453414-3 2002 We find that Lyn phosphorylates only the first tyrosine whereas Syk phosphorylates both tyrosines of the BCR immunoreceptor tyrosine-based activation motif (ITAM). Tyrosine 88-97 SH2 ankyrin repeat kinase Drosophila melanogaster 64-67 12453414-3 2002 We find that Lyn phosphorylates only the first tyrosine whereas Syk phosphorylates both tyrosines of the BCR immunoreceptor tyrosine-based activation motif (ITAM). Tyrosine 88-96 SH2 ankyrin repeat kinase Drosophila melanogaster 64-67 12453414-4 2002 Furthermore, we show that Syk is a positive allosteric enzyme, which is strongly activated by the binding to the phosphorylated ITAM tyrosines, thus initiating a positive feedback loop at the receptor. Tyrosine 133-142 SH2 ankyrin repeat kinase Drosophila melanogaster 26-29 12487370-4 2002 Upon binding LIF or cardiotrophin-1, the LIF receptor alpha subunit (LIFRalpha) dimerizes with gp130, leading to activation of constitutively associated Jak1 proteins and LIFRalpha-gp130 tyrosine phosphorylation. Tyrosine 187-195 LIF, interleukin 6 family cytokine Rattus norvegicus 13-16 12487370-4 2002 Upon binding LIF or cardiotrophin-1, the LIF receptor alpha subunit (LIFRalpha) dimerizes with gp130, leading to activation of constitutively associated Jak1 proteins and LIFRalpha-gp130 tyrosine phosphorylation. Tyrosine 187-195 cardiotrophin 1 Rattus norvegicus 20-35 12487370-4 2002 Upon binding LIF or cardiotrophin-1, the LIF receptor alpha subunit (LIFRalpha) dimerizes with gp130, leading to activation of constitutively associated Jak1 proteins and LIFRalpha-gp130 tyrosine phosphorylation. Tyrosine 187-195 LIF, interleukin 6 family cytokine Rattus norvegicus 41-44 12487370-5 2002 We found that pretreatment of neonatal rat ventricular myocytes with endothelin-1 rapidly inhibited LIF-induced LIFRalpha tyrosine phosphorylation and Jak1 activation. Tyrosine 122-130 LIF, interleukin 6 family cytokine Rattus norvegicus 100-103 12410527-3 2002 SeV suppresses IFN-stimulated tyrosine phosphorylation of signal transducers and activators of transcription (STATs) at an early phase of infection and further inhibits the downstream signalling without degrading any of the signalling components in most cell lines. Tyrosine 30-38 signal transducer and activator of transcription 1 Homo sapiens 110-115 12590956-6 2002 A positive correlation is observed between inhibition of clot retraction and inhibition of tyrosine dephosphorylation across a number of GP IIb/IIIa antagonist pharmacophores. Tyrosine 91-99 integrin subunit alpha 2b Homo sapiens 137-143 12400005-3 2002 PKC activation induces the intracellular movement and co-localization of RACK1 and Src, and the tyrosine phosphorylation of RACK1. Tyrosine 96-104 receptor for activated C kinase 1 Homo sapiens 124-129 12400005-6 2002 Moreover, Src activity is necessary for both the tyrosine phosphorylation of RACK1 and the binding of RACK1 to Src"s SH2 domain that occur following PKC activation. Tyrosine 49-57 receptor for activated C kinase 1 Homo sapiens 77-82 12400005-6 2002 Moreover, Src activity is necessary for both the tyrosine phosphorylation of RACK1 and the binding of RACK1 to Src"s SH2 domain that occur following PKC activation. Tyrosine 49-57 receptor for activated C kinase 1 Homo sapiens 102-107 12400005-7 2002 To identify the tyrosine(s) on RACK1 that is phosphorylated by Src, we generated and tested a series of RACK1 mutants. Tyrosine 16-24 receptor for activated C kinase 1 Homo sapiens 31-36 12400005-8 2002 We found that Src phosphorylates RACK1 on Tyr 228 and/or Tyr 246, highly-conserved tyrosines located in the sixth WD repeat that interact with Src"s SH2 domain. Tyrosine 42-45 receptor for activated C kinase 1 Homo sapiens 33-38 12400005-8 2002 We found that Src phosphorylates RACK1 on Tyr 228 and/or Tyr 246, highly-conserved tyrosines located in the sixth WD repeat that interact with Src"s SH2 domain. Tyrosine 83-92 receptor for activated C kinase 1 Homo sapiens 33-38 12400011-6 2002 Specifically, we demonstrate that tyrosine phosphorylated EphA2 interacts with the PTB and SH2 domains of SHC. Tyrosine 34-42 EPH receptor A2 Homo sapiens 58-63 12400011-6 2002 Specifically, we demonstrate that tyrosine phosphorylated EphA2 interacts with the PTB and SH2 domains of SHC. Tyrosine 34-42 SHC adaptor protein 1 Homo sapiens 106-109 12177051-5 2002 Using surface plasmon resonance analysis, we observed that an immunoreceptor tyrosine-based inhibitory motif (ITIM) located in the C-terminal part of the B2 receptor interacted specifically with the protein-tyrosine phosphatase SHP-2. Tyrosine 77-85 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 228-233 12181320-0 2002 Substrate conformational restriction and CD45-catalyzed dephosphorylation of tail tyrosine-phosphorylated Src protein. Tyrosine 82-90 protein tyrosine phosphatase receptor type C Homo sapiens 41-45 12183462-0 2002 Tyrosine-sulfated peptides functionally reconstitute a CCR5 variant lacking a critical amino-terminal region. Tyrosine 0-8 C-C motif chemokine receptor 5 Homo sapiens 55-59 12183462-2 2002 An acidic, tyrosine-rich, and tyrosine-sulfated domain of the CCR5 amino terminus plays a critical role in the ability of CCR5 to serve as an HIV-1 coreceptor, and tyrosine-sulfated peptides based on this region physically associate with the HIV-1 envelope glycoprotein gp120 and slow HIV-1 entry into CCR5-expressing cells. Tyrosine 11-19 C-C motif chemokine receptor 5 Homo sapiens 62-66 12183462-2 2002 An acidic, tyrosine-rich, and tyrosine-sulfated domain of the CCR5 amino terminus plays a critical role in the ability of CCR5 to serve as an HIV-1 coreceptor, and tyrosine-sulfated peptides based on this region physically associate with the HIV-1 envelope glycoprotein gp120 and slow HIV-1 entry into CCR5-expressing cells. Tyrosine 11-19 C-C motif chemokine receptor 5 Homo sapiens 122-126 12183462-2 2002 An acidic, tyrosine-rich, and tyrosine-sulfated domain of the CCR5 amino terminus plays a critical role in the ability of CCR5 to serve as an HIV-1 coreceptor, and tyrosine-sulfated peptides based on this region physically associate with the HIV-1 envelope glycoprotein gp120 and slow HIV-1 entry into CCR5-expressing cells. Tyrosine 11-19 C-C motif chemokine receptor 5 Homo sapiens 122-126 12183462-2 2002 An acidic, tyrosine-rich, and tyrosine-sulfated domain of the CCR5 amino terminus plays a critical role in the ability of CCR5 to serve as an HIV-1 coreceptor, and tyrosine-sulfated peptides based on this region physically associate with the HIV-1 envelope glycoprotein gp120 and slow HIV-1 entry into CCR5-expressing cells. Tyrosine 30-38 C-C motif chemokine receptor 5 Homo sapiens 62-66 12183462-2 2002 An acidic, tyrosine-rich, and tyrosine-sulfated domain of the CCR5 amino terminus plays a critical role in the ability of CCR5 to serve as an HIV-1 coreceptor, and tyrosine-sulfated peptides based on this region physically associate with the HIV-1 envelope glycoprotein gp120 and slow HIV-1 entry into CCR5-expressing cells. Tyrosine 30-38 C-C motif chemokine receptor 5 Homo sapiens 122-126 12183462-2 2002 An acidic, tyrosine-rich, and tyrosine-sulfated domain of the CCR5 amino terminus plays a critical role in the ability of CCR5 to serve as an HIV-1 coreceptor, and tyrosine-sulfated peptides based on this region physically associate with the HIV-1 envelope glycoprotein gp120 and slow HIV-1 entry into CCR5-expressing cells. Tyrosine 30-38 C-C motif chemokine receptor 5 Homo sapiens 122-126 12183462-2 2002 An acidic, tyrosine-rich, and tyrosine-sulfated domain of the CCR5 amino terminus plays a critical role in the ability of CCR5 to serve as an HIV-1 coreceptor, and tyrosine-sulfated peptides based on this region physically associate with the HIV-1 envelope glycoprotein gp120 and slow HIV-1 entry into CCR5-expressing cells. Tyrosine 30-38 C-C motif chemokine receptor 5 Homo sapiens 62-66 12183462-2 2002 An acidic, tyrosine-rich, and tyrosine-sulfated domain of the CCR5 amino terminus plays a critical role in the ability of CCR5 to serve as an HIV-1 coreceptor, and tyrosine-sulfated peptides based on this region physically associate with the HIV-1 envelope glycoprotein gp120 and slow HIV-1 entry into CCR5-expressing cells. Tyrosine 30-38 C-C motif chemokine receptor 5 Homo sapiens 122-126 12183462-2 2002 An acidic, tyrosine-rich, and tyrosine-sulfated domain of the CCR5 amino terminus plays a critical role in the ability of CCR5 to serve as an HIV-1 coreceptor, and tyrosine-sulfated peptides based on this region physically associate with the HIV-1 envelope glycoprotein gp120 and slow HIV-1 entry into CCR5-expressing cells. Tyrosine 30-38 C-C motif chemokine receptor 5 Homo sapiens 122-126 12183462-3 2002 Here we show that the same tyrosine-sulfated peptides, but not their unsulfated analogs, can restore the HIV-1 coreceptor activity of a CCR5 variant lacking residues 2-17 of its amino terminus. Tyrosine 27-35 C-C motif chemokine receptor 5 Homo sapiens 136-140 12183462-5 2002 These observations show that a tyrosine-sulfated region of the CCR5 amino terminus can function independently to mediate association of chemokines and the HIV-1 envelope glycoprotein with the remaining domains of CCR5. Tyrosine 31-39 C-C motif chemokine receptor 5 Homo sapiens 63-67 12183462-5 2002 These observations show that a tyrosine-sulfated region of the CCR5 amino terminus can function independently to mediate association of chemokines and the HIV-1 envelope glycoprotein with the remaining domains of CCR5. Tyrosine 31-39 C-C motif chemokine receptor 5 Homo sapiens 213-217 12370370-3 2002 Recent studies have established that clustering FcgammaR on human myeloid cells causes tyrosine phosphorylation of Src homology 2 domain-containing inositol polyphosphate phosphatase (SHIP). Tyrosine 87-95 inositol polyphosphate-5-phosphatase D Homo sapiens 115-182 12370370-3 2002 Recent studies have established that clustering FcgammaR on human myeloid cells causes tyrosine phosphorylation of Src homology 2 domain-containing inositol polyphosphate phosphatase (SHIP). Tyrosine 87-95 inositol polyphosphate-5-phosphatase D Homo sapiens 184-188 12370370-4 2002 However, it is not known how these immunoreceptor tyrosine-based activation motif (ITAM)-bearing phagocytic FcgammaR activate SHIP, or whether the activation of SHIP by ITAMs has any functional relevance. Tyrosine 50-58 inositol polyphosphate-5-phosphatase D Homo sapiens 126-130 12370375-3 2002 Binding of IL-4 by either the type 1 or 2 IL-4R, or of IL-13 by the type 2 IL-4R, initiates Jak-dependent tyrosine phosphorylation of the IL-4Ralpha-chain and the transcription factor, STAT6. Tyrosine 106-114 interleukin 4 receptor, alpha Mus musculus 42-47 12370375-3 2002 Binding of IL-4 by either the type 1 or 2 IL-4R, or of IL-13 by the type 2 IL-4R, initiates Jak-dependent tyrosine phosphorylation of the IL-4Ralpha-chain and the transcription factor, STAT6. Tyrosine 106-114 interleukin 4 receptor, alpha Mus musculus 75-80 12370375-3 2002 Binding of IL-4 by either the type 1 or 2 IL-4R, or of IL-13 by the type 2 IL-4R, initiates Jak-dependent tyrosine phosphorylation of the IL-4Ralpha-chain and the transcription factor, STAT6. Tyrosine 106-114 interleukin 4 receptor, alpha Mus musculus 138-148 12147684-5 2002 Insulin stimulated tyrosine phosphorylation of PDK-1WT, but PDK-1CAAX was already tyrosine-phosphorylated at the basal state. Tyrosine 82-90 3-phosphoinositide dependent protein kinase 1 Homo sapiens 60-69 12151401-0 2002 Tyrosine phosphorylation of Kv1.2 modulates its interaction with the actin-binding protein cortactin. Tyrosine 0-8 cortactin Homo sapiens 91-100 12151401-4 2002 We report that the potassium channel Kv1.2 associates with the actin-binding protein cortactin and that the binding is modulated by tyrosine phosphorylation. Tyrosine 132-140 cortactin Homo sapiens 85-94 12372421-1 2002 IL-12 activates STAT4 by inducing tyrosine phosphorylation, homo-dimerization, and nuclear translocation in NK cells and thereby stimulates proliferation and activation of these cells. Tyrosine 34-42 signal transducer and activator of transcription 4 Homo sapiens 16-21 12390682-12 2002 Secondly, the predicted UL18 binding region of LIR-1 is altered substantially in LIR-2: the 76-84 loop mainchain is displaced 11 A with respect to LIR-1, and Tyrosine 38 adopts an alternative rotamer conformation. Tyrosine 158-166 membrane glycoprotein UL18 Human betaherpesvirus 5 24-28 12390682-12 2002 Secondly, the predicted UL18 binding region of LIR-1 is altered substantially in LIR-2: the 76-84 loop mainchain is displaced 11 A with respect to LIR-1, and Tyrosine 38 adopts an alternative rotamer conformation. Tyrosine 158-166 leukocyte immunoglobulin like receptor B1 Homo sapiens 47-52 12149261-1 2002 LMW-PTP controls PDGF-r kinase activity through TYR-857 dephosphorylation. Tyrosine 48-51 acid phosphatase 1 Homo sapiens 0-7 12149261-7 2002 Here we report that LMW-PTP affects the kinase activity of the receptor through the binding and dephosphorylation of Tyr-857 and influences many of the signal outputs from the receptor. Tyrosine 117-120 acid phosphatase 1 Homo sapiens 20-27 12149261-9 2002 In addition, we report a slight action of LMW-PTP on Tyr-716, which directs MAPK activation through Grb2 binding. Tyrosine 53-56 acid phosphatase 1 Homo sapiens 42-49 12149261-10 2002 On the basis of these results, we propose a key role for LMW-PTP in PDGF-r down-regulation through the dephosphorylation of the activation loop Tyr-857, thus determining a general negative regulation of all downstream signals, with the exception of those elicited by internalized receptors. Tyrosine 144-147 acid phosphatase 1 Homo sapiens 57-64 12359261-7 2002 Of these, three are null mutations, but the third one shows an interesting serine to tyrosine substitution (at amino acid position 89 of our partial sequence which corresponds to position 323 of the CPT sequence reported as NM_020244 in GenBank) in 11-9-14 cells. Tyrosine 85-93 choline phosphotransferase 1 Homo sapiens 199-202 12217858-10 2002 We conclude that ROMK1 can be phosphorylated by PTK and that tyrosine residue 337 is the key site for the phosphorylation. Tyrosine 61-69 potassium inwardly-rectifying channel, subfamily J, member 1 Rattus norvegicus 17-22 12225946-4 2002 Herein, we demonstrate that FGF10 stimulation of mouse lung epithelial cells (MLE15) overexpressing mSpry2 results in both mSpry2 tyrosine phosphorylation and differential binding of mSpry2 to several key upstream target proteins in the MAP kinase-activating pathway. Tyrosine 130-138 fibroblast growth factor 10 Mus musculus 28-33 12225946-4 2002 Herein, we demonstrate that FGF10 stimulation of mouse lung epithelial cells (MLE15) overexpressing mSpry2 results in both mSpry2 tyrosine phosphorylation and differential binding of mSpry2 to several key upstream target proteins in the MAP kinase-activating pathway. Tyrosine 130-138 sprouty RTK signaling antagonist 2 Mus musculus 100-106 12438173-6 2002 Leptin (3-30 nM) caused a significant increase in (14)C-catecholamine synthesis from [(14)C] tyrosine, but not from [(14)C] DOPA. Tyrosine 93-101 leptin Bos taurus 0-6 12135708-6 2002 Upon Epo stimulation, the tyrosine-phosphorylated PLC-gamma2 was found to be associated with the tyrosine-phosphorylated Grb2-associated binder (GAB)2, SHC and SHP2 proteins. Tyrosine 26-34 src homology 2 domain-containing transforming protein C1 Mus musculus 152-155 12135708-6 2002 Upon Epo stimulation, the tyrosine-phosphorylated PLC-gamma2 was found to be associated with the tyrosine-phosphorylated Grb2-associated binder (GAB)2, SHC and SHP2 proteins. Tyrosine 97-105 src homology 2 domain-containing transforming protein C1 Mus musculus 152-155 12232802-4 2002 Enhanced sensitivity to stress-induced cell death requires the C-terminal activation domain of STAT-1 and the phosphorylation sites at tyrosine 701 and serine 727. Tyrosine 135-143 signal transducer and activator of transcription 1 Homo sapiens 95-101 12374673-3 2002 EXPERIMENTAL DESIGN: In this study we have separately determined activation of STAT1, STAT3, and STAT5 by measuring their DNA binding activity and tyrosine phosphorylation in breast cancer tissue samples. Tyrosine 147-155 signal transducer and activator of transcription 1 Homo sapiens 79-84 12374673-5 2002 RESULTS: Survival analysis demonstrated that patients with high STAT1 activation have substantially longer overall and relapse-free survival, irrespective of whether STAT1 activation was determined by its DNA binding activity (P = 0.003 and 0.010, respectively) or by its tyrosine phosphorylation (P = 0.046 and 0.011, respectively). Tyrosine 272-280 signal transducer and activator of transcription 1 Homo sapiens 64-69 12537404-9 2002 When combined with one intravenous injection of polyhemoglobin-tyrosinase, the systemic tyrosine level can be lowered within one hour. Tyrosine 88-96 tyrosinase Homo sapiens 63-73 12176891-7 2002 By immunoprecipitation experiments with specific antibodies, the tyrosine phosphorylation of the tyrosine kinase Syk and the phospholipase Cgamma2 (PLCgamma2) isozyme was demonstrated in decorin-adherent platelets. Tyrosine 65-73 spleen associated tyrosine kinase Homo sapiens 113-116 12207350-1 2002 KARAP/DAP12 is a broadly distributed transmembrane signaling polypeptide with an immunoreceptor tyrosine-based activation motif, and is non-covalently associated with a variety of activating surface receptors. Tyrosine 96-104 TYRO protein tyrosine kinase binding protein Mus musculus 0-5 12207350-1 2002 KARAP/DAP12 is a broadly distributed transmembrane signaling polypeptide with an immunoreceptor tyrosine-based activation motif, and is non-covalently associated with a variety of activating surface receptors. Tyrosine 96-104 TYRO protein tyrosine kinase binding protein Mus musculus 6-11 12196573-2 2002 Because activation of trk receptors involves phosphorylation of specific tyrosine residues (Segal et al., 1996), the availability of antibodies that selectively recognize the phosphorylated form of trk receptors at the Shc site permits an immunohistochemical assessment of trk receptor activation. Tyrosine 73-81 neurotrophic receptor tyrosine kinase 1 Rattus norvegicus 22-25 12196573-2 2002 Because activation of trk receptors involves phosphorylation of specific tyrosine residues (Segal et al., 1996), the availability of antibodies that selectively recognize the phosphorylated form of trk receptors at the Shc site permits an immunohistochemical assessment of trk receptor activation. Tyrosine 73-81 src homology 2 domain-containing transforming protein C1 Mus musculus 219-222 12186560-1 2002 The linker for activation of T-cells (LAT) is a palmitoylated integral membrane adaptor protein that resides in lipid membrane rafts and contains nine consensus putative tyrosine phosphorylation sites, several of which have been shown to serve as SH2 binding sites. Tyrosine 170-178 linker for activation of T cells Mus musculus 38-41 12186560-3 2002 The LAT tyrosine residues Y(132), Y(171), Y(191), and Y(226) have been shown previously to be critical for binding to Gads, Grb2, and PLCgamma1. Tyrosine 8-16 linker for activation of T cells Mus musculus 4-7 12186560-3 2002 The LAT tyrosine residues Y(132), Y(171), Y(191), and Y(226) have been shown previously to be critical for binding to Gads, Grb2, and PLCgamma1. Tyrosine 8-16 growth factor receptor bound protein 2 Mus musculus 124-128 12186560-3 2002 The LAT tyrosine residues Y(132), Y(171), Y(191), and Y(226) have been shown previously to be critical for binding to Gads, Grb2, and PLCgamma1. Tyrosine 8-16 phospholipase C, gamma 1 Mus musculus 134-143 12186560-4 2002 In this report, we show by generation of LAT truncation mutants that the Syk-family kinase ZAP-70 and the Tec-family kinase Itk favor phosphorylation of carboxy-terminal tyrosines in LAT. Tyrosine 170-179 linker for activation of T cells Mus musculus 41-44 12186560-4 2002 In this report, we show by generation of LAT truncation mutants that the Syk-family kinase ZAP-70 and the Tec-family kinase Itk favor phosphorylation of carboxy-terminal tyrosines in LAT. Tyrosine 170-179 linker for activation of T cells Mus musculus 183-186 12186560-5 2002 By direct binding studies using purified recombinant proteins or phosphopeptides and by mutagenesis of individual tyrosines in LAT to phenylalanine residues, we demonstrate that Y(171) and potentially Y(226) are docking sites for the Vav guanine nucleotide exchange factor. Tyrosine 114-123 linker for activation of T cells Mus musculus 127-130 12186560-6 2002 Further, overexpression of a kinase-deficient mutant of Itk in T-cells reduced both the tyrosine phosphorylation of endogenous LAT and the recruitment of Vav to LAT complexes. Tyrosine 88-96 linker for activation of T cells Mus musculus 127-130 12060651-3 2002 In addition, overexpression studies indicate that the carboxyl-terminal SH2 domain of SHP-2 is required to maintain tyrosine phosphorylation of Stat5 and its interaction with SHP-2. Tyrosine 116-124 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 86-91 12060651-3 2002 In addition, overexpression studies indicate that the carboxyl-terminal SH2 domain of SHP-2 is required to maintain tyrosine phosphorylation of Stat5 and its interaction with SHP-2. Tyrosine 116-124 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 175-180 12065593-7 2002 Surface plasmon resonance analysis revealed beta-arrestin 1 binding to the second intracellular loop of CCR5, which required an intact Asp-Arg-Tyr triplet. Tyrosine 143-146 arrestin, beta 1 Rattus norvegicus 44-59 12070153-5 2002 Phosphopeptide competition analysis revealed multiple tyrosine residues within the C-tail that can act as the docking sites for both Stat1 and Stat3. Tyrosine 54-62 signal transducer and activator of transcription 1 Homo sapiens 133-138 12135605-4 2002 Here we show that (1) IGF-IR colocalizes with caveolin 1 in the lipid rafts enriched fractions on plasmamembrane in R-IGF-IR(WT) cells, (2) IGF-I induces caveolin 1 phosphorylation at the level of tyrosine 14, (3) this effect is rapid and results in the translocation of caveolin 1 and in the formation of membrane patches on cell surface. Tyrosine 197-205 insulin like growth factor 1 receptor Homo sapiens 22-28 12149456-0 2002 Clinical resistance to the kinase inhibitor STI-571 in chronic myeloid leukemia by mutation of Tyr-253 in the Abl kinase domain P-loop. Tyrosine 95-98 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 110-113 12149456-3 2002 Here we identify mutations of Tyr-253 in the nucleotide-binding (P) loop of the Abl kinase domain to Phe or His in patients with advanced CML and acquired STI-571 resistance. Tyrosine 30-33 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 80-83 12149456-5 2002 The response of Abl proteins to STI-571 was influenced by the regulatory state of the kinase and by tyrosine phosphorylation. Tyrosine 100-108 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 16-19 12149456-6 2002 The sensitivity of purified c-Abl to STI-571 was increased by a dysregulating mutation (P112L) in the Src homology 3 domain of Abl but decreased by phosphorylation at the regulatory Tyr-393. Tyrosine 182-185 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 28-33 12149456-6 2002 The sensitivity of purified c-Abl to STI-571 was increased by a dysregulating mutation (P112L) in the Src homology 3 domain of Abl but decreased by phosphorylation at the regulatory Tyr-393. Tyrosine 182-185 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 30-33 12149481-3 2002 TMC specifically blocked tyrosine phosphorylation of intracellular signal mediators downstream of Src tyrosine kinases in a T cell-specific manner, leading to apoptosis due to cleavage of Bcl-2, caspase-9, caspase-3, and poly(ADP-ribose) polymerase, but not caspase-1. Tyrosine 25-33 caspase 1 Rattus norvegicus 258-267 12198373-0 2002 Ethanol-induced Cas tyrosine phosphorylation and Fyn kinase activation in rat brain. Tyrosine 20-28 BCAR1 scaffold protein, Cas family member Rattus norvegicus 16-19 12198373-3 2002 RESULTS: Immunoprecipitation experiments showed that Crk-associated substrate (Cas) was tyrosine-phosphorylated in response to ethanol administration. Tyrosine 88-96 BCAR1 scaffold protein, Cas family member Rattus norvegicus 53-77 12198373-3 2002 RESULTS: Immunoprecipitation experiments showed that Crk-associated substrate (Cas) was tyrosine-phosphorylated in response to ethanol administration. Tyrosine 88-96 BCAR1 scaffold protein, Cas family member Rattus norvegicus 79-82 12198373-4 2002 Fyn kinase was shown to be activated by ethanol administration and to phosphorylate Cas on tyrosine residue in vitro. Tyrosine 91-99 BCAR1 scaffold protein, Cas family member Rattus norvegicus 84-87 12198373-6 2002 CONCLUSIONS: Cas was tyrosine-phosphorylated in rat brain by ethanol administration, and Fyn kinase was most likely involved in the process. Tyrosine 21-29 BCAR1 scaffold protein, Cas family member Rattus norvegicus 13-16 12114187-6 2002 Mechanical stretch increased tyrosine phosphorylation of rat AFAP and its binding to c-Src within the initial several minutes. Tyrosine 29-37 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 85-90 12154000-4 2002 VEGF treatment of human umbilical vein endothelial cells (HUVECs) and KDR-transfected porcine aortic endothelial cells leads to the rapid tyrosine phosphorylation of FRS2. Tyrosine 138-146 kinase insert domain receptor Homo sapiens 70-73 12138178-1 2002 Upon interferon (IFN) stimulation, Stat1 becomes tyrosine phosphorylated and translocates into the nucleus, where it binds to DNA to activate transcription. Tyrosine 49-57 signal transducer and activator of transcription 1 Homo sapiens 35-40 12138178-2 2002 The activity of Stat1 is dependent on tyrosine phosphorylation, and its inactivation in the nucleus is accomplished by a previously unknown protein tyrosine phosphatase (PTP). Tyrosine 38-46 signal transducer and activator of transcription 1 Homo sapiens 16-21 12138178-6 2002 Furthermore, the dephosphorylation of IFN-induced tyrosine-phosphorylated Stat1 is defective in TC-PTP-null mouse embryonic fibroblasts (MEFs) and primary thymocytes. Tyrosine 50-58 signal transducer and activator of transcription 1 Mus musculus 74-79 12138178-6 2002 Furthermore, the dephosphorylation of IFN-induced tyrosine-phosphorylated Stat1 is defective in TC-PTP-null mouse embryonic fibroblasts (MEFs) and primary thymocytes. Tyrosine 50-58 protein tyrosine phosphatase, non-receptor type 2 Mus musculus 96-102 12145341-6 2002 Thus, the simultaneous substitution of M576 in TM6 and H615 in TM7 of the hFSHR with the cognate rFSHR residues (threonine and tyrosine, respectively) now renders the hFSHR(D581G) mutant constitutively active. Tyrosine 127-135 follicle stimulating hormone receptor Homo sapiens 74-79 12145341-6 2002 Thus, the simultaneous substitution of M576 in TM6 and H615 in TM7 of the hFSHR with the cognate rFSHR residues (threonine and tyrosine, respectively) now renders the hFSHR(D581G) mutant constitutively active. Tyrosine 127-135 follicle stimulating hormone receptor Homo sapiens 167-172 12114320-3 2002 Exposure of human umbilical vein endothelial cells to hypoxia results in HIF protein stabilization as early as 10 minutes, with a maximum at 3 hours, and also in Shc tyrosine phosphorylation, with a maximum at 10 minutes. Tyrosine 166-174 SHC adaptor protein 1 Homo sapiens 162-165 12150951-2 2002 We have recently found that tyrosine phosphorylation of APP-Y(682) promotes docking of Shc proteins that modulate growth factor signaling to the ERK and PI3K/Akt pathways. Tyrosine 28-36 SHC adaptor protein 1 Homo sapiens 87-90 12070037-2 2002 We previously demonstrated that pervanadate treatment of human erythrocytes induces band-3 Tyr phosphorylation, which is catalyzed by the sequential action of tyrosine kinase Syk and tyrosine kinase(s) belonging to the Src family. Tyrosine 91-94 spleen associated tyrosine kinase Homo sapiens 175-178 12070037-3 2002 In this study, we show that Tyr phosphorylation of band 3, elicited by pervanadate, N-ethylmaleimide, or diamide, greatly increases band-3 interaction with the tyrosine phosphatase SHP-2 in parallel with the translocation of SHP-2 to erythrocyte membranes. Tyrosine 28-31 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 181-186 12070037-3 2002 In this study, we show that Tyr phosphorylation of band 3, elicited by pervanadate, N-ethylmaleimide, or diamide, greatly increases band-3 interaction with the tyrosine phosphatase SHP-2 in parallel with the translocation of SHP-2 to erythrocyte membranes. Tyrosine 28-31 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 225-230 12070037-4 2002 These events seem to be mediated by Src-like catalyzed phosphorylation of band 3 because both SHP-2 translocation to cellular membranes and its interaction with Tyr-phosphorylated protein are greatly counteracted by PP2, a specific inhibitor of Src kinases. Tyrosine 161-164 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 94-99 12070037-7 2002 Experiments performed with intact erythrocytes in the presence of the SHP-2 inhibitor calpeptin suggest that, once recruited to Tyr-phosphorylated band 3, the tyrosine phosphatase dephosphorylates the protein. Tyrosine 128-131 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 70-75 12437102-2 2002 Site-directed mutagenesis of the conserved Tyr (Y226) of recombinant mouse meprin alpha was used to test the hypothesis that this residue is essential for zinc binding and enzymatic activity. Tyrosine 43-46 meprin 1 alpha Mus musculus 75-87 12100025-0 2002 Anti-CD45 isoform antibodies enhance phagocytosis and gene expression of IL-8 and TNF-alpha in human neutrophils by differential suppression on protein tyrosine phosphorylation and p56lck tyrosine kinase. Tyrosine 152-160 protein tyrosine phosphatase receptor type C Homo sapiens 5-9 12100025-5 2002 Anti-CD45RA and anti-CD45RO, but not anti-CD45, enhanced TNF-alpha mRNA expression and decreased protein tyrosine phosphorylation of PMN. Tyrosine 105-113 protein tyrosine phosphatase receptor type C Homo sapiens 5-9 12100025-7 2002 These results suggest that the cross-linking of CD45 isoforms by their specific antibodies stimulated different PMN activities by differential suppression on protein tyrosine phosphorylation and Src family tyrosine kinase p56lck. Tyrosine 166-174 protein tyrosine phosphatase receptor type C Homo sapiens 48-52 12142569-8 2002 Hypothermia also increased tissue levels and tyrosine phosphorylation of TrkB, the receptor for BDNF. Tyrosine 45-53 brain-derived neurotrophic factor Rattus norvegicus 96-100 12142572-6 2002 In conclusion, SAH during acute stage causes an increase in NAD(P)H oxidase-dependent superoxide formation in cerebral vessels, which is due to activation of tyrosine phosphorylation-dependent increased expression of gp91phox mRNA and translocation of Rac protein, thereby resulting in a significant reduction of autoregulatory vasodilation. Tyrosine 158-166 cytochrome b-245 beta chain Rattus norvegicus 217-225 12124436-0 2002 Shp-2 positively regulates brain-derived neurotrophic factor-promoted survival of cultured ventral mesencephalic dopaminergic neurons through a brain immunoglobulin-like molecule with tyrosine-based activation motifs/Shp substrate-1. Tyrosine 184-192 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 0-5 12124436-0 2002 Shp-2 positively regulates brain-derived neurotrophic factor-promoted survival of cultured ventral mesencephalic dopaminergic neurons through a brain immunoglobulin-like molecule with tyrosine-based activation motifs/Shp substrate-1. Tyrosine 184-192 brain derived neurotrophic factor Homo sapiens 27-60 12051728-5 2002 In contrast, IL-10 inhibited IFN-alpha-mediated tyrosine phosphorylation of STAT1 by induction of a Janus kinase inhibitor, JAB. Tyrosine 48-56 interleukin 10 Homo sapiens 13-18 12051728-5 2002 In contrast, IL-10 inhibited IFN-alpha-mediated tyrosine phosphorylation of STAT1 by induction of a Janus kinase inhibitor, JAB. Tyrosine 48-56 signal transducer and activator of transcription 1 Homo sapiens 76-81 12008046-5 2002 Moreover, the CD45 deficient Jurkat variant, J45.01 responds readily with tyrosine phosphorylation and subsequent apoptosis to galectin-1 treatment in a similar degree as its wild type counterpart, Jurkat does. Tyrosine 74-82 protein tyrosine phosphatase receptor type C Homo sapiens 14-18 12115644-3 2002 In pervanadate (PV)-treated B cells, multiple proteins are tyrosine phosphorylated upon expression of the BCR, indicating that the BCR can signal in an antigen-independent fashion. Tyrosine 59-67 BCR activator of RhoGEF and GTPase Homo sapiens 106-109 12115644-5 2002 In comparison to cells expressing the wild-type receptors, those with a mutant BCR respond to PV treatment with reduced and retarded tyrosine phosphorylation of substrate proteins. Tyrosine 133-141 BCR activator of RhoGEF and GTPase Homo sapiens 79-82 12121665-0 2002 Immature CD4(+)CD8(+) thymocytes form a multifocal immunological synapse with sustained tyrosine phosphorylation. Tyrosine 88-96 CD8a molecule Homo sapiens 15-18 12068083-13 2002 Additionally, IFNbeta induced Stat1 phosphorylation at both tyrosine 701 (Y701) and serine 727 (S727) residues. Tyrosine 60-68 signal transducer and activator of transcription 1 Homo sapiens 30-35 12064824-7 2002 In H9 cells, tyrosine phosphorylation of not only focal adhesion kinase but also CasL was induced after treatment with RANTES. Tyrosine 13-21 C-C motif chemokine ligand 5 Homo sapiens 119-125 12099386-2 2002 The interaction of GH with GH receptors (GHR) on target cells promotes the association of the cellular tyrosine kinase JAK2 with the GHR, initiating tyrosine phosphorylation of GHR and JAK2, and activation of multiple signaling cascades. Tyrosine 103-111 growth hormone receptor Homo sapiens 27-39 12099386-2 2002 The interaction of GH with GH receptors (GHR) on target cells promotes the association of the cellular tyrosine kinase JAK2 with the GHR, initiating tyrosine phosphorylation of GHR and JAK2, and activation of multiple signaling cascades. Tyrosine 103-111 growth hormone receptor Homo sapiens 41-44 12099386-2 2002 The interaction of GH with GH receptors (GHR) on target cells promotes the association of the cellular tyrosine kinase JAK2 with the GHR, initiating tyrosine phosphorylation of GHR and JAK2, and activation of multiple signaling cascades. Tyrosine 103-111 growth hormone receptor Homo sapiens 133-136 12099386-2 2002 The interaction of GH with GH receptors (GHR) on target cells promotes the association of the cellular tyrosine kinase JAK2 with the GHR, initiating tyrosine phosphorylation of GHR and JAK2, and activation of multiple signaling cascades. Tyrosine 103-111 growth hormone receptor Homo sapiens 133-136 12024016-6 2002 In vivo, BRCA1 is phosphorylated at tyrosine residues in an ATM-dependent, radiation-dependent manner. Tyrosine 36-44 BRCA1 DNA repair associated Homo sapiens 9-14 12024016-7 2002 Tyrosine phosphorylation of BRCA1, however, is not required for the disruption of the BRCA1-c-Abl complex. Tyrosine 0-8 BRCA1 DNA repair associated Homo sapiens 28-33 12065886-6 2002 Tyr(11)-SRIH-14, compound 2 (sst(2)) or compound 5 (sst(5)) inhibited forskolin and corticotropin-releasing hormone (CRH)-induced increases in intracellular cAMP. Tyrosine 0-3 corticotropin releasing hormone Mus musculus 84-115 12065886-6 2002 Tyr(11)-SRIH-14, compound 2 (sst(2)) or compound 5 (sst(5)) inhibited forskolin and corticotropin-releasing hormone (CRH)-induced increases in intracellular cAMP. Tyrosine 0-3 corticotropin releasing hormone Mus musculus 117-120 11886862-6 2002 Inhibition of lamellipodia formation by mutation of either serine 696 or tyrosine 1062 was associated with decrease of the Rac1-guanine nucleotide exchange factor (GEF) activity, suggesting that this activity is regulated by two different signaling pathways via serine 696 and tyrosine 1062 in RET. Tyrosine 73-81 Rho/Rac guanine nucleotide exchange factor 2 Homo sapiens 123-162 11886862-6 2002 Inhibition of lamellipodia formation by mutation of either serine 696 or tyrosine 1062 was associated with decrease of the Rac1-guanine nucleotide exchange factor (GEF) activity, suggesting that this activity is regulated by two different signaling pathways via serine 696 and tyrosine 1062 in RET. Tyrosine 73-81 Rho/Rac guanine nucleotide exchange factor 2 Homo sapiens 164-167 11886862-6 2002 Inhibition of lamellipodia formation by mutation of either serine 696 or tyrosine 1062 was associated with decrease of the Rac1-guanine nucleotide exchange factor (GEF) activity, suggesting that this activity is regulated by two different signaling pathways via serine 696 and tyrosine 1062 in RET. Tyrosine 277-285 Rho/Rac guanine nucleotide exchange factor 2 Homo sapiens 123-162 11886862-6 2002 Inhibition of lamellipodia formation by mutation of either serine 696 or tyrosine 1062 was associated with decrease of the Rac1-guanine nucleotide exchange factor (GEF) activity, suggesting that this activity is regulated by two different signaling pathways via serine 696 and tyrosine 1062 in RET. Tyrosine 277-285 Rho/Rac guanine nucleotide exchange factor 2 Homo sapiens 164-167 11861643-3 2002 We have recently generated 14 site-directed mutants of human MAO A and B, and we found that four key amino acids, Lys-305, Trp-397, Tyr-407, and Tyr-444, in MAO A and their corresponding amino acids in MAO B, Lys-296, Trp-388, Tyr-398, and Tyr-435, play important roles in MAO catalytic activity. Tyrosine 145-148 monoamine oxidase B Homo sapiens 202-207 11861643-3 2002 We have recently generated 14 site-directed mutants of human MAO A and B, and we found that four key amino acids, Lys-305, Trp-397, Tyr-407, and Tyr-444, in MAO A and their corresponding amino acids in MAO B, Lys-296, Trp-388, Tyr-398, and Tyr-435, play important roles in MAO catalytic activity. Tyrosine 145-148 monoamine oxidase B Homo sapiens 202-207 11861643-3 2002 We have recently generated 14 site-directed mutants of human MAO A and B, and we found that four key amino acids, Lys-305, Trp-397, Tyr-407, and Tyr-444, in MAO A and their corresponding amino acids in MAO B, Lys-296, Trp-388, Tyr-398, and Tyr-435, play important roles in MAO catalytic activity. Tyrosine 145-148 monoamine oxidase B Homo sapiens 202-207 11861643-4 2002 Based on the polyamine oxidase three-dimensional crystal structure, it is suggested that Lys-305, Trp-397, and Tyr-407 in MAO A and Lys-296, Trp-388, and Tyr-398 in MAO B may be involved in the non-covalent binding to FAD. Tyrosine 111-114 polyamine oxidase Homo sapiens 13-30 11861643-4 2002 Based on the polyamine oxidase three-dimensional crystal structure, it is suggested that Lys-305, Trp-397, and Tyr-407 in MAO A and Lys-296, Trp-388, and Tyr-398 in MAO B may be involved in the non-covalent binding to FAD. Tyrosine 111-114 monoamine oxidase B Homo sapiens 165-170 11861643-4 2002 Based on the polyamine oxidase three-dimensional crystal structure, it is suggested that Lys-305, Trp-397, and Tyr-407 in MAO A and Lys-296, Trp-388, and Tyr-398 in MAO B may be involved in the non-covalent binding to FAD. Tyrosine 154-157 polyamine oxidase Homo sapiens 13-30 11861643-5 2002 Tyr-407 and Tyr-444 in MAO A (Tyr-398 and Tyr-435 in MAO B) may form an aromatic sandwich that stabilizes the substrate binding. Tyrosine 0-3 monoamine oxidase B Homo sapiens 53-58 11861643-5 2002 Tyr-407 and Tyr-444 in MAO A (Tyr-398 and Tyr-435 in MAO B) may form an aromatic sandwich that stabilizes the substrate binding. Tyrosine 12-15 monoamine oxidase B Homo sapiens 53-58 11861643-5 2002 Tyr-407 and Tyr-444 in MAO A (Tyr-398 and Tyr-435 in MAO B) may form an aromatic sandwich that stabilizes the substrate binding. Tyrosine 12-15 monoamine oxidase B Homo sapiens 53-58 11861643-5 2002 Tyr-407 and Tyr-444 in MAO A (Tyr-398 and Tyr-435 in MAO B) may form an aromatic sandwich that stabilizes the substrate binding. Tyrosine 12-15 monoamine oxidase B Homo sapiens 53-58 11875080-2 2002 Upon receptor engagement, STATs become tyrosine phosphorylated, translocate to the nucleus, and induce expression of target genes. Tyrosine 39-47 signal transducer and activator of transcription 1 Homo sapiens 26-31 11875080-7 2002 A proximal region of the EPO-R lacking cytoplasmic tyrosines couples to STAT1 and STAT3 phosphorylation as well as ERK and p38(HOG) activation, but not JNK/SAPK. Tyrosine 51-60 signal transducer and activator of transcription 1 Homo sapiens 72-77 11877420-0 2002 Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc. Tyrosine 0-8 src homology 2 domain-containing transforming protein C1 Mus musculus 106-109 11877420-4 2002 The APP cytoplasmic tail contains a PTB-binding motif (Y(682)ENPTY(687)) that, when phosphorylated on Tyr(682), precipitated the PTB domain of Shc A and Shc C, as well as endogenous full-length Shc A. Tyrosine 102-105 src homology 2 domain-containing transforming protein C1 Mus musculus 143-158 11877420-4 2002 The APP cytoplasmic tail contains a PTB-binding motif (Y(682)ENPTY(687)) that, when phosphorylated on Tyr(682), precipitated the PTB domain of Shc A and Shc C, as well as endogenous full-length Shc A. Tyrosine 102-105 src homology 2 domain-containing transforming protein C1 Mus musculus 143-148 11877420-9 2002 Tyrosine phosphorylation of APP may promote the interaction with Shc proteins. Tyrosine 0-8 src homology 2 domain-containing transforming protein C1 Mus musculus 65-68 11997028-4 2002 Most importantly significant shifts were observed in both the carboxy terminus and tyrosine side chain of the neurotensin(8-13), suggesting that these sites are important in the interaction of the neurotensin with the agonist-binding site on the neurotensin receptor. Tyrosine 83-91 neurotensin Rattus norvegicus 110-121 11997028-4 2002 Most importantly significant shifts were observed in both the carboxy terminus and tyrosine side chain of the neurotensin(8-13), suggesting that these sites are important in the interaction of the neurotensin with the agonist-binding site on the neurotensin receptor. Tyrosine 83-91 neurotensin Rattus norvegicus 197-208 11997028-4 2002 Most importantly significant shifts were observed in both the carboxy terminus and tyrosine side chain of the neurotensin(8-13), suggesting that these sites are important in the interaction of the neurotensin with the agonist-binding site on the neurotensin receptor. Tyrosine 83-91 neurotensin Rattus norvegicus 197-208 12082638-6 2002 Western blot analysis of -/- and +/+ lymphomas showed that the related Crk protein was tyrosine phosphorylated and could be found complexed with Bcr-Abl P190. Tyrosine 87-95 c-abl oncogene 1, non-receptor tyrosine kinase Mus musculus 149-152 12082638-6 2002 Western blot analysis of -/- and +/+ lymphomas showed that the related Crk protein was tyrosine phosphorylated and could be found complexed with Bcr-Abl P190. Tyrosine 87-95 RAS protein-specific guanine nucleotide-releasing factor 1 Mus musculus 153-157 11827956-7 2002 Tyrosine phosphorylation of SH2-B beta was observed when coexpressed with activated FGFR3 mutants such as the weakly activated mutant N540K or the strongly activated mutant K650E, both associated with human developmental syndromes. Tyrosine 0-8 fibroblast growth factor receptor 3 Homo sapiens 84-89 11827956-8 2002 The extent of tyrosine phosphorylation of SH2-B beta correlates with receptor activation, suggesting that FGFR3 activation mediates tyrosine phosphorylation of SH2-B beta. Tyrosine 14-22 fibroblast growth factor receptor 3 Homo sapiens 106-111 11827956-8 2002 The extent of tyrosine phosphorylation of SH2-B beta correlates with receptor activation, suggesting that FGFR3 activation mediates tyrosine phosphorylation of SH2-B beta. Tyrosine 132-140 fibroblast growth factor receptor 3 Homo sapiens 106-111 11827956-9 2002 Furthermore, two tyrosine phosphorylation sites of FGFR3, Tyr-724 and Tyr-760, are required for optimal binding of the Src homology-2 (SH2) domain of SH2-B beta. Tyrosine 17-25 fibroblast growth factor receptor 3 Homo sapiens 51-56 11827956-9 2002 Furthermore, two tyrosine phosphorylation sites of FGFR3, Tyr-724 and Tyr-760, are required for optimal binding of the Src homology-2 (SH2) domain of SH2-B beta. Tyrosine 58-61 fibroblast growth factor receptor 3 Homo sapiens 51-56 11827956-9 2002 Furthermore, two tyrosine phosphorylation sites of FGFR3, Tyr-724 and Tyr-760, are required for optimal binding of the Src homology-2 (SH2) domain of SH2-B beta. Tyrosine 70-73 fibroblast growth factor receptor 3 Homo sapiens 51-56 11854294-8 2002 Co-immunoprecipitation experiments revealed that PDGF-mediated tyrosine phosphorylation of LRPs cytoplasmic domain results in increased association of the adaptor protein Shc with LRP and that Shc recognizes the second NPXY motif within LRPs cytoplasmic domain. Tyrosine 63-71 SHC adaptor protein 1 Homo sapiens 171-174 11854294-8 2002 Co-immunoprecipitation experiments revealed that PDGF-mediated tyrosine phosphorylation of LRPs cytoplasmic domain results in increased association of the adaptor protein Shc with LRP and that Shc recognizes the second NPXY motif within LRPs cytoplasmic domain. Tyrosine 63-71 SHC adaptor protein 1 Homo sapiens 193-196 11994426-7 2002 Accordingly, a lower tyrosine-phosphorylation of CD22 and SHP-1 recruitment was demonstrated in presence of the sialoside. Tyrosine 21-29 protein tyrosine phosphatase non-receptor type 6 Homo sapiens 58-63 11934669-3 2002 The association between myocellular Cr and c-Src-related tyrosine phosphorylation of the CreaT and the influence of oral Cr supplementation on this association were investigated during sepsis. Tyrosine 57-65 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 43-48 11934669-7 2002 Western blotting of the immunoprecipitated CreaT with an anti-phosphotyrosine or anti-phospho-c-Src (Y-416) antibody revealed that tyrosine phosphorylation of the CreaT and tyrosine-phosphorylated c-Src (Tyr(416)) expression in the CreaT-c-Src complex were significantly increased after CLP compared with sham operation. Tyrosine 131-139 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 94-99 11934669-7 2002 Western blotting of the immunoprecipitated CreaT with an anti-phosphotyrosine or anti-phospho-c-Src (Y-416) antibody revealed that tyrosine phosphorylation of the CreaT and tyrosine-phosphorylated c-Src (Tyr(416)) expression in the CreaT-c-Src complex were significantly increased after CLP compared with sham operation. Tyrosine 131-139 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 197-202 11934669-7 2002 Western blotting of the immunoprecipitated CreaT with an anti-phosphotyrosine or anti-phospho-c-Src (Y-416) antibody revealed that tyrosine phosphorylation of the CreaT and tyrosine-phosphorylated c-Src (Tyr(416)) expression in the CreaT-c-Src complex were significantly increased after CLP compared with sham operation. Tyrosine 131-139 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 197-202 11934669-9 2002 Although oral Cr supplementation increased myocellular free Cr levels equivalently in CLP and sham-operated animals, c-Src-related tyrosine phosphorylation of the CreaT in homogenates and plasma membrane fractions of gastrocnemius muscles was, however, downregulated in Cr-supplemented CLP animals compared with Cr-supplemented sham-operated rats. Tyrosine 131-139 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 117-122 11934669-10 2002 During sepsis, increased myocellular free Cr levels are associated with enhanced tyrosine phosphorylation of the CreaT, which is likely induced by active c-Src. Tyrosine 81-89 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 154-159 11934669-11 2002 Oral Cr supplementation downregulates c-Src-related tyrosine phosphorylation of the CreaT. Tyrosine 52-60 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 38-43 12108545-5 2002 Stimulation of CEACAM1 by ligation on the cell surface with antibodies induced formation of large CEACAM1 clusters and a rapid and transient CEACAM1 tyrosine dephosphorylation. Tyrosine 149-157 CEA cell adhesion molecule 1 Rattus norvegicus 15-22 11964282-3 2002 Many of the Siglecs (including CD33) have been reported to be tyrosine phosphorylated in the cytosolic tails under specific stimulation conditions. Tyrosine 62-70 LOW QUALITY PROTEIN: myeloid cell surface antigen CD33 Cricetulus griseus 31-35 12367580-2 2002 The in vitro effects of imatinib on BCR/ABL+ leukemic cells include inhibition of Bcr/Abl tyrosine phosphorylation, block of proliferation, and induction of apoptosis. Tyrosine 90-98 BCR activator of RhoGEF and GTPase Homo sapiens 36-39 11882386-3 2002 In the human cell line (SH-SY5Y), STAT1 and STAT3 activation by CNTF-like cytokines showed tyrosine phosphorylation peaking at 0.5 h and inactivating within 2 h. Tyrosine phosphorylation of the receptor-associated tyrosine kinases Jak1 and Jak2 showed a similar time course of activation and inactivation in response to CNTF. Tyrosine 91-99 signal transducer and activator of transcription 1 Homo sapiens 34-39 11882386-3 2002 In the human cell line (SH-SY5Y), STAT1 and STAT3 activation by CNTF-like cytokines showed tyrosine phosphorylation peaking at 0.5 h and inactivating within 2 h. Tyrosine phosphorylation of the receptor-associated tyrosine kinases Jak1 and Jak2 showed a similar time course of activation and inactivation in response to CNTF. Tyrosine 91-99 ciliary neurotrophic factor Homo sapiens 64-68 11882386-3 2002 In the human cell line (SH-SY5Y), STAT1 and STAT3 activation by CNTF-like cytokines showed tyrosine phosphorylation peaking at 0.5 h and inactivating within 2 h. Tyrosine phosphorylation of the receptor-associated tyrosine kinases Jak1 and Jak2 showed a similar time course of activation and inactivation in response to CNTF. Tyrosine 162-170 signal transducer and activator of transcription 1 Homo sapiens 34-39 11882386-3 2002 In the human cell line (SH-SY5Y), STAT1 and STAT3 activation by CNTF-like cytokines showed tyrosine phosphorylation peaking at 0.5 h and inactivating within 2 h. Tyrosine phosphorylation of the receptor-associated tyrosine kinases Jak1 and Jak2 showed a similar time course of activation and inactivation in response to CNTF. Tyrosine 162-170 ciliary neurotrophic factor Homo sapiens 64-68 11882386-3 2002 In the human cell line (SH-SY5Y), STAT1 and STAT3 activation by CNTF-like cytokines showed tyrosine phosphorylation peaking at 0.5 h and inactivating within 2 h. Tyrosine phosphorylation of the receptor-associated tyrosine kinases Jak1 and Jak2 showed a similar time course of activation and inactivation in response to CNTF. Tyrosine 162-170 ciliary neurotrophic factor Homo sapiens 320-324 11882391-8 2002 Surprisingly however, a reduction in the phosphorylation of cdc2 on the tyrosine-15 (Tyr-15) residue was only observed when both dMyt1 and dWee1 expression was reduced via RNAi and not by Wee1 alone. Tyrosine 72-80 Wee1 kinase Drosophila melanogaster 139-144 11882391-8 2002 Surprisingly however, a reduction in the phosphorylation of cdc2 on the tyrosine-15 (Tyr-15) residue was only observed when both dMyt1 and dWee1 expression was reduced via RNAi and not by Wee1 alone. Tyrosine 72-80 Wee1 kinase Drosophila melanogaster 140-144 11882391-8 2002 Surprisingly however, a reduction in the phosphorylation of cdc2 on the tyrosine-15 (Tyr-15) residue was only observed when both dMyt1 and dWee1 expression was reduced via RNAi and not by Wee1 alone. Tyrosine 85-88 Wee1 kinase Drosophila melanogaster 139-144 11882391-8 2002 Surprisingly however, a reduction in the phosphorylation of cdc2 on the tyrosine-15 (Tyr-15) residue was only observed when both dMyt1 and dWee1 expression was reduced via RNAi and not by Wee1 alone. Tyrosine 85-88 Wee1 kinase Drosophila melanogaster 140-144 11984870-10 2002 Our laboratory has focused on the role of the nonreceptor tyrosine phosphatase PTP1B in regulating the phosphorylation of beta-catenin on tyrosine residues. Tyrosine 58-66 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 79-84 11923223-7 2002 Among the proteins, which are tyrosine -nitrated by ammonia, glyceraldehyde-3-phosphate dehydrogenase, the peripheral-type benzodiazepine receptor, Erk-1, and glutamine synthetase are identified. Tyrosine 30-38 glyceraldehyde-3-phosphate dehydrogenase Rattus norvegicus 61-101 11923223-7 2002 Among the proteins, which are tyrosine -nitrated by ammonia, glyceraldehyde-3-phosphate dehydrogenase, the peripheral-type benzodiazepine receptor, Erk-1, and glutamine synthetase are identified. Tyrosine 30-38 translocator protein Rattus norvegicus 107-146 11923223-7 2002 Among the proteins, which are tyrosine -nitrated by ammonia, glyceraldehyde-3-phosphate dehydrogenase, the peripheral-type benzodiazepine receptor, Erk-1, and glutamine synthetase are identified. Tyrosine 30-38 glutamate-ammonia ligase Rattus norvegicus 159-179 11981820-2 2002 Here we show that immobilized anti-CD82 monoclonal antibody (mAb) as well as anti-alpha4beta1 integrin mAb induced tyrosine phosphorylation of pp105/Crk-associated substrate lymphocyte type (Cas-L) in human peripheral T cells and H9 cells. Tyrosine 115-123 CD82 molecule Homo sapiens 35-39 11947929-0 2002 Lymphocyte binding to MAdCAM-1 via alpha4beta7 integrin activates a signal transduction pathway involving tyrosine phosphorylation of paxillin and p105(Cas-L). Tyrosine 106-114 mucosal vascular addressin cell adhesion molecule 1 Mus musculus 22-46 11947929-0 2002 Lymphocyte binding to MAdCAM-1 via alpha4beta7 integrin activates a signal transduction pathway involving tyrosine phosphorylation of paxillin and p105(Cas-L). Tyrosine 106-114 neural precursor cell expressed, developmentally down-regulated gene 9 Mus musculus 147-151 11947929-0 2002 Lymphocyte binding to MAdCAM-1 via alpha4beta7 integrin activates a signal transduction pathway involving tyrosine phosphorylation of paxillin and p105(Cas-L). Tyrosine 106-114 neural precursor cell expressed, developmentally down-regulated gene 9 Mus musculus 152-157 11947929-3 2002 Here we demonstrate that ligation of alpha4beta7 integrin with MAdCAM-1 induces a prominent tyrosine phosphorylation of paxillin and a 105-kDa protein (p105) that is reactive with an anti-p130(Cas) antibody, in the mouse T-cell line TK-1. Tyrosine 92-100 neural precursor cell expressed, developmentally down-regulated gene 9 Mus musculus 152-156 11947929-5 2002 We also demonstrated that crosslinking of alpha4beta7 integrin with MAdCAM-1 induces the rapid tyrosine phosphorylation of paxillin and p105(Cas-L) in normal lymphocytes and that PMA stimulation enhances the tyrosine phosphorylation of p105(Cas-L) but not of paxillin. Tyrosine 95-103 neural precursor cell expressed, developmentally down-regulated gene 9 Mus musculus 141-146 11947929-5 2002 We also demonstrated that crosslinking of alpha4beta7 integrin with MAdCAM-1 induces the rapid tyrosine phosphorylation of paxillin and p105(Cas-L) in normal lymphocytes and that PMA stimulation enhances the tyrosine phosphorylation of p105(Cas-L) but not of paxillin. Tyrosine 208-216 neural precursor cell expressed, developmentally down-regulated gene 9 Mus musculus 141-146 11947929-6 2002 These results suggest that intracellular signals initiated by alpha4beta7 integrin involve the tyrosine phosphorylation of paxillin and p105(Cas-L), which are differentially regulated, at least in part, by mechanisms that are PMA-sensitive or -insensitive. Tyrosine 95-103 neural precursor cell expressed, developmentally down-regulated gene 9 Mus musculus 141-146 12009018-3 2002 This PGE2-mediated channel opening induces the recruitment of various tyrosine-phosphorylated proteins on the hSlo alpha-subunit of BK. Tyrosine 70-78 potassium calcium-activated channel subfamily M alpha 1 Homo sapiens 110-114 12009018-4 2002 Because the C-terminal domain of hSlo encompasses an immunoreceptor tyrosine-based activation motif (ITAM), we show that the Syk nonreceptor tyrosine kinase, reported yet to be expressed mainly in hematopoietic cells, is expressed also in osteoblastic cells, and recruited on this ITAM after a PGE2-induced docking/activation process. Tyrosine 68-76 potassium calcium-activated channel subfamily M alpha 1 Homo sapiens 33-37 12009018-4 2002 Because the C-terminal domain of hSlo encompasses an immunoreceptor tyrosine-based activation motif (ITAM), we show that the Syk nonreceptor tyrosine kinase, reported yet to be expressed mainly in hematopoietic cells, is expressed also in osteoblastic cells, and recruited on this ITAM after a PGE2-induced docking/activation process. Tyrosine 68-76 spleen associated tyrosine kinase Homo sapiens 125-128 11994384-1 2002 Functional PRL receptors are expressed in the human endometrium during the secretory phase of the menstrual cycle in which PRL stimulates tyrosine phosphorylation of Janus kinase 2 and STAT (signal transducer and activator of transcription) 1 and 5. Tyrosine 138-146 signal transducer and activator of transcription 1 Homo sapiens 191-248 11970985-0 2002 CTLA-4 suppresses proximal TCR signaling in resting human CD4(+) T cells by inhibiting ZAP-70 Tyr(319) phosphorylation: a potential role for tyrosine phosphatases. Tyrosine 94-97 zeta chain of T cell receptor associated protein kinase 70 Homo sapiens 87-93 11970986-7 2002 Concurrently, enhanced p62(dok) tyrosine phosphorylation and association with RasGAP are observed, suggesting that SHIP may mediate Fc gamma RIIB inhibitory function in mast cells via recruitment of p62(dok) and RasGAP. Tyrosine 32-40 nucleoporin 62 Mus musculus 23-26 11994533-2 2002 METHODS: Annexin V was iodinated with (125)I using 2 different techniques: direct iodination with IODO-BEADS, resulting in the iodination of tyrosine residues; and use of the Bolton-Hunter reagent, which binds to lysine. Tyrosine 141-149 annexin A5 Mus musculus 9-18 11994533-15 2002 CONCLUSION: Direct iodination of annexin V on tyrosine residues is a poor technique suffering from rapid deiodination in vivo. Tyrosine 46-54 annexin A5 Mus musculus 33-42 11967329-9 2002 In addition, GP1 amino acid position 259 also appears to be important, since all arenaviruses showing high-affinity alpha-DG binding possess a bulky aromatic amino acid (tyrosine or phenylalanine) at this position. Tyrosine 170-178 GTP binding protein 1 Homo sapiens 13-16 11971963-5 2002 c-Abl phosphorylates the Rad9 Bcl-2 homology 3 domain (Tyr-28) in vitro and in cells exposed to DNA-damaging agents. Tyrosine 55-58 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 0-5 11971983-5 2002 The interaction of spectrin with LMW-PTP A led us to look for a tyrosine-phosphorylated residue in alpha II-spectrin. Tyrosine 64-72 acid phosphatase 1 Homo sapiens 33-40 11988503-2 2002 Cells of Saccharomyces cerevisiae contain two catalytically redundant DAHP synthases, encoded by the genes ARO3 and ARO4, whose activities are feedback-inhibited by phenylalanine and tyrosine, respectively. Tyrosine 183-191 3-deoxy-7-phosphoheptulonate synthase ARO3 Saccharomyces cerevisiae S288C 107-111 11988503-9 2002 C. albicans ARO4 complements an aro3 aro4 double mutation in S. cerevisiae, an effect inhibited by excess tyrosine. Tyrosine 106-114 3-deoxy-7-phosphoheptulonate synthase ARO3 Saccharomyces cerevisiae S288C 32-36 11960624-0 2002 Non-genomic stimulation of tyrosine phosphorylation cascades by 1,25(OH)(2)D(3) by VDR-dependent and -independent mechanisms in muscle cells. Tyrosine 27-35 vitamin D receptor Homo sapiens 83-86 11960624-3 2002 We have now obtained evidence using antisense technology indicating that VDR-dependent activation of Src mediates the fast stimulation of tyrosine phosphorylation of c-myc elicited by the hormone. Tyrosine 138-146 vitamin D receptor Homo sapiens 73-76 11960624-4 2002 This non-genomic action of 1,25(OH)(2)D(3) requires tyrosine phosphorylation of the VDR. Tyrosine 52-60 vitamin D receptor Homo sapiens 84-87 12069755-4 2002 Tyrosine-phosphorylated LRP1 is specifically associated with the cellular docking protein Shc. Tyrosine 0-8 SHC adaptor protein 1 Homo sapiens 90-93 12018856-2 2002 Although STAT1 activation is primarily induced upon tyrosine phosphorylation by Jak1 and Jak2 (the IFN-gamma receptor-associated tyrosine kinases), the full activation of STAT1 is thought to involve serine phosphorylation by unidentified protein kinases. Tyrosine 52-60 signal transducer and activator of transcription 1 Homo sapiens 9-14 12018856-4 2002 This was shown by target DNA binding activity, nuclear translocation, and tyrosine phosphorylation of STAT1. Tyrosine 74-82 signal transducer and activator of transcription 1 Homo sapiens 102-107 11827972-2 2002 It is tyrosine-phosphorylated following beta(1) integrin and/or T cell receptor stimulation and is thus considered to be important for immunological reactions. Tyrosine 6-14 integrin subunit beta 1 Homo sapiens 40-56 11960349-4 2002 Furthermore, treatment of AML blasts with the cytostatic agent VP16, as an alternative way to induce apoptosis, resulted in a similar degree of degradation of JAK kinases and concomitant reduction of IL-6-mediated STAT3 tyrosine phosphorylation. Tyrosine 220-228 host cell factor C1 Homo sapiens 63-67 11777931-6 2002 While the abundance of Flk-1 is unaffected by hypoxia, the receptor exhibits a higher level of tyrosine phosphorylation, as do downstream signaling kinases, including extracellular signal-regulated protein kinase, p90RSK and STAT3a, demonstrating activation of the VEGF pathway. Tyrosine 95-103 vascular endothelial growth factor A Mus musculus 265-269 11960378-4 2002 Our efforts to elucidate potential mechanism(s) for this activated protein have shown that coexpression of Stat3alpha and the vascular endothelial growth factor receptor-2 (VEGFR-2) result in ligand-independent activation of Stat3alpha tyrosine phosphorylation and subsequent transcriptional activation in non-endothelial cells. Tyrosine 236-244 kinase insert domain receptor Homo sapiens 126-171 11960378-4 2002 Our efforts to elucidate potential mechanism(s) for this activated protein have shown that coexpression of Stat3alpha and the vascular endothelial growth factor receptor-2 (VEGFR-2) result in ligand-independent activation of Stat3alpha tyrosine phosphorylation and subsequent transcriptional activation in non-endothelial cells. Tyrosine 236-244 kinase insert domain receptor Homo sapiens 173-180