PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18370551-2 1998 OBJECTIVE: This trial reports the 6-month results of a pilot study using lymphoblastoid interferon alpha (IFNalpha) and acetylcysteine (N-acetylcysteine) separately and in combination in patients with chronic hepatitis C, genotype 1b, who were nonresponders to previous treatment with recombinant IFNalpha alone. Acetylcysteine 120-134 interferon alpha 1 Homo sapiens 297-305 11278370-6 2001 The ability of IFN-alpha and vanadate to induce apoptosis did not require expression of p53 and was blocked by N-acetyl-l-cysteine. Acetylcysteine 111-130 interferon alpha 1 Homo sapiens 15-24 18370551-2 1998 OBJECTIVE: This trial reports the 6-month results of a pilot study using lymphoblastoid interferon alpha (IFNalpha) and acetylcysteine (N-acetylcysteine) separately and in combination in patients with chronic hepatitis C, genotype 1b, who were nonresponders to previous treatment with recombinant IFNalpha alone. Acetylcysteine 136-152 interferon alpha 1 Homo sapiens 297-305 22825687-11 2012 In the femoral head, co-treatment with NAC and MPSL significantly decreased the expression of TRIM21 at 3 h and significantly increased the expression of interferon (IFN)-alpha at 24 h when compared with the MPSL group. Acetylcysteine 39-42 interferon alpha 1 Homo sapiens 154-176 28623559-5 2017 Importantly, the ROS scavenger N-acetyl cysteine (NAC) prevented mitochondrial dysfunctions, type I IFN-stimulated transcript levels, inflammatory cell infiltrate, and muscle weakness in an experimental autoimmune myositis mouse model. Acetylcysteine 31-48 interferon alpha 1 Homo sapiens 100-103 28623559-5 2017 Importantly, the ROS scavenger N-acetyl cysteine (NAC) prevented mitochondrial dysfunctions, type I IFN-stimulated transcript levels, inflammatory cell infiltrate, and muscle weakness in an experimental autoimmune myositis mouse model. Acetylcysteine 50-53 interferon alpha 1 Homo sapiens 100-103 23590859-0 2013 N-acetyl-cysteine prevents toxic oxidative effects induced by IFN-alpha in human neurons. Acetylcysteine 0-17 interferon alpha 1 Homo sapiens 62-71 23590859-9 2013 A co-treatment with N-acetyl-cysteine (NAC; 5 mm), a potent antioxidant and mitochondrial modulator, was able to counteract all of these IFN-alpha-induced effects. Acetylcysteine 20-37 interferon alpha 1 Homo sapiens 137-146 23590859-9 2013 A co-treatment with N-acetyl-cysteine (NAC; 5 mm), a potent antioxidant and mitochondrial modulator, was able to counteract all of these IFN-alpha-induced effects. Acetylcysteine 39-42 interferon alpha 1 Homo sapiens 137-146 23590859-11 2013 We suggest that NAC, already tested for the treatment of psychiatric disorders, may be useful to prevent IFN-alpha-induced central side-effects in a safe and effective way. Acetylcysteine 16-19 interferon alpha 1 Homo sapiens 105-114 8228388-6 1993 In IFN-unresponsive patients, the addition of 600 mg tid of oral N-acetyl cysteine (NAC), a glutathione precursor, resulted in a steady decrease of ALT values in all patients, with complete normalization in 41% of cases after 5-6 months of combined therapy. Acetylcysteine 65-82 interferon alpha 1 Homo sapiens 3-6 8228388-6 1993 In IFN-unresponsive patients, the addition of 600 mg tid of oral N-acetyl cysteine (NAC), a glutathione precursor, resulted in a steady decrease of ALT values in all patients, with complete normalization in 41% of cases after 5-6 months of combined therapy. Acetylcysteine 84-87 interferon alpha 1 Homo sapiens 3-6 8228388-8 1993 Supplementation of IFN with NAC induced a near normalization of intralymphocytic glutathione, but plasma levels were only moderately increased. Acetylcysteine 28-31 interferon alpha 1 Homo sapiens 19-22 8228388-10 1993 In conclusion, NAC enhances the response to IFN in CHC. Acetylcysteine 15-18 interferon alpha 1 Homo sapiens 44-47 31196186-15 2019 Treatment of leukemic cell lines with NAC prevented the DFX-mediated phosphorylation of STAT1 as well as the expression of the IFN-stimulated genes. Acetylcysteine 38-41 interferon alpha 1 Homo sapiens 127-130