PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28081748-8	2016	Inhibition of ROS generation by NAC resulted in a significant reduction of HVJ-E-induced Erk1/2, JNK, and p38 MAPK activation.	Acetylcysteine	32-35	mitogen-activated protein kinase 3	Mus musculus	89-95	
33268712-6	2020	Together, the results of this study suggest that renal interstitial fibrosis induced by UUO was ameliorated by NAC via several mechanisms including increased glutathione peroxidase activity, reduced phosphorylation of ERK1/2, and reduced expression of TNF-alpha and type III collagen mRNAs.	Acetylcysteine	111-114	mitogen-activated protein kinase 3	Mus musculus	218-224	
27322250-9	2016	Further, pretreatment with antioxidant N-acetylcysteine (NAC) effectively abrogated cypermethrin-induced cell cytotoxicity, G1 cell cycle arrest, DNA damage, PARP activity, and JNK and ERK1/2 activation.	Acetylcysteine	39-55	mitogen-activated protein kinase 3	Mus musculus	185-191	
27322250-9	2016	Further, pretreatment with antioxidant N-acetylcysteine (NAC) effectively abrogated cypermethrin-induced cell cytotoxicity, G1 cell cycle arrest, DNA damage, PARP activity, and JNK and ERK1/2 activation.	Acetylcysteine	57-60	mitogen-activated protein kinase 3	Mus musculus	185-191	
24157283-8	2014	NAC and the specific JNK inhibitor (SP600125) and ERK1/2 inhibitor (PD98059) abrogated iAs-induced cell cytotoxicity, caspase-3/-7 activity, and JNK and ERK1/2 activation.	Acetylcysteine	0-3	mitogen-activated protein kinase 3	Mus musculus	153-159	
24976129-6	2014	In addition, the N-acetylcysteine inhibited ROS/RNS generation, elevation of antioxidants level, expression of ERK1/2, Akt, tuberin phosphorylation, resulted in deceased 8-OHdG accumulation and upregulation of OGG1 protein expression suggesting no involvement of Akt and ERK1/2MAPK pathways after CEES and LPS challenge.	Acetylcysteine	17-33	mitogen-activated protein kinase 3	Mus musculus	111-117	
24976129-6	2014	In addition, the N-acetylcysteine inhibited ROS/RNS generation, elevation of antioxidants level, expression of ERK1/2, Akt, tuberin phosphorylation, resulted in deceased 8-OHdG accumulation and upregulation of OGG1 protein expression suggesting no involvement of Akt and ERK1/2MAPK pathways after CEES and LPS challenge.	Acetylcysteine	17-33	mitogen-activated protein kinase 3	Mus musculus	271-277	
26184564-4	2015	Previously, we demonstrated that N-acetyl cysteine (NAC) pretreatment up-regulates DUSP4 expression in endothelial cells, regulating p38 and ERK1/2 activities, and thus providing a protective effect against oxidative stress.	Acetylcysteine	33-50	mitogen-activated protein kinase 3	Mus musculus	141-147	
26184564-4	2015	Previously, we demonstrated that N-acetyl cysteine (NAC) pretreatment up-regulates DUSP4 expression in endothelial cells, regulating p38 and ERK1/2 activities, and thus providing a protective effect against oxidative stress.	Acetylcysteine	52-55	mitogen-activated protein kinase 3	Mus musculus	141-147	
17448897-8	2007	We observed that BzATP stimulates MAP kinase (ERK1/ERK2, p38, and JNK1/JNK2) phosphorylation and that the antioxidants N-acetylcysteine and ascorbic acid strongly attenuate BzATP-mediated JNK1/JNK2 and p38 phosphorylation but only slightly reduce BzATP-induced ERK1/ERK2 phosphorylation.	Acetylcysteine	119-135	mitogen-activated protein kinase 3	Mus musculus	261-265	
22678775-6	2012	The activation of ERK1/2 proteins by dioscoreanone was due to both an arylating reaction, which was suppressed by N-acetyl cysteine, and a redox cycling reaction of NQOR, which was inhibited by dicoumarol.	Acetylcysteine	114-131	mitogen-activated protein kinase 3	Mus musculus	18-24	
22033125-11	2012	The antioxidant N-acetylcysteine (NAC) protected cells from TEGDMA-induced cell death, and inhibited the activation of ERK1/2, p38 and JNK by TEGDMA.	Acetylcysteine	16-32	mitogen-activated protein kinase 3	Mus musculus	119-125	
22033125-11	2012	The antioxidant N-acetylcysteine (NAC) protected cells from TEGDMA-induced cell death, and inhibited the activation of ERK1/2, p38 and JNK by TEGDMA.	Acetylcysteine	34-37	mitogen-activated protein kinase 3	Mus musculus	119-125	
16024921-8	2005	The increases in phosphorylation of ERK1/2 and p38 were detected 20 min following the hypertonic treatment and were both prevented by N-acetyl-l-cysteine.	Acetylcysteine	134-153	mitogen-activated protein kinase 3	Mus musculus	36-42	
9571990-9	1998	NAC prevented activation of mitogen-activated protein (MAP) kinases p42MAPK and p44MAPK and inhibited expression of cyclin D1, but had no effect on the levels of proliferating cell nuclear antigen.	Acetylcysteine	0-3	mitogen-activated protein kinase 3	Mus musculus	80-87