PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22339659-1 2012 Lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, was belonged to the superfamily of the flavin adenine dinucleotide (FAD)-dependent amine oxidases. Flavin-Adenine Dinucleotide 119-146 lysine demethylase 1A Homo sapiens 0-29 22132744-5 2012 The flavin adenine dinucleotide-binding amine oxidase domain of LSD1 is homologous with two polyamine oxidases, SMO (spermine oxidase) and APAO (N(1)-acetylpolyamine oxidase). Flavin-Adenine Dinucleotide 4-31 lysine demethylase 1A Homo sapiens 64-68 22339659-1 2012 Lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, was belonged to the superfamily of the flavin adenine dinucleotide (FAD)-dependent amine oxidases. Flavin-Adenine Dinucleotide 119-146 lysine demethylase 1A Homo sapiens 31-35 22339659-1 2012 Lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, was belonged to the superfamily of the flavin adenine dinucleotide (FAD)-dependent amine oxidases. Flavin-Adenine Dinucleotide 148-151 lysine demethylase 1A Homo sapiens 0-29 22339659-1 2012 Lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, was belonged to the superfamily of the flavin adenine dinucleotide (FAD)-dependent amine oxidases. Flavin-Adenine Dinucleotide 148-151 lysine demethylase 1A Homo sapiens 31-35 19381934-4 2009 Amine oxidase LSD1 family requires flavin adenine dinucleotide (FAD) whereas dioxygenase Jmjc domain-containing proteins family relies on Fe(II) and alpha-ketoglutarate. Flavin-Adenine Dinucleotide 35-62 lysine demethylase 1A Homo sapiens 14-18 20970991-4 2010 Lysine demethylase 1 (KDM1, also known as LSD1) is a flavin adenine dinucleotide (FAD)-containing enzyme that removes mono-/di-methylation. Flavin-Adenine Dinucleotide 53-80 lysine demethylase 1A Homo sapiens 22-26 20970991-4 2010 Lysine demethylase 1 (KDM1, also known as LSD1) is a flavin adenine dinucleotide (FAD)-containing enzyme that removes mono-/di-methylation. Flavin-Adenine Dinucleotide 53-80 lysine demethylase 1A Homo sapiens 42-46 20970991-4 2010 Lysine demethylase 1 (KDM1, also known as LSD1) is a flavin adenine dinucleotide (FAD)-containing enzyme that removes mono-/di-methylation. Flavin-Adenine Dinucleotide 82-85 lysine demethylase 1A Homo sapiens 22-26 20970991-4 2010 Lysine demethylase 1 (KDM1, also known as LSD1) is a flavin adenine dinucleotide (FAD)-containing enzyme that removes mono-/di-methylation. Flavin-Adenine Dinucleotide 82-85 lysine demethylase 1A Homo sapiens 42-46 19624733-4 2009 The 852-residue sequence of LSD1 comprises an amine oxidase domain which identifies a family of enzymes that catalyze the FAD-dependent oxidation of amine substrates ranging from amino acids to aromatic neurotransmitters. Flavin-Adenine Dinucleotide 122-125 lysine demethylase 1A Homo sapiens 28-32 19381934-4 2009 Amine oxidase LSD1 family requires flavin adenine dinucleotide (FAD) whereas dioxygenase Jmjc domain-containing proteins family relies on Fe(II) and alpha-ketoglutarate. Flavin-Adenine Dinucleotide 64-67 lysine demethylase 1A Homo sapiens 14-18 17529991-3 2007 LSD1 is a flavin adenine dinucleotide (FAD)-dependent amine oxidase that demethylates histone H3 Lys4 (H3-K4). Flavin-Adenine Dinucleotide 10-37 lysine demethylase 1A Homo sapiens 0-4 17569509-5 2007 Because LSD1 belongs to the family of flavin adenine dinucleotide (FAD)-dependent amine oxidases, certain inhibitors of monoamine oxidases (MAOs), including the clinically used antidepressant trans-2-phenylcyclopropylamine (PCPA; tranylcypromine; Parnate), are also capable of inhibiting LSD1. Flavin-Adenine Dinucleotide 38-65 lysine demethylase 1A Homo sapiens 8-12 17569509-5 2007 Because LSD1 belongs to the family of flavin adenine dinucleotide (FAD)-dependent amine oxidases, certain inhibitors of monoamine oxidases (MAOs), including the clinically used antidepressant trans-2-phenylcyclopropylamine (PCPA; tranylcypromine; Parnate), are also capable of inhibiting LSD1. Flavin-Adenine Dinucleotide 67-70 lysine demethylase 1A Homo sapiens 8-12 17569509-7 2007 Our structural and mass spectrometry analyses are consistent with PCPA forming a covalent adduct with FAD in LSD1 that is distinct from the FAD-PCPA adduct of MAO B. Flavin-Adenine Dinucleotide 102-105 lysine demethylase 1A Homo sapiens 109-113 18039463-1 2008 Lysine-specific demethylase 1 (LSD1) is the first discovered histone demethylase, which demethylates Lys4 or Lys9 of histone H3, using FAD. Flavin-Adenine Dinucleotide 135-138 lysine demethylase 1A Homo sapiens 0-29 18039463-1 2008 Lysine-specific demethylase 1 (LSD1) is the first discovered histone demethylase, which demethylates Lys4 or Lys9 of histone H3, using FAD. Flavin-Adenine Dinucleotide 135-138 lysine demethylase 1A Homo sapiens 31-35 17529991-3 2007 LSD1 is a flavin adenine dinucleotide (FAD)-dependent amine oxidase that demethylates histone H3 Lys4 (H3-K4). Flavin-Adenine Dinucleotide 39-42 lysine demethylase 1A Homo sapiens 0-4 17101443-5 2006 One is the FAD (flavin adenine dinucleotide)-dependent amine oxidase family LSD1 (lysine-specific demethylase), the other is the Fe(II) and alpha-KG (alpha-ketoglutarate)-dependent dioxygenase family JHDM (JmjC domain-containing histone demethylase). Flavin-Adenine Dinucleotide 11-14 lysine demethylase 1A Homo sapiens 76-80 17101443-5 2006 One is the FAD (flavin adenine dinucleotide)-dependent amine oxidase family LSD1 (lysine-specific demethylase), the other is the Fe(II) and alpha-KG (alpha-ketoglutarate)-dependent dioxygenase family JHDM (JmjC domain-containing histone demethylase). Flavin-Adenine Dinucleotide 16-43 lysine demethylase 1A Homo sapiens 76-80 33729758-2 2021 Lysine-specific demethylase 1 (LSD1) determines the methylation status of H3K4 through flavin adenine dinucleotide (FAD)-mediated histone demethylation. Flavin-Adenine Dinucleotide 87-114 lysine demethylase 1A Homo sapiens 0-29 34718134-2 2022 LSD1 employs FAD as its cofactor, which catalyzes the demethylation of H3K4 and H3K9. Flavin-Adenine Dinucleotide 13-16 lysine demethylase 1A Homo sapiens 0-4 34423983-2 2021 Lysine-specific demethylase 1 (LSD1) catalyzes histone demethylation in a flavin adenine dinucleotide (FAD)-dependent manner. Flavin-Adenine Dinucleotide 74-101 lysine demethylase 1A Homo sapiens 0-29 34423983-2 2021 Lysine-specific demethylase 1 (LSD1) catalyzes histone demethylation in a flavin adenine dinucleotide (FAD)-dependent manner. Flavin-Adenine Dinucleotide 74-101 lysine demethylase 1A Homo sapiens 31-35 34423983-2 2021 Lysine-specific demethylase 1 (LSD1) catalyzes histone demethylation in a flavin adenine dinucleotide (FAD)-dependent manner. Flavin-Adenine Dinucleotide 103-106 lysine demethylase 1A Homo sapiens 0-29 34423983-2 2021 Lysine-specific demethylase 1 (LSD1) catalyzes histone demethylation in a flavin adenine dinucleotide (FAD)-dependent manner. Flavin-Adenine Dinucleotide 103-106 lysine demethylase 1A Homo sapiens 31-35 34323202-1 2022 BACKGROUND: As a FAD (Flavin Adenine Dinucleotide) - dependent histone demethylase discovered in 2004, LSD1 (lysine specific demethylase 1) was reported to be overexpressed in diverse tumors, regulating target genes transcription associated with cancer development. Flavin-Adenine Dinucleotide 22-49 lysine demethylase 1A Homo sapiens 103-107 34323202-1 2022 BACKGROUND: As a FAD (Flavin Adenine Dinucleotide) - dependent histone demethylase discovered in 2004, LSD1 (lysine specific demethylase 1) was reported to be overexpressed in diverse tumors, regulating target genes transcription associated with cancer development. Flavin-Adenine Dinucleotide 22-49 lysine demethylase 1A Homo sapiens 109-138 33729758-2 2021 Lysine-specific demethylase 1 (LSD1) determines the methylation status of H3K4 through flavin adenine dinucleotide (FAD)-mediated histone demethylation. Flavin-Adenine Dinucleotide 87-114 lysine demethylase 1A Homo sapiens 31-35 33729758-2 2021 Lysine-specific demethylase 1 (LSD1) determines the methylation status of H3K4 through flavin adenine dinucleotide (FAD)-mediated histone demethylation. Flavin-Adenine Dinucleotide 116-119 lysine demethylase 1A Homo sapiens 0-29 33729758-2 2021 Lysine-specific demethylase 1 (LSD1) determines the methylation status of H3K4 through flavin adenine dinucleotide (FAD)-mediated histone demethylation. Flavin-Adenine Dinucleotide 116-119 lysine demethylase 1A Homo sapiens 31-35 33527838-4 2021 Molecular docking indicated raloxifene might bind LSD1 in the flavin adenine dinucleotide (FAD) binding cavity in a reversible manner. Flavin-Adenine Dinucleotide 62-89 lysine demethylase 1A Homo sapiens 50-54 33527838-4 2021 Molecular docking indicated raloxifene might bind LSD1 in the flavin adenine dinucleotide (FAD) binding cavity in a reversible manner. Flavin-Adenine Dinucleotide 91-94 lysine demethylase 1A Homo sapiens 50-54 27059868-3 2016 Lysine-specific demethylase 1 (LSD1), a well-characterized histone-modifying enzyme, demethylates dimethylated histone H3 lysine 4 (H3K4) through a flavin adenine dinucleotide (FAD)-dependent oxidative reaction. Flavin-Adenine Dinucleotide 148-175 lysine demethylase 1A Homo sapiens 0-29 33088686-3 2020 Herein, for the first time, we reported the discovery of a series of 5-cyano-6-phenylpyrimidine derivatives as LSD1 inhibitors using flavin adenine dinucleotide (FAD) similarity-based designing strategy, of which compound 14q was finally identified to repress LSD1 with IC50 = 183 nmol/L. Flavin-Adenine Dinucleotide 133-160 lysine demethylase 1A Homo sapiens 111-115 33088686-3 2020 Herein, for the first time, we reported the discovery of a series of 5-cyano-6-phenylpyrimidine derivatives as LSD1 inhibitors using flavin adenine dinucleotide (FAD) similarity-based designing strategy, of which compound 14q was finally identified to repress LSD1 with IC50 = 183 nmol/L. Flavin-Adenine Dinucleotide 162-165 lysine demethylase 1A Homo sapiens 111-115 33088686-3 2020 Herein, for the first time, we reported the discovery of a series of 5-cyano-6-phenylpyrimidine derivatives as LSD1 inhibitors using flavin adenine dinucleotide (FAD) similarity-based designing strategy, of which compound 14q was finally identified to repress LSD1 with IC50 = 183 nmol/L. Flavin-Adenine Dinucleotide 162-165 lysine demethylase 1A Homo sapiens 260-264 32166890-1 2020 Lysine-specific demethylase 1 (LSD1) is a flavin adenine dinucleotide (FAD)-dependent enzyme that catalyzes the demethylation of histone H3 and regulates gene expression. Flavin-Adenine Dinucleotide 42-69 lysine demethylase 1A Homo sapiens 0-29 32166890-1 2020 Lysine-specific demethylase 1 (LSD1) is a flavin adenine dinucleotide (FAD)-dependent enzyme that catalyzes the demethylation of histone H3 and regulates gene expression. Flavin-Adenine Dinucleotide 42-69 lysine demethylase 1A Homo sapiens 31-35 32166890-1 2020 Lysine-specific demethylase 1 (LSD1) is a flavin adenine dinucleotide (FAD)-dependent enzyme that catalyzes the demethylation of histone H3 and regulates gene expression. Flavin-Adenine Dinucleotide 71-74 lysine demethylase 1A Homo sapiens 0-29 32166890-1 2020 Lysine-specific demethylase 1 (LSD1) is a flavin adenine dinucleotide (FAD)-dependent enzyme that catalyzes the demethylation of histone H3 and regulates gene expression. Flavin-Adenine Dinucleotide 71-74 lysine demethylase 1A Homo sapiens 31-35 32166890-7 2020 Structural analyses of LSD1 co-crystallized with S2101, S2116, S2157, or another N -alkylated inhibitor (FCPA-MPE) confirmed that the N -substituents enhance the potency of a 2-PCPA-based inhibitor of LSD1, without constituting the adduct formed with FAD. Flavin-Adenine Dinucleotide 251-254 lysine demethylase 1A Homo sapiens 23-27 29921310-2 2018 KDM1A, containing a flavin adenine dinucleotide (FAD)-dependent amine oxidase domain, demethylates histone 3 lysine 4 and histone 3 lysine 9 (H3K4me1/2 and H3K9me1/2). Flavin-Adenine Dinucleotide 20-47 lysine demethylase 1A Homo sapiens 0-5 29921310-2 2018 KDM1A, containing a flavin adenine dinucleotide (FAD)-dependent amine oxidase domain, demethylates histone 3 lysine 4 and histone 3 lysine 9 (H3K4me1/2 and H3K9me1/2). Flavin-Adenine Dinucleotide 49-52 lysine demethylase 1A Homo sapiens 0-5 29247860-1 2018 FAD-dependent lysine-specific demethylase 1 (LSD1) is overexpressed or deregulated in many cancers such as AML and prostate cancer and hence is a promising anticancer target with first inhibitors in clinical trials. Flavin-Adenine Dinucleotide 0-3 lysine demethylase 1A Homo sapiens 14-43 29247860-1 2018 FAD-dependent lysine-specific demethylase 1 (LSD1) is overexpressed or deregulated in many cancers such as AML and prostate cancer and hence is a promising anticancer target with first inhibitors in clinical trials. Flavin-Adenine Dinucleotide 0-3 lysine demethylase 1A Homo sapiens 45-49 29156705-1 2017 LSD1 (Lysine Specific Demethylase1)/KDM1A (Lysine Demethylase 1A), a flavin adenine dinucleotide (FAD)-dependent histone H3K4/K9 demethylase, sustains oncogenic potential of leukemia stem cells in primary human leukemia cells. Flavin-Adenine Dinucleotide 69-96 lysine demethylase 1A Homo sapiens 0-4 29156705-1 2017 LSD1 (Lysine Specific Demethylase1)/KDM1A (Lysine Demethylase 1A), a flavin adenine dinucleotide (FAD)-dependent histone H3K4/K9 demethylase, sustains oncogenic potential of leukemia stem cells in primary human leukemia cells. Flavin-Adenine Dinucleotide 69-96 lysine demethylase 1A Homo sapiens 6-34 29156705-1 2017 LSD1 (Lysine Specific Demethylase1)/KDM1A (Lysine Demethylase 1A), a flavin adenine dinucleotide (FAD)-dependent histone H3K4/K9 demethylase, sustains oncogenic potential of leukemia stem cells in primary human leukemia cells. Flavin-Adenine Dinucleotide 69-96 lysine demethylase 1A Homo sapiens 36-41 29156705-1 2017 LSD1 (Lysine Specific Demethylase1)/KDM1A (Lysine Demethylase 1A), a flavin adenine dinucleotide (FAD)-dependent histone H3K4/K9 demethylase, sustains oncogenic potential of leukemia stem cells in primary human leukemia cells. Flavin-Adenine Dinucleotide 69-96 lysine demethylase 1A Homo sapiens 43-64 29156705-1 2017 LSD1 (Lysine Specific Demethylase1)/KDM1A (Lysine Demethylase 1A), a flavin adenine dinucleotide (FAD)-dependent histone H3K4/K9 demethylase, sustains oncogenic potential of leukemia stem cells in primary human leukemia cells. Flavin-Adenine Dinucleotide 98-101 lysine demethylase 1A Homo sapiens 0-4 29156705-1 2017 LSD1 (Lysine Specific Demethylase1)/KDM1A (Lysine Demethylase 1A), a flavin adenine dinucleotide (FAD)-dependent histone H3K4/K9 demethylase, sustains oncogenic potential of leukemia stem cells in primary human leukemia cells. Flavin-Adenine Dinucleotide 98-101 lysine demethylase 1A Homo sapiens 6-34 29156705-1 2017 LSD1 (Lysine Specific Demethylase1)/KDM1A (Lysine Demethylase 1A), a flavin adenine dinucleotide (FAD)-dependent histone H3K4/K9 demethylase, sustains oncogenic potential of leukemia stem cells in primary human leukemia cells. Flavin-Adenine Dinucleotide 98-101 lysine demethylase 1A Homo sapiens 36-41 29156705-1 2017 LSD1 (Lysine Specific Demethylase1)/KDM1A (Lysine Demethylase 1A), a flavin adenine dinucleotide (FAD)-dependent histone H3K4/K9 demethylase, sustains oncogenic potential of leukemia stem cells in primary human leukemia cells. Flavin-Adenine Dinucleotide 98-101 lysine demethylase 1A Homo sapiens 43-64 28279976-3 2017 This ability of LSD1 is attenuated during prolonged hypoxia, with a decrease in the cellular level of flavin adenine dinucleotide (FAD), a metabolic cofactor of LSD1, causing HIF-1alpha downregulation in later stages of hypoxia. Flavin-Adenine Dinucleotide 102-129 lysine demethylase 1A Homo sapiens 16-20 28279976-3 2017 This ability of LSD1 is attenuated during prolonged hypoxia, with a decrease in the cellular level of flavin adenine dinucleotide (FAD), a metabolic cofactor of LSD1, causing HIF-1alpha downregulation in later stages of hypoxia. Flavin-Adenine Dinucleotide 102-129 lysine demethylase 1A Homo sapiens 161-165 28279976-3 2017 This ability of LSD1 is attenuated during prolonged hypoxia, with a decrease in the cellular level of flavin adenine dinucleotide (FAD), a metabolic cofactor of LSD1, causing HIF-1alpha downregulation in later stages of hypoxia. Flavin-Adenine Dinucleotide 131-134 lysine demethylase 1A Homo sapiens 16-20 28279976-3 2017 This ability of LSD1 is attenuated during prolonged hypoxia, with a decrease in the cellular level of flavin adenine dinucleotide (FAD), a metabolic cofactor of LSD1, causing HIF-1alpha downregulation in later stages of hypoxia. Flavin-Adenine Dinucleotide 131-134 lysine demethylase 1A Homo sapiens 161-165 29198865-4 2018 Enzymatic assays showed that PCPA peptides containing a longer side chain, which can react with FAD in the active site, are potent LSD1-selective inhibitors. Flavin-Adenine Dinucleotide 96-99 lysine demethylase 1A Homo sapiens 131-135 29088714-2 2017 LSD1 is a flavin-containing AO that specifically catalyzes the demethylation of mono- and di-methylated histone H3 lysine 4 through an FAD-dependent oxidative reaction. Flavin-Adenine Dinucleotide 135-138 lysine demethylase 1A Homo sapiens 0-4 27634040-1 2016 Lysine demethylation of proteins such as histones is catalyzed by several classes of enzymes, including the FAD-dependent amine oxidases KDM1A/B. Flavin-Adenine Dinucleotide 108-111 lysine demethylase 1A Homo sapiens 137-144 27059868-3 2016 Lysine-specific demethylase 1 (LSD1), a well-characterized histone-modifying enzyme, demethylates dimethylated histone H3 lysine 4 (H3K4) through a flavin adenine dinucleotide (FAD)-dependent oxidative reaction. Flavin-Adenine Dinucleotide 148-175 lysine demethylase 1A Homo sapiens 31-35 27059868-3 2016 Lysine-specific demethylase 1 (LSD1), a well-characterized histone-modifying enzyme, demethylates dimethylated histone H3 lysine 4 (H3K4) through a flavin adenine dinucleotide (FAD)-dependent oxidative reaction. Flavin-Adenine Dinucleotide 177-180 lysine demethylase 1A Homo sapiens 0-29 27059868-3 2016 Lysine-specific demethylase 1 (LSD1), a well-characterized histone-modifying enzyme, demethylates dimethylated histone H3 lysine 4 (H3K4) through a flavin adenine dinucleotide (FAD)-dependent oxidative reaction. Flavin-Adenine Dinucleotide 177-180 lysine demethylase 1A Homo sapiens 31-35 26673564-1 2016 Lysine-specific demethylase 1A (KDM1A/LSD1) is a FAD-dependent enzyme that catalyzes the oxidative demethylation of histone H3K4me1/2 and H3K9me1/2 repressing and activating transcription, respectively. Flavin-Adenine Dinucleotide 49-52 lysine demethylase 1A Homo sapiens 32-37 26673564-1 2016 Lysine-specific demethylase 1A (KDM1A/LSD1) is a FAD-dependent enzyme that catalyzes the oxidative demethylation of histone H3K4me1/2 and H3K9me1/2 repressing and activating transcription, respectively. Flavin-Adenine Dinucleotide 49-52 lysine demethylase 1A Homo sapiens 38-42 25827878-4 2015 The LSD1/KDM1 family of amine oxidases require flavin adenine dinucleotide (FAD) for reaction, while the larger Jumonji C (JmjC) family of hydroxylases utilize Fe(II) and alpha-ketoglutarate as cofactors to demethylate histones. Flavin-Adenine Dinucleotide 47-74 lysine demethylase 1A Homo sapiens 4-8 25827878-4 2015 The LSD1/KDM1 family of amine oxidases require flavin adenine dinucleotide (FAD) for reaction, while the larger Jumonji C (JmjC) family of hydroxylases utilize Fe(II) and alpha-ketoglutarate as cofactors to demethylate histones. Flavin-Adenine Dinucleotide 47-74 lysine demethylase 1A Homo sapiens 9-13 25827878-4 2015 The LSD1/KDM1 family of amine oxidases require flavin adenine dinucleotide (FAD) for reaction, while the larger Jumonji C (JmjC) family of hydroxylases utilize Fe(II) and alpha-ketoglutarate as cofactors to demethylate histones. Flavin-Adenine Dinucleotide 76-79 lysine demethylase 1A Homo sapiens 4-8 25827878-4 2015 The LSD1/KDM1 family of amine oxidases require flavin adenine dinucleotide (FAD) for reaction, while the larger Jumonji C (JmjC) family of hydroxylases utilize Fe(II) and alpha-ketoglutarate as cofactors to demethylate histones. Flavin-Adenine Dinucleotide 76-79 lysine demethylase 1A Homo sapiens 9-13 25103574-2 2014 Lysine-specific demethylase 1 (LSD1) is a flavin adenine dinucleotide (FAD)-dependent demethylase that catalyzes the demethylation of H3K4me1 and H3K4me2, thereby mediating gene repression. Flavin-Adenine Dinucleotide 42-69 lysine demethylase 1A Homo sapiens 0-29 25103574-2 2014 Lysine-specific demethylase 1 (LSD1) is a flavin adenine dinucleotide (FAD)-dependent demethylase that catalyzes the demethylation of H3K4me1 and H3K4me2, thereby mediating gene repression. Flavin-Adenine Dinucleotide 42-69 lysine demethylase 1A Homo sapiens 31-35 25103574-2 2014 Lysine-specific demethylase 1 (LSD1) is a flavin adenine dinucleotide (FAD)-dependent demethylase that catalyzes the demethylation of H3K4me1 and H3K4me2, thereby mediating gene repression. Flavin-Adenine Dinucleotide 71-74 lysine demethylase 1A Homo sapiens 0-29 25103574-2 2014 Lysine-specific demethylase 1 (LSD1) is a flavin adenine dinucleotide (FAD)-dependent demethylase that catalyzes the demethylation of H3K4me1 and H3K4me2, thereby mediating gene repression. Flavin-Adenine Dinucleotide 71-74 lysine demethylase 1A Homo sapiens 31-35 26230878-3 2015 MAO and LSD-1 are both flavin adenine dinucleotide-dependent MAOs, and the MAO inhibitor, tranylcypromine, is currently undergoing clinical trials for cancer treatment because it acts as an irreversible LSD-1 inhibitor. Flavin-Adenine Dinucleotide 23-50 lysine demethylase 1A Homo sapiens 8-13 23988016-1 2013 We report classical molecular dynamics (MD) simulations and combined quantum mechanics/molecular mechanics (QM/MM) calculations to elucidate the catalytic mechanism of the rate-determining amine oxidation step in the lysine-specific demethylase 1 (LSD1)-catalyzed demethylation of the histone tail lysine (H3K4), with flavin adenine dinucleotide (FAD) acting as cofactor. Flavin-Adenine Dinucleotide 318-345 lysine demethylase 1A Homo sapiens 217-246 23988016-1 2013 We report classical molecular dynamics (MD) simulations and combined quantum mechanics/molecular mechanics (QM/MM) calculations to elucidate the catalytic mechanism of the rate-determining amine oxidation step in the lysine-specific demethylase 1 (LSD1)-catalyzed demethylation of the histone tail lysine (H3K4), with flavin adenine dinucleotide (FAD) acting as cofactor. Flavin-Adenine Dinucleotide 318-345 lysine demethylase 1A Homo sapiens 248-252 23988016-1 2013 We report classical molecular dynamics (MD) simulations and combined quantum mechanics/molecular mechanics (QM/MM) calculations to elucidate the catalytic mechanism of the rate-determining amine oxidation step in the lysine-specific demethylase 1 (LSD1)-catalyzed demethylation of the histone tail lysine (H3K4), with flavin adenine dinucleotide (FAD) acting as cofactor. Flavin-Adenine Dinucleotide 347-350 lysine demethylase 1A Homo sapiens 217-246 23988016-1 2013 We report classical molecular dynamics (MD) simulations and combined quantum mechanics/molecular mechanics (QM/MM) calculations to elucidate the catalytic mechanism of the rate-determining amine oxidation step in the lysine-specific demethylase 1 (LSD1)-catalyzed demethylation of the histone tail lysine (H3K4), with flavin adenine dinucleotide (FAD) acting as cofactor. Flavin-Adenine Dinucleotide 347-350 lysine demethylase 1A Homo sapiens 248-252