PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15314069-6	2004	The molecular basis for Ca(2+)/CaM inhibition of rod CNG channels has been proposed to involve the binding of Ca(2+)/CaM to a site in the NH(2)-terminal region of the CNGB1 subunit, which disrupts an interaction between the NH(2)-terminal region of CNGB1 and the COOH-terminal region of CNGA1.	cafestol palmitate	31-34	cyclic nucleotide gated channel subunit alpha 1	Homo sapiens	287-292	
15314069-6	2004	The molecular basis for Ca(2+)/CaM inhibition of rod CNG channels has been proposed to involve the binding of Ca(2+)/CaM to a site in the NH(2)-terminal region of the CNGB1 subunit, which disrupts an interaction between the NH(2)-terminal region of CNGB1 and the COOH-terminal region of CNGA1.	cafestol palmitate	117-120	cyclic nucleotide gated channel subunit alpha 1	Homo sapiens	287-292	
15314069-7	2004	Here, we test this mechanism for Ca(2+)/CaM-dependent inhibition of CNGA1/CNGB1 channels by simultaneously monitoring protein interactions with fluorescence spectroscopy and channel function with patch-clamp recording.	cafestol palmitate	40-43	cyclic nucleotide gated channel subunit alpha 1	Homo sapiens	68-73	
15314069-9	2004	Further, we show that the NH(2)- and COOH-terminal regions of CNGB1 and CNGA1 subunits, respectively, are in close proximity, and that Ca(2+)/CaM binding causes a relative rearrangement or separation of these regions.	cafestol palmitate	142-145	cyclic nucleotide gated channel subunit alpha 1	Homo sapiens	72-77	
12626507-5	2003	In contrast, two subunit types (CNGA1 and CNGB1) appear sufficient to mirror the native properties of rod CNG channels, including the inhibition by Ca2+/CaM.	cafestol palmitate	153-156	cyclic nucleotide gated channel subunit alpha 1	Homo sapiens	32-37	
12626507-8	2003	Ca2+/CaM also binds the N-terminal region of CNGB1 subunits and disrupts an intersubunit, N- and C-terminal interaction between CNGB1 and CNGA1 subunits in rod channels.	cafestol palmitate	5-8	cyclic nucleotide gated channel subunit alpha 1	Homo sapiens	138-143	
12048242-2	2002	Calcium/calmodulin (Ca(2+)/CaM) binds to a site in the N-terminal region of CNGB1 subunits and inhibits the opening conformational change in CNGA1/CNGB1 channels.	cafestol palmitate	27-30	cyclic nucleotide gated channel subunit alpha 1	Homo sapiens	141-146	
12048242-6	2002	These results suggest that Ca(2+)/CaM-dependent inhibition of rod channels is caused by the direct binding of Ca(2+)/CaM to a site in the N-terminal region in CNGB1, which disrupts the interaction between this region and a distal C-terminal region of CNGA1.	cafestol palmitate	34-37	cyclic nucleotide gated channel subunit alpha 1	Homo sapiens	251-256	
12048242-6	2002	These results suggest that Ca(2+)/CaM-dependent inhibition of rod channels is caused by the direct binding of Ca(2+)/CaM to a site in the N-terminal region in CNGB1, which disrupts the interaction between this region and a distal C-terminal region of CNGA1.	cafestol palmitate	117-120	cyclic nucleotide gated channel subunit alpha 1	Homo sapiens	251-256