PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30827936-5	2019	We use the IT1t-CXCR4 crystal structure and molecular dynamics (MD) simulations to develop two hypotheses for the activation of the N1193.35A CAM.	cafestol palmitate	142-145	C-X-C motif chemokine receptor 4	Homo sapiens	16-21	
15882617-4	2005	CAF-secreted SDF-1 also stimulates tumor growth directly, acting through the cognate receptor, CXCR4, which is expressed by carcinoma cells.	cafestol palmitate	0-3	C-X-C motif chemokine receptor 4	Homo sapiens	95-100	
34298657-5	2021	Besides well-established IL-33/ST2 and SDF1/CXCR4 (stromal-derived factor 1/C-X-C motif chemokine receptor 4) signaling, the CAF-induced IL-33 upregulated CXCR4 via cancer cell induction of IL-33 self-production.	cafestol palmitate	125-128	C-X-C motif chemokine receptor 4	Homo sapiens	155-160	
34298657-10	2021	Besides paracrine signaling, the CAF-induced IL-33 reciprocally enhanced the autocrine cancer-cell self-production of IL-33 and the corresponding CXCR4 upregulation, leading to the activation of SDF1/CXCR4 signaling subsequent to cancer progression.	cafestol palmitate	33-36	C-X-C motif chemokine receptor 4	Homo sapiens	146-151	
34298657-10	2021	Besides paracrine signaling, the CAF-induced IL-33 reciprocally enhanced the autocrine cancer-cell self-production of IL-33 and the corresponding CXCR4 upregulation, leading to the activation of SDF1/CXCR4 signaling subsequent to cancer progression.	cafestol palmitate	33-36	C-X-C motif chemokine receptor 4	Homo sapiens	200-205	
27822411-5	2016	CAF-derived CXCL12 promoted tumor cell EMT and invasion directly, acting through CXCR4 on pancreatic cancer cells.	cafestol palmitate	0-3	C-X-C motif chemokine receptor 4	Homo sapiens	81-86	
27693460-8	2016	We further disclosed that the CAF-secreted TGF-beta and SDF1 enhanced the expression of VE-cadherin, MMP2 and laminin5gamma2 via TGF-betaR1 and CXCR4 in tumor cells, thereby promoted VM formation.	cafestol palmitate	30-33	C-X-C motif chemokine receptor 4	Homo sapiens	144-149