PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9000104-1	1996	The enzyme dUTPase catalyses the hydrolysis of dUTP to dUMP and pyrophosphate, thereby suppressing incorporation of uracil into DNA and providing a pool of dUMP, the precursor of dTTP.	thymidine 5'-triphosphate	179-183	Deoxyuridine triphosphatase	Drosophila melanogaster	11-18	
18586121-1	2008	Deoxyuridine 5"-triphosphate nucleotidohydrolase (dUTPase) catalyzes the hydrolysis of dUTP to dUMP and pyrophosphate and plays an important role in nucleotide metabolism and DNA replication controlling relative cellular levels of dTTP/dUTP, both of which can be incorporated into DNA.	thymidine 5'-triphosphate	231-235	Deoxyuridine triphosphatase	Drosophila melanogaster	50-57	
17848562-1	2007	Human dUTPase is essential in controlling relative cellular levels of dTTP/dUTP, both of which can be incorporated into DNA.	thymidine 5'-triphosphate	70-74	Deoxyuridine triphosphatase	Drosophila melanogaster	6-13	
14996835-1	2004	dUTPase prevents uracil incorporation into DNA by strict regulation of the cellular dUTP:dTTP ratio.	thymidine 5'-triphosphate	89-93	Deoxyuridine triphosphatase	Drosophila melanogaster	0-7	
12369927-1	2001	Deoxyuridine pyrophosphatase (dUTPase) cleaves the alpha-beta phosphodiester bond of dUTP to form pyrophosphate and dUMP, preventing incorporation of uracil into DNA and providing the substrate for dTTP synthesis.	thymidine 5'-triphosphate	198-202	Deoxyuridine triphosphatase	Drosophila melanogaster	30-37	
31796083-12	2019	In addition, incubation with these inhibitors was associated with a depletion of the dTTP pool corroborating the central role of dUTPase in dTTP synthesis.	thymidine 5'-triphosphate	85-89	Deoxyuridine triphosphatase	Drosophila melanogaster	129-136	
8805593-2	1996	dUTPase hydrolyzes dUTP to dUMP and pyrophosphate, simultaneously reducing dUTP levels and providing the dUMP for dTTP biosynthesis.	thymidine 5'-triphosphate	114-118	Deoxyuridine triphosphatase	Drosophila melanogaster	0-7	
6145605-5	1984	The data reported suggest that, in this biological system, the main role of dUTPase is to degrade dUTP to prevent misincorporation of uracil into DNA during crossing-over, rather than to participate in the biosynthetic pathway of dTTP.	thymidine 5'-triphosphate	230-234	Deoxyuridine triphosphatase	Drosophila melanogaster	76-83	
810487-10	1975	We propose that infection at high pH prevents the PBS2-induced dUTPase inhibitor from blocking the B. subtilis dUTPase activity, thereby allowing the degradation of dUTP and the synthesis of dTTP (both of which are DNA polymerase substrates), so that thymine replaces some of the uracil normally found in PBS2 DNA.	thymidine 5'-triphosphate	191-195	Deoxyuridine triphosphatase	Drosophila melanogaster	63-70	
810487-10	1975	We propose that infection at high pH prevents the PBS2-induced dUTPase inhibitor from blocking the B. subtilis dUTPase activity, thereby allowing the degradation of dUTP and the synthesis of dTTP (both of which are DNA polymerase substrates), so that thymine replaces some of the uracil normally found in PBS2 DNA.	thymidine 5'-triphosphate	191-195	Deoxyuridine triphosphatase	Drosophila melanogaster	111-118	
31910901-2	2020	To begin to investigate how the pyrimidine biosynthetic pathway fulfills the demand for dTTP, we determined the catalytic properties and structure of the key enzyme deoxyuridine triphosphate nucleotidohydrolase (dUTPase) that hydrolyzes dUTP to dUMP, the precursor of dTTP.	thymidine 5'-triphosphate	88-92	Deoxyuridine triphosphatase	Drosophila melanogaster	212-219	
31910901-2	2020	To begin to investigate how the pyrimidine biosynthetic pathway fulfills the demand for dTTP, we determined the catalytic properties and structure of the key enzyme deoxyuridine triphosphate nucleotidohydrolase (dUTPase) that hydrolyzes dUTP to dUMP, the precursor of dTTP.	thymidine 5'-triphosphate	268-272	Deoxyuridine triphosphatase	Drosophila melanogaster	212-219	
31796083-12	2019	In addition, incubation with these inhibitors was associated with a depletion of the dTTP pool corroborating the central role of dUTPase in dTTP synthesis.	thymidine 5'-triphosphate	140-144	Deoxyuridine triphosphatase	Drosophila melanogaster	129-136	
29405473-2	2018	dUTPase prevents uracil misincorporation in DNA by balancing the intracellular ratio between dUTP and dTTP.	thymidine 5'-triphosphate	102-106	Deoxyuridine triphosphatase	Drosophila melanogaster	0-7	
22655049-3	2012	Due to its pivotal role in mycobacterial thymidylate synthesis dUTPase, which hydrolyzes dUTP into the dTTP precursor dUMP, has been suggested as a target for new antitubercular agents.	thymidine 5'-triphosphate	103-107	Deoxyuridine triphosphatase	Drosophila melanogaster	63-70	
30902068-4	2019	dUTPase is known to prevent uracil misincorporation in DNA by balancing the intracellular ratio between dUTP and dTTP, and contributes to genome stability.	thymidine 5'-triphosphate	113-117	Deoxyuridine triphosphatase	Drosophila melanogaster	0-7	
28729658-1	2017	dUTPase superfamily enzymes generate dUMP, the obligate precursor for de novo dTTP biosynthesis, from either dUTP (monofunctional dUTPase, Dut) or dCTP (bifunctional dCTP deaminase/dUTPase, Dcd:dut).	thymidine 5'-triphosphate	78-82	Deoxyuridine triphosphatase	Drosophila melanogaster	0-7	
28729658-1	2017	dUTPase superfamily enzymes generate dUMP, the obligate precursor for de novo dTTP biosynthesis, from either dUTP (monofunctional dUTPase, Dut) or dCTP (bifunctional dCTP deaminase/dUTPase, Dcd:dut).	thymidine 5'-triphosphate	78-82	Deoxyuridine triphosphatase	Drosophila melanogaster	130-137	
28729658-1	2017	dUTPase superfamily enzymes generate dUMP, the obligate precursor for de novo dTTP biosynthesis, from either dUTP (monofunctional dUTPase, Dut) or dCTP (bifunctional dCTP deaminase/dUTPase, Dcd:dut).	thymidine 5'-triphosphate	78-82	Deoxyuridine triphosphatase	Drosophila melanogaster	130-137