PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33628636-15	2021	In addition, quercetin, which has the most targets, can act on the main targets (BAX, CDK1, CCNB1, SERPINE1, CHEK2, and IGFBP3) of the P53 pathway to treat HCC.	Quercetin	13-22	cyclin dependent kinase 1	Homo sapiens	86-90	
1423313-3	1992	Expression of the growth-related genes histone H4, cyclin A and B, and p34cdc2 was suppressed in cells blocked with quercetin.	Quercetin	116-125	cyclin dependent kinase 1	Homo sapiens	71-78	
34988084-6	2021	Molecular docking showed that two core active components, quercetin and licochalcone A, exhibited the highest component-like properties (DL), and could bind well to CDK1 and MAPK1 protein.	Quercetin	58-67	cyclin dependent kinase 1	Homo sapiens	165-169	
34988084-7	2021	The experimental validation of these two components showed that quercetin inhibited cell growth through CDK1 dephosphorylation-mediated cell cycle arrest at G2/M phase in human AML U937 and HL60 cells, and licochalcone A induced cell differentiation in these leukemia cells via activation of MAPK1 and upregulation of CD11b.	Quercetin	64-73	cyclin dependent kinase 1	Homo sapiens	104-108	
19009557-7	2009	In addition, quercetin down-regulated the cyclin B1 and CDK1, essential components of G(2)/M cell cycle progression.	Quercetin	13-22	cyclin dependent kinase 1	Homo sapiens	56-60	
11562764-8	2001	We also found that quercetin markedly increased Cdk-inhibitor p21CIP1/WAF1 protein level after treatment for 48 h or longer, and the induction of p21CIP1/WAF1 increased its association with Cdc2-cyclin B1 complex, however, up-regulation of p53 by quercetin was not observed.	Quercetin	19-28	cyclin dependent kinase 1	Homo sapiens	190-194	
15456784-5	2004	Additionally, quercetin inhibited the cell growth, increased the fractions of G(2)/M phase, and raised the levels of cyclin B1 and phospho-cdc2 (threonine 161) proteins.	Quercetin	14-23	cyclin dependent kinase 1	Homo sapiens	139-143	
16049707-3	2005	In this study, we investigated the effects of quercetin on proliferation and cell cycle arrest by modulation of Cdc2/Cdk-1 protein in prostate cancer cells (PC-3).	Quercetin	46-55	cyclin dependent kinase 1	Homo sapiens	112-116	
16049707-3	2005	In this study, we investigated the effects of quercetin on proliferation and cell cycle arrest by modulation of Cdc2/Cdk-1 protein in prostate cancer cells (PC-3).	Quercetin	46-55	cyclin dependent kinase 1	Homo sapiens	117-122	
16049707-6	2005	Addition of quercetin led to substantial decrease in the expression of Cdc2/Cdk-1, cyclin B1 and phosphorylated pRb and increase in p21.	Quercetin	12-21	cyclin dependent kinase 1	Homo sapiens	71-75	
16049707-6	2005	Addition of quercetin led to substantial decrease in the expression of Cdc2/Cdk-1, cyclin B1 and phosphorylated pRb and increase in p21.	Quercetin	12-21	cyclin dependent kinase 1	Homo sapiens	76-81	
11562764-8	2001	We also found that quercetin markedly increased Cdk-inhibitor p21CIP1/WAF1 protein level after treatment for 48 h or longer, and the induction of p21CIP1/WAF1 increased its association with Cdc2-cyclin B1 complex, however, up-regulation of p53 by quercetin was not observed.	Quercetin	247-256	cyclin dependent kinase 1	Homo sapiens	190-194