PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15538571-20 2005 CONCLUSIONS: These results indicate that quercetin induced apoptosis of murine melanoma B16-BL6 cells by injuring their mitochondria, increasing the activity of caspase-3, inhibiting the expression of Bcl-2 and PKC-alpha, and inducing the translocation of PKC-delta. Quercetin 41-50 caspase 3 Mus musculus 161-170 17046822-6 2006 Additional experiments demonstrated that quercetin and anti-sense hsp70 modulated CpG-B ODN-induced anti-apoptosis via a caspase-3-independent pathway by down-regulating the survival gene bcl-x(L) and by increasing translocation of apoptosis-inducing factor. Quercetin 41-50 caspase 3 Mus musculus 121-130 15538571-13 2005 Quercetin promoted caspase-3 activity in a dose-dependent manner, which was also regulated by PMA and doxorubicin with a pattern similar to that seen in their effect on apoptosis, mitochondrial membrane potential and Bcl-2 expression, but none of these were directly affected by PMA and doxorubicin. Quercetin 0-9 caspase 3 Mus musculus 19-28 29285175-5 2017 Quercetin additionally suppressed the protein expression levels of B-cell lymphoma (Bcl)-2, Bcl-2 associated X apoptosis regulator, Caspase-3, poly ADP-ribose polymerase, and signal transducer and activator of transcription (STAT) 3 phosphorylation, nuclear factor (NF)-kappaB and protein kinase B (Akt) phosphorylation levels in alcohol-induced liver injured mice. Quercetin 0-9 caspase 3 Mus musculus 132-141 32088935-12 2020 Expression of the Caspase3 gene increased dramatically in the collected blastocysts from diabetic mice and reduced following quercetin treatment. Quercetin 125-134 caspase 3 Mus musculus 18-26 30618732-9 2018 Furthermore, quercetin rescued the mitochondrial apoptotic pathway and neuronal degeneration by regulating Bax/Bcl2, and decreasing activated cytochrome c, caspase-3 activity and cleaving PARP-1 in the cortical and hippocampal regions of the mouse brain. Quercetin 13-22 caspase 3 Mus musculus 156-165 29720871-13 2018 We also observed that quercetin could inhibit palmitic acid-induced cell apoptosis via suppressing the activation of caspase-3, -9, -12; increasing the ratio of Bcl-2/BAX and reversing the impaired mitochondrial membrane potential. Quercetin 22-31 caspase 3 Mus musculus 117-130 11920648-6 2002 In vitro quercetin and trans-resveratrol, but not rutin, markedly enhanced apoptosis, causing mitochondrial depolarization and cytochrome c release followed by caspase-3 activation. Quercetin 9-18 caspase 3 Mus musculus 160-169 11920648-7 2002 In addition, the effect of a combination of quercetin and trans-resveratrol on mitochondrial cytochrome c release and caspase-3 activity was greater than the expected additive response. Quercetin 44-53 caspase 3 Mus musculus 118-127 34249264-8 2021 Results: When INS1 cells and diabetic mice were treated with quercetin, the levels of SOD2, CAT, and Sirt3 proteins were increased, the levels of cleaved Caspase-3 and the ratio of Bax to BCL-2 were decreased at different degrees, along with reduced blood glucose levels and elevated insulin levels in diabetic mice. Quercetin 61-70 caspase 3 Mus musculus 154-163 29035884-10 2017 Pretreatment with quercetin also inhibited osteoblast apoptosis, significantly restored the down-regulated expression of Bcl-2 and Bcl-XL and decreased the upregulated expression of caspase-3, Bax, and cytochrome c in MC3T3-E1 cells induced by LPS. Quercetin 18-27 caspase 3 Mus musculus 182-191 27919735-7 2017 Also, in vitro experiments, quercetin displayed inhibitory role in LPS-induced ROS production, inflammatory response and apoptosis, which were linked with PI3K/AKT-regulated Caspase-3 and NF-kappaB activation. Quercetin 28-37 caspase 3 Mus musculus 174-183 27919735-4 2017 50 and 100mg/kg quercetin were used in our study, showing significant inhibitory role in high fructose-induced atherosclerosis via reducing reactive oxygen species (ROS) levels, Caspase-3 activation, inflammatory cytokines releasing, the number of terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL)-positive cells and collagen contents as well as modulating apoptosis- and inflammation-related proteins expression. Quercetin 16-25 caspase 3 Mus musculus 178-187 27513201-5 2016 Pretreatment for 1 h with quercetin before dieldrin application could significantly suppress dieldrin-induced apoptotic characteristics, including nuclear condensation, DNA fragmentation, and caspase-3/7 activation. Quercetin 26-35 caspase 3 Mus musculus 192-201 28129681-11 2016 Immunohistochemical scores of IL-25, IL-33, TSLP, caspase-3 and TUNEL were lower in quercetin-treated mice t compared to untreated mice with allergic airway inflammation (p<0.05). Quercetin 84-93 caspase 3 Mus musculus 50-59 27450812-0 2016 Quercetin ameliorates ischemia/reperfusion-induced cognitive deficits by inhibiting ASK1/JNK3/caspase-3 by enhancing the Akt signaling pathway. Quercetin 0-9 caspase 3 Mus musculus 94-103 27591402-4 2016 Quercetin protected against cholesterol-induced apoptosis of Min6 cells by inhibiting caspase-3 and -9 activation and cytochrome c release. Quercetin 0-9 caspase 3 Mus musculus 86-102 27450812-10 2016 Further, western blot analysis revealed that quercetin increased p-Akt expression and decreased p-ASK1, p-JNK3 and cleaved caspase-3 expression after cerebral I/R injury and led to inhibition of neuronal apoptosis. Quercetin 45-54 caspase 3 Mus musculus 123-132 24905073-5 2014 Western-blot analysis of caspase-3 showed that quercetin inhibited the cleaved activation of caspase-3 induced by clivorine. Quercetin 47-56 caspase 3 Mus musculus 25-34 25359171-5 2015 Also, supplementation with curcumin and quercetin separately to BP-treated mice brought a significant improvement in the enzyme activities of caspase 9 as well as caspase 3 but the improvement was more pronounced following combined treatment. Quercetin 40-49 caspase 3 Mus musculus 163-172 26076811-9 2015 Further, quercetin improves apoptotic potential, as observed by the levels of caspase 3, caspase 9, PARP, PKCdelta, and nuclear condensation. Quercetin 9-18 caspase 3 Mus musculus 78-87 25543474-6 2014 Quercetin could activate caspase-3 and promote leukemic cell apoptosis. Quercetin 0-9 caspase 3 Mus musculus 25-34 24905073-5 2014 Western-blot analysis of caspase-3 showed that quercetin inhibited the cleaved activation of caspase-3 induced by clivorine. Quercetin 47-56 caspase 3 Mus musculus 93-102 21337715-10 2011 Additionally, quercetin protected germ cells from cadmium-induced apoptosis by downregulating the expression of Bax and caspase-3 and upregulating Bcl-XL expression. Quercetin 14-23 caspase 3 Mus musculus 120-129 23997041-5 2013 However, simultaneous supplementation with quercetin (75 mg/kg) attenuated the toxicity induced by PNP through renewal of the antioxidant enzyme"s status, alleviating apoptosis by regulating the expressions of Bax and Bcl-xl, XBP-1 and HO-1mRNAs, and the regulation of caspase-3 activity. Quercetin 43-52 caspase 3 Mus musculus 269-278 22138401-4 2012 Quercetin suppressed H(2)O(2)-induced apoptotic events, including hypodiploid cells, activation of caspase 3 enzyme activity and lactate dehydrogenase release. Quercetin 0-9 caspase 3 Mus musculus 99-108 20361964-13 2010 Although quercetin treatment could recover systemic anti-oxidative capacity, suppress the systemic expression of NO, COX and PGE-2, and decrease ocular A2E levels, it could not effectively suppress the transcripts of the ocular inflammatory factors Tnf-alpha, Cox-2 and Inos, or the pro-apoptotic factors Fas, FasL and Caspase-3 in DKO mice. Quercetin 9-18 caspase 3 Mus musculus 319-328 22393949-8 2011 Depletion of these two chaperones by quercetin might result in triggering of caspase-3 in treated tumours. Quercetin 37-46 caspase 3 Mus musculus 77-86 20533396-0 2010 Quercetin accumulation by chronic administration causes the caspase-3 activation in liver and brain of mice. Quercetin 0-9 caspase 3 Mus musculus 60-69 20533396-6 2010 Nevertheless, quercetin induced apoptosis in both the liver and brain, as evidenced by increased caspase-3 expression and activity. Quercetin 14-23 caspase 3 Mus musculus 97-106