PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28008970-4 2016 Here, TERS in combination with atomic force microscopy (AFM), and conventional Raman spectroscopy characterizes insulin assemblies generated during inhibition and dissection experiments in the presence of benzonitrile, dimethylsulfoxide, quercetin, and beta-carotene. Quercetin 238-247 insulin Homo sapiens 112-119 30062709-7 2018 Fasting blood glucose (p < 0.001), insulin (p = 0.02), and homeostatic model assessment of insulin resistance (p = 0.009) decreased within the quercetin group; however, no significant differences were observed compared with the placebo group (p = 0.074, p = 0.226, p = 0.22, respectively). Quercetin 146-155 insulin Homo sapiens 38-45 30062709-7 2018 Fasting blood glucose (p < 0.001), insulin (p = 0.02), and homeostatic model assessment of insulin resistance (p = 0.009) decreased within the quercetin group; however, no significant differences were observed compared with the placebo group (p = 0.074, p = 0.226, p = 0.22, respectively). Quercetin 146-155 insulin Homo sapiens 94-101 29064290-0 2017 Quercetin/oleic acid-based G-protein-coupled receptor 40 ligands as new insulin secretion modulators. Quercetin 0-9 insulin Homo sapiens 72-79 29064290-2 2017 RESULTS: Starting from quercetin and oleic acid, that have effect on insulin secretion, a small set of hybrid molecules was synthesized. Quercetin 23-32 insulin Homo sapiens 69-76 27824398-3 2017 Quercetin reduces serum glucose, insulin, triglycerides, and cholesterol levels and increases the expression and secretion of adiponectin. Quercetin 0-9 insulin Homo sapiens 33-40 27824398-4 2017 The aim of this study was to determine the effect of quercetin on the adiponectin-mediated insulin sensitivity in PCOS patients. Quercetin 53-62 insulin Homo sapiens 91-98 27824398-10 2017 Oral quercetin supplementation was effective in improving the adiponectin-mediated insulin resistance and hormonal profile of women with PCOS. Quercetin 5-14 insulin Homo sapiens 83-90 28642704-2 2017 Taking advantage of protein kinase inhibitors, we proved that the effect of quercetin on 2-NBDG uptake in L6 myotubes was not through insulin signaling pathway, but through adenosine monophosphate kinase (AMPK) pathway and its downstream target p38 MAPK. Quercetin 76-85 insulin Homo sapiens 134-141 25709214-2 2015 In a previous study, we have reported that quercetin stimulated glucose uptake in cultured C2C12 skeletal muscle through an insulin-independent mechanism involving adenosine monophosphate-activated protein kinase (AMPK). Quercetin 43-52 insulin Homo sapiens 124-131 23504962-0 2013 Quercetin and quercetin-3-O-glucuronide are equally effective in ameliorating endothelial insulin resistance through inhibition of reactive oxygen species-associated inflammation. Quercetin 0-9 insulin Homo sapiens 90-97 24491314-13 2014 Thus, quercetin with the central activity may be a therapeutic for high fructose-induced insulin resistance and hyperlipidemia in humans. Quercetin 6-15 insulin Homo sapiens 89-96 25241191-0 2014 RETRACTED: Quercetin suppresses insulin receptor signaling through inhibition of the insulin ligand-receptor binding and therefore impairs cancer cell proliferation. Quercetin 11-20 insulin Homo sapiens 32-39 25241191-0 2014 RETRACTED: Quercetin suppresses insulin receptor signaling through inhibition of the insulin ligand-receptor binding and therefore impairs cancer cell proliferation. Quercetin 11-20 insulin Homo sapiens 85-92 25241191-2 2014 In this study, we demonstrate that quercetin suppresses insulin induced dimerization of the insulin receptor (IR) through interfering with ligand-receptor interactions, which reduces the phosphorylation of IR and Akt. Quercetin 35-44 insulin Homo sapiens 56-63 25241191-2 2014 In this study, we demonstrate that quercetin suppresses insulin induced dimerization of the insulin receptor (IR) through interfering with ligand-receptor interactions, which reduces the phosphorylation of IR and Akt. Quercetin 35-44 insulin Homo sapiens 92-99 24491314-4 2014 Quercetin, a natural flavonoid, has been reported to ameliorate high fructose-induced rat insulin resistance and hyperlipidemia. Quercetin 0-9 insulin Homo sapiens 90-97 24491314-8 2014 Quercetin effectively restored high fructose-induced hypothalamic insulin signaling defect by up-regulating the phosphorylation of insulin receptor and protein kinase B. Quercetin 0-9 insulin Homo sapiens 66-73 23504962-3 2013 This study aims to parallelly investigate whether quercetin and quercetin-3-O-glucuronide exert protection against palmitate (PA)-induced inflammation and insulin resistance in the endothelium. Quercetin 50-59 insulin Homo sapiens 155-162 23504962-9 2013 Quercetin and quercetin-3-O-glucuronide facilitated PI3K signaling by positive regulation of serine/tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) and restoration of downstream Akt/eNOS activation, leading to an increased insulin-mediated NO level. Quercetin 0-9 insulin Homo sapiens 128-135 23504962-10 2013 CONCLUSION: The above-mentioned evidence indicates that quercetin and quercetin-3-O-glucuronide are equally effective in inhibiting ROS-associated inflammation and ameliorating insulin resistant endothelial dysfunction by beneficial regulation of IRS-1 function. Quercetin 56-65 insulin Homo sapiens 177-184 20943792-0 2010 Quercetin is equally or more effective than resveratrol in attenuating tumor necrosis factor-{alpha}-mediated inflammation and insulin resistance in primary human adipocytes. Quercetin 0-9 insulin Homo sapiens 127-134 21235242-9 2011 Furthermore, the in vitro and in vivo effects of the active constituents of NNE, quercetin, and catechin, on glucose-induced insulin secretion and blood glucose regulation were evaluated. Quercetin 81-90 insulin Homo sapiens 125-132 23348005-0 2013 Quercetin ameliorate insulin resistance and up-regulates cellular antioxidants during oleic acid induced hepatic steatosis in HepG2 cells. Quercetin 0-9 insulin Homo sapiens 21-28 23348005-7 2013 Quercetin (10 muM) increased cell proliferation by 3.05 folds with decreased TAG content (45%) and was effective in increasing insulin mediated glucose uptake by 2.65 folds. Quercetin 0-9 insulin Homo sapiens 127-134 23348005-13 2013 Hence, quercetin effectively reversed NAFLD symptoms by decreased triacyl glycerol accumulation, insulin resistance, inflammatory cytokine secretion and increased cellular antioxidants in OA induced hepatic steatosis in HepG2 cells. Quercetin 7-16 insulin Homo sapiens 97-104 24648896-0 2013 Quercetin improves insulin resistance and hepatic lipid accumulation in vitro in a NAFLD cell model. Quercetin 0-9 insulin Homo sapiens 19-26 24648896-2 2013 The aim of this study was to investigate the effect of quercetin on insulin resistance and lipid metabolic abnormalities in free fatty acid (FFA)- and insulin-induced HepG2 cell model of NAFLD, and to determine the possible underlying mechanism. Quercetin 55-64 insulin Homo sapiens 68-75 24648896-2 2013 The aim of this study was to investigate the effect of quercetin on insulin resistance and lipid metabolic abnormalities in free fatty acid (FFA)- and insulin-induced HepG2 cell model of NAFLD, and to determine the possible underlying mechanism. Quercetin 55-64 insulin Homo sapiens 151-158 24648896-5 2013 Quercetin was found to enhance tyrosine phosphorylation in the insulin-signaling pathway and to downregulate the expression levels of the sterol regulatory element-binding protein-1c (SREBP-1c) and fatty acid synthase (FAS) in quercetin-treated groups, compared to the control group. Quercetin 0-9 insulin Homo sapiens 63-70 24648896-6 2013 These results demonstrated that quercetin was able to improve insulin resistance and hepatic lipid accumulation by suppressing two lipogenesis gene expression levels of SREBP-1c and FAS. Quercetin 32-41 insulin Homo sapiens 62-69 22945467-5 2012 Results indicated quercetin to be the most effective therapeutic candidate with respect to renal edema, hypertension, serum creatinine, hematocrit, cardiopathy, aorta calcification, glomerular amyloidosis, erythrocyte depletion in bone marrow, collagen deposition, expressions of TNF-alpha, cleaved caspase-3, IkappaBalpha, PPARalpha, and serum insulin. Quercetin 18-27 insulin Homo sapiens 345-352 20943792-12 2010 Quercetin prevented the TNF-alpha-mediated serine phosphorylation of insulin receptor substrate-1 and protein tyrosine phosphatase-1B gene expression and the suppression of insulin-stimulated glucose uptake, whereas trans-RSV prevented only the TNF-alpha-mediated serine phosphorylation of insulin receptor substrate-1. Quercetin 0-9 insulin Homo sapiens 69-76 20943792-13 2010 CONCLUSION: These data suggest that quercetin is equally or more effective than trans-RSV in attenuating TNF-alpha-mediated inflammation and insulin resistance in primary human adipocytes. Quercetin 36-45 insulin Homo sapiens 141-148 20943792-1 2010 BACKGROUND: Quercetin and trans-resveratrol (trans-RSV) are plant polyphenols reported to reduce inflammation or insulin resistance associated with obesity. Quercetin 12-21 insulin Homo sapiens 113-120 20943792-2 2010 Recently, we showed that grape powder extract, which contains quercetin and trans-RSV, attenuates markers of inflammation in human adipocytes and macrophages and insulin resistance in human adipocytes. Quercetin 62-71 insulin Homo sapiens 162-169 20943792-4 2010 OBJECTIVE: The aim of this study was to examine the extent to which quercetin and trans-RSV prevented inflammation or insulin resistance in primary cultures of human adipocytes treated with tumor necrosis factor-alpha (TNF-alpha)-an inflammatory cytokine elevated in the plasma and adipose tissue of obese, diabetic individuals. Quercetin 68-77 insulin Homo sapiens 118-125 34813734-7 2022 Importantly, a senolytic cocktail, dasatinib plus quercetin, eliminates p21high cells in human fat ex vivo and mitigates insulin resistance following xenotransplantation into immuno-deficient mice. Quercetin 50-59 insulin Homo sapiens 121-128 35468007-2 2022 Quercetin has significant anti-diabetic effects and may be helpful in lowering blood sugar and increasing insulin sensitivity. Quercetin 0-9 insulin Homo sapiens 106-113 34101925-4 2021 According to these data, quercetin may also have a role in the management of metabolic disorders via different mechanisms such as increasing adiponectin, decreasing leptin, anti-oxidant activity, reduction of insulin resistance, the elevation of insulin level, and blocking of calcium channel. Quercetin 25-34 insulin Homo sapiens 209-216 34101925-4 2021 According to these data, quercetin may also have a role in the management of metabolic disorders via different mechanisms such as increasing adiponectin, decreasing leptin, anti-oxidant activity, reduction of insulin resistance, the elevation of insulin level, and blocking of calcium channel. Quercetin 25-34 insulin Homo sapiens 246-253 35600955-8 2022 Results: The network pharmacology analysis showed that quercetin, luteolin, and kaempferol are the most significant active components in BHHD; STAT3, Jun, AKT1, MAPK3, MAPK1, and TP53 are the most critical drug targets; regulating hormones, reversing insulin (INS) resistance, exerting anti-inflammatory effects, and improving fertility might be the most important mechanisms of BHHD in the treatment of PCOS. Quercetin 55-64 insulin Homo sapiens 251-258 35571883-0 2022 Short-Term Oral Quercetin Supplementation Improves Post-exercise Insulin Sensitivity, Antioxidant Capacity and Enhances Subsequent Cycling Time to Exhaustion in Healthy Adults: A Pilot Study. Quercetin 16-25 insulin Homo sapiens 65-72 35571883-8 2022 Results: The results showed that 7-day quercetin supplementation significantly attenuated the post-exercise glucose-induced insulin response, increased total antioxidant capacity (TAC) and superoxidase dismutase (SOD) activities, and mitigated malondialdehyde (MDA) levels during the recovery period (p < 0.05). Quercetin 39-48 insulin Homo sapiens 124-131 35571883-11 2022 Conclusion: Our findings concluded that 7-day oral quercetin supplementation enhances high-intensity cycling time to exhaustion, which may be due in part to the increase in whole-body insulin-stimulated glucose uptake and attenuation of exercise-induced oxygen stress and pro-inflammation. Quercetin 51-60 insulin Homo sapiens 184-191 35468007-3 2022 Quercetin appears to affect many factors and signaling pathways involved in insulin resistance and the pathogenesis of type 2 of diabetes. Quercetin 0-9 insulin Homo sapiens 76-83 35468007-7 2022 In this article, after a brief review of the pathogenesis of insulin resistance and type 2 diabetes, we will review the latest findings on the anti-diabetic effects of quercetin with a molecular perspective. Quercetin 168-177 insulin Homo sapiens 61-68 35432205-16 2022 Importantly, in immune-deficient mice transplanted with fat from obese patients, dasatinib plus quercetin, a senolytic cocktail that reduces the number of both p21 high and p16 high cells, improves both glucose tolerance and insulin resistance. Quercetin 96-105 insulin Homo sapiens 225-232 35124182-0 2022 Enhanced alleviation of insulin resistance via the IRS-1/Akt/FOXO1 pathway by combining quercetin and EGCG and involving miR-27a-3p and miR-96-5p. Quercetin 88-97 insulin Homo sapiens 24-31 35124182-3 2022 Quercetin, EGCG or their combination attenuated insulin resistance and decreased hepatic gluconeogenesis in high-fat-high-fructose diet (HFFD)-fed C57BL/6 mice and in palmitic acid (PA)-treated HepG2 cells. Quercetin 0-9 insulin Homo sapiens 48-55 35124182-9 2022 This is the first report on the contributions of miR-27a-3p and miR-96-5p to the synergistic and protective effect of the quercetin-EGCG co-treatment against PA-induced insulin resistance through inhibiting FOXO1 expression. Quercetin 122-131 insulin Homo sapiens 169-176 30848564-6 2019 In addition, subgroup analysis revealed a significant reduction in insulin concentrations following supplementation with quercetin in studies that enrolled individuals aged <45 years (WMD: -1.36; 95% CI [-1.76, -0.97]) and that used quercetin in dosages of >=500 mg/day (WMD: -1.57; 95% CI [-1.98, -1.16]). Quercetin 121-130 insulin Homo sapiens 67-74 30848564-6 2019 In addition, subgroup analysis revealed a significant reduction in insulin concentrations following supplementation with quercetin in studies that enrolled individuals aged <45 years (WMD: -1.36; 95% CI [-1.76, -0.97]) and that used quercetin in dosages of >=500 mg/day (WMD: -1.57; 95% CI [-1.98, -1.16]). Quercetin 236-245 insulin Homo sapiens 67-74