PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20803121-10 2010 Moreover, quercetin increased the AIF protein released from mitochondria to nuclei and the GADD153 protein translocation from endoplasmic reticulum to the nuclei. Quercetin 10-19 DNA damage inducible transcript 3 Homo sapiens 91-98 35149956-9 2022 PERK, CHOP, and the concomitant responses of quercetin in restoring the ER homeostasis in cellular organelles like mitochondria and ER, against Cu-induced toxic insults by modulating autophagic pathways. Quercetin 45-54 DNA damage inducible transcript 3 Homo sapiens 6-10 19017364-6 2009 Moreover, our studies reveal that HSP70 knockdown or quercetin induces other typical components of the UPR, including CHOP expression, eIF2alpha and JNK phosphorylation, caspases activation and XBP-1 splicing. Quercetin 53-62 DNA damage inducible transcript 3 Homo sapiens 118-122 34150114-8 2021 The of Caspase-3, GRP78, and CHOP expression levels in the quercetin intervention group rose significantly in comparison with the blank control group (P<0.05). Quercetin 59-68 DNA damage inducible transcript 3 Homo sapiens 29-33 24612139-0 2014 Quercetin enhances apoptotic effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in ovarian cancer cells through reactive oxygen species (ROS) mediated CCAAT enhancer-binding protein homologous protein (CHOP)-death receptor 5 pathway. Quercetin 0-9 DNA damage inducible transcript 3 Homo sapiens 174-223 24666891-6 2014 Quercetin administration modulated expression level of ER stress genes coding for glucose-regulated protein 78 (GRP78) and C/EBP-homologous protein (CHOP), and antioxidant enzymes such as superoxide dismutase and catalase, along with free radical generation assessed by malondialdehyde assay. Quercetin 0-9 DNA damage inducible transcript 3 Homo sapiens 123-147 24666891-6 2014 Quercetin administration modulated expression level of ER stress genes coding for glucose-regulated protein 78 (GRP78) and C/EBP-homologous protein (CHOP), and antioxidant enzymes such as superoxide dismutase and catalase, along with free radical generation assessed by malondialdehyde assay. Quercetin 0-9 DNA damage inducible transcript 3 Homo sapiens 149-153 24666891-8 2014 CONCLUSION: The current study indicates that quercetin modulated stress responsive genes GRP78 and CHOP, helping endothelial cells prevent TUN-induced ER stress. Quercetin 45-54 DNA damage inducible transcript 3 Homo sapiens 99-103 22431435-9 2014 Quercetin also stimulated the protein expression of ATF, GRP78, and GADD153 which is a hall marker of ER stress. Quercetin 0-9 DNA damage inducible transcript 3 Homo sapiens 68-75 24612139-0 2014 Quercetin enhances apoptotic effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in ovarian cancer cells through reactive oxygen species (ROS) mediated CCAAT enhancer-binding protein homologous protein (CHOP)-death receptor 5 pathway. Quercetin 0-9 DNA damage inducible transcript 3 Homo sapiens 225-229 24612139-5 2014 The induction of DR5 was mediated through activation of JNK and through upregulation of a transcription factor CCAAT enhancer-binding protein homologous protein (CHOP); as silencing of these signaling molecules abrogated the effect of quercetin. Quercetin 235-244 DNA damage inducible transcript 3 Homo sapiens 111-160 24612139-5 2014 The induction of DR5 was mediated through activation of JNK and through upregulation of a transcription factor CCAAT enhancer-binding protein homologous protein (CHOP); as silencing of these signaling molecules abrogated the effect of quercetin. Quercetin 235-244 DNA damage inducible transcript 3 Homo sapiens 162-166 24612139-6 2014 Upregulation of DR5 was mediated through the generation of reactive oxygen species (ROS), as ROS scavengers reduced the effect of quercetin on JNK activation, CHOP upregulation, DR induction, TRAIL sensitization, downregulated the expression of cell survival proteins and upregulated the proapoptotic proteins. Quercetin 130-139 DNA damage inducible transcript 3 Homo sapiens 159-163 24612139-7 2014 Furthermore, quercetin enhances TRAIL mediated inhibition of tumor growth of human SKOV-3 xenograft was associated with induction of apoptosis, activation of caspase-3, CHOP and DR5. Quercetin 13-22 DNA damage inducible transcript 3 Homo sapiens 169-173 24612139-8 2014 Overall, our data suggest that quercetin enhances apoptotic death of ovarian cancer cells to TRAIL through upregulation of CHOP-induced DR5 expression following ROS mediated endoplasmic reticulum-stress. Quercetin 31-40 DNA damage inducible transcript 3 Homo sapiens 123-127 24368982-11 2013 Treatment with quercetin also increased the expression of Grp78/Bip and GADD153/CHOP protein and induced mitochondrial dysfunction. Quercetin 15-24 DNA damage inducible transcript 3 Homo sapiens 72-79 24368982-11 2013 Treatment with quercetin also increased the expression of Grp78/Bip and GADD153/CHOP protein and induced mitochondrial dysfunction. Quercetin 15-24 DNA damage inducible transcript 3 Homo sapiens 80-84