PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35352237-6 2022 Furthermore, quercetin decreased the pro-inflammatory cell environment upon LPS-induced endothelial activation, in terms of tumor necrosis factor- alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-8 (IL-8), and sVCAM-1 expression. Quercetin 13-22 C-X-C motif chemokine ligand 8 Homo sapiens 188-201 9292787-0 1997 Quercetin, a bioflavonoid, inhibits the induction of interleukin 8 and monocyte chemoattractant protein-1 expression by tumor necrosis factor-alpha in cultured human synovial cells. Quercetin 0-9 C-X-C motif chemokine ligand 8 Homo sapiens 53-66 34308732-7 2021 Quercetin decreased the production of IL-1beta, IL-6, IL-8, TNF-alpha, iNOS, and COX-2, as well as signal transduction via the Akt/AMPK/mTOR pathway. Quercetin 0-9 C-X-C motif chemokine ligand 8 Homo sapiens 54-58 34493195-7 2022 RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients. Quercetin 101-110 C-X-C motif chemokine ligand 8 Homo sapiens 236-241 9292787-6 1997 RESULTS: Addition of quercetin suppressed TNF-alpha induced increase in the mRNA for IL-8 and MCP-1 in a dose dependent manner. Quercetin 21-30 C-X-C motif chemokine ligand 8 Homo sapiens 85-89 9292787-8 1997 H2O2 mediated induction of IL-8 and MCP-1 genes was also inhibited by quercetin. Quercetin 70-79 C-X-C motif chemokine ligand 8 Homo sapiens 27-31 9292787-10 1997 CONCLUSION: Quercetin suppresses TNF-alpha mediated stimulation of IL-8 and MCP-1 expression, at least in part, by inhibiting the activation of NF-kappa B. Quercetin 12-21 C-X-C motif chemokine ligand 8 Homo sapiens 67-71 8367538-5 1993 This effect was qualitatively similar to that induced by NaF, suggesting that quercetin may, like NaF, also inhibit type I photooxidations, which contribute to hemolysis. Quercetin 78-87 C-X-C motif chemokine ligand 8 Homo sapiens 57-60 35352237-6 2022 Furthermore, quercetin decreased the pro-inflammatory cell environment upon LPS-induced endothelial activation, in terms of tumor necrosis factor- alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-8 (IL-8), and sVCAM-1 expression. Quercetin 13-22 C-X-C motif chemokine ligand 8 Homo sapiens 203-207 32898874-7 2020 However, an inhibitory effect of the identified quercetin-3-O-rhamnoside and its aglycone, quercetin, on the release of IL-8 and IL-6 could not be demonstrated. Quercetin 48-57 C-X-C motif chemokine ligand 8 Homo sapiens 120-124 35593365-12 2022 The results indicated that quercetin and wogonin had better affinity with CXCL8, CCL2 or IL1B. Quercetin 27-36 C-X-C motif chemokine ligand 8 Homo sapiens 74-79 35593365-14 2022 The expression CXCL8, CCL2 or IL1B were down-regulated after quercetin or wogonin treating, compared with LPS-induced A549 cells (P < 0.01). Quercetin 61-70 C-X-C motif chemokine ligand 8 Homo sapiens 15-20 31212975-11 2019 Taken together, these results provide evidence that quercetin protects ARPE-19 cells from the IL-1beta-stimulated increase in ICAM-1, sICAM-1, IL-6, IL-8 and MCP-1 production by blocking the activation of MAPK and NF-kappaB signaling pathways to ameliorate the inflammatory response. Quercetin 52-61 C-X-C motif chemokine ligand 8 Homo sapiens 149-153 31610186-5 2019 Quercetin caused further increase in LPS-induced IL-6 and IL-8 levels. Quercetin 0-9 C-X-C motif chemokine ligand 8 Homo sapiens 58-62 31212975-5 2019 The results showed that quercetin could dose-dependently decrease the mRNA and protein levels of ICAM-1, IL-6, IL-8 and monocyte chemoattractant protein-1 (MCP-1). Quercetin 24-33 C-X-C motif chemokine ligand 8 Homo sapiens 111-115 32179074-3 2020 KEY FINDINGS: Pre-treatment with quercetin significantly reversed the LPS-induced upregulation of pro-fibrotic factors (IL-6, IL-8, COL-1, COL-3, LC3) and fibrotic signaling mediators (mTOR and AKT), and it induced the downregulation of ATG5 in the WI-38 cells. Quercetin 33-42 C-X-C motif chemokine ligand 8 Homo sapiens 126-130 32509050-9 2020 The IL-8 level was suppressed more significantly by quercetin metabolites in the perfusion co-culture, as compared to static culture. Quercetin 52-61 C-X-C motif chemokine ligand 8 Homo sapiens 4-8 31531360-8 2019 Our results demonstrated that quercetin inhibited the LPS-induced production of IL-1beta, IL-6, IL-8, and TNF-alpha in a dose-dependent manner. Quercetin 30-39 C-X-C motif chemokine ligand 8 Homo sapiens 96-100 31531360-11 2019 In conclusion, these results suggested that quercetin attenuated the production of IL-1beta, IL-6, IL-8, and TNF-alpha in P. gingivalis LPS-treated HGFs by activating PPAR-gamma which subsequently suppressed the activation of NF-kappaB. Quercetin 44-53 C-X-C motif chemokine ligand 8 Homo sapiens 99-103 28987380-7 2017 Ex vivo incubation with quercetin in blood of both IPF patients and healthy controls reduces LPS-induced production of the pro-inflammatory cytokines IL-8 and TNFalpha. Quercetin 24-33 C-X-C motif chemokine ligand 8 Homo sapiens 150-154 30471617-14 2019 In Mrgprx2 knockdown LAD2 cells, the effect of Quercetin (200 muM) reduced C48/80 induced calcium flux and the release of beta-hexosaminidase, histamine, MCP-1 and IL-8 compared with non-atopic control (NC) transfected LAD2 human mast cells, suggesting that Quercetin anti-pseudo-allergic effect was related to Mrgprx2. Quercetin 47-56 C-X-C motif chemokine ligand 8 Homo sapiens 164-168 29030990-6 2018 Moreover, nanohydrogel of quercetin was able to reduce significantly IL-8, IL-6, and VEGF production in pro-inflammatory conditions with interesting implications on the mechanism of glioblastoma cells drug resistance. Quercetin 26-35 C-X-C motif chemokine ligand 8 Homo sapiens 69-73 22487368-5 2012 Quercetin, one of the active components in Calendula, has been shown to inhibit recombinant human matrix metalloproteinase (MMP) activity and decrease the expression of tumor necrosis factor-alpha, interleukin-1beta (IL), IL-6 and IL-8 in phorbol 12-myristate 13-acetate and calcium ionophore-stimulated human mast cells. Quercetin 0-9 C-X-C motif chemokine ligand 8 Homo sapiens 231-235 25532488-6 2016 OTA-induced NO, TNF-alpha, IL-6, and IL-8 were significantly reduced in the quercetin pretreated samples indicating its anti-inflammatory role. Quercetin 76-85 C-X-C motif chemokine ligand 8 Homo sapiens 37-41 23348005-9 2013 Quercetin (10 muM) decreased TNF-alpha and IL-8 by 59.74% and 41.11% respectively and inhibited generation of lipid peroxides by 50.5%. Quercetin 0-9 C-X-C motif chemokine ligand 8 Homo sapiens 43-47 27415000-11 2016 Importantly, stimulated expression of IL-1beta and IL-8 in HaCaT-TNF-alpha were blocked by Quercetin, a flavanol shown to possess anti-TNF-alpha activities. Quercetin 91-100 C-X-C motif chemokine ligand 8 Homo sapiens 51-55 26507542-6 2016 Quercetin also prevented INDO-induced ICAM-1 and P-selectin expressions and the increase of myeloperoxidase activity in gastric and ileal tissues and NF-kappaB activation and IL-8 production in Caco-2 cells. Quercetin 0-9 C-X-C motif chemokine ligand 8 Homo sapiens 175-179 22661653-8 2012 Quercetin reduced IL-6, IL-8 and TNFalpha protein production in supernatants of all GO samples (n=4) in a dose-dependent manner; however, only the reduction in IL-6 was statistically significant (p<0.05). Quercetin 0-9 C-X-C motif chemokine ligand 8 Homo sapiens 24-28 22661653-9 2012 Quercetin had a significant suppression of tissue IL-6, IL-8, IL-1beta and TNFalpha mRNA expression in cultured orbital tissues from three GO samples relative to untreated control tissue (p<0.05). Quercetin 0-9 C-X-C motif chemokine ligand 8 Homo sapiens 56-60 22470478-9 2012 However, Que is more effective than cromolyn in inhibiting IL-8 and TNF release from LAD2 mast cells stimulated by SP. Quercetin 9-12 C-X-C motif chemokine ligand 8 Homo sapiens 59-63 17588137-5 2007 RESULTS: Quercetin decreased the gene expression and production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, and IL-8 in PMACI-stimulated HMC-1 cells. Quercetin 9-18 C-X-C motif chemokine ligand 8 Homo sapiens 136-140 21282043-9 2011 Consequently, quercetin suppressed UV irradiation-induced expression of inflammatory cytokines IL-1beta (~60%), IL-6 (~80%), IL-8 (~76%) and TNF-alpha (~69%). Quercetin 14-23 C-X-C motif chemokine ligand 8 Homo sapiens 125-129 22039452-3 2011 Quercetin significantly attenuated intercellular adhesion molecule-1 (ICAM-1), interleukin (IL) -6, IL-8, and cyclooxygenase (COX) -2 mRNA expression, and inhibited IL-1beta-induced increases in ICAM-1, IL-6, and IL-8 mRNA. Quercetin 0-9 C-X-C motif chemokine ligand 8 Homo sapiens 100-104 22039452-3 2011 Quercetin significantly attenuated intercellular adhesion molecule-1 (ICAM-1), interleukin (IL) -6, IL-8, and cyclooxygenase (COX) -2 mRNA expression, and inhibited IL-1beta-induced increases in ICAM-1, IL-6, and IL-8 mRNA. Quercetin 0-9 C-X-C motif chemokine ligand 8 Homo sapiens 213-217 20943792-7 2010 RESULTS: Quercetin, and to a lesser extent trans-RSV, attenuated the TNF-alpha-induced expression of inflammatory genes such as interleukin (IL)-6, IL-1beta, IL-8, and monocyte chemoattractant protein-1 (MCP-1) and the secretion of IL-6, IL-8, and MCP-1. Quercetin 9-18 C-X-C motif chemokine ligand 8 Homo sapiens 158-162 20943792-7 2010 RESULTS: Quercetin, and to a lesser extent trans-RSV, attenuated the TNF-alpha-induced expression of inflammatory genes such as interleukin (IL)-6, IL-1beta, IL-8, and monocyte chemoattractant protein-1 (MCP-1) and the secretion of IL-6, IL-8, and MCP-1. Quercetin 9-18 C-X-C motif chemokine ligand 8 Homo sapiens 238-242 19470239-2 2009 In this study, we demonstrated that several flavonoids, including kaempferol, quercetin, fisetin, and chrysin block TNF-alpha induced IL-8 promoter activation and gene expression in HEK 293 cells. Quercetin 78-87 C-X-C motif chemokine ligand 8 Homo sapiens 134-138 21275387-0 2011 Quercetin reduces neutrophil recruitment induced by CXCL8, LTB4, and fMLP: inhibition of actin polymerization. Quercetin 0-9 C-X-C motif chemokine ligand 8 Homo sapiens 52-57 19010653-9 2009 Quercetin significantly decreased ex vivo LPS-induced TNFalpha- and IL-8 production in a concentration-dependent manner in both groups. Quercetin 0-9 C-X-C motif chemokine ligand 8 Homo sapiens 68-72 18297698-2 2008 This study was undertaken to determine whether SK, either alone or in combination with quercitin (QT) is able to modulate the release of IL-6 and IL-8 from peripheral blood mononuclear cells (PBMCs). Quercetin 87-96 C-X-C motif chemokine ligand 8 Homo sapiens 146-150 18297698-2 2008 This study was undertaken to determine whether SK, either alone or in combination with quercitin (QT) is able to modulate the release of IL-6 and IL-8 from peripheral blood mononuclear cells (PBMCs). Quercetin 98-100 C-X-C motif chemokine ligand 8 Homo sapiens 146-150 16794257-3 2006 Pretreatment with quercetin and the PI 3-kinase inhibitor LY294002 each reduced TNF-alpha-induced IL-8 and monocyte chemoattractant protein (MCP)-1 (also called CCL2) expression in cultured human airway epithelial cells. Quercetin 18-27 C-X-C motif chemokine ligand 8 Homo sapiens 98-102 15912140-6 2005 Release of IL-6, IL-8 and TNF-alpha was inhibited by 82-93% at 100 microM quercetin and kaempferol, and 31-70% by myricetin and morin. Quercetin 74-83 C-X-C motif chemokine ligand 8 Homo sapiens 17-21 15180920-4 2004 Resveratrol and the related molecule quercetin, but not deoxyrhapontin, inhibited IL-8 and granulocyte-macrophage colony-stimulating factor release from A549 cells. Quercetin 37-46 C-X-C motif chemokine ligand 8 Homo sapiens 82-147