PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33066828-0 2020 Quercetin regulates fibrogenic responses of endometrial stromal cell by upregulating miR-145 and inhibiting the TGF-beta1/Smad2/Smad3 pathway. Quercetin 0-9 SMAD family member 3 Homo sapiens 128-133 35067813-6 2022 RESULTS: The results showed that the levels of mRNA expression of TGF-beta, alphaSMA, Collagen1 genes, and phosphorylated smad3 protein were significantly reduced in fructose-activated HSCs after treatment with Quercetin compared to fructose-activated HSCs. Quercetin 211-220 SMAD family member 3 Homo sapiens 122-127 35067813-7 2022 CONCLUSION: Quercetin is effective in reducing the expression of fibrogenic genes in fructose-activated human HSCs through downregulation of the TGF-beta/smad3 signaling pathway. Quercetin 12-21 SMAD family member 3 Homo sapiens 154-159 33066828-1 2020 OBJECTIVES: Aim of this study is to explore whether quercetin can inhibit the enlarged fibrogenic responses of endometrial stromal cells by increasing the level of microRNA-145 (miR-145) and mediating the TGFbeta1/Smad2/Smad3 signaling pathway, and to discuss the mechanism of signal transduction, further to provide experimental basis for revealing the pathophysiological mechanism and seeking new strategies for effective prevention and treatment of endometrial fibrosis. Quercetin 52-61 SMAD family member 3 Homo sapiens 220-225 33066828-9 2020 Furthermore, quercetin regulates cell fibrogenic responses of endometrial stromal cells via miR-145/TGF-beta1/Smad2/Smad3 pathway. Quercetin 13-22 SMAD family member 3 Homo sapiens 116-121 33066828-10 2020 CONCLUSIONS: These findings indicated that quercetin have a significant anti-fibrotic effect and could upregulate miR-145 and inhibit activation of TGF-beta1/Smad2/Smad3 pathway to regulate TGF-beta1 induced fibrogenic responses of endometrial stromal cells, which may serve as a potential therapeutic agent for endometrial fibrosis. Quercetin 43-52 SMAD family member 3 Homo sapiens 164-169 27052477-4 2016 MTORC1, mTORC2, beta-catenin as well as Smad signaling were activated in the obstructive kidneys, whereas quercetin could markedly reduce their abundance except Smad3 phosphorylation. Quercetin 106-115 SMAD family member 3 Homo sapiens 161-166 15580028-9 2004 Quercetin also strongly suppressed the basal expression of Smad2, Smad3, and Smad4 as well as the phosphorylation of Smad2 and Smad3 and the formation of the Smad2-Smad3-Smad4 complex. Quercetin 0-9 SMAD family member 3 Homo sapiens 66-71 15580028-9 2004 Quercetin also strongly suppressed the basal expression of Smad2, Smad3, and Smad4 as well as the phosphorylation of Smad2 and Smad3 and the formation of the Smad2-Smad3-Smad4 complex. Quercetin 0-9 SMAD family member 3 Homo sapiens 127-132 15580028-9 2004 Quercetin also strongly suppressed the basal expression of Smad2, Smad3, and Smad4 as well as the phosphorylation of Smad2 and Smad3 and the formation of the Smad2-Smad3-Smad4 complex. Quercetin 0-9 SMAD family member 3 Homo sapiens 127-132