PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33066828-0	2020	Quercetin regulates fibrogenic responses of endometrial stromal cell by upregulating miR-145 and inhibiting the TGF-beta1/Smad2/Smad3 pathway.	Quercetin	0-9	SMAD family member 3	Homo sapiens	128-133	
35067813-6	2022	RESULTS: The results showed that the levels of mRNA expression of TGF-beta, alphaSMA, Collagen1 genes, and phosphorylated smad3 protein were significantly reduced in fructose-activated HSCs after treatment with Quercetin compared to fructose-activated HSCs.	Quercetin	211-220	SMAD family member 3	Homo sapiens	122-127	
35067813-7	2022	CONCLUSION: Quercetin is effective in reducing the expression of fibrogenic genes in fructose-activated human HSCs through downregulation of the TGF-beta/smad3 signaling pathway.	Quercetin	12-21	SMAD family member 3	Homo sapiens	154-159	
33066828-1	2020	OBJECTIVES: Aim of this study is to explore whether quercetin can inhibit the enlarged fibrogenic responses of endometrial stromal cells by increasing the level of microRNA-145 (miR-145) and mediating the TGFbeta1/Smad2/Smad3 signaling pathway, and to discuss the mechanism of signal transduction, further to provide experimental basis for revealing the pathophysiological mechanism and seeking new strategies for effective prevention and treatment of endometrial fibrosis.	Quercetin	52-61	SMAD family member 3	Homo sapiens	220-225	
33066828-9	2020	Furthermore, quercetin regulates cell fibrogenic responses of endometrial stromal cells via miR-145/TGF-beta1/Smad2/Smad3 pathway.	Quercetin	13-22	SMAD family member 3	Homo sapiens	116-121	
33066828-10	2020	CONCLUSIONS: These findings indicated that quercetin have a significant anti-fibrotic effect and could upregulate miR-145 and inhibit activation of TGF-beta1/Smad2/Smad3 pathway to regulate TGF-beta1 induced fibrogenic responses of endometrial stromal cells, which may serve as a potential therapeutic agent for endometrial fibrosis.	Quercetin	43-52	SMAD family member 3	Homo sapiens	164-169	
27052477-4	2016	MTORC1, mTORC2, beta-catenin as well as Smad signaling were activated in the obstructive kidneys, whereas quercetin could markedly reduce their abundance except Smad3 phosphorylation.	Quercetin	106-115	SMAD family member 3	Homo sapiens	161-166	
15580028-9	2004	Quercetin also strongly suppressed the basal expression of Smad2, Smad3, and Smad4 as well as the phosphorylation of Smad2 and Smad3 and the formation of the Smad2-Smad3-Smad4 complex.	Quercetin	0-9	SMAD family member 3	Homo sapiens	66-71	
15580028-9	2004	Quercetin also strongly suppressed the basal expression of Smad2, Smad3, and Smad4 as well as the phosphorylation of Smad2 and Smad3 and the formation of the Smad2-Smad3-Smad4 complex.	Quercetin	0-9	SMAD family member 3	Homo sapiens	127-132	
15580028-9	2004	Quercetin also strongly suppressed the basal expression of Smad2, Smad3, and Smad4 as well as the phosphorylation of Smad2 and Smad3 and the formation of the Smad2-Smad3-Smad4 complex.	Quercetin	0-9	SMAD family member 3	Homo sapiens	127-132