PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22394507-0 2012 Quercetin abrogates IL-6/STAT3 signaling and inhibits glioblastoma cell line growth and migration. Quercetin 0-9 interleukin 6 Homo sapiens 20-24 22661653-8 2012 Quercetin reduced IL-6, IL-8 and TNFalpha protein production in supernatants of all GO samples (n=4) in a dose-dependent manner; however, only the reduction in IL-6 was statistically significant (p<0.05). Quercetin 0-9 interleukin 6 Homo sapiens 18-22 22661653-8 2012 Quercetin reduced IL-6, IL-8 and TNFalpha protein production in supernatants of all GO samples (n=4) in a dose-dependent manner; however, only the reduction in IL-6 was statistically significant (p<0.05). Quercetin 0-9 interleukin 6 Homo sapiens 160-164 22661653-9 2012 Quercetin had a significant suppression of tissue IL-6, IL-8, IL-1beta and TNFalpha mRNA expression in cultured orbital tissues from three GO samples relative to untreated control tissue (p<0.05). Quercetin 0-9 interleukin 6 Homo sapiens 50-54 22394507-5 2012 In this study, we show that quercetin is a potent inhibitor of the IL-6-induced STAT3 signaling pathway in T98G and U87 glioblastoma cells. Quercetin 28-37 interleukin 6 Homo sapiens 67-71 22394507-6 2012 Exposure to quercetin resulted in the reduction of GP130, JAK1 and STAT3 activation by IL-6, as well as a marked decrease of the proliferative and migratory properties of glioblastoma cells induced by IL-6. Quercetin 12-21 interleukin 6 Homo sapiens 87-91 22394507-6 2012 Exposure to quercetin resulted in the reduction of GP130, JAK1 and STAT3 activation by IL-6, as well as a marked decrease of the proliferative and migratory properties of glioblastoma cells induced by IL-6. Quercetin 12-21 interleukin 6 Homo sapiens 201-205 22394507-8 2012 Moreover, quercetin reduced the recruitment of STAT3 at the cyclin D1 promoter and inhibited Rb phosphorylation in the presence of IL-6. Quercetin 10-19 interleukin 6 Homo sapiens 131-135 22394507-9 2012 Overall, these results provide new insight into the role of quercetin as a blocker of the STAT3 activation pathway stimulated by IL-6, with a potential role in the prevention and treatment of glioblastoma. Quercetin 60-69 interleukin 6 Homo sapiens 129-133 22284780-11 2012 Specifically, apiegenin, baicalein, curcumin, EGCG, genistein, luteolin, oridonin, quercetin, and wogonin repress NF-kappaB (NF-kappaB, a proinflammatory transcription factor) and inhibit proinflammatory cytokines such as TNF-alpha and IL-6. Quercetin 83-92 interleukin 6 Homo sapiens 236-240 22487368-5 2012 Quercetin, one of the active components in Calendula, has been shown to inhibit recombinant human matrix metalloproteinase (MMP) activity and decrease the expression of tumor necrosis factor-alpha, interleukin-1beta (IL), IL-6 and IL-8 in phorbol 12-myristate 13-acetate and calcium ionophore-stimulated human mast cells. Quercetin 0-9 interleukin 6 Homo sapiens 222-226 20484173-5 2010 Intake of flavonols, especially of isorhamnetin, kaempferol, and quercetin, was inversely associated with serum IL-6 concentrations (highest versus lowest flavonol intake quartile, 1.80 versus 2.20 pg/mL) and high-risk (OR, 0.51; 95% CI, 0.26-0.98) and advanced adenoma recurrence (OR, 0.17; 95% CI, 0.06-0.50). Quercetin 65-74 interleukin 6 Homo sapiens 112-116 20828867-9 2011 The cytokine IL-6 production was significantly increased in ox-LDL treated group and was decreased by quercetin treatment. Quercetin 102-111 interleukin 6 Homo sapiens 13-17 21186817-4 2011 The results showed that p-coumaric acid, quercetin, and resveratrol have greater inhibition (p < 0.05) of a TNF-alpha-induced increase in the production of interleukin-6 (IL-6) among 21 tested polyphenolic compounds. Quercetin 41-50 interleukin 6 Homo sapiens 159-172 21186817-4 2011 The results showed that p-coumaric acid, quercetin, and resveratrol have greater inhibition (p < 0.05) of a TNF-alpha-induced increase in the production of interleukin-6 (IL-6) among 21 tested polyphenolic compounds. Quercetin 41-50 interleukin 6 Homo sapiens 174-178 20943792-7 2010 RESULTS: Quercetin, and to a lesser extent trans-RSV, attenuated the TNF-alpha-induced expression of inflammatory genes such as interleukin (IL)-6, IL-1beta, IL-8, and monocyte chemoattractant protein-1 (MCP-1) and the secretion of IL-6, IL-8, and MCP-1. Quercetin 9-18 interleukin 6 Homo sapiens 232-236 21108840-7 2010 CYT and quercetin, an active compound of CYT, significantly inhibited LPS-induced interleukin (IL)-1beta, IL-6, and tumor necrosis factor (TNF)-alpha production and expression in PBMCs. Quercetin 8-17 interleukin 6 Homo sapiens 106-110 21282043-9 2011 Consequently, quercetin suppressed UV irradiation-induced expression of inflammatory cytokines IL-1beta (~60%), IL-6 (~80%), IL-8 (~76%) and TNF-alpha (~69%). Quercetin 14-23 interleukin 6 Homo sapiens 112-116 22039452-3 2011 Quercetin significantly attenuated intercellular adhesion molecule-1 (ICAM-1), interleukin (IL) -6, IL-8, and cyclooxygenase (COX) -2 mRNA expression, and inhibited IL-1beta-induced increases in ICAM-1, IL-6, and IL-8 mRNA. Quercetin 0-9 interleukin 6 Homo sapiens 79-98 22039452-3 2011 Quercetin significantly attenuated intercellular adhesion molecule-1 (ICAM-1), interleukin (IL) -6, IL-8, and cyclooxygenase (COX) -2 mRNA expression, and inhibited IL-1beta-induced increases in ICAM-1, IL-6, and IL-8 mRNA. Quercetin 0-9 interleukin 6 Homo sapiens 203-207 18297698-2 2008 This study was undertaken to determine whether SK, either alone or in combination with quercitin (QT) is able to modulate the release of IL-6 and IL-8 from peripheral blood mononuclear cells (PBMCs). Quercetin 87-96 interleukin 6 Homo sapiens 137-141 18297698-2 2008 This study was undertaken to determine whether SK, either alone or in combination with quercitin (QT) is able to modulate the release of IL-6 and IL-8 from peripheral blood mononuclear cells (PBMCs). Quercetin 98-100 interleukin 6 Homo sapiens 137-141 17191106-4 2006 In this report we show that quercetin, a natural compound able to act as an inhibitor of mast cell secretion, causes a decrease in the release of tryptase and IL-6 and the down-regulation of histidine decarboxylase (HDC) mRNA from human mast cell (HMC)-1 cells. Quercetin 28-37 interleukin 6 Homo sapiens 159-163 18720166-1 2008 Quercetin (QUER) and luteolin (LUTE) are dietary flavonoids capable of regulating the production of cytokines, such as tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6). Quercetin 0-9 interleukin 6 Homo sapiens 164-177 18720166-1 2008 Quercetin (QUER) and luteolin (LUTE) are dietary flavonoids capable of regulating the production of cytokines, such as tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6). Quercetin 0-9 interleukin 6 Homo sapiens 179-183 17634198-8 2007 Treatment of the Caco-2 cells with live L. paracasei increased cellular levels of hsp70 and hsp27 and the potentiating effect on IL-6 production was inhibited by quercetin and by hsp70 or hsp27 siRNA. Quercetin 162-171 interleukin 6 Homo sapiens 129-133 17588137-5 2007 RESULTS: Quercetin decreased the gene expression and production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, and IL-8 in PMACI-stimulated HMC-1 cells. Quercetin 9-18 interleukin 6 Homo sapiens 126-130 17191106-5 2006 As quercetin dramatically inhibits mast cell tryptase and IL-6 release and HDC mRNA transcription by HMC-1 cell line, these results nominate quercetin as a therapeutical compound in association with other therapeutical molecules for neurological diseases mediated by mast cell degranulation. Quercetin 3-12 interleukin 6 Homo sapiens 58-62 17191106-5 2006 As quercetin dramatically inhibits mast cell tryptase and IL-6 release and HDC mRNA transcription by HMC-1 cell line, these results nominate quercetin as a therapeutical compound in association with other therapeutical molecules for neurological diseases mediated by mast cell degranulation. Quercetin 141-150 interleukin 6 Homo sapiens 58-62 16532021-5 2006 We also investigated the effect of the flavonol quercetin that was recently shown to strongly inhibit IL-6 secretion in response to allergic stimulation from hCBMCs.IL-1 stimulated p38, but did not activate extracellular signal-regulated kinase (ERK) or c-jun N-terminal kinase (JNK); it also did not activate protein kinase C (PKC) isozymes alpha, beta, mu and zeta, except for PKC-theta, which was phosphorylated. Quercetin 48-57 interleukin 6 Homo sapiens 102-106 16532021-8 2006 These results indicate that IL-1-stimulated IL-6 production from human mast cells is regulated by biochemical pathways distinct from IgE-induced degranulation and that quercetin can block both IL-6 secretion and two key signal transduction steps involved. Quercetin 168-177 interleukin 6 Homo sapiens 44-48 16532021-8 2006 These results indicate that IL-1-stimulated IL-6 production from human mast cells is regulated by biochemical pathways distinct from IgE-induced degranulation and that quercetin can block both IL-6 secretion and two key signal transduction steps involved. Quercetin 168-177 interleukin 6 Homo sapiens 193-197 12724357-6 2003 Alternatively, incubation of untreated 8701-BC cells with quercetin, a flavonoid known to decrease the amount of free hsf1, is found to induce upregulation of uPa and downregulation of MMP-1, and an increase of matrigel invasion by cells, thus providing further supporting data of the involvement of hsf unavailability on the modulation of uPa and MMP-1 expression and on cell invasive behaviour. Quercetin 58-67 interleukin 6 Homo sapiens 118-121 16426496-0 2005 The inhibitory effect of quercetin on IL-6 production by LPS-stimulated neutrophils. Quercetin 25-34 interleukin 6 Homo sapiens 38-42 16426496-3 2005 In the present study, we investigated the effects of quercetin on IL-6 production by LPS-stimulated neutrophils in human. Quercetin 53-62 interleukin 6 Homo sapiens 66-70 16426496-7 2005 However, after pre-treatment of neutrophils with quercetin (40 microM) for 30 min, the inducible effects of LPS on the increase of IL-6 secretion, intracellular IL-6 level and IL-6 mRNA expression by neutrophils were abrogated. Quercetin 49-58 interleukin 6 Homo sapiens 131-135 16426496-7 2005 However, after pre-treatment of neutrophils with quercetin (40 microM) for 30 min, the inducible effects of LPS on the increase of IL-6 secretion, intracellular IL-6 level and IL-6 mRNA expression by neutrophils were abrogated. Quercetin 49-58 interleukin 6 Homo sapiens 161-165 16426496-7 2005 However, after pre-treatment of neutrophils with quercetin (40 microM) for 30 min, the inducible effects of LPS on the increase of IL-6 secretion, intracellular IL-6 level and IL-6 mRNA expression by neutrophils were abrogated. Quercetin 49-58 interleukin 6 Homo sapiens 161-165 16426496-9 2005 Thus, our data suggested that quercetin might exert its anti-inflammatory effect through negatively modulating pro-inflammatory factors, such as IL-6. Quercetin 30-39 interleukin 6 Homo sapiens 145-149 16426496-10 2005 The inhibitory effects of quercetin on IL-6 production by neutrophils may provide a theoretical basis on future therapy of inflammation. Quercetin 26-35 interleukin 6 Homo sapiens 39-43 15912140-6 2005 Release of IL-6, IL-8 and TNF-alpha was inhibited by 82-93% at 100 microM quercetin and kaempferol, and 31-70% by myricetin and morin. Quercetin 74-83 interleukin 6 Homo sapiens 11-15 15051824-6 2004 Quercetin reduced linoleic acid-mediated binding activity of NF-kappaB and AP-1 and mRNA levels of inflammatory genes such as interleukin-6 (IL-6) and vascular cell adhesion molecule-1 (VCAM-1). Quercetin 0-9 interleukin 6 Homo sapiens 126-139 15051824-6 2004 Quercetin reduced linoleic acid-mediated binding activity of NF-kappaB and AP-1 and mRNA levels of inflammatory genes such as interleukin-6 (IL-6) and vascular cell adhesion molecule-1 (VCAM-1). Quercetin 0-9 interleukin 6 Homo sapiens 141-145 11424089-4 2001 Our finding that a bioflavonoid quercetin (QCT), a well known inhibitor of hsp gene expression, significantly inhibited the transcriptional activation of HSF and HIF-1 strongly suggests that QCT-sensitive molecule(s) is involved in the transcriptional activation of HSF and HIF-1 by hypoxia. Quercetin 32-41 interleukin 6 Homo sapiens 154-157 11893605-6 2002 The same treatment resulted in increased gene and protein expression of IL-6, a response that was blocked by quercetin. Quercetin 109-118 interleukin 6 Homo sapiens 72-76 11885806-2 2002 Our study was designed to determine whether heat shock and drugs like cisplatin, etoposide and quercetin have an effect on the expression of heat shock protein 27 in tumour cells such as: HeLa (cervical cancer), Hep-2 (larynx cancer), A549 (lung cancer) and also in normal human skin fibroblasts (HSF) cultured in two-dimensional (2D) and three-dimensional (3D) conditions. Quercetin 95-104 interleukin 6 Homo sapiens 297-300 12476615-2 2002 Our study was designed to determine whether heat shock and drugs like cisplatin, etoposide and quercetin influence the expression of heat shock protein 72 in tumour cells: HeLa (cervical cancer), Hep-2 (larynx cancer), A549 (lung cancer) and normal human skin fibroblasts (HSF). Quercetin 95-104 interleukin 6 Homo sapiens 273-276 12476615-5 2002 Quercetin inhibited heat shock protein expression in Hep-2 cells but induced in HSF. Quercetin 0-9 interleukin 6 Homo sapiens 80-83 11424089-4 2001 Our finding that a bioflavonoid quercetin (QCT), a well known inhibitor of hsp gene expression, significantly inhibited the transcriptional activation of HSF and HIF-1 strongly suggests that QCT-sensitive molecule(s) is involved in the transcriptional activation of HSF and HIF-1 by hypoxia. Quercetin 32-41 interleukin 6 Homo sapiens 266-269 8688318-7 1996 In order to transfer these data to tumour cells constitutively expressing stress hsp70 due to the constitutive activity of the original hsp70 promoter we sought to supress the heat shock response pathway by the natural flavonoid quercetin, known to inactivate the heat shock transcription factor (HSF). Quercetin 229-238 interleukin 6 Homo sapiens 264-295 9367858-6 1997 In contrast, quercetin inhibited both HSF DNA-binding activity and HSF expression in HeLa cells. Quercetin 13-22 interleukin 6 Homo sapiens 38-41 9367858-6 1997 In contrast, quercetin inhibited both HSF DNA-binding activity and HSF expression in HeLa cells. Quercetin 13-22 interleukin 6 Homo sapiens 67-70 9367858-7 1997 Our studies suggest that quercetin"s action is cell-type specific, and in breast cancer cells may involve regulation of HSF transcriptional activity, rather than regulation of its DNA-binding activity. Quercetin 25-34 interleukin 6 Homo sapiens 120-123 10590836-3 1999 As the cellular heat shock response also involves the activation of heat shock transcription factor (HSF), we have, in the present study, examined the role of HSF in the stress potentiation of GR by use of a flavonoid compound, quercetin, recently shown to selectively inhibit the stress response in a variety of human and murine cell lines. Quercetin 228-237 interleukin 6 Homo sapiens 101-104 10590836-3 1999 As the cellular heat shock response also involves the activation of heat shock transcription factor (HSF), we have, in the present study, examined the role of HSF in the stress potentiation of GR by use of a flavonoid compound, quercetin, recently shown to selectively inhibit the stress response in a variety of human and murine cell lines. Quercetin 228-237 interleukin 6 Homo sapiens 159-162 10590836-6 1999 In L929 cells stably transfected with a CAT reporter plasmid under the control of the HSF-responsive hsp70 promoter (LHSECAT cells), pretreatment with quercetin was found to cause a dose- and time-dependent inactivation of HSF activity following heat shock, but only when added before the stress event. Quercetin 151-160 interleukin 6 Homo sapiens 86-89 10590836-6 1999 In L929 cells stably transfected with a CAT reporter plasmid under the control of the HSF-responsive hsp70 promoter (LHSECAT cells), pretreatment with quercetin was found to cause a dose- and time-dependent inactivation of HSF activity following heat shock, but only when added before the stress event. Quercetin 151-160 interleukin 6 Homo sapiens 223-226 10590836-9 1999 Thus, quercetin appears to be an effective and selective inhibitor of HSF stress-induced activation and its ability to prevent the stress potentiation of GR suggests either a direct or indirect involvement by stress-activated HSF in this process, or the existence of a regulatory step common to both the heat shock and HSPE responses. Quercetin 6-15 interleukin 6 Homo sapiens 70-73 10590836-9 1999 Thus, quercetin appears to be an effective and selective inhibitor of HSF stress-induced activation and its ability to prevent the stress potentiation of GR suggests either a direct or indirect involvement by stress-activated HSF in this process, or the existence of a regulatory step common to both the heat shock and HSPE responses. Quercetin 6-15 interleukin 6 Homo sapiens 226-229 8688318-7 1996 In order to transfer these data to tumour cells constitutively expressing stress hsp70 due to the constitutive activity of the original hsp70 promoter we sought to supress the heat shock response pathway by the natural flavonoid quercetin, known to inactivate the heat shock transcription factor (HSF). Quercetin 229-238 interleukin 6 Homo sapiens 297-300 34803913-7 2021 Quercetin significantly reduced plasma markers of cell damage (CK (p<0.005), LDH (p<0.001) and Mb (p<0.05)) and the interleukin 6 level (IL-6 (p<0.05)) during recovery period following EIMD compared to placebo. Quercetin 0-9 interleukin 6 Homo sapiens 116-129 7702609-2 1995 After treatment of cells with nonlethal concentrations of quercetin, the binding of heat shock factor (HSF) to the heat shock element (HSE) was inhibited as detected by gel shift assay. Quercetin 58-67 interleukin 6 Homo sapiens 84-101 7702609-2 1995 After treatment of cells with nonlethal concentrations of quercetin, the binding of heat shock factor (HSF) to the heat shock element (HSE) was inhibited as detected by gel shift assay. Quercetin 58-67 interleukin 6 Homo sapiens 103-106 7702609-3 1995 We examined whether quercetin inhibits heat shock response by inhibiting HSF trimer-formation and found it was not the case. Quercetin 20-29 interleukin 6 Homo sapiens 73-76 1321338-6 1992 Treatment with quercetin inhibited the binding of HSF to the HSE in whole-cell extracts activated in vivo by heat shock and in cytoplasmic extracts activated in vitro by elevated temperature or by urea. Quercetin 15-24 interleukin 6 Homo sapiens 50-53 1321338-8 1992 The formation of the HSF-HSE complex was not inhibited when quercetin was added only during the binding reaction of HSF to the HSE after in vitro heat activation. Quercetin 60-69 interleukin 6 Homo sapiens 21-24 1321338-8 1992 The formation of the HSF-HSE complex was not inhibited when quercetin was added only during the binding reaction of HSF to the HSE after in vitro heat activation. Quercetin 60-69 interleukin 6 Homo sapiens 116-119 1321338-9 1992 Quercetin thus interacts with HSF and inhibits the induction of HSPs after heat shock through inhibition of HSF activation. Quercetin 0-9 interleukin 6 Homo sapiens 30-33 1321338-9 1992 Quercetin thus interacts with HSF and inhibits the induction of HSPs after heat shock through inhibition of HSF activation. Quercetin 0-9 interleukin 6 Homo sapiens 108-111 34834040-5 2021 In addition, quercetin suppressed the nuclear translocation of nuclear factor kappa B (NF-kappaB) and reduced levels of inflammatory cytokine tumor necrosis factor (TNF)-alpha, interleukin (IL)-1, and IL-6, which had increased significantly after LPS exposure. Quercetin 13-22 interleukin 6 Homo sapiens 201-205 7595543-3 1995 Complete to nearly complete inhibition of interleukin-1 beta-induced interleukin-6 production was observed with the flavonoids genistein and quercetin, the bisindole alkaloids staurosporine and K-252a, or the tyrphostin AG879. Quercetin 141-150 interleukin 6 Homo sapiens 69-82 34803913-7 2021 Quercetin significantly reduced plasma markers of cell damage (CK (p<0.005), LDH (p<0.001) and Mb (p<0.05)) and the interleukin 6 level (IL-6 (p<0.05)) during recovery period following EIMD compared to placebo. Quercetin 0-9 interleukin 6 Homo sapiens 137-141 34754315-10 2021 Molecular docking results showed that quercetin, luteolin, kaempferol, tanshinone IIa, wogonin, naringenin, nobiletin, dihydrotanshinlactone, beta-sitosterol, and salviolone have good affinity with core target proteins IL6, PTGS2, MAPK1, MAPK3, and CGRP1. Quercetin 38-47 interleukin 6 Homo sapiens 219-222 34791846-12 2021 CONCLUSIONS: The active ingredients of Kushen Decoction, such as quercetin, (+)-14alpha-hydroxymatrine and apigenin, may act on targets like AKT1, TNF, IL-6 to modulate TLR, NLR and NF-kappaB signaling pathways to play a synergistic role in the treatment of cryptosporidiosis in the hematologic and immune system. Quercetin 65-74 interleukin 6 Homo sapiens 152-156 34746302-16 2021 The hub components possibly include quercetin, stigmasterol, kaempferol, and beta-sitosterol and act through pairing with hub targets, such as AKT1, VEGFA, and IL6, to regulate neuronal death, G protein-coupled amine receptor activity, reactive oxygen species metabolic process, membrane raft, MAPK signaling pathway, and cellular senescence for the treatment of PD. Quercetin 36-45 interleukin 6 Homo sapiens 160-163 34308732-7 2021 Quercetin decreased the production of IL-1beta, IL-6, IL-8, TNF-alpha, iNOS, and COX-2, as well as signal transduction via the Akt/AMPK/mTOR pathway. Quercetin 0-9 interleukin 6 Homo sapiens 48-52 34660782-11 2021 This study revealed that SZRD has the characteristics and advantages of "multicomponent, multitarget, and multipathway" in the treatment of PDSD; among these, the combination of the main active components of quercetin and kaempferol with the key targets of AKT1, IL6, MAPK1, TP53, and VEGFA may be one of the important mechanisms. Quercetin 208-217 interleukin 6 Homo sapiens 263-266 34493195-7 2022 RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients. Quercetin 101-110 interleukin 6 Homo sapiens 251-254 34380011-9 2021 In QUE pre-treated samples, TNF-alpha and IL-6 were significantly further reduced, indicating the anti-inflammatory role of QUE. Quercetin 3-6 interleukin 6 Homo sapiens 42-46 34380011-9 2021 In QUE pre-treated samples, TNF-alpha and IL-6 were significantly further reduced, indicating the anti-inflammatory role of QUE. Quercetin 124-127 interleukin 6 Homo sapiens 42-46 34353059-16 2021 Its active compounds, including quercetin and kaempferol, can exert their therapeutic effects on OA by acting on TNF, PTGS2, MMP2, IL-6, IL-1beta, and other key targets to regulate inflammation, immunity, autophagy, and endocrine-related signaling pathways. Quercetin 32-41 interleukin 6 Homo sapiens 131-135 34479552-11 2021 CONCLUSIONS: Luteoklin, quercetin, kaempferol and other active compounds in Epicedium can regulate multiple signaling pathways and targets such as IL6, AKT1, and EGF, therefore playing therapeutic roles in depression. Quercetin 24-33 interleukin 6 Homo sapiens 147-150 35352237-6 2022 Furthermore, quercetin decreased the pro-inflammatory cell environment upon LPS-induced endothelial activation, in terms of tumor necrosis factor- alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-8 (IL-8), and sVCAM-1 expression. Quercetin 13-22 interleukin 6 Homo sapiens 166-179 34497749-13 2021 Quercetin and Luteolin were verified to have good binding capability with the hub potential targets IL6, MAPK1, AKT1 through molecular docking. Quercetin 0-9 interleukin 6 Homo sapiens 100-103 35352237-6 2022 Furthermore, quercetin decreased the pro-inflammatory cell environment upon LPS-induced endothelial activation, in terms of tumor necrosis factor- alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-8 (IL-8), and sVCAM-1 expression. Quercetin 13-22 interleukin 6 Homo sapiens 181-185 35366469-13 2022 The binding of five active ingredients originated from Gancao-Banxia to IL-6-STAT3 was verified by molecular docking, namely quercetin, coniferin, licochalcone a, Licoagrocarpin and (3S,6S)-3-(benzyl)-6-(4-hydroxybenzyl)piperazine-2,5-quinone, maximizing therapeutic efficacy. Quercetin 125-134 interleukin 6 Homo sapiens 72-76 35064144-10 2022 Then, in vitro experiments showed that quercetin interfered with Th1/Th2 balance by acting on IL-6 and IFN-gamma to modulate the immune system in treating OLP. Quercetin 39-48 interleukin 6 Homo sapiens 94-98 35432570-10 2022 The molecular docking results showed effective ingredients (quercetin, kaempferol, and 7-methoxy-2-methyl isoflavone) have good docking results with targets (IL-6, PTGS2, and TNF). Quercetin 60-69 interleukin 6 Homo sapiens 158-162 35442463-17 2022 CONCLUSIONS: (1) Icariin, quercetin and luteolin may act on target proteins, including IL-6, ESR1, EGFR, MAPK8, VEGFA and CASP8, to participate in the regulation of the human cytomegalovirus infection pathway, the PI3K-Akt signaling pathway, the TNF signaling pathway and other signaling pathways in order to effectively treat CAD. Quercetin 26-35 interleukin 6 Homo sapiens 87-91 33146673-7 2021 RESULTS: The network pharmacology research showed that TCM could decrease IL-6 using several compounds, such as quercetin, ursolic acid, luteolin, and rutin. Quercetin 112-121 interleukin 6 Homo sapiens 74-78 3218613-6 1988 Increasing substrate concentration (9-144 nmols) relieved the inhibition of HSF-PLA2 activity by quercetin indicating probable interaction with the substrate. Quercetin 97-106 interleukin 6 Homo sapiens 76-79 34035828-9 2021 Further analysis showed that the HGD activity of quercetin, formononetin, kaempferol, isorhamnetin, and beta-sitosterol ingredients is possible through VEGFA, IL6, TNF, AKT1, and TP53 targets involved in TNF, toll-like receptors, and MAPK-related pathways, which have anti-inflammatory, antiapoptosis, antioxidation, and autophagy effects, relieve renal fibrosis and renal cortex injury, and improve renal function, thus delaying the development of DN. Quercetin 49-58 interleukin 6 Homo sapiens 159-162 34035828-10 2021 The molecular docking results showed that quercetin, formononetin, kaempferol, isorhamnetin, beta-sitosterol had a good binding activity with VEGFA, IL6, TNF, AKT1, and TP53. Quercetin 42-51 interleukin 6 Homo sapiens 149-152 33278444-9 2021 Moreover, quercetin-glycyrrhizin nanogels were more effective in down-regulating the inflammation-related gene expression of tumor necrosis factor-alpha, interleukin-6, inducible nitric oxide synthase and monocyte chemotactic protein-1. Quercetin 10-19 interleukin 6 Homo sapiens 154-167 33146673-11 2021 Quercetin, ursolic acid, luteolin, and rutin could inhibit COVID-19 by downregulating IL-6. Quercetin 0-9 interleukin 6 Homo sapiens 86-90 33520015-11 2020 Finally, 6 key proteins of TNF, IL-10, IL-2, IL-6, STAT1 and CCL2 were selected and successfully docked with 4 active ingredients of quercetin, luteolin, wogonin and kaempferol. Quercetin 133-142 interleukin 6 Homo sapiens 45-49 33657989-0 2021 Quercetin Induces Apoptosis in Glioblastoma Cells by Suppressing Axl/IL-6/STAT3 Signaling Pathway. Quercetin 0-9 interleukin 6 Homo sapiens 69-73 33657989-8 2021 Quercetin also decreased IL-6 release and phosphorylation of STAT3 in GBM cells. Quercetin 0-9 interleukin 6 Homo sapiens 25-29 33657989-11 2021 In conclusion, we suggest quercetin as a potential anticancer agent, which may improve cancer microenvironment of GBM via the Axl/IL-6/STAT3 pathway. Quercetin 26-35 interleukin 6 Homo sapiens 130-134 32898874-7 2020 However, an inhibitory effect of the identified quercetin-3-O-rhamnoside and its aglycone, quercetin, on the release of IL-8 and IL-6 could not be demonstrated. Quercetin 48-57 interleukin 6 Homo sapiens 129-133 33204288-12 2020 Molecular docking showed that quercetin, kaempferol, baicalein, and wogonin have good binding activity with IL6, VEGFA, EGFR, and NFKBIA targets. Quercetin 30-39 interleukin 6 Homo sapiens 108-111 32957884-5 2021 Previous studies have shown that quercetin reduces the entry of the virus into the cell by blocking the ACE2 receptor, as well as reducing the level of interleukin-6 in SARS and MERS patients. Quercetin 33-42 interleukin 6 Homo sapiens 152-165 32179074-3 2020 KEY FINDINGS: Pre-treatment with quercetin significantly reversed the LPS-induced upregulation of pro-fibrotic factors (IL-6, IL-8, COL-1, COL-3, LC3) and fibrotic signaling mediators (mTOR and AKT), and it induced the downregulation of ATG5 in the WI-38 cells. Quercetin 33-42 interleukin 6 Homo sapiens 120-124 32536965-14 2020 Second, the molecular docking results showed that there was a certain affinity between the core compounds (kaempferol, quercetin, 7-Methoxy-2-methyl isoflavone, naringenin, formononetin) and core target genes (IL6, IL1B, CCL2). Quercetin 119-128 interleukin 6 Homo sapiens 210-213 31804760-12 2020 Meanwhile, Quercetin attenuated LPS-stimulated apoptosis, production of IL-6, and TNF-alpha in experimental cells. Quercetin 11-20 interleukin 6 Homo sapiens 72-76 31531360-8 2019 Our results demonstrated that quercetin inhibited the LPS-induced production of IL-1beta, IL-6, IL-8, and TNF-alpha in a dose-dependent manner. Quercetin 30-39 interleukin 6 Homo sapiens 90-94 31547402-0 2019 Quercetin Interrupts the Positive Feedback Loop Between STAT3 and IL-6, Promotes Autophagy, and Reduces ROS, Preventing EBV-Driven B Cell Immortalization. Quercetin 0-9 interleukin 6 Homo sapiens 66-70 31547402-3 2019 The results obtained indicated that quercetin inhibited thectivation of signal transducer and activator of transcription 3 (STAT3) induced by EBV infection and reduced molecules such as interleukin-6 (IL-6) and reactive oxidative species (ROS) known to be essential for the immortalization process. Quercetin 36-45 interleukin 6 Homo sapiens 186-199 31547402-3 2019 The results obtained indicated that quercetin inhibited thectivation of signal transducer and activator of transcription 3 (STAT3) induced by EBV infection and reduced molecules such as interleukin-6 (IL-6) and reactive oxidative species (ROS) known to be essential for the immortalization process. Quercetin 36-45 interleukin 6 Homo sapiens 201-205 31960917-6 2020 Pre-treating ARPE-19 cells with quercetin clearly attenuated high glucose-induced viability loss, apoptosis, MCP-1 and IL-6 overproduction, and ROS generation. Quercetin 32-41 interleukin 6 Homo sapiens 119-123 31497913-5 2020 The results demonstrated that quercetin can significantly inhibit expression and secretion of IL-1beta, IL-6, and TNF-alpha in LPS-induced bone marrow-derived macrophages (BMDMs) and reduce activity of Mincle/Syk/NF-kappaB signaling in vitro. Quercetin 30-39 interleukin 6 Homo sapiens 104-108 31497913-6 2020 We also found that quercetin can strongly reduce the concentration of serum creatinine, BUN, IL-1beta, IL-6, and TNF-alpha in cisplatin-induced AKI model. Quercetin 19-28 interleukin 6 Homo sapiens 103-107 31610186-5 2019 Quercetin caused further increase in LPS-induced IL-6 and IL-8 levels. Quercetin 0-9 interleukin 6 Homo sapiens 49-53 31338984-5 2019 It is demonstrated that the loss of function of miR-369-3p in LPS-stimulated DCs during quercetin exposure led to an increase of CCAAT/enhancer binding protein beta (C/EBP-beta) mRNA and protein and its downstream targets tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL6). Quercetin 88-97 interleukin 6 Homo sapiens 266-279 31338984-5 2019 It is demonstrated that the loss of function of miR-369-3p in LPS-stimulated DCs during quercetin exposure led to an increase of CCAAT/enhancer binding protein beta (C/EBP-beta) mRNA and protein and its downstream targets tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL6). Quercetin 88-97 interleukin 6 Homo sapiens 281-284 31228705-4 2019 Owing to the ROS scavenging ability of quercetin, Qu-FeIIP effectively reduces intracellular ROS and in vivo inflammatory factors (TNF-alpha, IL-6, IFN-gamma) levels. Quercetin 39-48 interleukin 6 Homo sapiens 142-146 31531360-11 2019 In conclusion, these results suggested that quercetin attenuated the production of IL-1beta, IL-6, IL-8, and TNF-alpha in P. gingivalis LPS-treated HGFs by activating PPAR-gamma which subsequently suppressed the activation of NF-kappaB. Quercetin 44-53 interleukin 6 Homo sapiens 93-97 31212975-5 2019 The results showed that quercetin could dose-dependently decrease the mRNA and protein levels of ICAM-1, IL-6, IL-8 and monocyte chemoattractant protein-1 (MCP-1). Quercetin 24-33 interleukin 6 Homo sapiens 105-109 31212975-11 2019 Taken together, these results provide evidence that quercetin protects ARPE-19 cells from the IL-1beta-stimulated increase in ICAM-1, sICAM-1, IL-6, IL-8 and MCP-1 production by blocking the activation of MAPK and NF-kappaB signaling pathways to ameliorate the inflammatory response. Quercetin 52-61 interleukin 6 Homo sapiens 143-147 28923363-4 2018 In fact, pure flavonoids (e.g., quercetin, genistein, hesperetin, epigallocatechin-3-gallate) or enriched-extracts, can reduce the expression of pro-inflammatory cytokines (IL-6, TNF-alpha, IL-1beta and COX-2), down-regulate inflammatory markers and prevent neural damage. Quercetin 32-41 interleukin 6 Homo sapiens 173-177 30849307-10 2019 Quercetin treatment mitigated the LPS-caused inflammatory damage of WI-38 lung fibroblasts via enhancing cell viability, inhibiting cell apoptosis and reducing the production of inflammatory cytokines IL-6 and TNF-a. Quercetin 0-9 interleukin 6 Homo sapiens 201-205 29030990-6 2018 Moreover, nanohydrogel of quercetin was able to reduce significantly IL-8, IL-6, and VEGF production in pro-inflammatory conditions with interesting implications on the mechanism of glioblastoma cells drug resistance. Quercetin 26-35 interleukin 6 Homo sapiens 75-79 30680297-11 2018 Conclusion: Our results indicated that the levels of IL-17, IL-33, and IL-6 in supernatants from patients" cultured T cells were increased after stimulation with HMGB-1 following employing quercetin. Quercetin 189-198 interleukin 6 Homo sapiens 71-75 26609631-7 2016 We further show that quercetin, a dietary compound having preventive properties for lung cancer, decreased BPDE-stimulated IL-6 secretion from human lung fibroblasts through inhibition of the NF-kappaB and ERK pathways. Quercetin 21-30 interleukin 6 Homo sapiens 123-127 27915130-7 2017 The inhibitory action of intact- and gamma-irradiated quercetin on the production of IL-6 and TNF-alpha was not observed in the down-regulation of Tollip. Quercetin 54-63 interleukin 6 Homo sapiens 85-89 26609631-0 2016 Quercetin inhibits multiple pathways involved in interleukin 6 secretion from human lung fibroblasts and activity in bronchial epithelial cell transformation induced by benzo[a]pyrene diol epoxide. Quercetin 0-9 interleukin 6 Homo sapiens 49-62 29026320-0 2017 Quercetin inhibits epithelial-mesenchymal transition, decreases invasiveness and metastasis, and reverses IL-6 induced epithelial-mesenchymal transition, expression of MMP by inhibiting STAT3 signaling in pancreatic cancer cells. Quercetin 0-9 interleukin 6 Homo sapiens 106-110 29026320-8 2017 As expected, the EMT and MMP secretion increased with activation of the STAT3 signaling pathway, and quercetin reversed IL-6-induced EMT, invasion, and migration. Quercetin 101-110 interleukin 6 Homo sapiens 120-124 26609631-9 2016 Finally, quercetin blocked IL-6-induced STAT3 activation in HBECs, and IL-6 enhancement of HBEC transformation by BPDE was abolished by quercetin treatment. Quercetin 9-18 interleukin 6 Homo sapiens 27-31 26609631-9 2016 Finally, quercetin blocked IL-6-induced STAT3 activation in HBECs, and IL-6 enhancement of HBEC transformation by BPDE was abolished by quercetin treatment. Quercetin 136-145 interleukin 6 Homo sapiens 27-31 26609631-9 2016 Finally, quercetin blocked IL-6-induced STAT3 activation in HBECs, and IL-6 enhancement of HBEC transformation by BPDE was abolished by quercetin treatment. Quercetin 136-145 interleukin 6 Homo sapiens 71-75 27421015-7 2016 Quercetin suppressed the secretion of tumor necrosis factor-a, interleukin (IL)-1b, and IL-6 in LPS-stimulated human PBMCs. Quercetin 0-9 interleukin 6 Homo sapiens 88-92 26066604-5 2015 Quercetin and RES decreased IL-6 and IP-10 secretion in a dose-dependent manner in both cell lines. Quercetin 0-9 interleukin 6 Homo sapiens 28-32 27038916-6 2016 The amounts of proinflammatory cytokines produced by macrophages, such as interleukin 1 beta, interleukin 6, and tumor necrosis factor alpha, were reduced significantly for the quercetin-loaded silica nanoparticles. Quercetin 177-186 interleukin 6 Homo sapiens 94-107 26468028-4 2015 The reference drug quercetin dihydrate induced an insignificant change in the level of IL-2 and IL-6 and small increase in IFN-gamma content. Quercetin 19-38 interleukin 6 Homo sapiens 96-100 25532488-6 2016 OTA-induced NO, TNF-alpha, IL-6, and IL-8 were significantly reduced in the quercetin pretreated samples indicating its anti-inflammatory role. Quercetin 76-85 interleukin 6 Homo sapiens 27-31 27279714-12 2016 In addition, quercetin could reduce the inflammation factors production of TNF-alpha, Cox-2, and IL-6. Quercetin 13-22 interleukin 6 Homo sapiens 97-101 25830055-0 2015 Quercetin Down-regulates IL-6/STAT-3 Signals to Induce Mitochondrial-mediated Apoptosis in a Nonsmall- cell Lung-cancer Cell Line, A549. Quercetin 0-9 interleukin 6 Homo sapiens 25-29 25830055-5 2015 RESULTS: Results revealed that quercetin could induce apoptosis in A549 cells through mitochondrial depolarization by causing an imbalance in B-cell lymphoma 2/ Bcl2 Antagonist X (Bcl2/Bax) ratio and by down-regulating the interleukine-6/signal transducer and activator of transcription 3 (IL-6/STAT3) signaling pathway. Quercetin 31-40 interleukin 6 Homo sapiens 290-294 25830055-6 2015 An analysis of the data revealed that quercetin could block nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) activity at early hours, which might cause a down-regulation of the IL-6 titer, and the IL-6 expression, in turn, could inhibit p-STAT3 expression. Quercetin 38-47 interleukin 6 Homo sapiens 203-207 25830055-6 2015 An analysis of the data revealed that quercetin could block nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) activity at early hours, which might cause a down-regulation of the IL-6 titer, and the IL-6 expression, in turn, could inhibit p-STAT3 expression. Quercetin 38-47 interleukin 6 Homo sapiens 223-227 25245014-7 2015 Furthermore, the quercetin treatment diminishes IL-6 production by peritoneal cells, a cytokine important to the maintenance of B-1 cells in vitro. Quercetin 17-26 interleukin 6 Homo sapiens 48-52 25245014-8 2015 Importantly, the IL-6 addition to B-1 cell culture prevents cells from apoptosis, even in the presence of quercetin. Quercetin 106-115 interleukin 6 Homo sapiens 17-21 23504962-7 2013 Also, quercetin and quercetin-3-O-glucuronide inhibited ROS-associated inflammation by inhibition of interleukin-6 and tumor necrosis factor-alpha production with suppression of IKKbeta/NF-kappaB phosphorylation. Quercetin 6-15 interleukin 6 Homo sapiens 101-146 24038588-3 2014 The results showed that the JAK/STAT pathway activation by proinflammatory cytokine interleukin-6 and interferon-gamma in CCA cells was suppressed by pretreatment with quercetin and EGCG, evidently by a decrease of the elevated phosphorylated-STAT1 and STAT3 proteins in a dose-dependent manner. Quercetin 168-177 interleukin 6 Homo sapiens 84-97 24049596-9 2013 Quercetin supplementation significantly reduced the serum concentration of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) (P = 0.01 and P < 0.0001, respectively); however, the mean changes in serum levels of IL-6, TNF-alpha, and high-sensitivity C-reactive protein were not significant between the groups. Quercetin 0-9 interleukin 6 Homo sapiens 119-132 24049596-9 2013 Quercetin supplementation significantly reduced the serum concentration of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) (P = 0.01 and P < 0.0001, respectively); however, the mean changes in serum levels of IL-6, TNF-alpha, and high-sensitivity C-reactive protein were not significant between the groups. Quercetin 0-9 interleukin 6 Homo sapiens 134-138 24049596-9 2013 Quercetin supplementation significantly reduced the serum concentration of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) (P = 0.01 and P < 0.0001, respectively); however, the mean changes in serum levels of IL-6, TNF-alpha, and high-sensitivity C-reactive protein were not significant between the groups. Quercetin 0-9 interleukin 6 Homo sapiens 229-233