PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18394220-6 2008 The inhibitory effect on iNOS and COX-2 protein level was stronger for quercetin at 5-50 micromol/l. Quercetin 71-80 nitric oxide synthase 2 Homo sapiens 25-29 17184768-1 2007 We examined the ability of the flavonoids quercetin and kaempferol to modulate inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and reactive C-protein (CRP) expression, and to induce changes in the nuclear factor kappa B (NF-kappaB) pathway in the human hepatocyte-derived cell line Chang Liver. Quercetin 42-51 nitric oxide synthase 2 Homo sapiens 112-116 17477920-2 2007 We have studied the effect of the lycopene, quercetin and tyrosol natural antioxidants on the inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) gene expression in RAW 264.7 macrophages stimulated by gliadin in association with IFN-gamma. Quercetin 44-53 nitric oxide synthase 2 Homo sapiens 127-131 17184768-6 2007 The present study suggests that the modulation of iNOS, COX-2 and CRP by quercetin or kaempferol may contribute to the anti-inflammatory effects of these two structurally similar flavonoids in Chang Liver cells, via mechanisms likely to involve blockade of NF-kappaB activation and the resultant up-regulation of the pro-inflammatory genes. Quercetin 73-82 nitric oxide synthase 2 Homo sapiens 50-54 18274639-0 2007 Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. Quercetin 64-73 nitric oxide synthase 2 Homo sapiens 262-266 18274639-5 2007 Genistein, kaempferol, quercetin, and daidzein also inhibited the activation of the signal transducer and activator of transcription 1 (STAT-1), another important transcription factor for iNOS. Quercetin 23-32 nitric oxide synthase 2 Homo sapiens 188-192 32025234-7 2020 Network analysis showed PTGS2, ESR1, and NOS2 to be the three key targets, and beta-sitosterol, quercetin, and berberine were the three major active ingredients; among them one of the major active ingredients, quercetin, was discriminated by TLC. Quercetin 210-219 nitric oxide synthase 2 Homo sapiens 41-45 15930438-7 2005 In summary, quercetin, a natural flavonol widely distributed in the human diet, inhibits NO production in IL-1beta-stimulated hepatocytes through the inhibition of iNOS expression. Quercetin 12-21 nitric oxide synthase 2 Homo sapiens 164-168 12144868-0 2002 Downregulation of COX-2 and iNOS by amentoflavone and quercetin in A549 human lung adenocarcinoma cell line. Quercetin 54-63 nitric oxide synthase 2 Homo sapiens 28-32 12144868-6 2002 In another set of experiment, quercetin inhibited iNOS protein expression completely without affecting iNOS mRNA expression. Quercetin 30-39 nitric oxide synthase 2 Homo sapiens 50-54 10086329-6 1999 Northern blot analysis indicated that quercetin (0.1 and 0.2 mM) inhibited LPS-dependent production of inducible nitric oxide synthase (iNOS) mRNA and decreased NO release, as measured by the Griess reaction. Quercetin 38-47 nitric oxide synthase 2 Homo sapiens 103-134 10086329-6 1999 Northern blot analysis indicated that quercetin (0.1 and 0.2 mM) inhibited LPS-dependent production of inducible nitric oxide synthase (iNOS) mRNA and decreased NO release, as measured by the Griess reaction. Quercetin 38-47 nitric oxide synthase 2 Homo sapiens 136-140 33454441-8 2021 In addition, molecular docking revealed that both berberine and quercetin could bond with NOS2 and PPARalpha, respectively. Quercetin 64-73 nitric oxide synthase 2 Homo sapiens 90-94 12144868-9 2002 Taken together, our data indicated that amentoflavone and quercetin differentially exerted supression of PGE(2) biosynthesis via downregulation of COX-2/iNOS expression. Quercetin 58-67 nitric oxide synthase 2 Homo sapiens 153-157 20828867-10 2011 Quercetin mediated reduction of TLR2 and TLR4 expression and the inhibition of nuclear translocation of NF-kappaB p65 in turn decreased the inflammatory enzymes like 5-LOX and COX and also decreased the mRNA expression of inducible enzymes like COX-2 and iNOS. Quercetin 0-9 nitric oxide synthase 2 Homo sapiens 255-259 24038588-4 2014 The cytokine-mediated up-regulation of inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule-1 (ICAM-1) via JAK/STAT cascade was abolished by both quercetin and EGCG pretreatment. Quercetin 168-177 nitric oxide synthase 2 Homo sapiens 39-70 24038588-4 2014 The cytokine-mediated up-regulation of inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule-1 (ICAM-1) via JAK/STAT cascade was abolished by both quercetin and EGCG pretreatment. Quercetin 168-177 nitric oxide synthase 2 Homo sapiens 72-76 24296267-3 2014 Meanwhile, the HSF1 transcription inhibitor quercetin increased UVA-induced apoptosis, activation of JNK, expression of XO and iNOS and release of NO/ROS. Quercetin 44-53 nitric oxide synthase 2 Homo sapiens 127-131 23556141-5 2012 The present work focuses on the molecular docking analysis of quercetin and its analogues against iNOS enzyme. Quercetin 62-71 nitric oxide synthase 2 Homo sapiens 98-102 23556141-6 2012 Earlier there are reports of quercetin inhibiting iNOS enzyme in certain experiments as anti cancer agent. Quercetin 29-38 nitric oxide synthase 2 Homo sapiens 50-54 30069224-9 2018 Treatment of cells with quercetin at more than 1.0 nM suppressed STAT6 activation and iNOS mRNA expression induced by IL-4 stimulation. Quercetin 24-33 nitric oxide synthase 2 Homo sapiens 86-90 30035737-4 2018 In contrast to Spasmex, Mirabegron and Quercetin in combination with Testosterone and Estradiol contributed to stabilization of eNOS and nNOs expression already at early observation phases, and reduced the level of iNOS expression with its further disappearance in the later observation period. Quercetin 39-48 nitric oxide synthase 2 Homo sapiens 215-219 27405734-3 2016 The quercetin 3,7-O-dimethyl ether (QDE) isolated from the herbs of S. pubescens suppressed the lipopolysaccharide (LPS)-induced nitric oxide and inducible nitric oxide synthase (iNOS) protein production in mouse macrophages. Quercetin 4-13 nitric oxide synthase 2 Homo sapiens 179-183 20361964-6 2010 Quercetin treatment protected ARPE-19 cells from H(2)O(2)-induced oxidative injury, enhanced BCL-2 transcript levels, increased the BCL-2/BAX ratio, suppressed the transcription of pro-apoptotic factors such as BAX, FADD, CASPASE-3 and CASPASE-9, inhibited the transcription of inflammatory factors such as TNF-alpha, COX-2 and INOS, and decreased the levels of COX and NO in the culture medium. Quercetin 0-9 nitric oxide synthase 2 Homo sapiens 328-332