PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33260381-3 2020 Morin, quercetin, and fucoxanthin inhibited the enzyme activity of CYP1A2 and CYP3A4 in a dose-dependent manner. Quercetin 7-16 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 67-73 33260381-4 2020 The IC50 values of morin, quercetin, and fucoxanthin were 41.8, 22.5, and 30.3 muM for CYP1A2 and 86.6, 16.1, and 24.4 muM for CYP3A4, respectively. Quercetin 26-35 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 87-93 21256954-3 2011 In contrast to kaempferol, BaP and quercetin efficiently induced CYP1A1, CYP1A2 and CYP1B1-mRNA in Caco-2 cells. Quercetin 35-44 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 73-79 25196644-5 2014 Both caffeic acid and quercetin were potent competitive inhibitors of CYP1A2 (Ki = 1.16 and 0.93 muM, respectively) and CYP2C9 (Ki = 0.95 and 1.67 muM, respectively). Quercetin 22-31 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 70-76 25025048-0 2014 Quercetin significantly inhibits the metabolism of caffeine, a substrate of cytochrome P450 1A2 unrelated to CYP1A2*1C (-2964G>A) and *1F (734C>A) gene polymorphisms. Quercetin 0-9 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 76-95 25025048-0 2014 Quercetin significantly inhibits the metabolism of caffeine, a substrate of cytochrome P450 1A2 unrelated to CYP1A2*1C (-2964G>A) and *1F (734C>A) gene polymorphisms. Quercetin 0-9 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 109-115 25025048-2 2014 Previous studies indicated that quercetin inhibited the activity of CYP1A2, and the combination of quercetin with the substrates of CYP1A2 might produce herb-drug interactions. Quercetin 32-41 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 68-74 25025048-2 2014 Previous studies indicated that quercetin inhibited the activity of CYP1A2, and the combination of quercetin with the substrates of CYP1A2 might produce herb-drug interactions. Quercetin 99-108 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 68-74 25025048-2 2014 Previous studies indicated that quercetin inhibited the activity of CYP1A2, and the combination of quercetin with the substrates of CYP1A2 might produce herb-drug interactions. Quercetin 99-108 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 132-138 25025048-3 2014 This research aims to determine the effects of quercetin and the CYP1A2 gene polymorphisms, namely, CYP1A2*1C (-2964G>A) and *1F (734C>A), on the metabolism of caffeine. Quercetin 47-56 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 100-106 28872689-7 2017 KEY FINDINGS: Luteolin and quercetin inhibited human CYP isoforms to varying degrees, with greatest potency towards CYP1A2 and CYP2C8. Quercetin 27-36 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 116-122 23434495-9 2013 Both quercetin (CYP2C8 inhibitor) and ketoconazole (CYP3A4 inhibitor) showed 60-100% inhibition of M1-M4 and M6 formations in HLMs, while M5 formation was mainly inhibited by alpha-naphthoflavone (CYP1A2 inhibitor, 70-80%) and quercetin (90%). Quercetin 5-14 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 197-203 16762476-6 2006 The apiaceous constituents psoralen, 5-methoxypsoralen (5-MOP), 8-methoxypsoralen (8-MOP), and apigenin were potent inhibitors of hCYP1A2-mediated MROD activity in yeast microsomes, whereas quercetin was a modest hCYP1A2 inhibitor. Quercetin 190-199 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 130-137 19215233-0 2009 Simultaneous action of the flavonoid quercetin on cytochrome P450 (CYP) 1A2, CYP2A6, N-acetyltransferase and xanthine oxidase activity in healthy volunteers. Quercetin 37-46 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 50-75 19215233-3 2009 The aim of the present study was to investigate the effects of quercetin on cytochrome P450 (CYP) 1A2, CYP2A6, N-acetyltransferase (NAT2) and xanthine oxidase (XO) activity in healthy volunteers using caffeine as a probe drug. Quercetin 63-72 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 76-101 19215233-16 2009 The results of the present study indicate that quercetin inhibits CYP1A2 function, but enhances CYP2A6, NAT2 and XO activity. Quercetin 47-56 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 66-72 19215233-18 2009 Thus, we conclude that quercetin affects CYP1A2, CYP2A6, NAT2 and XO activity in vivo. Quercetin 23-32 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 41-47 16970932-9 2006 Quercetin significantly inhibited the DNA strand breaks and the increase in CYP1A2 protein induced by AC or beta-carotene in combination with BaP or by AC alone. Quercetin 0-9 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 76-82 16970932-11 2006 Quercetin increased the safety of high doses of beta-carotene, possibly through interaction with beta-carotene"s oxidative products or through inhibition of CYP1A2 expression. Quercetin 0-9 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 157-163 12949046-5 2003 In intact HepG2 cells, quercetin inhibited cytochrome P450 (CYP)1A2, the main phase I enzyme responsible for PhIP bioactivation. Quercetin 23-32 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 43-67 14698415-10 2004 These results indicate that quercetin and naringenin can exhibit inhibitory or stimulating effects on CYP1A2 mediated mutagenesis by MeIQ, depending on their concentrations. Quercetin 28-37 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 102-108 16226778-5 2006 In contrast, the aglycones of quercetin, kaempferol, and isorhamentin inhibited CYP1B1, CYP1A1, and CYP1A2. Quercetin 30-39 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 100-106 16226778-6 2006 Among the three flavonol aglycones, isorhamentin was the most potent in inhibiting CYP1B1 (apparent Ki = 3 +/- 0.1 nM), whereas quercetin was the least potent in inhibiting CYP1A2 (apparent Ki = 418 +/- 50 nM). Quercetin 128-137 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 173-179