PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30524241-8 2018 We found that isoflurane GA caused upregulations of hippocampal NLRP3, cleaved caspase-1, interleukin-1beta (IL-1beta), and IL-18 and the activation of pyroptosis, which is NLRP3 inflammasome-dependent; this consequently gave rise to neuronal damage and cognitive impairment in aged mice. Isoflurane 14-24 interleukin 1 beta Mus musculus 90-107 30524241-8 2018 We found that isoflurane GA caused upregulations of hippocampal NLRP3, cleaved caspase-1, interleukin-1beta (IL-1beta), and IL-18 and the activation of pyroptosis, which is NLRP3 inflammasome-dependent; this consequently gave rise to neuronal damage and cognitive impairment in aged mice. Isoflurane 14-24 interleukin 1 beta Mus musculus 109-117 29665808-13 2018 Isoflurane activated NLRP3-caspase-1 pathway and increased the secretion of IL-18 and IL-1beta in cells pretreated with lipopolysaccharide but not in cells without pretreatment. Isoflurane 0-10 interleukin 1 beta Mus musculus 86-94 27061744-5 2016 Our results elucidate that MINO down-regulated the isoflurane-induced and surgery-induced enhancement in the protein levels of pro-inflammatory cytokine tumour necrosis factor alpha, interleukin (IL)-1beta, interferon-gamma and microglia marker Iba-1, and up-regulated protein levels of the anti-inflammatory cytokine IL-4 and IL-10. Isoflurane 51-61 interleukin 1 beta Mus musculus 183-205 27023766-11 2016 Mice anesthetized with isoflurane and sevoflurane showed thinner alveolar septa, lower VILI scores, lower polymorph neutrophil counts, and lower interleukin-1beta concentrations than ketamine mice. Isoflurane 23-33 interleukin 1 beta Mus musculus 145-162 26254234-8 2016 Our results showed that exploratory laparotomy with isoflurane anesthesia impaired the contextual fear memory, increased expression of Nox2, 8-OH-dG, CD11b, and IL-1beta, and down-regulated BDNF expression in the hippocampus at 7 d post-surgery. Isoflurane 52-62 interleukin 1 beta Mus musculus 161-169 25406893-5 2015 Mice subjected to isoflurane with laparotomy, compared with mice receiving isoflurane alone, had >2-fold upregulation of genes in inflammation (Osm, IL1rn, IL1b, and Csf1), oxidative stress (Hmox1), heat shock (Hspa1b), growth arrest (Cdkn1a), and DNA repair (Ugt1a2). Isoflurane 18-28 interleukin 1 beta Mus musculus 159-163 25406893-5 2015 Mice subjected to isoflurane with laparotomy, compared with mice receiving isoflurane alone, had >2-fold upregulation of genes in inflammation (Osm, IL1rn, IL1b, and Csf1), oxidative stress (Hmox1), heat shock (Hspa1b), growth arrest (Cdkn1a), and DNA repair (Ugt1a2). Isoflurane 75-85 interleukin 1 beta Mus musculus 159-163 24084689-8 2014 Isoflurane significantly inhibited both brain injury (P<0.001, respectively) and inflammation (myeloperoxidase, P=0.022; interleukin-1beta, P=0.002; TNF-alpha, P=0.015; P-selectin, P=0.010; ICAM-1, P=0.016; p-JNK, P<0.001; cyclooxygenase-2, P=0.003, respectively). Isoflurane 0-10 interleukin 1 beta Mus musculus 124-141 25553444-5 2015 Furthermore, mice overexpressing miR-155 had higher levels of TNF-alpha and IL-1 beta in BALF when exposed to isoflurane after LPS challenge.Conversely, downregulation of miR-155 promoted isoflurane effects on HIF-1 alpha expression. Isoflurane 110-120 interleukin 1 beta Mus musculus 76-85 25553444-5 2015 Furthermore, mice overexpressing miR-155 had higher levels of TNF-alpha and IL-1 beta in BALF when exposed to isoflurane after LPS challenge.Conversely, downregulation of miR-155 promoted isoflurane effects on HIF-1 alpha expression. Isoflurane 188-198 interleukin 1 beta Mus musculus 76-85 25147596-5 2014 ISO also reduced the production of tumor necrosis factor-alpha, interleukin-1beta, IL-6, high-mobility group box-1, macrophage inflammatory protein-1alpha, macrophage inflammatory protein-2, and monocyte chemoattractant protein-1 as assessed by enzyme-linked immunosorbent assays. Isoflurane 0-3 interleukin 1 beta Mus musculus 64-81 24349401-9 2013 In the mouse experiments, LPS was injected intraperitoneally, and isoflurane suppressed IL-1beta in the brain and adrenocorticotropic hormone in plasma, but not IL-1beta in plasma. Isoflurane 66-76 interleukin 1 beta Mus musculus 88-96 19388896-0 2009 Isoflurane attenuates pulmonary interleukin-1beta and systemic tumor necrosis factor-alpha following mechanical ventilation in healthy mice. Isoflurane 0-10 interleukin 1 beta Mus musculus 32-49 21190757-0 2012 The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-alpha, IL-6, and IL-1beta. Isoflurane 26-36 interleukin 1 beta Mus musculus 94-102 21190757-3 2012 We therefore set out to determine the effects of the common anesthetic isoflurane on the levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-1beta, the proinflammatory cytokines, in vitro and in vivo, employing Western blot, immunohistochemistry, enzyme-linked immunosorbent assay (ELISA), and reverse transcriptase polymerase chain reaction (RT-PCR). Isoflurane 71-81 interleukin 1 beta Mus musculus 158-166 23251531-13 2012 Isoflurane also impaired the cognitive functions of 10-week old C57BL/6J mice and increased IL-1beta in their hippocampi. Isoflurane 0-10 interleukin 1 beta Mus musculus 92-100 21864548-2 2011 It has been shown that interleukin-1beta (IL-1beta) contributes to the cognitive impairment of mice after surgery and isoflurane anesthesia. Isoflurane 118-128 interleukin 1 beta Mus musculus 23-40 21864548-2 2011 It has been shown that interleukin-1beta (IL-1beta) contributes to the cognitive impairment of mice after surgery and isoflurane anesthesia. Isoflurane 118-128 interleukin 1 beta Mus musculus 42-50 19388896-13 2009 CONCLUSIONS: The present study is the first to show that isoflurane attenuates the pulmonary IL-1beta and systemic TNF-alpha response following MV in healthy mice. Isoflurane 57-67 interleukin 1 beta Mus musculus 93-101 21190757-4 2012 Here, we show that a clinically relevant isoflurane anesthesia increased the protein and messenger ribonucleic acid (mRNA) levels of TNF-alpha, IL-6, and IL-1beta in the brain tissues of mice. Isoflurane 41-51 interleukin 1 beta Mus musculus 154-162 17596528-6 2007 Mice subjected to renal IR under isoflurane anesthesia also showed a reduction in inflammation evidenced by a reduced renal influx of neutrophils and macrophages, reduced ICAM-1 expression, less upregulation of proinflammatory mRNAs (TNF-alpha, ICAM-1, KC, and IL-1beta) as well as reduced nuclear translocation of NF-kappaB 24 h after renal IR injury. Isoflurane 33-43 interleukin 1 beta Mus musculus 261-269 18441091-5 2008 Pulmonary inflammation was induced in male B6C3F1 mice by intratracheal administration of IL-1beta and TNF-alpha under isoflurane anesthesia. Isoflurane 119-129 interleukin 1 beta Mus musculus 90-98 17414419-10 2007 Renal cortices of isoflurane-treated mice had significantly reduced expression of intercellular adhesion molecule 1, TNF-alpha, and IL-1beta messenger RNA and showed less apoptosis. Isoflurane 18-28 interleukin 1 beta Mus musculus 132-140