PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22329685-2 2012 Hint1 activity is connected to lysyl-tRNA synthetase (LysRS), a member of the universal aminoacyl tRNA synthetase family that catalyzes specific aminoacylation of their cognate tRNAs, through an aminoacyl adenylate (aa-AMP) intermediate. aa-amp 216-222 histidine triad nucleotide binding protein 1 Homo sapiens 0-5 22329685-6 2012 Because Ap(4)A can result from condensation of other aa-AMP"s with ATP, the specificity of the Hint1 aa-AMP-hydrolysis activity is of interest. aa-amp 53-59 histidine triad nucleotide binding protein 1 Homo sapiens 95-100 22329685-7 2012 Here we show that Hint1 has broad specificity for adenylate hydrolysis, whose structural basis we revealed through high-resolution structures of Hint1 in complex with three different aa-AMP analogues. aa-amp 183-189 histidine triad nucleotide binding protein 1 Homo sapiens 18-23 22329685-7 2012 Here we show that Hint1 has broad specificity for adenylate hydrolysis, whose structural basis we revealed through high-resolution structures of Hint1 in complex with three different aa-AMP analogues. aa-amp 183-189 histidine triad nucleotide binding protein 1 Homo sapiens 145-150