PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20097249-6 2010 In vitro studies were performed using previously developed cell lines which overexpress hCES1 with both p-nitrophenyl acetate and d-MPH serving as known substrates. 4-nitrophenyl acetate 104-125 carboxylesterase 1 Homo sapiens 88-93 21540359-4 2011 With 4-nitrophenyl acetate (4-NPA) as the probe substrate, the K(m) values of recombinant CES1-b and CES2 matched those of human liver microsomes (HLM) and human intestinal microsomes (HIM) with approximately 200 and 180 muM, respectively. 4-nitrophenyl acetate 5-26 carboxylesterase 1 Homo sapiens 90-94 34142538-3 2021 In this work, the molecular mechanism of the hydrolysis reaction of para-nitrophenyl acetate in the active site of human carboxylesterase was determined using modern methods of molecular modeling. 4-nitrophenyl acetate 68-92 carboxylesterase 1 Homo sapiens 121-137 24141856-8 2014 Additionally, we screened a panel of therapeutic drugs and drugs of abuse to assess their inhibition of the hydrolysis of p-nitrophenyl acetate by recombinant CES1 and human liver microsomes. 4-nitrophenyl acetate 122-143 carboxylesterase 1 Homo sapiens 159-163 24751575-6 2014 We screened 542 chemicals for the inhibition potency toward hydrolase activities of p-nitrophenyl acetate by recombinant CES1, CES2, and AADAC. 4-nitrophenyl acetate 84-105 carboxylesterase 1 Homo sapiens 121-125