PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30653843-1	2019	OBJECTIVE: To assess the efficacy and safety of the anti-interleukin-1alpha/beta (anti-IL-1alpha/beta) dual variable domain immunoglobulin lutikizumab (ABT-981) in patients with knee osteoarthritis (OA) and evidence of synovitis.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	152-155	interleukin 1 alpha	Homo sapiens	57-75	
30653843-1	2019	OBJECTIVE: To assess the efficacy and safety of the anti-interleukin-1alpha/beta (anti-IL-1alpha/beta) dual variable domain immunoglobulin lutikizumab (ABT-981) in patients with knee osteoarthritis (OA) and evidence of synovitis.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	152-155	interleukin 1 alpha	Homo sapiens	87-96	
28964890-9	2017	ABT-981 significantly reduced absolute neutrophil count and serum concentrations of IL-1alpha/IL-1beta, high-sensitivity C-reactive protein, and matrix metalloproteinase (MMP)-derived type 1 collagen.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	0-3	interleukin 1 alpha	Homo sapiens	84-93	
27150261-3	2016	The aim of these studies was to evaluate the pharmacokinetics of ABT-981, a dual variable domain immunoglobulin (DVD-Ig) capable of simultaneously binding IL-1alpha and IL-1beta, in healthy subjects and patients with osteoarthritis of the knee.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	65-68	interleukin 1 alpha	Homo sapiens	155-164	
25764208-0	2015	Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig(TM)) molecule that specifically and potently neutralizes both IL-1alpha and IL-1beta.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	35-38	interleukin 1 alpha	Homo sapiens	152-161	
25764208-4	2015	Here, we describe the generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig) of the IgG1/k subtype that specifically and potently neutralizes IL-1alpha and IL-1beta.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	57-60	interleukin 1 alpha	Homo sapiens	178-187	
25764208-6	2015	ABT-981 specifically binds to IL-1alpha and IL-1beta, and is physically capable of binding 2 human IL-1alpha and 2 human IL-1beta molecules simultaneously.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	0-3	interleukin 1 alpha	Homo sapiens	30-39	
25764208-6	2015	ABT-981 specifically binds to IL-1alpha and IL-1beta, and is physically capable of binding 2 human IL-1alpha and 2 human IL-1beta molecules simultaneously.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	0-3	interleukin 1 alpha	Homo sapiens	99-108