PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18634893-3	2008	METHODS: The assay consisted of human liver microsomes and a cocktail of probe substrates metabolized by the five major CYP isoforms (tacrine for CYP1A2, diclofenac for CYP2C9, (S)-mephenytoin for CYP2C19, dextromethorphan for CYP2D6 and midazolam for CYP3A4).	Diclofenac	154-164	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	120-123	
18838506-1	2009	In vitro experiments were conducted to compare k(inact), K(I) and inactivation efficiency (k(inact)/K(I)) of cytochrome P450 (P450) 2C9 by tienilic acid and (+/-)-suprofen using (S)-flurbiprofen, diclofenac, and (S)-warfarin as reporter substrates.	Diclofenac	196-206	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	109-135	
16192110-9	2005	For the specific CYP inhibitors or substrates examined (furafylline, diclofenac, S(+)-mephenytoin, quinidine and troleandomycin), only diclofenac inhibited the formation of 4-OH valsartan.	Diclofenac	135-145	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	17-20	
18034666-1	2007	The nonsteroidal anti-inflammatory drug diclofenac is extensively metabolized by cytochrome P450 (CYP) enzymes, mainly by CYP2C9.	Diclofenac	40-50	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	81-96	
18034666-1	2007	The nonsteroidal anti-inflammatory drug diclofenac is extensively metabolized by cytochrome P450 (CYP) enzymes, mainly by CYP2C9.	Diclofenac	40-50	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	98-101	
18034666-2	2007	Our objective was to study the effect of voriconazole, a potent inhibitor of several CYP enzymes, on the pharmacokinetics of diclofenac.	Diclofenac	125-135	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	85-88	
18034666-10	2007	In conclusion, voriconazole increased exposure to diclofenac, probably mainly by inhibition of its cytochrome P450 (CYP)-mediated metabolism.	Diclofenac	50-60	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	99-114	
18034666-10	2007	In conclusion, voriconazole increased exposure to diclofenac, probably mainly by inhibition of its cytochrome P450 (CYP)-mediated metabolism.	Diclofenac	50-60	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	116-119	
34272716-3	2021	In evaluating a time-saving assay using diclofenac as the CYP2C9 probe substrate, a discrepancy was observed in which minimal inhibition was detected using diclofenac whereas using (S)-warfarin resulted in potent inhibition, supporting the presence of dual-binding sites in the relatively large CYP2C9 active site cavity.These observations provided further insights into explaining the reported ineffective inactivation of CYP2C9 for the pan-CYP inactivator 1-aminobenzotriazole (ABT).	Diclofenac	40-50	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	442-445	
11037108-5	2000	Human CYP probe substrates used for characterization of mouse CYP activities included bufuralol, testosterone, dextromethorphan, phenacetin, diclofenac and S-mephenytoin.	Diclofenac	141-151	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	6-9	
32279279-3	2020	METHODS: The activity of these enzymes was determined by the following CYP-specific reactions: caffeine 3-N-demethylation/CYP1A2, diclofenac 4"-hydroxylation/CYP2C9, perazine N-demethylation/CYP2C19, bufuralol 1"-hydroxylation/CYP2D6 and testosterone 6beta-hydroxylation/CYP3A4, respectively, using HPLC.	Diclofenac	130-140	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	71-74	
32941854-7	2020	CYP activities were measured in the incubation medium using the CYP-specific reactions: caffeine 3-N-demethylation (CYP1A1/2), diclofenac 4"-hydroxylation (CYP2C9), perazine N-demethylation (CYP2C19) and testosterone 6beta-hydroxylation (CYP3A4).	Diclofenac	127-137	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-3	
28960974-5	2017	We pinpointed numerous reactive cysteines as the targets of RMs of diclofenac, including the active (heme-binding) sites on several key CYP450 isoforms (1A2, 2E1 and 3A4 for human, 2C39 and 3A11 for mouse).	Diclofenac	67-77	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	136-142	
27747722-10	2015	CONCLUSION: The close relationship between diclofenac and pantoprazole, and the cytochrome P450 and P-glycoprotein systems offers a strong indication that a drug interaction may be occurring.	Diclofenac	43-53	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	80-95	
26481538-4	2015	CYP isoenzyme activities were determined using the CYP-specific reactions: caffeine 3-N-demethylation (CYP1A2), diclofenac 4"-hydroxylation (CYP2C9), perazine N-demethylation (CYP2C19), bufuralol 1"-hydroxylation (CYP2D6) and testosterone 6beta-hydroxylation (CYP3A4).	Diclofenac	112-122	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-3	
26481538-4	2015	CYP isoenzyme activities were determined using the CYP-specific reactions: caffeine 3-N-demethylation (CYP1A2), diclofenac 4"-hydroxylation (CYP2C9), perazine N-demethylation (CYP2C19), bufuralol 1"-hydroxylation (CYP2D6) and testosterone 6beta-hydroxylation (CYP3A4).	Diclofenac	112-122	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	51-54	
32219694-4	2020	Activities of CYP enzymes were determined using the CYP-specific reactions: caffeine 3-N-demethylation (CYP1A2), diclofenac 4"-hydroxylation (CYP2C9), perazine N-demethylation (CYP2C19), bufuralol 1"-hydroxylation (CYP2D6), and testosterone 6beta-hydroxylation (CYP3A4).	Diclofenac	113-123	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	14-17	
32219694-4	2020	Activities of CYP enzymes were determined using the CYP-specific reactions: caffeine 3-N-demethylation (CYP1A2), diclofenac 4"-hydroxylation (CYP2C9), perazine N-demethylation (CYP2C19), bufuralol 1"-hydroxylation (CYP2D6), and testosterone 6beta-hydroxylation (CYP3A4).	Diclofenac	113-123	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	52-55