PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2789072-0 1989 Effect of diclofenac on prostaglandin E and hyaluronic acid production by human synovial fibroblasts stimulated with interleukin-1. Diclofenac 10-20 interleukin 1 alpha Homo sapiens 117-130 2512925-0 1989 Inhibitory effects of diclofenac and indomethacin on interleukin-1-induced changes in PGE2 release. Diclofenac 22-32 interleukin 1 alpha Homo sapiens 53-66 2512925-2 1989 The inhibitory effects of two non-steroidal anti-inflammatory drugs (NSAIDS), diclofenac and indomethacin, on interleukin-1 (IL-1)-induced changes in arachidonic acid (AA) release and prostaglandin E2(PGE2) production by human synovial cells was investigated. Diclofenac 78-88 interleukin 1 alpha Homo sapiens 110-123 2512925-3 1989 Both diclofenac and indomethacin potently inhibited IL-1 alpha-induced PGE2 release, with IC50 values of 1.6 +/- 0.02 nM and 5.5 +/- 0.1 nM, respectively. Diclofenac 5-15 interleukin 1 alpha Homo sapiens 52-62 2512925-8 1989 These results suggest that whilst at nanomolar concentrations, diclofenac and indomethacin can inhibit IL-1 alpha-induced PGE2 output, at micromolar concentrations an effect on free AA levels is also evident. Diclofenac 63-73 interleukin 1 alpha Homo sapiens 103-113