PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31770578-4 2020 While the mechanism in unknown, we tested the effect of l-ornithine, since it is abundantly present in PT luminal fluid and can activate calcium-sensing receptor (CaSR), a GPCR, expressed in the PT luminal membrane. polyornithine 56-67 calcium sensing receptor Homo sapiens 163-167 31770578-5 2020 We used human kidney 2 (HK-2) cells, a PT cells line, and performed Ca2+ imaging and electrophysiological experiments to show that l-ornithine has a concentration-dependent effect on CaSR activation. polyornithine 131-142 calcium sensing receptor Homo sapiens 183-187 31770578-9 2020 Moreover, l-ornithine-activation of CaSR can reverse ROS production and apoptosis via mitogen-activated protein kinase p38 activation. polyornithine 10-21 calcium sensing receptor Homo sapiens 36-40