PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25921248-0	2015	Deoxycytidine-kinase knockdown as a novel myeloprotective strategy in the context of fludarabine, cytarabine or cladribine therapy.	fludarabine	85-96	deoxycytidine kinase	Homo sapiens	0-20	
27280468-0	2016	Targeted Delivery of Deoxycytidine Kinase to Her2-Positive Cells Enhances the Efficacy of the Nucleoside Analog Fludarabine.	fludarabine	112-123	deoxycytidine kinase	Homo sapiens	21-41	
24972933-0	2014	Downregulation of deoxycytidine kinase in cytarabine-resistant mantle cell lymphoma cells confers cross-resistance to nucleoside analogs gemcitabine, fludarabine and cladribine, but not to other classes of anti-lymphoma agents.	fludarabine	150-161	deoxycytidine kinase	Homo sapiens	18-38	
3335008-1	1988	Previous studies have indicated that deoxycytidine kinase (dCK) is requisite and rate limiting in the phosphorylation of 1-beta-D-arabinofuranosylcytosine (ara-C) and 9-beta-D-arabinofuranosyl-2-fluoroadenine (F-ara-A) on the pathway to their respective cytotoxic 5"-triphosphates.	fludarabine	167-208	deoxycytidine kinase	Homo sapiens	37-57	
21030078-0	2011	Relationship between deoxycytidine kinase (DCK) genotypic variants and fludarabine toxicity in patients with follicular lymphoma.	fludarabine	71-82	deoxycytidine kinase	Homo sapiens	21-41	
21030078-0	2011	Relationship between deoxycytidine kinase (DCK) genotypic variants and fludarabine toxicity in patients with follicular lymphoma.	fludarabine	71-82	deoxycytidine kinase	Homo sapiens	43-46	
21030078-1	2011	DCK catalyzes the intracellular phosphorylation of fludarabine.	fludarabine	51-62	deoxycytidine kinase	Homo sapiens	0-3	
21030078-2	2011	The promoter and coding region of the DCK gene were analyzed in 74 follicular lymphoma (FL) patients receiving a therapeutic regimen that included fludarabine.	fludarabine	147-158	deoxycytidine kinase	Homo sapiens	38-41	
16436271-1	2006	Deoxycytidine kinase (dCK) and deoxyguanosine kinase (dGK) catalyze the first step in the intracellular cascade of fludarabine (2-fluoroadenine-beta-D-arabinofuranoside) and cladribine (2-chlorodeoxyadenosine) phosphorylation, which leads to activation of these prodrugs, commonly used for treatment of chronic lymphocytic leukemia (CLL).	fludarabine	115-126	deoxycytidine kinase	Homo sapiens	0-20	
12504799-0	2003	Down-regulation of deoxycytidine kinase in human leukemic cell lines resistant to cladribine and clofarabine and increased ribonucleotide reductase activity contributes to fludarabine resistance.	fludarabine	172-183	deoxycytidine kinase	Homo sapiens	19-39	
11463492-2	2001	Recent studies have suggested that dGK in addition to deoxycytidine kinase phosphorylates several anti-cancer agents, such as 9-beta-D-arabinofuranosylguanine (Ara-G), cladribine (CdA), and fludarabine.	fludarabine	190-201	deoxycytidine kinase	Homo sapiens	54-74	
20137114-0	2010	[Correlation of deoxycytidine kinase gene expression with fludarabine resistance in patients with chronic lymphocytic leukemia].	fludarabine	58-69	deoxycytidine kinase	Homo sapiens	16-36	
20137114-1	2010	The study was purposed to explore the relationship between the expression of deoxycytidine kinase (dCK) gene and fludarabine (Flud) resistance in patients with chronic lymphocytic leukemia (CLL).	fludarabine	113-124	deoxycytidine kinase	Homo sapiens	77-97	
20137114-1	2010	The study was purposed to explore the relationship between the expression of deoxycytidine kinase (dCK) gene and fludarabine (Flud) resistance in patients with chronic lymphocytic leukemia (CLL).	fludarabine	126-130	deoxycytidine kinase	Homo sapiens	77-97	
11135355-3	2000	Interaction between fludarabine or cladribine with deoxycytidine kinase results in a significant enhancement of the activity of cytarabine.	fludarabine	20-31	deoxycytidine kinase	Homo sapiens	51-71	
10444166-5	1999	In addition a deletion in one of the alleles of the deoxycytidine kinase was detected in the fludarabine-resistant line.	fludarabine	93-104	deoxycytidine kinase	Homo sapiens	52-72	
9145844-5	1997	Thymidine and fludarabine, which are agents that enhance the activity of deoxycytidine kinase, were tested in strategies for increasing the cellular content of 3TC 5"-phosphates.	fludarabine	14-25	deoxycytidine kinase	Homo sapiens	73-93	
3335008-1	1988	Previous studies have indicated that deoxycytidine kinase (dCK) is requisite and rate limiting in the phosphorylation of 1-beta-D-arabinofuranosylcytosine (ara-C) and 9-beta-D-arabinofuranosyl-2-fluoroadenine (F-ara-A) on the pathway to their respective cytotoxic 5"-triphosphates.	fludarabine	210-217	deoxycytidine kinase	Homo sapiens	37-57