PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28701757-10	2017	Elimination of IDO1 by fludarabine enhanced antitumour responses.	fludarabine	23-34	indoleamine 2,3-dioxygenase 1	Homo sapiens	15-19	
25940712-8	2015	Finally, we found that fludarabine and cyclophosphamide, frequently used before CART administration, downregulated IDO expression in lymphoma cells and improved the antitumor activity of CD19-CART in vivo.	fludarabine	23-34	indoleamine 2,3-dioxygenase 1	Homo sapiens	115-118	
24911872-0	2014	Fludarabine downregulates indoleamine 2,3-dioxygenase in tumors via a proteasome-mediated degradation mechanism.	fludarabine	0-11	indoleamine 2,3-dioxygenase 1	Homo sapiens	26-53	
24911872-6	2014	Interestingly, fludarabine was efficient in suppressing protein expression and consequently IDO activity in two different cell lines derived from breast cancer and melanoma when IDO was activated with interferon-gamma (IFN-gamma) or supernatants prepared from activated T lymphocytes.	fludarabine	15-26	indoleamine 2,3-dioxygenase 1	Homo sapiens	92-95	
24911872-6	2014	Interestingly, fludarabine was efficient in suppressing protein expression and consequently IDO activity in two different cell lines derived from breast cancer and melanoma when IDO was activated with interferon-gamma (IFN-gamma) or supernatants prepared from activated T lymphocytes.	fludarabine	15-26	indoleamine 2,3-dioxygenase 1	Homo sapiens	178-181	
24911872-10	2014	Strikingly, we have found that the inhibition of proteasome partially protected IDO from fludarabine-induced degradation, indicating that fludarabine induces IDO degradation through a proteasome-dependent pathway.	fludarabine	89-100	indoleamine 2,3-dioxygenase 1	Homo sapiens	80-83	
24911872-10	2014	Strikingly, we have found that the inhibition of proteasome partially protected IDO from fludarabine-induced degradation, indicating that fludarabine induces IDO degradation through a proteasome-dependent pathway.	fludarabine	89-100	indoleamine 2,3-dioxygenase 1	Homo sapiens	158-161	
24911872-10	2014	Strikingly, we have found that the inhibition of proteasome partially protected IDO from fludarabine-induced degradation, indicating that fludarabine induces IDO degradation through a proteasome-dependent pathway.	fludarabine	138-149	indoleamine 2,3-dioxygenase 1	Homo sapiens	80-83	
24911872-10	2014	Strikingly, we have found that the inhibition of proteasome partially protected IDO from fludarabine-induced degradation, indicating that fludarabine induces IDO degradation through a proteasome-dependent pathway.	fludarabine	138-149	indoleamine 2,3-dioxygenase 1	Homo sapiens	158-161	
24911872-11	2014	Currently used in the clinic to treat some malignancies, fludarabine has the potential for use in the treatment of human tumors through induction of IDO degradation and consequently, for the promotion of T cell-mediated anti-tumor response.	fludarabine	57-68	indoleamine 2,3-dioxygenase 1	Homo sapiens	149-152	
20435158-5	2010	Meanwhile, fludarabine, an inhibitor of STAT1 activation, blocked IFN-gamma-mediated IDO expression.	fludarabine	11-22	indoleamine 2,3-dioxygenase 1	Homo sapiens	85-88