PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12802926-6 2003 In the current literature we found case reports of only 6 patients with H-RS who were treated with fludarabine (FA) before transformation, and, to our knowledge the presented patient is the first to develop H-RS after treatment with 2-CdA combined with cyclophosphamide. fludarabine 99-110 cytidine deaminase Homo sapiens 235-238 22490700-5 2012 Here, we show that the S74E mutation increased the k(cat) for cladribine (CdA) by 8- or 3-fold, depending on whether the phosphoryl donor was ATP or UTP, for clofarabine (CAFdA) by about 2-fold with both ATP and UTP, and for fludarabine (F-Ara-A) by 2-fold, but only with UTP. fludarabine 225-236 cytidine deaminase Homo sapiens 74-77 22490700-5 2012 Here, we show that the S74E mutation increased the k(cat) for cladribine (CdA) by 8- or 3-fold, depending on whether the phosphoryl donor was ATP or UTP, for clofarabine (CAFdA) by about 2-fold with both ATP and UTP, and for fludarabine (F-Ara-A) by 2-fold, but only with UTP. fludarabine 238-245 cytidine deaminase Homo sapiens 74-77 11999570-11 2002 Our observations suggest that in WM patients resistant to 2-CdA, stabilization of the disease or even remission can be obtained with fludarabine. fludarabine 133-144 cytidine deaminase Homo sapiens 60-63 12688323-5 2003 Fludarabin, cisplatin, etoposide and 2-CdA also induced ladder-type fragmentation of DNA, endonuclease activity in a Tunel assay, and electron microscopic signs of apoptosis in HMC-1 cells. fludarabine 0-10 cytidine deaminase Homo sapiens 39-42 12691305-9 2003 After the use of CsA in combination with either the highest concentrations of 2-CdA or F-ara-A, statistically significant differences compared with CsA used alone were observed (p = 0.008, p = 0.03 for CsA with 2-CdA, and p = 0.0007, p = 0.005 for CsA with F-ara-A, respectively, for normal and CML CFU-GM). fludarabine 87-94 cytidine deaminase Homo sapiens 213-216 10719048-1 2000 WSU-CLL cells, a fludarabine resistant B-cell chronic lymphocytic leukemia cell line, has been shown to exhibit enhanced sensitivity to 2-chlorodeoxyadenosine (2-CdA) following 48-72 h exposure to bryostatin 1. fludarabine 17-28 cytidine deaminase Homo sapiens 162-165 11463492-2 2001 Recent studies have suggested that dGK in addition to deoxycytidine kinase phosphorylates several anti-cancer agents, such as 9-beta-D-arabinofuranosylguanine (Ara-G), cladribine (CdA), and fludarabine. fludarabine 190-201 cytidine deaminase Homo sapiens 180-183 8684013-0 1996 2-Chlorodeoxyadenosine (2-CdA) in chronic lymphocytic leukemia refractory to fludarabine? fludarabine 77-88 cytidine deaminase Homo sapiens 26-29 9010576-12 1996 Whether or not cross-resistance occurs among the purine analogs has not been fully determined, but occasional patients with disease refractory to fludarabine have responded to 2-CdA. fludarabine 146-157 cytidine deaminase Homo sapiens 178-181 10606241-10 1999 The HL60/CdA cells showed cross-resistance to 2-chloro-2"-arabino-fluoro-2"-deoxyadenosine, Fara-A, arabinofuranosyl cytosine, difluorodeoxyguanosine, and difluorodeoxycytidine toxicity, most likely because of the decreased phosphorylation of these analogues by dCK. fludarabine 92-98 cytidine deaminase Homo sapiens 9-12 9178834-1 1997 The purine analogs fludarabine (FAMP) and 2-chlorodeoxyadenosine (2-CDA) are highly active in chronic lymphocytic leukemia (CLL). fludarabine 19-30 cytidine deaminase Homo sapiens 68-71 9020373-10 1997 In conclusion, treatment with 2-CdA in heavily pretreated patients with chronic lymphoproliferative disorders is well tolerated and obtains high response rates, even in patients relapsed after treatment with fludarabine. fludarabine 208-219 cytidine deaminase Homo sapiens 32-35 8767527-8 1996 Concerning 2-CDA and FAMP cross-resistance, out of 61 samples resistant to 2-CDA, 29.5% were sensitive to FAMP. fludarabine 21-25 cytidine deaminase Homo sapiens 77-80 8767527-8 1996 Concerning 2-CDA and FAMP cross-resistance, out of 61 samples resistant to 2-CDA, 29.5% were sensitive to FAMP. fludarabine 106-110 cytidine deaminase Homo sapiens 77-80 8767527-9 1996 Conversely, 13.9% out of 43 samples resistant to FAMP were sensitive to 2-CDA. fludarabine 49-53 cytidine deaminase Homo sapiens 74-77