PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12802926-6	2003	In the current literature we found case reports of only 6 patients with H-RS who were treated with fludarabine (FA) before transformation, and, to our knowledge the presented patient is the first to develop H-RS after treatment with 2-CdA combined with cyclophosphamide.	fludarabine	99-110	cytidine deaminase	Homo sapiens	235-238	
22490700-5	2012	Here, we show that the S74E mutation increased the k(cat) for cladribine (CdA) by 8- or 3-fold, depending on whether the phosphoryl donor was ATP or UTP, for clofarabine (CAFdA) by about 2-fold with both ATP and UTP, and for fludarabine (F-Ara-A) by 2-fold, but only with UTP.	fludarabine	225-236	cytidine deaminase	Homo sapiens	74-77	
22490700-5	2012	Here, we show that the S74E mutation increased the k(cat) for cladribine (CdA) by 8- or 3-fold, depending on whether the phosphoryl donor was ATP or UTP, for clofarabine (CAFdA) by about 2-fold with both ATP and UTP, and for fludarabine (F-Ara-A) by 2-fold, but only with UTP.	fludarabine	238-245	cytidine deaminase	Homo sapiens	74-77	
12691305-9	2003	After the use of CsA in combination with either the highest concentrations of 2-CdA or F-ara-A, statistically significant differences compared with CsA used alone were observed (p = 0.008, p = 0.03 for CsA with 2-CdA, and p = 0.0007, p = 0.005 for CsA with F-ara-A, respectively, for normal and CML CFU-GM).	fludarabine	87-94	cytidine deaminase	Homo sapiens	213-216	
12688323-5	2003	Fludarabin, cisplatin, etoposide and 2-CdA also induced ladder-type fragmentation of DNA, endonuclease activity in a Tunel assay, and electron microscopic signs of apoptosis in HMC-1 cells.	fludarabine	0-10	cytidine deaminase	Homo sapiens	39-42	
10606241-10	1999	The HL60/CdA cells showed cross-resistance to 2-chloro-2"-arabino-fluoro-2"-deoxyadenosine, Fara-A, arabinofuranosyl cytosine, difluorodeoxyguanosine, and difluorodeoxycytidine toxicity, most likely because of the decreased phosphorylation of these analogues by dCK.	fludarabine	92-98	cytidine deaminase	Homo sapiens	9-12	
11999570-11	2002	Our observations suggest that in WM patients resistant to 2-CdA, stabilization of the disease or even remission can be obtained with fludarabine.	fludarabine	133-144	cytidine deaminase	Homo sapiens	60-63	
11463492-2	2001	Recent studies have suggested that dGK in addition to deoxycytidine kinase phosphorylates several anti-cancer agents, such as 9-beta-D-arabinofuranosylguanine (Ara-G), cladribine (CdA), and fludarabine.	fludarabine	190-201	cytidine deaminase	Homo sapiens	180-183	
10719048-1	2000	WSU-CLL cells, a fludarabine resistant B-cell chronic lymphocytic leukemia cell line, has been shown to exhibit enhanced sensitivity to 2-chlorodeoxyadenosine (2-CdA) following 48-72 h exposure to bryostatin 1.	fludarabine	17-28	cytidine deaminase	Homo sapiens	162-165	
9020373-10	1997	In conclusion, treatment with 2-CdA in heavily pretreated patients with chronic lymphoproliferative disorders is well tolerated and obtains high response rates, even in patients relapsed after treatment with fludarabine.	fludarabine	208-219	cytidine deaminase	Homo sapiens	32-35	
9178834-1	1997	The purine analogs fludarabine (FAMP) and 2-chlorodeoxyadenosine (2-CDA) are highly active in chronic lymphocytic leukemia (CLL).	fludarabine	19-30	cytidine deaminase	Homo sapiens	68-71	
8684013-0	1996	2-Chlorodeoxyadenosine (2-CdA) in chronic lymphocytic leukemia refractory to fludarabine?	fludarabine	77-88	cytidine deaminase	Homo sapiens	26-29	
8767527-8	1996	Concerning 2-CDA and FAMP cross-resistance, out of 61 samples resistant to 2-CDA, 29.5% were sensitive to FAMP.	fludarabine	21-25	cytidine deaminase	Homo sapiens	77-80	
8767527-8	1996	Concerning 2-CDA and FAMP cross-resistance, out of 61 samples resistant to 2-CDA, 29.5% were sensitive to FAMP.	fludarabine	106-110	cytidine deaminase	Homo sapiens	77-80	
8767527-9	1996	Conversely, 13.9% out of 43 samples resistant to FAMP were sensitive to 2-CDA.	fludarabine	49-53	cytidine deaminase	Homo sapiens	74-77	
9010576-12	1996	Whether or not cross-resistance occurs among the purine analogs has not been fully determined, but occasional patients with disease refractory to fludarabine have responded to 2-CdA.	fludarabine	146-157	cytidine deaminase	Homo sapiens	178-181