PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25268149-9 2016 The level of the tumor suppressor protein p53 in HeLa cells increased significantly upon treatment with free epirubicin, but remained relatively unchanged when cells were treated with equivalent dose of nanoparticle-loaded drug, suggesting a possible shift from p53-dependent DNA/RNA intercalation-based induction of cytotoxicity by free epirubicin to a caspase 3-induced cell death by the epirubicin-loaded PBCA formulation. Enbucrilate 408-412 tumor protein p53 Homo sapiens 42-45