PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1961720-5 1991 This enhancer operates in HepG2 and Hep3B cells, but not in Chinese hamster ovary cells or mouse erythroleukemia cells, and responds to cobalt but not to cyanide or 2-deoxyglucose, thus reflecting the physiological control of erythropoietin production accurately. Cobalt 136-142 erythropoietin Mus musculus 226-240 1289180-2 1992 Since it has been demonstrated that cobalt (Co) treatment rises renal EPO-mRNA and increases plasma EPO levels, the present study was conducted to determine whether there is a difference between PH and HT mice in relation to the erythropoietic response to Co and whether the stimulatory effect of Co on EPO secretion can be blunted by polycythemia. Cobalt 36-47 erythropoietin Mus musculus 70-73 1289180-2 1992 Since it has been demonstrated that cobalt (Co) treatment rises renal EPO-mRNA and increases plasma EPO levels, the present study was conducted to determine whether there is a difference between PH and HT mice in relation to the erythropoietic response to Co and whether the stimulatory effect of Co on EPO secretion can be blunted by polycythemia. Cobalt 36-47 erythropoietin Mus musculus 100-103 1289180-2 1992 Since it has been demonstrated that cobalt (Co) treatment rises renal EPO-mRNA and increases plasma EPO levels, the present study was conducted to determine whether there is a difference between PH and HT mice in relation to the erythropoietic response to Co and whether the stimulatory effect of Co on EPO secretion can be blunted by polycythemia. Cobalt 36-47 erythropoietin Mus musculus 100-103 163577-3 1975 In addition, cobalt increases the activity of an erythropoietin-generating enzyme (renal erythropoietic factor) with maximal enzyme activity occurring after the rise in cyclic AMP levels but before the increase in erythropoietin titers. Cobalt 13-19 erythropoietin Mus musculus 49-63 2387842-7 1990 These results suggest that the ribonucleoprotein containing the down-regulated RNA species may be a negative transcriptional factor and that activation of the erythropoietin gene by cobalt salts may involve, in part, decreased binding of this factor, thus allowing transcription to proceed. Cobalt 182-194 erythropoietin Mus musculus 159-173 163577-3 1975 In addition, cobalt increases the activity of an erythropoietin-generating enzyme (renal erythropoietic factor) with maximal enzyme activity occurring after the rise in cyclic AMP levels but before the increase in erythropoietin titers. Cobalt 13-19 erythropoietin Mus musculus 214-228 163577-9 1975 These results suggest that cyclic AMP plays a significant role in the renal production of erythropoietin following cobalt administration. Cobalt 115-121 erythropoietin Mus musculus 90-104 29887316-4 2018 EPO production was suppressed by palmitate (palmitate-conjugated bovine serum albumin [BSA]) or a high palmitate diet, but not oleic acid-conjugated BSA or a high oleic acid diet, especially under cobalt-induced pseudo-hypoxia both in vitro and in vivo. Cobalt 197-203 erythropoietin Mus musculus 0-3