PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9593123-1	1998	A TEM-1 beta-lactamase derivative containing the single amino acid substitution A237T slightly increased (from 24 to 32 microg/ml) the cephalothin MIC for Escherichia coli RYC1000 but did not influence the activities of cefotaxime, ceftazidime, and aztreonam (MICs of 0.03, 0.12, and 0.06 microg/ml, respectively).	Ceftazidime	232-243	TEM-1 beta-lactamase	Escherichia coli	2-22	
8067751-0	1994	Reversal of clavulanate resistance conferred by a Ser-244 mutant of TEM-1 beta-lactamase as a result of a second mutation (Arg to Ser at position 164) that enhances activity against ceftazidime.	Ceftazidime	182-193	TEM-1 beta-lactamase	Escherichia coli	68-88	
8067751-2	1994	The Arg-164-->Ser mutation in the TEM-1 beta-lactamase (TEM-12 enzyme) is known to enhance the activity of the enzyme against ceftazidime, resulting in resistance to the drug in a strain producing the mutant enzyme (D. A. Weber, C. C. Sanders, J. S. Bakken, and J. P. Quinn, J. Infect.	Ceftazidime	129-140	TEM-1 beta-lactamase	Escherichia coli	37-57	
2676935-0	1989	Mutants of the TEM-1 beta-lactamase conferring resistance to ceftazidime.	Ceftazidime	61-72	TEM-1 beta-lactamase	Escherichia coli	15-35	
2676935-1	1989	Spontaneous ceftazidime resistant mutants were obtained from an Escherichia coli K12 J62-2 expressing the TEM-1 beta-lactamase (mutation frequency = 10(-9).	Ceftazidime	12-23	TEM-1 beta-lactamase	Escherichia coli	106-126