PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23085266-0 2013 Zymosan induces NADPH oxidase activation in human neutrophils by inducing the phosphorylation of p47phox and the activation of Rac2: involvement of protein tyrosine kinases, PI3Kinase, PKC, ERK1/2 and p38MAPkinase. Zymosan 0-7 proline rich transmembrane protein 2 Homo sapiens 185-188 23085266-12 2013 These results show that zymosan alone is able to activate NADPH oxidase in human neutrophils via the phosphorylation of p47phox and Rac2 activation and that a protein tyrosine kinase, PI3Kinase, p38MAPK, ERK1/2 and PKC are involved in this process. Zymosan 24-31 proline rich transmembrane protein 2 Homo sapiens 215-218 8490103-5 1993 The results indicate that inhibition of PKC diminished LPS- or zymosan- induced TNF alpha production in a concentration-dependent manner. Zymosan 63-70 proline rich transmembrane protein 2 Homo sapiens 40-43 8034717-5 1994 Inhibition of PKC with the inhibitor, bisindolylmaleimide (GF109203X), or by prolonged exposure to PMA suppressed both arachidonic acid release and MAP kinase activation in PMA- and zymosan-stimulated macrophages but not in okadaic acid or A23187-treated cells. Zymosan 182-189 proline rich transmembrane protein 2 Homo sapiens 14-17 8034717-8 1994 The results demonstrate that PMA and zymosan trigger PKC activation that leads to the activation of MAP kinase and PLA2, whereas these responses are PKC independent in okadaic acid-treated cells. Zymosan 37-44 proline rich transmembrane protein 2 Homo sapiens 53-56 8490103-3 1993 In the present study, the role of protein kinase C (PKC) in the production of TNF alpha was investigated in human peripheral blood monocytes stimulated with either LPS or zymosan. Zymosan 171-178 proline rich transmembrane protein 2 Homo sapiens 34-50 8490103-3 1993 In the present study, the role of protein kinase C (PKC) in the production of TNF alpha was investigated in human peripheral blood monocytes stimulated with either LPS or zymosan. Zymosan 171-178 proline rich transmembrane protein 2 Homo sapiens 52-55 7561526-2 1995 In the present study, the involvement of Ca(2+)-, PKC-, and pH-dependent processes in the signaling to macrophage lysosomal secretion by zymosan was investigated. Zymosan 137-144 proline rich transmembrane protein 2 Homo sapiens 50-53 7561526-9 1995 This is of likely relevance for the secretory response to zymosan particles, a stimulus that both activates PKC and elevates lysosomal pH. Zymosan 58-65 proline rich transmembrane protein 2 Homo sapiens 108-111 8093086-2 1994 First, the PKC-activity was induced by phorbol 12-myristate 13-acetate (PMA) before the stimulation of Ca2+-signal with N-formyl-methionyl-leucyl-phenylalanine and serum-opsonized zymosan particles. Zymosan 180-187 proline rich transmembrane protein 2 Homo sapiens 11-14 8490103-8 1993 LPS and zymosan also induced an increase in membrane associated PKC activity in human monocytes, which could be inhibited by pretreatment of the cells with calphostin C. Finally, western blot analysis with PKC isoform-specific antibodies demonstrates that the alpha and xi are the predominent isoforms expressed in human monocytes. Zymosan 8-15 proline rich transmembrane protein 2 Homo sapiens 64-67 8490103-8 1993 LPS and zymosan also induced an increase in membrane associated PKC activity in human monocytes, which could be inhibited by pretreatment of the cells with calphostin C. Finally, western blot analysis with PKC isoform-specific antibodies demonstrates that the alpha and xi are the predominent isoforms expressed in human monocytes. Zymosan 8-15 proline rich transmembrane protein 2 Homo sapiens 206-209 8490103-9 1993 These data strongly suggest that an initial step in TNF alpha production by human monocytes challenged with physiological stimulants, such as LPS and zymosan, involves a PKC-dependent mechanism. Zymosan 150-157 proline rich transmembrane protein 2 Homo sapiens 170-173 1846746-6 1991 Sphingosine also blocked PAF synthesis in response to the calcium ionophore A23187 and opsonized zymosan particles by specific inhibition of PKC. Zymosan 97-104 proline rich transmembrane protein 2 Homo sapiens 141-144 1320039-5 1992 However, when PKC was depleted from unprimed BMM by prolonged (24 h) treatment with phorbol dibutyrate (PdBt) (10(-7) M) the ability of zymosan to induce the production of superoxide was greatly diminished. Zymosan 136-143 proline rich transmembrane protein 2 Homo sapiens 14-17 1320039-6 1992 Such a result could be interpreted as suggesting a role for PKC in the zymosan-induced response, a conclusion which contrasts with the inhibitor data. Zymosan 71-78 proline rich transmembrane protein 2 Homo sapiens 60-63 1846746-7 1991 Two other PKC inhibitors, stearylamine and staurosporine, also blocked PAF synthesis following A23187 or opsonized zymosan stimulation. Zymosan 115-122 proline rich transmembrane protein 2 Homo sapiens 10-13 1846746-8 1991 These experiments demonstrated that PKC activation was required for PAF synthesis in response to the calcium signal generated by A23187 or a receptor-mediated agonist, opsonized zymosan. Zymosan 178-185 proline rich transmembrane protein 2 Homo sapiens 36-39 3622775-1 1987 An immunocytochemical method was used to determine possible changes in the subcellular distribution of protein kinase C (PKC) in human neutrophils in response to opsonized latex beads and zymosan. Zymosan 188-195 proline rich transmembrane protein 2 Homo sapiens 103-119 3622775-1 1987 An immunocytochemical method was used to determine possible changes in the subcellular distribution of protein kinase C (PKC) in human neutrophils in response to opsonized latex beads and zymosan. Zymosan 188-195 proline rich transmembrane protein 2 Homo sapiens 121-124 3622775-2 1987 While in resting cells most of the PKC immunoreactivity was localized in the cytoplasm, a redistribution of PKC to the plasma and phagosomal membranes was observed in cells treated with latex beads or zymosan for 5-20 min, suggesting a participation of PKC in endocytosis. Zymosan 201-208 proline rich transmembrane protein 2 Homo sapiens 108-111 3622775-2 1987 While in resting cells most of the PKC immunoreactivity was localized in the cytoplasm, a redistribution of PKC to the plasma and phagosomal membranes was observed in cells treated with latex beads or zymosan for 5-20 min, suggesting a participation of PKC in endocytosis. Zymosan 201-208 proline rich transmembrane protein 2 Homo sapiens 108-111