PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19410299-5	2009	Zymosan enhanced dectin-1/TLR2/TLR4 expression and TNF-alpha/IL-10 production in all of three types of cell, whereas p-beta-glucan increased dectin-1/TLR4 and TNF-alpha/IL-12 production in AMs but inhibited IL-10 in mDCs.	Zymosan	0-7	interleukin 10	Homo sapiens	61-66	
20689730-2	2010	Peptidoglycan and mannan were strong stimuli in neutrophils, whereas the fungal extract zymosan was the most potent stimulus in monocyte-derived dendritic cells since it induced the production of PGE(2), PGD(2), and several cytokines including a robust IL-10 response.	Zymosan	88-95	interleukin 10	Homo sapiens	253-258	
20689730-5	2010	Therefore, in dendritic cells zymosan induces il10 transcription by a CRE-dependent mechanism that involves autocrine secretion of PGE(2), thus unraveling a functional cooperation between eicosanoid production and cytokine production.	Zymosan	30-37	interleukin 10	Homo sapiens	46-50	
19846883-6	2009	Zymosan also induced a rapid expression of cyclooxygenase-2 and the production of PGE(2) and IL-10.	Zymosan	0-7	interleukin 10	Homo sapiens	93-98	
19846883-7	2009	Addition of an anti-IL-10 neutralizing Ab or inhibitors of cyclooxygenase greatly reduced the ability of zymosan to down-regulate CysLT1 expression.	Zymosan	105-112	interleukin 10	Homo sapiens	20-25	
19846883-8	2009	Down-regulation of CysLT1 expression by zymosan could be reproduced by a combination of IL-10 and PGE(2), and was dependent on MAPK activation.	Zymosan	40-47	interleukin 10	Homo sapiens	88-93	
19564345-0	2009	The induction of IL-10 by zymosan in dendritic cells depends on CREB activation by the coactivators CREB-binding protein and TORC2 and autocrine PGE2.	Zymosan	26-33	interleukin 10	Homo sapiens	17-22	
19386697-5	2009	IL-10 is indeed able to protect these cell types in an in vitro model of complement lysis triggered by an anti-MHCI antibody or by binding of zymosan.	Zymosan	142-149	interleukin 10	Homo sapiens	0-5	
19564345-1	2009	Stimulation of human monocyte-derived dendritic cells with the yeast extract zymosan is characterized by a predominant production of IL-10 and a strong induction of cyclooxygenase-2, but the molecular mechanisms underlying this response are only partially understood.	Zymosan	77-84	interleukin 10	Homo sapiens	133-138	
11493622-6	2001	LPS, zymosan, and PMA caused marked and dose-dependent increases in TNF-alpha and IL-10 production.	Zymosan	5-12	interleukin 10	Homo sapiens	82-87	
16713974-2	2006	We report that IFN-gamma augments induction of TNFalpha by TLR ligands, immune complexes, and zymosan by suppressing IL-10 production and thereby interrupting Stat3-mediated feedback inhibition.	Zymosan	94-101	interleukin 10	Homo sapiens	117-122	
16251998-2	2006	We explored the capacity of targeted adenoviral expression of human or viral IL-10 to improve outcome in a zymosan-induced model of acute lung injury and multisystem organ failure.	Zymosan	107-114	interleukin 10	Homo sapiens	77-82	
15919371-1	2004	The virulence antigen (LcrV) of pathogenic yersiniae "silences" macrophages against stimulation with the TLR2-agonist zymosan A in a CD14/TLR2-dependent fashion via IL-10 induction.	Zymosan	118-127	interleukin 10	Homo sapiens	165-170	
16501050-8	2006	Zymosan induced the expression of tumor necrosis factor alpha (TNF-alpha), TNF-beta, IL-10, IL-6, and MCP-2/CCL8, whereas the cytokine signature of C3bi-coated zymosan also included interferon-inducible protein 10/CXC chemokine ligand 10, platelet-derived growth factor-BB, and I-309/CCL1.	Zymosan	0-7	interleukin 10	Homo sapiens	85-90	
11493622-8	2001	OX-RBC augmented LPS- and zymosan-induced IL-10 release by 400-600%.	Zymosan	26-33	interleukin 10	Homo sapiens	42-47	
10824456-7	2000	The amounts of drained TNF-alpha and IL-10 in the mesenteric lymph were significantly correlated with the dosage of zymosan.	Zymosan	116-123	interleukin 10	Homo sapiens	37-42	
11441115-5	2001	Pretreatment of mice with the intratracheal instillation of Ad expressing human IL-10 or viral IL-10 reduced weight loss, attenuated the proinflammatory cytokine response, and reduced mortality in the zymosan-induced model, whereas pretreatment with a control adenoviral recombinant did not significantly exacerbate the response.	Zymosan	201-208	interleukin 10	Homo sapiens	80-85	
11441115-5	2001	Pretreatment of mice with the intratracheal instillation of Ad expressing human IL-10 or viral IL-10 reduced weight loss, attenuated the proinflammatory cytokine response, and reduced mortality in the zymosan-induced model, whereas pretreatment with a control adenoviral recombinant did not significantly exacerbate the response.	Zymosan	201-208	interleukin 10	Homo sapiens	95-100	
25092526-8	2014	RESULTS: Mannan, beta-glucans (curdlan), chitosan, and zymosan induced the secretion of interleukin (IL)-1beta, IL-6, IL-23, IL-10, and tumor necrosis factor-alpha by PBMCs.	Zymosan	55-62	interleukin 10	Homo sapiens	125-130	
22560862-9	2012	A significant reduction in basal levels of IL-10 was observed in patients with poor glycemic control (HbA1c>8%) compared to patients with appropriate glycemic control (HbA1c<=6.5%) and healthy controls, an effect that was not observed in monocytes stimulated with zymosan.	Zymosan	270-277	interleukin 10	Homo sapiens	43-48	
21872333-0	2011	Apoptotic cells enhance IL-10 and reduce IL-23 production in human dendritic cells treated with zymosan.	Zymosan	96-103	interleukin 10	Homo sapiens	24-29	
21872333-3	2011	AC reduced the production of IL-23 and enhanced the production of IL-10 elicited by zymosan, but they did not influence IL-12 p70 production nor did they modify the effect of LPS.	Zymosan	84-91	interleukin 10	Homo sapiens	66-71	
21525379-5	2011	The purified PLT ectosomes (PLT-Ect) reduced the release of TNF-alpha and IL-10 by macrophages activated with LPS or zymosan A.	Zymosan	117-126	interleukin 10	Homo sapiens	74-79	
21420486-3	2011	We have found that IFN-beta suppressed IL-23 and IL-1beta production and increased IL-10 production by human dendritic cells (DC) activated with the TLR2 and dectin-1 agonist zymosan.	Zymosan	175-182	interleukin 10	Homo sapiens	83-88