PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21486701-5	2011	Furthermore, the GM-CSF secreted by zymosan-activated DCs enhanced IL-23 production, resulting in activation of a Th17 response.	Zymosan	36-43	interleukin 23 subunit alpha	Homo sapiens	67-72	
21872333-0	2011	Apoptotic cells enhance IL-10 and reduce IL-23 production in human dendritic cells treated with zymosan.	Zymosan	96-103	interleukin 23 subunit alpha	Homo sapiens	41-46	
21420486-5	2011	IFN-beta induced IL-27 expression by DC, and neutralisation of IL-27 abrogated the suppressive effects of IFN-beta on zymosan-induced IL-1 and IL-23 production and the generation of Th17 cells in vitro.	Zymosan	118-125	interleukin 23 subunit alpha	Homo sapiens	143-148	
19161420-4	2008	Mycobacterium tuberculosis and yeast zymosan induce IL-23, but in the absence of other stimuli, no IL-12 is induced in human dendritic cells (DCs).	Zymosan	37-44	interleukin 23 subunit alpha	Homo sapiens	52-57	
21402701-1	2011	The fungal analog zymosan induces IL-23 and low amounts of IL-12 p70.	Zymosan	18-25	interleukin 23 subunit alpha	Homo sapiens	34-39	
19161420-5	2008	The stimulation of IL-23 by M. tuberculosis was mostly explained by the triggering of Toll-like receptor (TLR2) and the cytoplasmic receptor nucleotide oligomerization domain (NOD)-containing protein 2, whereas zymosan induces IL-23 primarily by stimulating the beta-glucan receptor dectin-1 alone or in combination with TLR2.	Zymosan	211-218	interleukin 23 subunit alpha	Homo sapiens	19-24	
26673542-0	2016	Pharmacological inhibition of eicosanoids and platelet-activating factor signaling impairs zymosan-induced release of IL-23 by dendritic cells.	Zymosan	91-98	interleukin 23 subunit alpha	Homo sapiens	118-123	
18490488-2	2008	Mycobacterium tuberculosis H37Rv and zymosan preferentially induced IL-23.	Zymosan	37-44	interleukin 23 subunit alpha	Homo sapiens	68-73	
18490488-3	2008	IL-23 but not IL-12 was efficiently induced by the combination of nucleotide-binding oligodimerization domain and Toll-like receptor (TLR) 2 ligands, which mimics activation by M. tuberculosis, or by the human dectin-1 ligand beta-glucan alone or in combination with TLR2 ligands, mimicking induction by zymosan.	Zymosan	304-311	interleukin 23 subunit alpha	Homo sapiens	0-5	
26673542-3	2016	The combination of lipid mediators and the lipid extract of zymosan-conditioned medium increased the induction of IL23A by LPS (bacterial lipopolysaccharide), thus suggesting that unlike LPS, zymosan elicits the production of mediators at a concentration enough for optimal response.	Zymosan	60-67	interleukin 23 subunit alpha	Homo sapiens	114-119	
26673542-3	2016	The combination of lipid mediators and the lipid extract of zymosan-conditioned medium increased the induction of IL23A by LPS (bacterial lipopolysaccharide), thus suggesting that unlike LPS, zymosan elicits the production of mediators at a concentration enough for optimal response.	Zymosan	192-199	interleukin 23 subunit alpha	Homo sapiens	114-119	
24982422-5	2014	Assay of transcription factor binding to the il23a promoter showed an increase of Thr(P)-71-Thr(P)-69-activating transcription factor 2 (ATF2) binding in response to zymosan.	Zymosan	166-173	interleukin 23 subunit alpha	Homo sapiens	45-50	
26412948-6	2015	Our results demonstrated that PGE2 promoted zymosan-induced IL-23 production in a concentration dependent manner.	Zymosan	44-51	interleukin 23 subunit alpha	Homo sapiens	60-65	
26412948-8	2015	More importantly, ELISA data demonstrated that db-cAMP, a cAMP analog, and forskolin, an adenylate cyclase activator, can mimic the effect of PGE2 on zymosan-induced IL-23 production, and rp-cAMP, a protein kinase A (PKA) inhibitor, can block the effect of PGE2.	Zymosan	150-157	interleukin 23 subunit alpha	Homo sapiens	166-171	
26412948-9	2015	Moreover, PGE2 can increase zymosan-induced expression of the mRNA levels of both p19 and p40 subunits, which was mimicked by db-cAMP and forskolin.	Zymosan	28-35	interleukin 23 subunit alpha	Homo sapiens	82-85	
25092526-8	2014	RESULTS: Mannan, beta-glucans (curdlan), chitosan, and zymosan induced the secretion of interleukin (IL)-1beta, IL-6, IL-23, IL-10, and tumor necrosis factor-alpha by PBMCs.	Zymosan	55-62	interleukin 23 subunit alpha	Homo sapiens	118-123	
27889761-6	2016	RESULTS: Our results demonstrated that cilostazol suppressed zymosan-induced IL-23 protein production in a concentration dependent manner without affecting dendritic cell viability.	Zymosan	61-68	interleukin 23 subunit alpha	Homo sapiens	77-82	
24982422-9	2014	These data indicate the following: (i) zymosan decreases nuclear proapoptotic CHOP, most likely by promoting its accumulation in phagocytic vesicles; (ii) zymosan-induced il23a mRNA expression is best explained through coordinated kappaB- and ATF2-dependent transcription; and (iii) il23a expression relies on complementary phosphorylation of ATF2 on Thr-69 and Thr-71 dependent on PKC and MAPK activities.	Zymosan	39-46	interleukin 23 subunit alpha	Homo sapiens	171-176	
24982422-9	2014	These data indicate the following: (i) zymosan decreases nuclear proapoptotic CHOP, most likely by promoting its accumulation in phagocytic vesicles; (ii) zymosan-induced il23a mRNA expression is best explained through coordinated kappaB- and ATF2-dependent transcription; and (iii) il23a expression relies on complementary phosphorylation of ATF2 on Thr-69 and Thr-71 dependent on PKC and MAPK activities.	Zymosan	39-46	interleukin 23 subunit alpha	Homo sapiens	283-288	
24982422-9	2014	These data indicate the following: (i) zymosan decreases nuclear proapoptotic CHOP, most likely by promoting its accumulation in phagocytic vesicles; (ii) zymosan-induced il23a mRNA expression is best explained through coordinated kappaB- and ATF2-dependent transcription; and (iii) il23a expression relies on complementary phosphorylation of ATF2 on Thr-69 and Thr-71 dependent on PKC and MAPK activities.	Zymosan	155-162	interleukin 23 subunit alpha	Homo sapiens	171-176	
24982422-9	2014	These data indicate the following: (i) zymosan decreases nuclear proapoptotic CHOP, most likely by promoting its accumulation in phagocytic vesicles; (ii) zymosan-induced il23a mRNA expression is best explained through coordinated kappaB- and ATF2-dependent transcription; and (iii) il23a expression relies on complementary phosphorylation of ATF2 on Thr-69 and Thr-71 dependent on PKC and MAPK activities.	Zymosan	155-162	interleukin 23 subunit alpha	Homo sapiens	283-288