PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24369446-7	2013	Furthermore, ZY-induced nuclear translocation and DNA-binding activity of NF- kappa B p65 were also reduced by ISO.	Zymosan	13-15	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	74-85	
23438680-4	2013	Interestingly, we found that zymosan-induced production of MIP-2 was blocked by pre-treatment with U0126, an inhibitor of mitogen-activated protein kinase/extracellular-signal-regulated kinase (ERK), and with BAY11-7082, an inhibitor of nuclear factor (NF)-kappaB.	Zymosan	29-36	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	237-263	
11259437-3	2001	We demonstrated that activation of nuclear factor kappaB (NF-kappaB) is essential in zymosan A (a source of 1-->3-beta-glucans)-induced TNF-alpha production in macrophages (RAW264.7 cells).	Zymosan	85-94	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	58-67	
11259437-7	2001	Inhibition of NF-kappaB activation led to a dramatic reduction in both TNF-alpha promoter activity and TNF-alpha protein production in the response to zymosan A.	Zymosan	151-160	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	14-23	
11259437-8	2001	Mutation of a major NF-kappaB binding site (kappa3) in the gene promoter resulted in a significant decrease in the induction of the gene promoter by zymosan A, while mutation of Egr or CRE sites failed to inhibit the response to zymosan.	Zymosan	149-158	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	20-29	
11259437-8	2001	Mutation of a major NF-kappaB binding site (kappa3) in the gene promoter resulted in a significant decrease in the induction of the gene promoter by zymosan A, while mutation of Egr or CRE sites failed to inhibit the response to zymosan.	Zymosan	149-156	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	20-29	
29509714-9	2018	In conclusion, FTA alleviated zymosan-induced acute peritonitis through inhibition of NF-kappaB activation.	Zymosan	30-37	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	86-95	
21551236-0	2011	Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-kappaB signaling in resident macrophages.	Zymosan	70-77	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	123-132	
21104307-6	2011	Deletion on the CCAAT-enhancer binding protein (C/EBP) and nuclear factor kappa B (NF-kappa B) binding site resulted in an important decrease in reporter gene activity and a deletion of NF-kappa B and C/EBP with mutation of the cyclic adenosine monophosphate response element (CRE) and/or activator protein-1 totally abolished the reporter gene activity induced by zymosan.	Zymosan	365-372	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	59-81	
21104307-6	2011	Deletion on the CCAAT-enhancer binding protein (C/EBP) and nuclear factor kappa B (NF-kappa B) binding site resulted in an important decrease in reporter gene activity and a deletion of NF-kappa B and C/EBP with mutation of the cyclic adenosine monophosphate response element (CRE) and/or activator protein-1 totally abolished the reporter gene activity induced by zymosan.	Zymosan	365-372	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	83-93	
21104307-6	2011	Deletion on the CCAAT-enhancer binding protein (C/EBP) and nuclear factor kappa B (NF-kappa B) binding site resulted in an important decrease in reporter gene activity and a deletion of NF-kappa B and C/EBP with mutation of the cyclic adenosine monophosphate response element (CRE) and/or activator protein-1 totally abolished the reporter gene activity induced by zymosan.	Zymosan	365-372	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	186-196	
22915067-2	2012	The binding of zymosan with its specific Toll-like receptors (TLR2 and TLR6) on leukocytes initiates activation and phosphorylation of nuclear factor (NF)-kappaB, which leads to accumulation of NF-kappaB p65 subunits in the nucleus and subsequently up-regulation of the proinflammatory cytokine genes expression.	Zymosan	15-22	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	135-161	
17122962-16	2006	Moreover, the incubation of mice peritoneal macrophages with TNTP (100 mug/ml) inhibited zymosan (500 microg/ml)-induced NFkappaB translocation into the nucleus 6 h after stimulation.	Zymosan	89-96	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	121-129	
19699788-8	2009	This was achieved through the down-regulation of IKKalphabeta, IkappaBalpha, NF-kappaB activation via suppression of c-Raf-1/MEK1/2 (Mitogen-activated protein kinase/ERK kinase) and MAP kinase phosphorylation in the zymosan-induced mice air-pouch and Raw 264.7 cells.	Zymosan	216-223	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	77-86	
17122962-3	2006	Western blot analysis was performed to analyze nuclear factor-kappaB (NFkappaB) translocation in mice peritoneal macrophages stimulated in vitro with zymosan (500 microg/ml).	Zymosan	150-157	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	47-68	
17122962-3	2006	Western blot analysis was performed to analyze nuclear factor-kappaB (NFkappaB) translocation in mice peritoneal macrophages stimulated in vitro with zymosan (500 microg/ml).	Zymosan	150-157	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	70-78