PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29110153-0 2018 Protection by mTOR Inhibition on Zymosan-Induced Systemic Inflammatory Response and Oxidative/Nitrosative Stress: Contribution of mTOR/MEK1/ERK1/2/IKKbeta/IkappaB-alpha/NF-kappaB Signalling Pathway. Zymosan 33-40 mechanistic target of rapamycin kinase Rattus norvegicus 14-18 29110153-3 2018 In this study, we examined the role of mTOR in the production of proinflammatory and vasodilator mediators in zymosan-induced non-septic shock model in rats. Zymosan 110-117 mechanistic target of rapamycin kinase Rattus norvegicus 39-43 29110153-9 2018 ), a selective mTOR inhibitor, reversed these zymosan-induced changes in these tissues. Zymosan 46-53 mechanistic target of rapamycin kinase Rattus norvegicus 15-19 29110153-10 2018 These observations suggest that activation of mTOR/MEK1/ERK1/2/IKKbeta/IkappaB-alpha/NF-kappaB signalling pathway with proinflammatory and vasodilator mediator formation and NADPH oxidase system activity contributes to systemic inflammation in zymosan-induced non-septic shock. Zymosan 244-251 mechanistic target of rapamycin kinase Rattus norvegicus 46-50