PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19276356-1	2009	p21 loss has been implicated in conferring oncogenic activity to known tumor suppressor gene KLF4 and cancer drug tamoxifen.	Tamoxifen	114-123	H3 histone pseudogene 16	Homo sapiens	0-3	
23361053-2	2013	The p21-regulated serine/threonine kinase PAK1, implicated in tamoxifen resistance, phosphorylates EBP1 in vitro and in vivo at T261.	Tamoxifen	62-71	H3 histone pseudogene 16	Homo sapiens	4-7	
22589186-6	2012	Furthermore, we show that Tam- and siE6AP-mediated inhibition of E6AP leads to enhanced G0-G1 growth arrest and apoptosis, which is also evident from significant upregulation of cytochrome-c, Bax, p21, and PARP cleavage.	Tamoxifen	26-29	H3 histone pseudogene 16	Homo sapiens	197-200	
21922150-9	2012	Treatment of PA-1 cells with 10 microM tamoxifen resulted in an increase             in the levels of p21, p27, p16 and phospho-pRb, indicating typical G1 arrest.	Tamoxifen	39-48	H3 histone pseudogene 16	Homo sapiens	102-105	
20086099-8	2010	It has been known that p21 is required for a proper tamoxifen response in breast cancer.	Tamoxifen	52-61	H3 histone pseudogene 16	Homo sapiens	23-26	
20086099-9	2010	We show that the overexpression of 14-3-3tau inhibits tamoxifen-induced p21 induction and growth arrest in MCF7 cells.	Tamoxifen	54-63	H3 histone pseudogene 16	Homo sapiens	72-75	
10661763-4	1999	In this model, TAM resistance resulted in an increase in the detectable basal levels of cyclin E, GADD 153, p16, BAX, Bcl-XL, and wild-type and mutant p53, an increase in TAM induction of p16, and a decrease in the detectable basal levels of cyclin D1, p21 and p27.	Tamoxifen	15-18	H3 histone pseudogene 16	Homo sapiens	253-256	
14633737-9	2003	Treatment with Let, Tam, or E2W resulted in a dose- and time-dependent increase in active caspase-7 and up-regulation of p53 and p21 protein.	Tamoxifen	20-23	H3 histone pseudogene 16	Homo sapiens	129-132	
10661763-6	1999	In the TAM-resistant variant, p21 levels were essentially undetectable, while p27 was present and maintained its response to TAM Induction, albeit at a much lower level.	Tamoxifen	7-10	H3 histone pseudogene 16	Homo sapiens	30-33	
32722075-8	2020	In addition, LY and TAM combination induced the apoptotic genes Caspase-3, Caspase-7, and p53, as well as p21 as cell cycle promotor, and significantly downregulated the anti-apoptotic genes Bcl-2 and survivin.	Tamoxifen	20-23	H3 histone pseudogene 16	Homo sapiens	106-109	
9199341-2	1997	Addition of estradiol relieves the cell cycle block created by tamoxifen treatment, leading to marked activation of cyclin E-cdk2 complexes and phosphorylation of the retinoblastoma protein within 6 h. Cyclin D1 levels increase significantly while the levels of cyclin E, cdk2, and the p21 and p27 cdk inhibitors are relatively constant.	Tamoxifen	63-72	H3 histone pseudogene 16	Homo sapiens	286-289	
27432642-6	2016	The present study also demonstrated that combinational treatment is more effective in inducing G1 phase arrest and activating apoptosis compared tamoxifen alone, which may be due to upregulation of P21 expression and downregulation of the B-cell CLL/lymphoma 2(Bcl-2)/Bcl-2 associated X protein ratio.	Tamoxifen	145-154	H3 histone pseudogene 16	Homo sapiens	198-201	
30628639-0	2019	Long non-coding RNA UCA1 confers tamoxifen resistance in breast cancer endocrinotherapy through regulation of the EZH2/p21 axis and the PI3K/AKT signaling pathway.	Tamoxifen	33-42	H3 histone pseudogene 16	Homo sapiens	119-122	
25595558-7	2015	Consistent with this observation in SK-MEL28 cells, Sp1 was necessary for the tamoxifen-regulated  Raf-1:ER to induce p21(CIP1) transcription in U251 cells, in which TP53 is mutated.	Tamoxifen	78-87	H3 histone pseudogene 16	Homo sapiens	118-121